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Granulomatous lobular mastitis treated by a combined internal and external treatment of traditional Chinese medicine:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4748-4754页

作者： tian Meng Mei-Ling Chu Bing Wang Mei-na Ye Yi-Qin Cheng Hong-Feng Chen Department of Breast Surgery Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

BACKGROUND Granulomatous lobular mastitis(GLM)is a rare benign inflammatory disease of the breast and is classified under comedo mastitis in traditional Chinese medicine(TCM).The etiology of this disease is unknown,and it mainly occurs in women of childbearing *** diagnosis depends on histopathological *** present,there is no systematic and standardized treatment plan for *** the absence of evidence supporting an infectious etiology,affected patients might continue to receive multiple courses of antibiotics and unnecessary *** SUMMARY A 37-year-old Chinese woman with a history of coronavirus disease 2019 infection presented with swelling and pain in the left *** also had erythema,nodules in the lower extremities,arthritis in both knees,cough,and *** the early stage of GLM,the mass was not significantly reduced by conservative treatment with internal application of TCM;hence,surgical treatment was carried *** aim of postoperative treatment was to drain the pus,eliminate the necrosed tissue,and expand the muscles;fumigation and washing using TCM was *** Combined internal and external treatment with TCM,following the principle of“Prioritize internal treatment before ulceration and emphasize external treatment after ulceration”was effective in our patient with *** prognosis was *** believe that TCM offered valuable therapeutic benefits in this disease.

关键词： Granulomatous mastitis Traditional Chinese medicine Erythema Nodules in the lower extremities Arthritis in both knees Cough and headache Case report

Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-na MENG Yu-He ZHOU Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN Yan-Qing WANG De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

基于Dna指纹图谱的水牛角真伪及掺杂鉴别方法研究

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中国中药杂志 2024年第7期49卷 1826-1833页

作者：熊辕陈天韵张恬田娜蒋超中国中医科学院、中药资源中心、道地药材品质保障与资源持续利用全国重点实验室北京100700

是否存在掺杂是中药鉴定的难点问题。水牛角主要以水牛角丝或水牛角粉2种形态流通于药材市场,缺乏明显的鉴定特征,存在掺杂风险。然而目前水牛角的掺杂鉴定方法缺失。为解决中药水牛角的真伪及掺杂问题,控制药材水牛角的质量,保证临床... 详细信息

是否存在掺杂是中药鉴定的难点问题。水牛角主要以水牛角丝或水牛角粉2种形态流通于药材市场,缺乏明显的鉴定特征,存在掺杂风险。然而目前水牛角的掺杂鉴定方法缺失。为解决中药水牛角的真伪及掺杂问题,控制药材水牛角的质量,保证临床用药的真实性。使用Dna指纹图谱对来自药材企业和药材市场的43批样品进行鉴定,筛选出可鉴定水牛角和牦牛角的荧光Dna指纹图谱扩增引物,利用荧光毛细管分型技术获得水牛角的Dna指纹图谱。并检测了荧光毛细管分型技术对不同掺杂比例的鉴别效果。筛选出了2对可区分水牛角和牦牛角的荧光STR分型引物16Sa和CRc,建立Dna指纹图谱鉴别方法,牦牛角16Sa迁移峰为223.4~223.9 bp、水牛角为225.5~226.1 bp,牦牛角CRc迁移峰为518.8~524.8 bp、水牛角为535.9~542.5 bp。通过迁移峰的峰高可对掺伪比例在50%以下的掺杂品进行初步定量,定量结果与掺入比例相似。该研究建立了一种简单快捷,可用于中药水牛角及其掺杂品的通用Dna指纹图谱鉴别方法,能够实现对药材水牛角鉴定的同时对掺杂品进行半定量。

关键词：水牛角掺杂 Dna指纹图谱 STR分型分子鉴别动物药

数字经济发展对企业创新能力的影响——基于我国A股上市公司的经验证据

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技术经济与管理研究 2024年第2期 49-55页

作者：屈天佑李娜渤海大学经济学院辽宁锦州121000

选取2013—2020年中国A股上市公司的样本数据,实证检验数字经济发展对上市公司创新水平的影响以及内在作用机制。研究发现:数字经济的发展显著促进了企业的创新活动,对创新数量和创新质量的影响均非常显著。同时,数字经济的发展不仅促... 详细信息

选取2013—2020年中国A股上市公司的样本数据,实证检验数字经济发展对上市公司创新水平的影响以及内在作用机制。研究发现:数字经济的发展显著促进了企业的创新活动,对创新数量和创新质量的影响均非常显著。同时,数字经济的发展不仅促进了企业单独的创新活动,也提升了企业间联合创新的水平。且在考虑稳健性与内生性后结果依然显著成立。机制分析发现,数字经济主要通过增加研发投入和缓解融资约束两种渠道来促进企业创新。进一步研究发现,数字经济对民营企业的创新促进作用优于国有企业;数字经济对制造业行业的创新质量和创新数量的提升都起到了显著的促进作用,而对其他行业的促进效果不显著;相比于大型企业,数字经济对中小型企业创新质量的促进作用更为明显。

关键词：数字经济融资约束创新质量创新数量

Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 24-30页

作者： tian Jing ZHANG Wei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China national Key Laboratory of Electromagnetic Space Security Chengdu 610036China

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial *** the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation *** cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range *** principle is presented,and the validity is proven by simulation results.

关键词： adaptive radar beamforming training sample selection non-homogeneous detector electronic jamming jamming suppression

Transformer and GAN-Based Super-Resolution Reconstruction Network for Medical Images

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Tsinghua Science and Technology 2024年第1期29卷 197-206页

作者： Weizhi Du Shihao tian Arts&Sciences College Washington University in St.LouisSt.LouisMO 63130USA Department of Electric and Computing Engineering Cornell UniversityIthacaNY 14850USA

Super-resolution reconstruction in medical imaging has become more demanding due to the necessity of obtaining high-quality images with minimal radiation dose,such as in low-field magnetic resonance imaging(MRI).However,image super-resolution reconstruction remains a difficult task because of the complexity and high textual requirements for diagnosis *** this paper,we offer a deep learning based strategy for reconstructing medical images from low resolutions utilizing Transformer and generative adversarial networks(T-GANs).The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture ***,we weighted the combination of content loss,adversarial loss,and adversarial feature loss as the final multi-task loss function during the training of our proposed model *** comparison to established measures like peak signal-to-noise ratio(PSNR)and structural similarity index measure(SSIM),our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly.

关键词： super-resolution image reconstruction Transformer generative adversarial network(GAN)

Clinical research progress on acupuncture for the treatment of otogenic vertigo

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World Journal of Clinical Cases 2024年第19期12卷 3676-3683页

作者： An-na Yi Ge Yang Jia-Xin Wang Li-Qiong Zhang Peng Yuan Jing-tian Hong Lei Zhou Department of Acupuncture Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Chinese MedicineJinhua 321000Zhejiang ProvinceChina Department of Acupuncture Beijing Hospital of Integrated Traditional Chinese and Western MedicineBeijing 100089China Pain Rehabilitation Department Yongkang Orthopedic HospitalYongkang 321300Zhejiang ProvinceChina Department of Traditional Chinese Medicine and Surgery Fujian University of Traditional Chinese MedicineFuzhou 350108Fujian ProvinceChina Department of Orthopedics and Traumatology of Traditional Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Traditional Chinese Medicine Lanxi People's HospitalLanxi 321100Zhejiang ProvinceChina

Otogenic vertigo is a common disorder that affects the vestibular system,which often results in considerable discomfort and impaired daily *** Chinese medicine(TCM),including acupuncture and moxibustion,has been historically utilized to manage the symptoms of ***,the effectiveness and methodology of these treatments have rarely been investigated in the medical *** study reviews the existing literature on the point selection,method,and therapeutic effect of acupuncture and moxibustion to provide a reference for the TCM treatment of otogenic vertigo.A literature search was performed using the PubMed search *** terms used included otogenic vertigo,acupuncture treatment,and acupuncture point selection.A total of 34 relevant articles were retrieved from *** suggest that the clinical treatment of otogenic vertigo should consider the functions of zang-fu organs and meridians and select different acupuncture treatment methods according to syndrome differentiation based on the difference between deficiency and *** and moxibustion therapy should be based on acupoint selection,considering the syndrome differentiation,supplemented with *** treatment of otogenic vertigo with acupuncture and moxibustion refers to the selection of appropriate acupuncture methods under the guidance of TCM theory and following the principles of syndrome,disease,and meridian *** acupuncture methods include body acupuncture,auricular acupuncture,scalp acupuncture,acupoint injection,electroacupuncture,and *** are many acupuncture and moxibustion acupoints selected for the treatment of otogenic *** treatment according to the patient’s specific condition is effective and safe,which can help to improve the patient’s vertigo symptoms and cerebral blood perfusion.

关键词： Otogenic vertigo Acupuncture treatment Acupuncture point selection Review

Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO Zi Jin CHEN Xiao Ping HUA Shao Wei LI Feng Yu ZHAO Meng XING Chen Hao WANG Jie tian Feng Yu ZHANG Rui Qing LYU Xiao na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin MA Xue Jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China national Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic Center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei Medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification *** study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(M1 protein)-conjugated magnetic bead(M1 bead)enrichment of pathogens combined with *** Recombinant plasmids were used to evaluate the assay *** blood influenza bacteria were used for the specific *** and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR(M-RAP)and quantitative PCR(qPCR)*** analysis was used to evaluate the consistency between the two *** The M-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of SA,PA,and AB plasmids,respectively,without cross-reaction to other bacterial *** M-RAP assay obtained results for<10 CFU/mL pathogens in the blood within 4 h,with higher sensitivity than qPCR.M-RAP and qPCR for SA,PA,and AB yielded Kappa values of 0.839,0.815,and 0.856,respectively(P<0.05).Conclusion An M-RAP assay for SA,PA,and AB in blood samples utilizing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human Mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay Multiple detection

CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu Wang Yinmei tian tian tian Yuanyuan Guo Hu Zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China national Engineering Research Center for nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2