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Study on improving hematopoietic function of rats with blood deficiency syndrome by Shengxuebao mixture

Traditional Medicine Research 2024年第8期9卷 35-46页

作者： Yan Shu Hong-na Liu Yang Zhao Jin-Yi Cao Yue Chen Yi Qiao Hui guo Zhi-Fu Yang College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Tsing Hua De Ren Xi’an Happiness Pharmaceutical Co. Ltd.Xi’an 710400China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710000China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of PharmacySchool of Stomatologythe Fourth Military Medical UniversityXi’an 710000China

Background:Shengxuebao mixture(SXBM)is a novel herbal drug approved by China State Food and Drug Administration for the treatment of Leukopenia and iron deficiency anemia caused by radiotherapy and ***:To explore the mechanism of SXBM in treating blood deficiency syndrome(BDS).Firstly,network pharmacology and in vivo experiments were used to screen candidate targets and important signaling pathways of SXBM,GO functional enrichment and KEGG pathway analysis were ***,a BDS rat model was established to verify the results of the analysis of network pharmacological *** and routine peripheral blood examination were *** expressions of tumor necrosis factor-α,interleukin(IL)-6,HIF-1αand NF-κB were detected by Western blot,and the expressions of IL-6,IL-1βwere detected by ***:62 bioactive components,66 potential targets and 131 signaling pathways of BDS were successfully identified by network *** docking simulation techniques showed that key targets tumor necrosis factor-α,IL-6,IL-1βcan dock well with crucial components,and the BDS-related signaling pathways HIF-1 and JAK-STAT play a vital *** combined model experiment of acetylphenylhydrazine and cyclophosphamide showed that the model group had obvious blood deficiency,and the histopathology and blood routine were effectively restored after *** findings indicate that SXBM’s therapeutic effect on BDS primarily involves the mediation of the HIF-1α/NF-κB signaling pathway and the regulation of hematopoietic factor ***:This study not only affirmed the protective properties of SXBM against BDS but also provided insights into a potential mechanism for blood replenishment in the treatment of BDS using SXBM.

关键词： network pharmacology molecular docking technology blood deficiency syndrome hematopoietic factors HIF-1α/NF-κB

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Gestational diabetes mellitus combined with fulminant type 1 diabetes mellitus, four cases of double diabetes: A case report

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World Journal of Clinical Cases 2024年第4期12卷 787-794页

作者： Hui Li Yun Chai Wei-Hong guo Yu-Meng Huang Xiao-na Zhang Wen-Li Feng Qing He Jin Cui Ming Liu Department of Endocrinology and Metabolism Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose ***,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed *** patients were diagnosed with GDM during the second trimester and were *** blood glucose level elevated suddenly during the third trimester and then were diagnosed with *** patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before *** patient developed ketoacidosis,and three developed *** patients had cesarean section deliveries,and two had vaginal *** growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet *** frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present *** In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less *** pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA *** speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.

关键词： Fulminant type 1 diabetes mellitus Gestational diabetes mellitus Pregnancy-related fulminant type 1 diabetes mellitus Double diabetes Case report

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The Uptake and Distribution Evidence of nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

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Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： HONG Tao SUN Wei DENG Yuan LYU Jian Da JIN Cui Hong BAI Ying Long na Jun ZHANG Rui GAO Yuan PAN guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain Management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(Pnano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

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Innovations in metallurgical and materials processes:advancing liquid theory and honoring ***-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research International 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,***-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of *** under the assumption that molecul... 详细信息

关键词： chemistry liquid complexes

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Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming Wang Hong-Wei Tao Feng-Chan Wang Ping Han na Liu guo-Jing Zhao Hai-Bo Hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFJT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFJT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFJT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFJT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFJT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Results showed significant therapeutic effects of MFJT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation results that MFJT treatment induced apoptosis(downregulated Bcl-2 levels and upregulated Bax levels in lung tissue),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and superoxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERK1/2 phosphorylation,increased GSK3βlevels).Conclusion:Our study revealed MFJT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

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藏式古建筑木梁-石墙节点弯矩-转角力学模型

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建筑结构学报 2024年第9期45卷 240-252页

作者：崔玥杨娜郭婷北京交通大学土木建筑工程学院北京100044 中冶检测认证有限公司北京100088

藏式古建筑中木梁与石墙洞口呈简单搭接关系,该类木梁-石墙节点连接薄弱,震坏风险高。以藏式古建筑中的木梁-石墙节点为研究对象,分析其建造过程,剖析其受力机制,给出正反向转动过程中的受力状态判定条件,建立了木梁-石墙节点的弯矩-转... 详细信息

藏式古建筑中木梁与石墙洞口呈简单搭接关系,该类木梁-石墙节点连接薄弱,震坏风险高。以藏式古建筑中的木梁-石墙节点为研究对象,分析其建造过程,剖析其受力机制,给出正反向转动过程中的受力状态判定条件,建立了木梁-石墙节点的弯矩-转角力学模型;通过与有限元模型的对比分析,验证该力学模型的准确性。研究结果表明:建造过程中木梁头顶面与墙洞口之间存在缝隙;木梁-石墙节点的转动过程分为自由转动状态(木梁头在洞口内小幅度自由转动),临界状态(木梁头顶面、底面均与墙洞口接触),挤压状态(木梁顶面、底面弹性变形,木梁头顶面木材嵌压屈服,木梁头底面木材嵌压屈服)等3部分;根据所提木梁-石墙节点力学模型实现算法可快速完成实际节点的弯矩-转角关系计算;理论计算的木梁-石墙节点弯矩-转角曲线与有限元模拟曲线吻合较好,初始刚度误差小于30%,峰值荷载误差小于10%。

关键词：藏式古建筑木梁-石墙节点力学模型数值模拟弯矩-转角关系

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To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： Dou-Dou Lu Ling Yuan Zhao-Zhao Wang Jian-Jun Zhao Yu-Hua Du na Ning guo-Qing Chen Shi-Cong Huang Yi Yang Zhe Zhang Yi nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 ***,the mechanism of its anti-gastric cancer and regulate immunity are still remains *** To explore the mechanism of YGS anti-gastric cancer and immune *** Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric ***,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub *** the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were ***,molecular docking was used to verify the binding ability of YGS active ingredient and hub *** Firstly,obtained 55 common targets of gastric cancer and *** Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub *** 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer ***,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic *** YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer Yigong San Mechanism Immune

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音乐特藏资源的收藏与研究——以美国耶鲁大学欧文·吉尔摩音乐图书馆为例

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人民音乐 2024年第7期 81-85页

作者：郭娜中央音乐学院

特藏(Special Collections),是一个在图书馆学、文献学、情报学领域中具有特定含义的概念。美国研究图书馆协会(ARL)将其定义为以稀有书籍、手稿、照片和档案等形式存在的馆藏,具有历史性、珍稀性、独特性等特点,可为教学研究、学术发... 详细信息

特藏(Special Collections),是一个在图书馆学、文献学、情报学领域中具有特定含义的概念。美国研究图书馆协会(ARL)将其定义为以稀有书籍、手稿、照片和档案等形式存在的馆藏,具有历史性、珍稀性、独特性等特点,可为教学研究、学术发展和文化传承提供不可或缺的资源支撑。^(1)音乐特藏资源作为特藏范畴下的一个分支,主要是指图书馆、音乐机构或相关学术单位中特别收集、整理、保存并管理的,以音乐为主题或相关内容的、珍贵的、具有特殊价值的文献资料。

关键词：学术单位特藏资源音乐图书馆情报学领域图书馆学美国耶鲁大学美国研究图书馆协会特定含义

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淮河生态经济带极端天气变化对粮食生产影响研究

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长江流域资源与环境 2024年第5期33卷 1099-1109页

作者：郭利京金娜安徽财经大学经济学院安徽蚌埠233030

随着全球气候变化速度加快,高温、暴雨、干旱、低温等极端天气频发增加了农业气象灾害的发生频率,给粮食产量稳定供给带来了巨大的挑战。基于淮河生态经济带28个地市2001~2020年日气温、降雨气象数据和农业生产相关数据,利用广义最小二... 详细信息

随着全球气候变化速度加快,高温、暴雨、干旱、低温等极端天气频发增加了农业气象灾害的发生频率,给粮食产量稳定供给带来了巨大的挑战。基于淮河生态经济带28个地市2001~2020年日气温、降雨气象数据和农业生产相关数据,利用广义最小二乘法(FGLS)研究淮河生态经济带极端天气变化及其对粮食生产的影响。结果表明:(1)从时间趋势上看,极高温日数(SU35)呈现增长趋势、极低温日数(FD5)呈现下降趋势,年际倾向率分别为1.85、-2.24 d/10a,暴雨日数(R50)以及最长连续无降水日数(CDD)年际变化趋势不明显;从空间区域分布上看,淮河生态经济带中西部地区极高温日数较多、北部地区极低温日数较多,暴雨日数呈现由东部向中西部再到北部地区减少的趋势、最长连续无降水日数呈现相反变动趋势。(2)极端天气对粮食生产具有显著不利影响。极低温日数、极高温日数、最长连续无降水日数、暴雨日数每增加1%,粮食单产分别下降0.069%、0.021%、0.018%、0.008%。(3)极端天气对淮河生态经济带粮食生产影响具有区域异质性。极端天气主要影响中西部地区和北部地区的粮食生产,对东部地区粮食生产影响不显著。提出通过培育抗旱抗涝等作物新品种、提高极端天气变化监测能力、加强区域内政府间防灾减灾等协同联动、继续加强高标准农田建设等措施,维护淮河生态经济带粮食产量稳定。

关键词：极端天气自然灾害粮食产量淮河生态经济带

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Recurrent multisystem Langerhans cell histiocytosis involving the female genitalia: A case report

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World Journal of Clinical Cases 2024年第28期12卷 6222-6229页

作者： Chun-Yan Yuan Zhi-Rong Zhang Ming-Fang guo na Zhang Department of Gynaecology Fengdu People's HospitalChongqing 408200China Department of Gynecologic Oncology Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing University Cancer HospitalChongqing Cancer InstituteChongqing Cancer HospitalChongqing 400030China

BACKGROUND Langerhans cell histiocytosis(LCH)is a histiocytic proliferative disease caused by clonal proliferation of Langerhans cells,which is currently defined as an inflam-matory myeloid *** is rare in adults,with an incidence of 1–2 per million,and is highly heterogeneous in clinical presentation,with unpredictable disease progression and *** SUMMARY A 52-year-old postmenopausal female patient presented to the gynecology department in July 2023 with bilateral vulvar *** was diagnosed with recurrent multisystem *** patient had previously been diagnosed with a single-system and single-focal LCH in October 2021 due to a right maxillofacial mass,which resolved after surgical treatment.A chemotherapy regimen was developed after multidisciplinary *** cycles of chemotherapy resulted in partial remission,and maintenance chemotherapy is currently being *** Recurrent LCH involving the bilateral vulva has been poorly ***-hensive imaging and pathological evaluation is important for *** model of joint multidisciplinary specialist diagnosis and treatment is worthy of clinical application.

关键词： Langerhans cell histiocytosis Chemotherapy Vulva Recurrence Case report

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