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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

2011年全国药物化学学术会议——药物的源头创新

作者： na-na du~+,zong-gen peng~+,yan-xin liu,jian-rui li,li-mei gao,chong-wen bi,yan-xing han,yan-xiang wang,zhou-yi wu,jian-dong jiang,~* dan-qing song~* institute of medicinal biotechnology,chinese academy of medical science and peking union medical college,no.2 nanwei road,xuanwu district,beijing 100050,china.

Host heat shock cognate protein 70(Hsc70) plays an important role in HCV replication, and it has been demonstrated to be a novel target against HCV.N-p-methoxybenzyl matrinic acid(1) was found to be an effective Hsc70 down-regulator with good *** using 1 as the lead, twenty-two analogues were synthesized and evaluated for their anti-HCV activity in *** SAR analysis revealed that 1)the benzyl group at the 12-N atom was necessary for activity;2) introduction of electron-drawing substituents might significantly enhance the *** compounds were studied for their safe and pharmacokinetic studies in vivo,among which compounds 8c and 8m exhibited greater anti-HCV activity(SI>23) than that of *** addition,both of them showed good safety(LD>1000 mg/kg) and oral *** consider 8c and 8m to be promising anti-HCV drug candidates for further investigation.

关键词： Hsc70 anti-HCV N-substituted matrinic acid

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-yi Su Sun-bin ling Qiao-nan Shan Xu-Yong Wei rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-dan Xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang nan jiang Kun Zhang Zhao-Jie Su Zhi-Hai peng Ren Lang Tao jiang Qiang He lin-Sen Ye yang yang Yu-Ting He wen-Zhi Guo liu-gen Lan Xu-Yong Sun dong Chen Zhi-Shui Chen Da-Wei zhou Shao-Jun Ye Qi-Fa Ye Min Tian jian-Hua Shi Bo wang jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-yin yang Pu-Sen wang lin Zhong Jing-Sheng Ma Qi-gen li Sheng-dong wu Chang-jiang Lu Cai-De Lu dong-Hua Zhang Xuan wang Zi-Qiang li Mu-jian Teng Jun-Jie li wen-Tao jiang jian-Hua li Quan-Bao Zhang Ning-Qi Zhu Zheng-xin wang Kang He Qiang Xia Shao-Hua song Zhi-Ren Fu Wei Qiu Guo-Yue Lv rui-peng song Ji-zhou wang Zheng wang jian zhou Gang Chen ying-peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-zhou Si bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of general Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China institute of Hepatobiliary Diseases of wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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biomarkers of aging

science china.life sciences) 2023年第5期66卷 893-1066页

作者： Aging biomarker Consortium Hainan Bao jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping jiang ying Jing Dingfeng li Jiaming li Jingyi li Qinhao liang rui liang Feng liu Xiaoqian liu Zuojun liu Oscar Junhong Luo jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie xinhua Qiao xinpei Sun Xiaoqiang Tang jianfang wang Qiaoran wang Siyuan wang Xuan wang yaning wang Yuhan wang Rimo wu Kai Xia Fu-Hui Xiao lingyan Xu yingying Xu Haoteng yan liang yang ruici yang Yuanxin yang yilin ying Le Zhang Weiwei Zhang wenwan Zhang xing Zhang Zhuo Zhang Min zhou rui zhou qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci bi-Sen Ding Qiurong Ding Feng gao Jing-dong Jhan Kai Huang Zhenyu Ju qing-peng Kong Ji li jian li xin li Baohua liu Feng liu lin liu Qiang liu Qiang liu xingguo liu Yong liu xianghang Luo Shuai Ma xinran Ma Zhiyong Mao Jing Nie Yaojin peng Jing Qu Jie Ren ruibao Ren Moshi song zhou songyang yi Eve Sun Yu Sun mei Tian Shusen wang Si wang Xia wang Xiaoning wang yan-jiang wang Yunfang wang Catherine CL Wong Andy peng xiang yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui liu Aging biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging biology Xiangya HospitalCentral South UniversityChangsha 410008China national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao xiang-Qun Cui Guo-Ping li Yao-Quan Chu jian-Rong Shi Gang wang jian-nan Zhang Zhong-rui Bai Xiao-yan Chen Feng-Fei wang yan-xin Guo jian-Jun Chen bing du Xiao Kong Ya-Juan Lei yin-bi li yi-han song Yue wu yan-Xia Zhang xin-lin zhou Fang Zuo peng du lin He wen Hou yi-Qiao dong jian li Guang-Wei li Shuang li Jing song Yuan Tian Meng-xin wang Yong-Hui Hou Zhi-ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Lei Jia Fang-Hua jiang xiang jiang Zi-Bo jiang Ge Jin Ai-Hua li Qi li yin-dun Mao Zheng-Hong Tang qing-Sheng Tao liang-Ping Tu Da-qing wang dan wang jian-Ping wang Lei wang Shou-Guan wang Shu-qing wang Ya-nan wang You wang Yue-Fei wang Ming-Zhi Wei xiang-xiang Xue Xiao-Zheng xing ling-Zhe Xu xin-Qi Xu yan Xu De-Hua yang Shi-Hai yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-peng Zhang Jing Zhang li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou national Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg nanjing institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of science and Technologyof china Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-Wei liu yi-peng Jing Gang wang Hao-Tong Zhang jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-rui Bai Yue wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-xin Chen li Chen Xue-Lei Chen Xiao-yan Chen ying Chen Norbert Christlieb Jia-Ru Chu Chen-zhou Cui yi-Qiao dong bing du dong-Wei Fan Lei Feng jian-Ning Fu peng gao Xue-Fei Gong Bo-Zhong Gu yan-xin Guo Zhan-wen han Bo-liang He Jin-liang Hou Yong-Hui Hou wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Zhi-ying Huo Lei Jia Fang-Hua jiang xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li xin-nan li yan li yin-bi li Ye-Ping li Yuan liang Chien-Cheng lin Chao liu gen-Rong liu Guan-Qun liu Zhi-Gang liu wen-Zhi Lu Yu Luo yin-dun Mao Heidi Newberg Ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-yin Shen Huo-Ming Shi Jing song yi-han song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang Jia-Ning wang jian-ling wang jian-Ping wang Jun-Xian wang Lei wang Meng-xin wang Shou-Guan wang Shu-qing wang Xia wang Ya-nan wang You wang Yue-Fei wang You-Fen wang peng Wei Ming-Zhi Wei Hong wu Ke-Fei wu Xue-bing wu Yu-Zhong wu Xiao-Zheng xing ling-Zhe Xu xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-peng Zhang Hua-Wei Zhang jian-nan Zhang li-Pin Zhang Wei Zhang Yong Zhang yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang zhou Xu zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo national Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences nanjing institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of science and Technology of china Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

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Infectious Diseases of Poverty 2016年第1期5卷 670-679页

作者： Zhong-Jie li wen-Xiao Tu Xiao-Chun wang Guo-qing Shi Zun-dong yin Hai-Jun Su Tao Shen Da-peng Zhang jian-dong li Shan Lv Chun-li Cao rui-Qian Xie Hong-zhou Lu Rong-Meng jiang Zheng Cao Zhi-Jie An Lei-Lei li Jie Xu yan-wen Xiong Wei Zang Wei Zhang Hong-Wei Zhang wen-Sen Chen Hua ling wen Xu jian Cai Huan-Jin Luo Xue-Sheng xing Can-Jun Zheng Qiang Wei xin-Xu li mei li Hai jiang li-Quan Deng Ming-Quan Chen xiang Huo Feng Xu Xue-Hui Lai Xi-Chen Bai Long-Jie Ye jian-yi Yao wen-wu yin Jiao-Jin Sun lin Xiao Fu-Qiang liu Xiao-Qiang liu Hong-Wei Fan Zeng-Qiang Kou Ji-Kun zhou Hao Zhang Da-xin Ni Thomas TSamba Qun li Hong-Jie Yu Yu wang Xiao-Feng liang Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina national Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina national Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Bureau of Disease Prevention and Control National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina national institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina national institute of Parasitic Disease Chinese Center for Disease Control and PreventionShanghaiChina chinese Center for Health Education BeijingChina Department of Infectious Diseases Shanghai Public Health Clinical CenterShanghaiChina beijing Ditan Hospital Capital Medical UniversityBeijingChina Health News BeijingChina national institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Training Chinese Center for Health EducationBeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina Infection Management The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina chongqing Municipal Center for Disease Control and Prevention ChongqingChina Yunnan Provincial Center for Disease Control and Prevention KunmingChina Division of Infectious Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouChina Division of Acute Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and PreventionW

Background:The Ebola virus disease spread rapidly in West Africa in 2014,leading to the loss of thousands of *** engagement was one of the key strategies to interrupt Ebola transmission,and practical community level measures needed to be explored in the field and tailored to the specific context of ***:First,community-level education on Ebola virus disease(EVD)prevention was launched for the community’s social mobilizers in six districts in Sierra Leone beginning in November ***,from January to May of 2015,in three pilot communities,local trained community members were organized to engage in implementation of EVD prevention and transmission interruption measures,by involving them in alert case report,contact tracing,and social *** epidemiological indicators of transmission interruption in three study communities were ***:A total of 6016 community social mobilizers from 185 wards were trained by holding 279 workshops in the six districts,and EVD message reached an estimated 631680 *** three pilot communities,72 EVD alert cases were reported,with 70.8%of them detected by trained local community members,and 14 EVD cases were finally *** tracing detected 64.3%of EVD *** median duration of community infectivity for the cases was 1 *** secondary attack rate was 4.2%,and no third generation of infection was *** health worker was infected,and no unsafe burial and noncompliance to EVD control measures were *** community-based measures were modeled to reduce 77 EVD cases,and the EVD-free goal was achieved four months earlier in study communities than whole country of Sierra ***: The community-based strategy of social mobilization and community engagement was effective in casedetection and reducing the extent of Ebola transmission in a country with weak health system. The successfullypractical experience to reduce the risk of Ebola transmission in the

关键词： Ebola virus disease Community engagement Health education Outbreak control

Consensus statement on layout and delivery of automatic external defibrillator in china

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Journal of Hainan medical University 2020年第15期26卷 18-23页

作者： Yu Cao song Chen yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-wen Cheng wen-Wei Cheng Bang-han Ding yang Deng Jie Fu Bang-jiang Fang Mai-ying Fan li Gui Ping Gong Wei Guo Shu-bin Guo liang Huang Ji-Yuan han Zhong Ji Xian-Fei Ji xin-Cai Ji Hong-Xu Jin xin-Jun jiang wang-xiang jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li xin li Yong li Shang-Lun li Shuang-Ming li Xiao-Gang li Bao-Jun li Pei-wu li Chun-Sheng li Zhi-Jun li Chang-Luo li xiang-Min li yin-Ping li zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-xing liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma qing-bian Ma lin-Hao Ma Jun-Qi Ma Shi-nan Nie Jie-Miao Ou-yang peng peng Qiao Pei Shu-Ming Pan Guo-Zhong qing li-Jie Qin wu-ying Qiao Fei Shao Wei song xing-Yue song Zhen-Ju song Rong-Ju Sun De-Ya Shang du-Juan Sha Gui-Lan Tao Guo-Gang Tian ying-Ping Tian jian-Guang Tian Chao-yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping wu Zhi Wan Tao wang xin wang peng wang Zhong wang Tong wang Ri-xing wang yi-xin wang Xiao-dan wang ling wu Wei Wei Hua xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu wen yi li-Shan yang Shi-Jiao yan Jin-jian Yao Shou-Chun yan Xue-Zhong Yu Xian-Zhi Ye Xian-liang yan Fu-bing zhou Rong-bin zhou Ming zhou Qiang zhou Jin zhou Ping zhou Chang-Ju Zhu Hua-dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-song Zhang wen-wu Zhang wen-Zhong Zhang jian-Feng Zhang yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao yan Zhao Min Zhao bin Zhao Xiao-dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma college Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in china.2].

关键词： cardiac death respiratory

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri donghua Fan 樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev 费政勇 li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio Guardone 郭聪郭竞渊郭万磊 xinheng Guo 郭宇航 Paul Hackspacher Caren Hagner 韩然 yang han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航 jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 Cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil narine Kazarian Amina Khatun Yerevan Physics institute YerevanArmenia Universiélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile beijing institute of Spacecraft Environment Engineering BeijingChina beijing Normal University BeijingChina china.institute of Atomic Energy BeijingChina institute of High Energy Physics BeijingChina North china.Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of chinese academy of sciences BeijingChina Jilin University ChangchunChina college of Electronic science and Engineering National University of Defense TechnologyChangshaChina chongqing University ChongqingChina dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin institute of Technology HarbinChina University of science and Technology of china HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South china HengyangChina wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina institute of Modern Physics Chinese Academy of SciencesLanzhouChina nanjing University NanjingChina Guangxi University NanningChina East china.University of science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee institute Shanghai Jiao Tong UniversityShanghaiChina institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina nankai University TianjinChina wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO