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Idarucizumab reverses dabigatran-induced anticoagulation in treatment of gastric bleeding:A case report

World Journal of Clinical Cases 2022年第8期10卷 2537-2542页

作者： Yu Jia Shao-Hua Wang na-juan cui Quan-Xi Liu Wei Wang Xue Li Ya-Mei Gu Yan Zhu Department of Gastroenterology Hospital of Integrated Traditional Chinese and Western MedicineBeijing 100039China Department of General Practice Tiancun Community Health Service CentreBeijing 100049China

BACKGROUND The drug instructions for dabigatran recommend adjusting the dosage to 110 mg twice daily for patients with bleeding risk,and performing at least one renal function test per year for patients with moderate renal ***,owing to chronic insidiously worsening renal insufficiency,dabigatran can still accumulate abnormally,necessitating therapy with idarucizumab to reverse the anticoagulation due to severe erosive gastritis with widespread stomach mucosal *** SUMMARY A 76-year-old woman with a history of atrial fibrillation who took dabigatran 110 mg twice daily as directed to lessen the chance of stroke,was transported to the hospital with hematemesis and *** findings revealed severe lifethreatening,blood-loss-induced anemia with a hemoglobin(Hb)level of 41.0 g/L and marked coagulation abnormalities with thrombin time(TT)>180 s,most likely caused by dabigatran-induced metabolic *** acid suppressive,hemostatic,and blood transfusion therapy resulted in the misconception that the bleeding was controlled,with subsequent *** was administered in a timely manner to counteract dabigatran’s anticoagulant impact,and 12 h later,TT was determined to be 17.4 s,which was within the normal ***,the patient had no active bleeding signs and laboratory findings showed an Hb level of 104 g/L and TT of 17.7 *** Renal function,coagulation function,and dabigatran concentration should be regularly monitored in older *** pump inhibitor and dabigatran coadministration is still controversial in preventing upper gastrointestinal tract bleeding.

关键词： Idarucizumab Dabigatran Gastric bleeding Atrial fibrillation Case report

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Enhancing output performance of triboelectric nanogenerator by increasing charge storage capacity of electrodes

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nano Research 2025年第1期18卷 395-403页

作者： Congcong Hao Zekun Wang Mingzhe Cai Shuaining Cheng Zhongxin Wang Cong Zhai juan cui Yongqiu Zheng Chenyang Xue Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of Education North University of ChinaTaiyuan 030051China

ABSTRACT:The practical application of rotating triboelectric nanogenerators is often limited by the wear of high-friction surface materials and low surface charge *** addition to the charge pump replenishment strategy,suppressing charge decay is also crucial for increasing surface charge ***,we present a high performance rotary triboelectric nanogenerator(HPR-TENG)based on a coplanar charge pumping strategy and polyvinyl chloride(PVC)*** has been demonstrated that applying PVC film to the surface of the storage electrode of the main TENG(M-TENG)significantly enhances the M-TENG’s output ***,the HPR-TENG with three layers of PVC film pasted achieved the best output performance,with a peak-topeak output voltage of 2828 V,a peak-to-peak output current of 327μA and a charge transfer of 0.81μC at 500 *** addition,the output improvement effects of different materials are *** TENG with 3 layers of PVC film pasted on it has a maximum output power of 748 mW at a load resistance of 4×10^(6)Ω.HPR-TENG’s output performance remains consistent after 100,000 cycles,which shows excellent *** excellent electrical performance of the HPR-TENG can be used as the energy supply for the tip high-voltage breakdown sensor system,which can achieve 14 breakdowns in 10 *** to its extraordinary electrical performance,HPRTENG can not only serve as an energy supply for cutting-edge high-voltage breakdown sensor systems,but also has the potential to serve as an energy supply for high-pressure sterilization,high-pressure vacuum and water electrolysis.

关键词： triboelectric nanogenerator coplanar charge pump enhancing charge density suppressing charge decay polyvinyl chloride(PVC)film

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EMPIRICAL LIKELIHOOD CONFIDENCE REGION FOR PARAMETERS IN LINEAR ERRORS-IN-VARIABLES MODELS WITH MISSING DATA

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Journal of Systems Science & Complexity 2011年第3期24卷 540-553页

作者： juan ZHANG Hengjian cui Department of Statistics Capital University of Economics and Business Beijing 100070 China. Department of Statistics and Financial MatheTnatics School of Mathematical Sciences Beijing Normal University Beijing 100875 China School of Mathematical Sciences Capital Normal University Beijing 100048 China

The multivariate linear errors-in-variables model when the regressors are missing at random in the sense of Rubin （1976） is considered in this paper. A constrained empirical likelihood confidence region for a parameter β0 in this model is proposed, which is constructed by combining the score function corresponding to the weighted squared orthogonal distance based on inverse probability with a constrained region of β0. It is shown that the empirical log-likelihood ratio at the true parameter converges to the standard chi-square distribution. Simulations show that the coverage rate of the proposed confidence region is closer to the nominal level and the length of confidence interval is narrower than those of the normal approximation of inverse probability weighted adjusted least square estimator in most cases. A real example is studied and the result supports the theory and simulation＇s conclusion.

关键词： Confidence region coverage rate empirical likelihood ratio multivariate linear errors-in- variables model weighted adjusted LS estimation.

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C-reactive protein aggravates myocardial ischemia/reperfusion injury through activation of extracellular-signal-regulated kinase 1/2

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Journal of Geriatric Cardiology 2018年第7期15卷 502-513页

作者： Wei-na PEI Hai-juan HU Fan LIU Bing XIAO Ya-Bei ZUO Wei cui Department of Cardiology Second Hospital of Hebei Medical University and Institute of Cardiocerebrovascular Disease of Hebei Province Shijiazhuang Hebei China

Background Ischemia/reperfusion injury （IRI） is an inflammatory response that occurs when tissue is reperfused following a prolonged period of ischemia. Several studies have indicated that C-reactive protein （CRP） might play an important role in inducing IRI. However, the effects of CRP on myocardial IRI and the underlying mechanisms have not been fully elucidated. This study aimed to investigate the association between CRP and myocardial IRI and the underlying mechanisms. Methods We simulated ischemia/reperfusion using oxygen-glucose deprivation/ reoxygenation （OGD/R） in neonatal Sprague-Dawley rat cardiomyocytes; reperfusion injury was induced by three hours of hypoxia with glucose and serum deprivation followed by one hour of reperfusion. Cell viability was tested with MTS assays, and cardiomyocyte damage was evaluated by lactate dehydrogenase （LDH） leakage. Mitochondrial membrane potential was measured using tetramethylrhodamine ethyl ester （TMRE） and mitochondrial permeability transition pore （mPTP） opening was measured using calcein/AM; both TMRE and caocein/AM were visualized with laser scanning confocal microscopy. In addition, we studied the signaling pathways underlying CRP-mediated ischemia/reperfusion injury via Western blot analysis. Results Compared with the simple OGD/R group, after intervention with 10 pg/mL CRP, cell viability decreased markedly （82.36 % ± 6.18% vs. 64.84% ± 4.06%, P = 0.0007）, and the LDH leakage significantly increased （145.3 U/L ± 16.06 U/L vs. 208.2 U/L ± 19.23 U/L, P = 0.0122）. CRP also activated mPTP opening and reduced mitochondrial membrane potential during myocardial ischemia/reperfusion. Pretreatment with 1 pM atorvastatin （Ator） before CRP intervention protected cardiomyocytes from IRI. Mitochondrial KATP channel opener diazoxide and mPTP inhibitor cyclosporin A also offset the effects of CRP in this process. The level of phosphorylated extracellular-signal-regulated kinase （ERK） 1/2 was significantly higher after pre-tre

关键词： C-reactive protein Ischemia/reperfusion injury Mitochondrial permeability transition pore Mitochondrial KATP channel Statin

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Hypothesis Test for the Parameters of Linear Part in the Partial Linear EV Model

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Acta Mathematicae Applicatae Sinica 2015年第4期31卷 1153-1166页

作者： juan ZHANG Heng-jian cui Capital University of Economics and Business Capital Normal University

Hypothesis testing for the parametric component in the partial linear errors-in-variables （EV） regression models is discussed in this paper. Based on the corrected profile least square estimator, five test statistics are proposed and the asymptotic null distributions of them are deduced. Simulations have been done to show the performance of these test statistics under null and alternative hypothesis.

关键词： partial linear model measurement error bandwidth selection hypothesis testing

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Design and impact estimation of a reform program of China's tax and fee policies for low-grade oil and gas resources

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Petroleum Science 2011年第4期8卷 515-526页

作者： cui na Lei Yalin Fang Wei School of Humanities and Economic Management China University of Geosciences Beijing 100083 China

With China＇s rapid economic development,it is important to formulate reasonable and feasible tax and fee policies to promote the development and utilization of low-grade oil and gas resources to guarantee China＇s energy supply *** this paper,by analyzing major problems of China＇s current tax and fee policies for oil and gas resources,a reform program for low-grade oil and gas resources is designed from the aspects of tax/fee items and tax/fee *** impacts of this reform program on China and China＇s oil companies during the ＂Twelfth Five-Year Plan＂ are investigated according to the related data in *** results show that the proposed tax and fee reform program will lower the tax burden of oil companies,promote the development of low-grade oil and gas resources,and increase China＇s GDP and national fiscal *** that,it will bring positive social effects by increasing employment opportunities.

关键词： Low-grade oil and gas resources tax and fee policies reform program impact estimation

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Empirical Likelihood of Quantile Difference with Missing Response When High-dimensional Covariates Are Present

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Acta Mathematica Sinica,English Series 2021年第12期37卷 1803-1825页

作者： cui juan KONG Han Ying LIANG School of Mathematical Sciences Tongji UniversityShanghai 200092P.R.China

We,in this paper,investigate two-sample quantile difference by empirical likelihood method when the responses with high-dimensional covariates of the two populations are missing at *** particular,based on sufficient dimension reduction technique,we construct three empirical log-likelihood ratios for the quantile difference between two samples by using inverse probability weighting imputation,regression imputation as well as augmented inverse probability weighting imputation,respectively,and prove their asymptotic *** the same time,we give a test to check whether two populations have the same distribution.A simulation study is carried out to investigate finite sample behavior of the proposed methods too.

关键词： Empirical likelihood high-dimensional missing at random sufficient dimension reduction two-sample quantile difference

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Minimum Core Genome Sequence Typing of Brucella From China

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Infectious Microbes & Diseases 2023年第1期5卷 29-35页

作者： na Zhao Buyun cui national Institute of Hospital Administration National Health CommissionBeijingChina national Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesState Key Laboratory for Infectious Disease Prevention and ControlBeijingChina

The Gram-negative bacterial genus Brucella includes six classic species based on host specificity,pathogenicity and phenotypic *** more Brucella species were identified in *** many Brucella genomes have been sequenced,genome sequences and analysis of Brucella strains isolated in China are still *** efficient genome-based Brucella typing method is also *** this study,we used the minimum core genome(MCG)typing method to identify and type Brucella *** Brucella isolates fromChinawere newly *** genome sequences of 55 representative Brucella strainswere *** the 75 genomes,1089 genes and 52,030 single nucleotide polymorphisms(SNPs)shared by all isolates were considered as the MCG genes and MCG *** these 52,030 MCG SNPs,Brucella was divided into six MCG *** addition,average nucleotide identity(ANI)values and the distributions of 184 virulence genes were all *** proportions of virulence genes were 90.96%,93.56%,95.89%,86.04%,85.78%and 91.87%for MCG groups 1 to 6,*** intragroup ANI values were higher than the intergroup values,further confirming the validity of the MCG taxonomy *** melitensis and Brucella abortus,the two main Brucella species pathogenic to humans,were well separated from other *** the development and cost reduction of next-generation sequencing,theMCG typing method can be used for rapid identification of Brucella,which can contribute to the rapid diagnosis of brucellosis and ensure timely and effective treatment.

关键词： Brucella minimum core genome sequence typing

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Simulating Calculation of Frictional Force between Mold and Billet

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Journal of Iron and Steel Research International 1998年第1期5卷 13-16页

作者： Xu Guangming cui Jianzhong na Xinjie Northeastern University

Assumption about the inner surface of mold is made according to the forming mechanisms of frictional force. The frictional force between billet and mold can be analysed by calculating the thermal shrinkage and the shearing strength of the *** model is used to calculate the maximum drawing speed at different conditions. The results are very satisfactory.

关键词： simulating calculation frictional force mold billet

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Survey on Fake Information Generation,Dissemination and Detection

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Chinese Journal of Electronics 2024年第3期33卷 573-583页

作者： Wanqiu cui Dawei WANG na HAN School of national Security People's Public Security University of China Big Data Center of The Ministry of Public Security

The current booming development of the Internet has put the public in an era of information overload,in which false information is mixed and spread *** phenomenon has seriously disturbed the social network ***,a substantial amount of research is beginning to be devoted to the effective management of fake *** analyze the abnormal characteristics of fake information from its mechanism of generation and *** view of different exceptional features,we systematically sort out and evaluate the existing studies on false content *** commonly used public datasets,metrics,and performance are categorized and compared,hoping to provide a basis and guidance for related *** study found that the current active social platforms show different *** future direction should point to mining platform features of multi-domain sources,multi-data forms,and multi-language heterogeneity to provide more valuable clues for fake information.

关键词： Fake information Abnormal characteristics Detection methods Public datasets

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