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Celastrol inhibits inflammatory factors expression in glioblastoma

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Traditional Medicine Research 2024年第6期9卷 1-11页

作者： na Qin Shu-Xian Yang shi-Man Gao Ting Zhu Institute of Neuroregeneration&Neurorehabilitation Department of PathophysiologySchool of Basic MedicineQingdao UniversityQingdao 266071China Department of Pharmacy Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Women and Children’s Hospital Qingdao UniversityQingdao 266034China

Background:Glioblastoma is one of the most common primary intracranial tumors of the central nervous system in *** chemotherapy is an important component of glioblastoma treatment,its effectiveness remains *** to multiple immunosuppressive mechanisms,glioblastoma immunotherapy has not been effective in treating many patients as a result of the clinical breakthroughs in the ***,the development of cancer immunotherapy relies on the understanding of how tumors interact with the immune system and the analysis of their molecular *** study identified the key interactions between immune cells in the glioma microenvironment using Rna microarrays and single-cell ***:First,we screened differentially expressed genes in tumor and control samples from GSE29796 and GSE50161 datasets using *** differentially expressed genes were used to perform enrichment analysis and construct protein-protein interaction topological analysis to analyze the interaction between *** single-cell Rna sequencing data from the GSE162631 database,we identified immune cell types within the glioblastoma microenvironment,and validated the hub gene expression in these *** addition,based on the GEPIA and TIMER databases,hub genes were investigated and compared with immune infiltration to determine differential ***,CellChat was used to visualize the gene expression distribution and cell-to-cell communication analysis of the proteins between different types of ***:We found that monocytes/macrophages may communicate with each other in the tumor microenvironment through MIF-(CD74+CXCR4)and MIF-(CD74+CD44).In addition,our study indicated that celastrol has the ability to inhibit inflammatory factors expression by MIF/CD74 signaling pathway in U87 ***:This study improved the effectiveness of cancer immunotherapy strategies and developed new ideas for immunotherapy that can be applied to gl

关键词： glioblastoma monocytes/macrophages single-cell Rna sequencing MIF/CD74 signaling pathway celastrol

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当代我国社会经济价值观嬗变的报告

河南大学学报（社会科学版） 2010年第3期50卷 81-85页

作者：史娜辽宁大学马克思主义学院辽宁沈阳110036

我国社会主义市场经济的确立和发展,打破了原有的计划经济体制,为商品交易和经济发展注入了活力,我国社会的经济价值观领域也开始进入从传统向现代的全面转型时期。市场经济内在的诚信观、契约观和竞争意识等价值观的觉醒和发扬,使我国... 详细信息

我国社会主义市场经济的确立和发展,打破了原有的计划经济体制,为商品交易和经济发展注入了活力,我国社会的经济价值观领域也开始进入从传统向现代的全面转型时期。市场经济内在的诚信观、契约观和竞争意识等价值观的觉醒和发扬,使我国传统的经济价值观受到巨大冲击,同时也带来了资本主义经济价值观的外来影响。根据《中国公民价值观蓝皮书》的调查报告,可以看出我国公民的市场经济价值观转变基本成功,但是它与未来的现代经济价值观仍有一定差距。

关键词：市场经济经济价值观嬗变

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改革开放以来我国社会价值观的变革与建构

河南大学学报（社会科学版） 2010年第2期50卷 51-55页

作者：史娜辽宁大学马克思主义学院辽宁沈阳110036

中国自改革开放30年以来,社会主义市场经济迅猛发展,科学技术水平日益提高,物质财富极大丰富,老百姓的生活发生了翻天覆地的变化,社会的生产方式、经济政治制度和人们的价值观念亦发生了巨大变化,社会价值观呈现出多元化和多样性的特点... 详细信息

中国自改革开放30年以来,社会主义市场经济迅猛发展,科学技术水平日益提高,物质财富极大丰富,老百姓的生活发生了翻天覆地的变化,社会的生产方式、经济政治制度和人们的价值观念亦发生了巨大变化,社会价值观呈现出多元化和多样性的特点。在此背景下,准确地把握改革开放以来我国社会价值观变革的本质特征及其内在根源,确立科学合理的主导价值观并使之发挥积极的引导作用,对冲突的价值观进行合理整合,建构符合社会发展方向的价值观体系,这些是应对当今社会价值观变革的重要手段。

关键词：改革开放社会价值观变革社会主义核心价值体系整合建构

An Analytic Model of Subminiature Auditory Sensation System for Sound Source Localization

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Chinese Journal of Biomedical Engineering(English Edition) 2007年第4期16卷 148-154页

作者： WANG Qing-sheng TA na RAO Zhu-shi State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai 200240 China

It is reported that some types of insects have a remarkable ability to detect the direction of an incident sound even though its acoustic sensory organs are in very close proximity each other. Maybe the ears are jointed by a cuticular structure with which the separated motions can be coupled mechanically and thus be magnified. In this paper, a detailed model is setup to describe the principle of this type of localization using a mechanical coupled structure. The transfer functions and the responses of the model in terms of time and frequency are analyzed to describe the mechanism of its ability of directional hearing. This analytical model provides a method to design the experimental model for the predetermined incident sound pressure, and the analysis of this model shows that this structure have the ability to determine the direction of the incident stimulus.

关键词： parasitoid fly biomechanics coupled structure sound source' s orientation

shikaniTM Seeing Optical Stylet-aided tracheal intubation in patients with a large epiglottic cyst

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Chinese Medical Journal 2011年第17期124卷 2795-2798页

作者： LIN na LI Mei shi Song LI Tian-zuo ZHANG Bing-xi Department of Anesthesiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Large epiglottic cysts can block the glottis, leading to serious consequences. This condition presents a challenge in terms of airway management for anesthesiologists during induction of anesthesia. We report the use of a shikaniTM Seeing Optical Stylet combined with a Macintosh laryngoscope to aid tracheal intubation in seven patients with large epiglottic cysts. Use of this technique can avoid cyst rupture and allow smooth, safe intubation.

关键词： Optical Stylet epiglottic cyst intubation anesthesia airway management

Dna methylation of SMPD3-based diagnostic biomarkers of naSH and mild fibrosis

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Genes & Diseases 2024年第1期11卷 99-102页

作者： na Wu Mofan Feng Siran Yue Xinyu shi nan Tang Yalan Xiong Jianying Wang Lei Zhang Hualing Song Yi shi Guang He Guang Ji Baocheng Liu Shanghai Innovation Center of Traditional Chinese Medicine Health Service School of Public HealthShanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China

Non-alcoholic fatty liver disease(naFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with naFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(naSH),accompanied by bridging *** advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over ***,even slight inflammation or fibrosis in naFLD can significantly increase the likelihood of progression compared to steatosis *** underscores the importance of revising the present methods of monitoring naFLD patients to ensure early detection and effective management of the disease.

关键词： naFLD inflammation naSH

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1920年代日本马克思主义者的思想溯源

现代哲学 2022年第3期 43-49页

作者：施娜中山大学马克思主义哲学与中国现代化研究所广州510275 中山大学哲学系

日本是马克思主义传入中国的主要渠道之一,而日本的马克思主义思想又来自何处?对此,国内学界的探讨还不够深入。今年是“第一次日本共产党”成立100周年,值此时机,追溯日本马克思主义思想的来源显得尤为重要。1920年前后,日本掀起马克... 详细信息

日本是马克思主义传入中国的主要渠道之一,而日本的马克思主义思想又来自何处?对此,国内学界的探讨还不够深入。今年是“第一次日本共产党”成立100周年,值此时机,追溯日本马克思主义思想的来源显得尤为重要。1920年前后,日本掀起马克思主义思想的高潮,河上肇、山川均、堺利彦等是该时期的代表性人物。通过考察他们的文本可知:他们的思想源自包括俄国在内的欧美国家,他们在多学科思想的背景下接受马克思主义,因此,他们对马克思主义的理解以及发挥呈现出多元化乃至本地化的特点。

关键词：日本马克思主义思想溯源河上肇山川均堺利彦

Crystal engineering regulation achieving inverse temperature symmetry breaking ferroelasticity in a cationic displacement type hybrid perovskite system

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Chinese Chemical Letters 2024年第5期35卷 477-481页

作者： na Wang Wang Luo Huaiyi Shen Huakai Li Zejiang Xu Zhiyuan Yue Chao shi Hengyun Ye Leping Miao Chaotic Matter Science Research Center Department of MaterialsMetallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000China

Ferroelastic hybrid perovskite materials have been revealed the significance in the applications of switches,sensors,actuators,***,it remains a challenge to design high-temperature ferroelastic to meet the requirements for the practical ***,we reported an one-dimensional organicinorganic hybrid perovskites(OIHP)(3-methylpyrazolium)CdCl_(3)(3-MBCC),which possesses a mmmF2/m ferroelastic phase transition at 263 ***,utilizing crystal engineering,we replace-CH_(3) with-NH_(2) and-H,which increases the intermolecular force between organic cations and inorganic *** phase transition temperature of(3-aminopyrazolium)CdCl_(3)(3-ABCC),and(pyrazolium)CdCl_(3)(BCC)increased by 73 K and 10 K,***,BCC undergoes an unconventional inverse temperature symmetry breaking(ISTB)ferroelastic phase transition around 273 ***,it transforms from a high symmetry low-temperature paraelastic phase(point group 2/m)to a low symmetry high-temperature ferroelastic phase(point group ī)originating from the rare mechanism of displacement of organic cations phase *** means that crystal BCC retains in ferroelastic phase above 273 K until melting point(446 K).Furthermore,characteristic ferroelastic domain patterns on crystal BCC are confirmed with polarized optical *** study enriches the molecular mechanism of ferroelastics in the family of organic-inorganic hybrids and opens up a new avenue for exploring high-temperature ferroic materials.

关键词： Organic-inorganic hybrid perovskite Crystal engineering Inverse temperature symmetry breaking Displacement type phase transition Ferroelasticity

A Review on Reasons of Increasing Perennial Weeds and Control Technology of Perennial Weeds in Heilongjiang Province

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Journal of Northeast Agricultural University(English Edition) 2009年第1期16卷 78-80页

作者： ZHAO Changshan HE Fuli shi na YAN Chunxiu College of Agriculture Northeast Agricultural University Harbin 150030 China

The main reasons that perennial weeds has becoming the dominant weeds in Heilongjiang Province were summarized. The biological mechanism that explained why it was difficult to control perennial weeds was analyzed. During dormancy course, variation regularity of some inner matters in perennial weeds was researched and new tentative for controlling the perennial weeds was pointed out.

关键词： perennial weeds dormancy control