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Preparation of lactic acid bacteria compound starter cultures based on pasting properties and its improvement of glutinous rice flour and dough

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Food Science and Human Wellness 2024年第4期13卷 2090-2101页

作者： Dengyu Wang Linlin Liu Bing Wang Wenjian Xie Yanguo shi na Zhang Hongchen Fan Key Laboratory of Food Science and Engineering of Heilongjiang Ordinary Higher Colleges Key Laboratory of Grain Food and Comprehensive Processing of Heilongjiang ProvinceCollege of Food EngineeringHarbin University of CommerceHarbin 150076China

The effects of 5 lactic acid bacteria(LAB)fermentation on the pasting properties of glutinous rice flour were compared,and suitable fermentation strains were selected based on the changes of viscosity,setback value,and breakdown value to prepare LAB compound starter *** results revealed that Latilactobacillus sakei HSD004 and Lacticaseibacillus rhamnosus HSD005 had apparent advantages in increasing the viscosity and reducing the setback and breakdown values of glutinous rice *** particular,the compound starter created using the two abovementioned LAB in the ratio of 3:1 had better performance than that using a single LAB in improving the pasting properties and increasing the water and oil absorption capacity of glutinous rice ***,the gelatinization enthalpy of the fermented samples increased *** frozen glutinous rice dough stored for 28 days,the viscoelasticity of frozen dough prepared by compound starter was better than that of control dough,and the freezable water content was lower than that of control *** results indicate that compound LAB fermentation is a promising technology in the glutinous rice-based food processing industry,which has significance for its application.

关键词： Glutinous rice flour Glutinous rice dough Lactic acid bacteria compound starter cultures Pasting properties Viscoelasticity

Effects of K ions doping on the structure, morphology and optical properties of Cu_2FeSnS_4 thin films prepared by blade-coating process

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Optoelectronics Letters 2017年第4期13卷 291-294页

作者： WANG Shuo MA Rui-xin WANG Cheng-yan LI shi-na WANG Hua School of Metallurgy and Ecological Engineering University of Science and Technology Beo＇ing Beo＇ing 100083 China Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology Kunming 650093 China Beijing Key Laboratory of Special Melting and Preparation of High-end Metal Materials Beijing 100083 China

Quaternary chalcogenide Cu2FeSnS4 （CFTS） nanoparticles, as a kind of potential absorber layer material in thin film solar cells （TFSCs）, were successfully synthesized by using a convenient solvothermal method. Alkali element K is incorporated into CFTS thin films in order to fiLrther improve the surface morphology and the optical properties of related films. X-ray diffraction （XRD）, Raman spectroscopy and field emission scanning electron microscopy （FESEM） were used to characterize the phase purity, morphology and composition of CFTS particles and thin films. The results show that the particle elemental ratios of Cu/（Fe＋Sn） and Fe/Sn are 1.2 and 0.9, respectively, which are close to the characteristics of stoichiometric CFTS. The band gaps of CFTS films before and after doping K ions are estimated to be 1.44 eV and 1.4 eV with an error of ±0.02 eV.

关键词： Energy gap Field emission microscopes Morphology Optical properties Scanning electron microscopy Semiconductor doping Synthesis (chemical) Thin film solar cells Thin films X ray diffraction

Hereditary severe insulin resistance syndrome:Pathogenesis,pathophysiology,and clinical management

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Genes & Diseases 2023年第5期10卷 1846-1856页

作者： Junaid Iqbal Hong-Li Jiang Hui-Xuan Wu Long Li Ying-Hui Zhou nan Hu Fen Xiao Ting Wang shi-na Xu Hou-De Zhou national Clinical Research Center for Metabolic Diseases Hunan Provincial Key Laboratory for Metabolic Bone Diseasesand Department of Endocrinology and MetabolismThe Second XiangYa Hospital of Central South UniversityChangshaHunan 410011China

Severe insulin resistance has been linked to some of the most globally prevalent disorders,such as diabetes mellitus,nonalcoholic fatty liver disease,polycystic ovarian syndrome,and *** severe insulin resistance syndrome(H-SIRS)is a rare disorder classified into four principal categories:primary insulin receptor defects,lipodystrophies,complex syndromes,and obesity-related *** such as INSR,AKT2,TBC1D4,AGPAT2,BSCL2,CAV1,PTRF,LMna,PPARG,PLIN1,CIDEC,LIPE,PCYT1A,MC4R,LEP,POMC,SH2B1,RECQL2,RECQL3,ALMS1,PCNT,ZMPSTE24,PIK3R1,and POLD1 have been linked to *** clinical features include insulin resistance,hyperglycemia,hyperandrogenism,severe dyslipidemia,fatty liver,abnormal topography of adipose tissue,and low serum leptin and adiponectin *** of H-SIRS is based on the presence of typical clinical features associated with the various H-SIRS forms and the identification of mutations in H-SIRS-linked genes by genetic *** therapy,insulin sensitization,exogenous insulin therapy,and leptin replacement therapy have widely been adopted to manage *** rarity of H-SIRS,its highly variable clinical presentation,refusal to be tested for genetic mutations by patients’family members who are not severely sick,unavailability of genetic testing,and testing expenses contribute to the delayed or underdiagnoses of *** diagnosis facilitates early management of the condition,which results in improved glycemic control and delayed onset of diabetes and other complications related to severe insulin *** use of updated genetic sequencing technologies is recommended,and long-term studies are required for genotype–phenotype differentiation and formulation of diagnostic and treatment protocols.

关键词： Diabetes Genetics Insulin resistance Lipodystrophy Pathophysiology Therapy

基于滑动窗口集成即时学习算法的ALD工艺压强预测

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化工自动化及仪表 2024年第5期51卷 879-886页

作者：孙世娜陈焰伍祖铭刘振强明帅强夏洋昆明理工大学信息工程与自动化学院中国科学院嘉兴微电子仪器与设备工程中心嘉兴科民电子设备技术有限公司

原子层沉积(ALD)设备被广泛应用于半导体、新材料、光伏产业中制备高质量纳米膜。针对制膜过程中关闭真空计,导致压强数据缺失,无法判断反应源是否通入及设备是否正常运行的问题,采用软测量方法预测制膜过程中的压强。为提高软测量对不... 详细信息

原子层沉积(ALD)设备被广泛应用于半导体、新材料、光伏产业中制备高质量纳米膜。针对制膜过程中关闭真空计,导致压强数据缺失,无法判断反应源是否通入及设备是否正常运行的问题,采用软测量方法预测制膜过程中的压强。为提高软测量对不同工艺条件及配方的预测泛化能力,提出采用基于滑动窗口的集成即时学习法(BaggingMwLWPLS)对压强进行实时建模及预测,使用滑动窗口划分数据集,采用Bagging集成算法将局部加权偏最小二乘法(LWPLS)的预测值平均融合作为预测压强。结果表明:该方法能自适应预测不同工艺配方的实时压强,且预测快速、准确、不易受噪声干扰,实现设备压强状态和性能的实时监控。

关键词：工艺压强滑动窗口局部加权偏最小二乘集成学习自适应预测

百令胶囊治疗糖尿病肾病改善患者微炎症状态、肾功能的回顾性研究

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现代生物医学进展 2024年第12期24卷 2314-2317,2283页

作者：宋世娜张倩倩刘铁民孙书红王红娟山东大学齐鲁医院德州医院药剂科山东德州253000 山东大学齐鲁医院德州医院肾内科山东德州253000 山东大学齐鲁医院德州医院耳鼻喉科山东德州253000

目的:回顾性分析百令胶囊对糖尿病肾病患者机体微炎症状态、肾功能的影响。方法:2021年1月~2022年9月,回顾性收集120例糖尿病肾病患者临床资料,根据治疗方法分为降糖降脂组(56例)和百令胶囊组(64例)。降糖降脂组采用二甲双胍片、瑞舒伐... 详细信息

目的:回顾性分析百令胶囊对糖尿病肾病患者机体微炎症状态、肾功能的影响。方法:2021年1月~2022年9月,回顾性收集120例糖尿病肾病患者临床资料,根据治疗方法分为降糖降脂组(56例)和百令胶囊组(64例)。降糖降脂组采用二甲双胍片、瑞舒伐他汀钙片进行治疗,百令胶囊组在降糖降脂组的基础上采用百令胶囊进行治疗。比较两组治疗3个月后疗效及治疗前、治疗3个月后糖脂代谢指标、微炎症状态及肾功能。结果:百令胶囊组治疗3个月后总有效率高于降糖降脂组(P<0.05)。治疗3个月后两组血清空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、白介素-6(IL-6)、超敏-C反应蛋白(hs-CRP)、血肌酐(SCr)、尿素氮(BUN)水平及24 h尿白蛋白(24 h UTP)、尿白蛋白排泄率(UAER)与治疗前比较,降低,百令胶囊组低于降糖降脂组(P<0.05);两组血清白介素-10(IL-10)水平与治疗前比较,升高,百令胶囊组高于降糖降脂组(P<0.05)。结论:百令胶囊可有效改善糖尿病肾病患者糖脂代谢、肾功能及微炎症状态,疗效较好。

关键词：糖尿病肾病百令胶囊二甲双胍瑞舒伐他汀微炎症状态肾功能

Biomimetic mineralization synthesis of hydroxyapatite bacterial cellulose nanocomposites

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Progress in natural Science:Materials International 2011年第6期21卷 472-477页

作者： na YIN,shi-yan CHEN,Yang OUYANG Lian TANG,Jing-xuan YANG,Hua-ping WANG College of Materials Science and Engineering,Donghua University,Shanghai 201620,China College of Materials Science and Engineering Donghua University Shanghai 201620 China

Hydroxyapatite(HAp)/bacterial cellulose(BC) nanocomposites were prepared by an optimal biomimetic mineralization synthesis approach for bone tissue engineering *** with ultrafine three dimensional network was negatively charged by the adsorption of polyvinylpyrrolidone(PVP) to initiate the nucleation of *** HAp was grown in vitro along the nanofiber network of BC via dynamic simulated body fluid(SBF) *** was found that rod-like HAp particles in the nano-scale (100-200 nm) homogeneously deposited on the surface of ***-Fourier Transform Infrared Spectroscopy(ATR-FTIR) results showed that carbonate-containing HAp crystals resembling natural bones were formed by biomimetic mineralization method. Moreover,the amount of HAp observed increased with increasing mineralization *** the Ca/P overall ratio ranged from 1.37 to *** results from Inductively Coupled Plasma Atomic Emission Spectroscopy(ICP-AES) indicated that PVP treatment enhanced the apatite nucleation ability of BC with higher HAp deposit amount.

关键词： bacterial cellulose hydroxyapatite nanocomposites polyvinylpyrrolidone biomimetic mineralization

基于“脾为之卫”理论探讨肠道微生态的失衡与心力衰竭的关系

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中国动脉硬化杂志 2024年第3期32卷 263-270页

作者：刘长兴郭心怡王博宇时娜陈秋涵周亚滨王贺黑龙江中医药大学黑龙江省哈尔滨市150040 成都中医药大学四川省成都市610032 黑龙江中医药大学附属第一医院心血管二科黑龙江省哈尔滨市150040

心力衰竭是心血管疾病终末期的致命阶段,因其死亡率和再住院率一直居高不下,故给社会带来了巨大的医疗负担。肠道微生态(IM)是人体最大、最复杂的微生态系统,它是由数以万计的微生物寄居在人体的胃肠道内,这些微生物被统称为肠道菌群(GM... 详细信息

心力衰竭是心血管疾病终末期的致命阶段,因其死亡率和再住院率一直居高不下,故给社会带来了巨大的医疗负担。肠道微生态(IM)是人体最大、最复杂的微生态系统,它是由数以万计的微生物寄居在人体的胃肠道内,这些微生物被统称为肠道菌群(GM)。近些年来随着对肠道菌群研究的不断深入,越来越多的研究发现肠道菌群的失衡会改变心力衰竭患者体内基础代谢,促进全身炎症级联反应,是心力衰竭发生发展的关键诱因之一,因此以肠道微生物稳态作为治疗心力衰竭的新切入点将是医学研究的热点。然而中医理论“脾为之卫”涵盖了脾主运化、脾主升清、藏意主思等生理功能,肠道菌群与“脾为之卫”的职能有一定的相似性。文章从整体观念出发,以中医“脾为之卫”理论为切入,就肠道微生态失衡与心力衰竭发病机制进行阐述,为心力衰竭中医治疗或药物研究提供参考。

关键词：脾为之卫肠道微生态心力衰竭

固体甲醛的聚合度对α-氰基丙烯酸乙酯合成工艺的影响

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精细与专用化学品 2024年第5期32卷 45-48页

作者：王虹张朝纯施娜娜李定邦彭艳丽韩晓明张东卫季小付李娟河北诚信集团有限公司河北石家庄051130 河北诚信九天医药化工有限公司河北石家庄051130 河北省氰衍生物技术创新中心河北石家庄051130 河北省氰及衍生物研究与应用产业技术研究院河北石家庄051130

研究固体甲醛不同聚合度下的解聚时间,以及不同聚合度的固体甲醛对合成α-氰基丙烯酸乙酯收率的影响。通过研究发现,聚合度越大,在同一条件下的解聚时间越长,合成α-氰基丙烯酸乙酯的收率呈现降低的趋势。针对聚合度较高的固体甲醛,研... 详细信息

研究固体甲醛不同聚合度下的解聚时间,以及不同聚合度的固体甲醛对合成α-氰基丙烯酸乙酯收率的影响。通过研究发现,聚合度越大,在同一条件下的解聚时间越长,合成α-氰基丙烯酸乙酯的收率呈现降低的趋势。针对聚合度较高的固体甲醛,研究了在α-氰基丙烯酸乙酯生产体系中提高其反应活性的方法,影响其活性的关键因素为水和缩合(解聚)温度。

关键词： α-氰基丙烯酸乙酯固体甲醛聚合度解聚

基于网络药理学探讨甘草泻心汤治疗白塞病的作用机制

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中国合理用药探索 2024年第2期21卷 113-121页

作者：宋书珍王旭光宋世娜孙万晶胡国冰德州市人民医院药剂科德州253000 德州市人民医院中医科德州253000

目的:基于网络药理学方法分析甘草泻心汤治疗白塞病(BD)的潜在活性成分及其可能作用靶点和分子机制。方法:根据甘草泻心汤的药味组成,在中药系统药理学数据库,与分析平台(TCMSP)筛选各药材的有效活性成分及各成分相应的作用靶点;利用Gen... 详细信息

目的:基于网络药理学方法分析甘草泻心汤治疗白塞病(BD)的潜在活性成分及其可能作用靶点和分子机制。方法:根据甘草泻心汤的药味组成,在中药系统药理学数据库,与分析平台(TCMSP)筛选各药材的有效活性成分及各成分相应的作用靶点;利用GeneCard、OMIM、PharmGkb及DrugBank数据库,以“Behcet's disease”为检索词收集BD相关靶点,同时将药物靶点及疾病靶点数据进行比对获得交集靶点,通过Cytoscape 3.8.2软件对药物-疾病靶点进行可视化网络分析;将药物-疾病靶点结果进行基因本体论(GO)、京都基因和基因组百科全书(KEGG)富集分析。结果:TCSMP数据库共检索到甘草泻心汤主要活性成分174个,包括槲皮素、山柰酚、汉黄芩素、黄芩素、β-胡萝卜素、刺槐素;甘草泻心汤潜在作用靶点247个,BD相关靶点1006个,甘草泻心汤有效成分靶点与BD相关靶点的交集靶点共60个。核心靶点为HMOX1、IFNG、CAT、EGF、VEGFA、PTGS2、CXCL8、TP53、IL1B、STAT3、SERPINE1、MPO、CCL2、SELE、ICAM1、VCAM1、MMP9、CASP3、NFKBIA、IL1A。GO富集分析共得到1697条条目,主要涉及对脂多糖的反应、对细菌来源的分子反应、外源性凋亡信号通路等生物过程。KEGG富集分析得到114个信号通路,主要包括糖尿病并发症AGE-RAGE信号通路、流体剪切应力与动脉粥样硬化、肿瘤坏死因子信号通路等。结论:甘草泻心汤可通过多靶点、多通路治疗BD,本研究为深入揭示其作用机制提供了生物信息学基础。

关键词：甘草泻心汤白塞病网络药理学活性成分作用靶点