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A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery

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Microsystems & nanoengineering 2021年第4期7卷 169-179页

作者： Yoo na kang namsun Chou Jae-Won Jang Han Kyoung Choe Sohee Kim Department of Medical Assistant Robot Korea Institute of Machinery&Materials(KIMM)DaeguRepublic of Korea Center for BioMicrosystems Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Brain&Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea

The demand for multifunctional neural interfaces has grown due to the need to provide a better understanding of biological mechanisms related to neurological diseases and neural *** intracerebral drug injection using microfluidic neural interfaces is an effective way to deliver drugs to the brain,and it expands the utility of drugs by bypassing the blood-brain barrier(BBB).In addition,uses of implantable neural interfacing devices have been challenging due to inevitable acute and chronic tissue responses around the electrodes,pointing to a critical issue still to be *** neural interfaces comprised of a collection of microneedles in an array have been used for various applications,it has been challenging to integrate microfluidic channels with them due to their characteristic three-dimensional structures,which differ from two-dimensionally fabricated shank-type neural *** we present a method to provide such three-dimensional needle-type arrays with chemical delivery *** fabricated a microfluidic interconnection cable(pFIC)and integrated it with a flexible penetrating microelectrode array(FPMA)that has a 3-dimensional structure comprised of silicon microneedle electrodes supported by a flexible array *** successfully demonstrated chemical delivery through the developed device by recording neural signals acutely from in vivo brains before and after KCl *** suggests the potential of the developed microfluidic neural interface to contribute to neuroscience research by providing simultaneous signal recording and chemical delivery capabilities.

关键词： neural recording needle

Greenhouse Gas Emissions from Sewage Treatment in China during 2000-2009

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Advances in Climate Change Research 2012年第4期3卷 205-211页

作者： ZHOU Xing ZHENG You-Fei kang na ZHOU Wei YIN Ji-Fu Hebei Meteorological Bureau School of Environment Science and Engineering Nanjing University of Information Science & Technology School of Atmospheric Physics Nanjing University of Information Science & Technology

Based on the statistics from the China Statistical Yearbook （2000-2009） on environment and methods recommended by the IPCC, the amounts of greenhouse gas （GHG） emissions from domestic and industrial sewage treatment in China are estimated for the period of 2003-2009. CO2 emissions per capita from sewage treatment plants are also analyzed. The results show that the GHG emissions from sewage treatment plants increased steadily from 2003 to 2009; N20 emissions from domestic sewage are the major source of the total GHG emissions from domestic sewage; CH4 emissions from domestic sewage increase with the greatest speed; CH4 emissions from paper and pulp industry are the major source of industrial sewage emissions; CO2 emissions per capita increase constantly from 2003 to 2009.

关键词： sewage treatment CH4 N20 emissions

Chemical control of receptor kinase signaling by rapamycin-induced dimerization

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Molecular Plant 2021年第8期14卷 1379-1390页

作者： Sara Kim Jeonghyang Park Byeong Wook Jeon Geonhee Hwang na Young kang Yeim We Won-Young Park Eunkyoo Oh Jungmook Kim Department of Life Sciences Korea UniversitySeoulKorea Department of Bioenergy Science and Technology Chonnam National UniversityGwangjuKorea Kumho Life Science Laboratory Chonnam National UniversityGwangjuKorea Department of Integrative Food Bioscienee and BiotechnologyChonnam National UniversityGwangjuKorea

Membrane-localized leucine-rich repeat receptor kinases(LRR-RKs)sense diverse extracellular signals,and coordinate and specify cellular functions in ***,functional understanding and identification of the cellular signaling of most LRR-RKs remain a major challenge owing to their genetic redundancy,the lack of ligand information,and subtle phenotypes of LRR-RK ***,we report an engineered rapamycin-inducible dimerization(RiD)receptor system that triggers a receptor-specific LRR-RK signaling independent of their cognate ligands or endogenous *** the RiD-receptors,we demonstrated that the rapamycin-mediated association of chimeric cytosolic kinase domains from the BRI1/BAK1 receptor/co-receptor,but not the BRI1/BRI1 or BAK1/BAK1 homodimer,is sufficient to activate downstream brassinosteroid signaling and physiological ***,we showed that the engineered RiD-FLS2/BAK1 could activate flagellin-22-mediated immune signaling and *** the RiD system,we also identified the potential function of an unkmown orphan receptor in immune signaling and revealed the differential activities of SERK co-receptors of *** results indicate that the RiD method can serve as a synthetic biology tool for precise temporal manipulation of LRR-RK signaling and for understanding LRR-RK biology.

关键词： leucine-rich repeat receptor kinase brassinosteroids BRI1 BAK1 FLS2

Research advances in eco-hydrological process and function

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Research in Cold and Arid Regions 2014年第1期6卷 8-13页

作者： YongGang Yang HongLang Xiao ZuoDong Qin na kang CaiMei Li Institute of Loess Plateau Shanxi University Cold and Arid Regions Environmental Engineering Research Institute Chinese Academy of Sciences

Present studies on the coupling relationship and hydrology mechanism between basin ecosystem and hydrological process has become an international research frontier in hydrology. This paper investigates this coupling relationship, and also summarizes research and presents a method of combining isotopic technology with hydro-chemical methods, for the study of eco-hydrological process and function in different landscape zones. We then examine research trends for future direction and development of this field.

关键词： eco-hydrological process eco-hydrological function landscape zone isotope

重型柴油机冷却风扇和水泵的功率分配对热管理系统总能耗的影响

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天津大学学报（自然科学与工程技术版） 2015年第3期48卷 225-233页

作者：谢辉康娜天津大学内燃机燃烧学国家重点实验室天津300072

针对一款重型卡车用柴油机，在GT-SUITE平台上系统研究了电动风扇和电动水泵功率分配对热管理系统运行总能耗的影响规律，提出了风扇和水泵功率分配控制策略.为了减少水温控制的波动，降低系统控制能耗，提出采用一种基于主动扰动观测... 详细信息

针对一款重型卡车用柴油机，在GT-SUITE平台上系统研究了电动风扇和电动水泵功率分配对热管理系统运行总能耗的影响规律，提出了风扇和水泵功率分配控制策略.为了减少水温控制的波动，降低系统控制能耗，提出采用一种基于主动扰动观测的控制算法．通过稳态工况和 HUDDS 循环工况的仿真，验证了该算法降低能耗的效果．结果表明：稳态工况下风扇和水泵功率分配的不同可造成2%～56%的总能耗差异．HUDDS 工况下，通过风扇和水泵的功率分配控制，总能耗可节能约8%．相对于PID水温控制，采用主动抗扰控制算法可节约附件总能耗5%左右，出口水温和进出口温差的控制精度可分别改善24%和40%.

关键词：热管理系统一维建模风扇和水泵功率分配主动抗扰控制算法附件总能耗复合优化策略

An Exploration of the Economic Significance of Social Security

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Chinese Business Review 2005年第8期4卷 22-26页

作者： Shengrun na Xinghua kang Hainan University

The modem social security carries some elements of humanitarianism or social stability, but it is more an economic means. It can reduce overproduction, increase effective demand and facilitate the balance between the demand and supply, and prevent the frequent occurrence of economic crisis. All the creatures of the God are there for a reason. The amount of production is based on the amount of currency. But some parts of currency are transformed into savings, and savings cannot be turned into investment immediately. The entailing overproduction breaks the balance between the demand and supply, and results in economic crisis. In modem society, it is the social security or those ＂lazy bones＂ that represses and eliminates the overproduction, which can be expressed by the equation： Savings = Investment ＋ Social security （consumption）. In this way, the balance between the demand and supply is *** the social production and life can continue in a normal way.

关键词： social security economics significance exploration

Gut microbiota of hepatitis B virus-infected patients in the immunetolerant and immune-active phases and their implications in metabolite changes

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World Journal of Gastroenterology 2022年第35期28卷 5188-5202页

作者： Ya-nan Li na-Ling kang Jia-Ji Jiang Yue-Yong Zhu Yu-Rui Liu Da-Wu Zeng Fei Wang Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pharmacy Fujian Geriatric HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND The microbes and metabolomics of microbiota dysbiosis in the gut in the different phases of hepatitis B virus(HBV) infection are not fully *** To investigate the specific gut microbiota and metabolites of the immune-tolerant(IT) and immune-active(IA) phases of chronic hepatitis B(CHB).METHODS Clinical fecal samples from healthy individuals and patients in the IT and IA phases of HBV infection were collected. Next, non-target metabolomics, bioinformatics, and 16S rDna sequencing analyses were *** A total of 293 different metabolites in 14 phyla, 22 classes, 29 orders, 51 families, and 190 genera were identified. The four phyla of Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were the most abundant, accounting for 99.72%, 99.79%, and 99.55% in the healthy controls, IT-phase patients, and IA-phase patients, respectively. We further identified 16 genera with different richness in the IT phase and IA phase of HBV infection. Of the 134 named metabolites, 57 were upregulated and 77 were downregulated. A total of 101 different metabolic functions were predicted in this study, with 6 metabolic pathways having the highest enrichments, namely carbohydrate metabolism(14.85%), amino acid metabolism(12.87%), lipid metabolism(11.88%), metabolism of cofactors and vitamins(11.88%), xenobiotic biodegradation(9.9%), and metabolism of terpenoids and polyketides(7.92%).CONCLUSION These findings provide observational evidence of compositional alterations of the gut microbiome and some related metabolites in patients with IT-phase or IA-phase HBV infection. Further studies should investigate whether microbiota modulation can facilitate the progression of CHB and the cause-effect relationship between the gut microbiota and CHB.

关键词： Microbes Metabolomics Gut microbiota Immune-tolerant phase Hepatitis B virus

Fabrication of high-strength duplex nanoporous Cu by dealloying a dual-phase Mg-Cu precursor alloy

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Journal of Magnesium and Alloys 2020年第3期8卷 910-916页

作者： Si-Young Lee Soo-Min Baek Eun-Ji Gwak na-Ri kang Ju-Young Kim Su-Hyeon Kim Jung Gu Lee Sung Soo Park School of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Korea Institute of Materials Science Changwon 51508Republic of Korea School of Materials Science and Engineering University of UlsanUlsan 44610Republic of Korea

Duplex nanoporous Cu was successfully fabricated by dealloying a dual-phase Mg-Cu precursor alloy consisting of intermetallic Mg2Cu and *** duplex nanoporous Cu with embedded nanoporous struts exhibited highly enhanced strength compared to the typical monolithic nanoporous Cu under both compressive and flexural test conditions at room temperature;the duplex np-Cu sample exhibited a 12 times higher compressive strength and a 40 times greater flexural strength than the monolithic np-Cu *** responsible for the strength enhancement in the duplex nanoporous Cu are discussed.

关键词： Mg-Cu alloy nanoporous Cu Dealloying Duplex structure Strength

Elicitation of strong immune responses by a Dna vaccine expressing a secreted form of hepatitis C virus envelope protein E2 in murine and porcine animal models

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World Journal of Gastroenterology 2006年第44期12卷 7126-7135页

作者： Yi-Ping Li Hye na kang Lorne A Babiuk Qiang Liu Vaccine and Infectious Disease Organization University of Saskatchewan Saskatoon Saskatchewan Canada Danish Institute for Food and Veterinary Research Arhus N Denmark Korea Food and Drug Administration Seoul Republic of Korea

AIM： To characterize the immunogenicity of a hepatitis C virus （HCV） E2 Dna vaccine alone or with a protein vaccine boost in murine and porcine animal models. METHODS： A Dna vaccine expressing a secreted form of HCV E2 protein was constructed and used to vaccinate mice and piglets with or without boosting with a recombinant E2 protein vaccine formulated with CpG ODN and 10% Emulsigen. The immunogenicity of HCV E2 vaccines was analyzed by ELISA for antibody responses, MTT assay for lymphocyte proliferation, ELISPOT for the number of interferon-γ secreting cells, and cytotoxic T lymphocyte assays. RESULTS： Intradermal injection of E2 Dna vaccine induced strong Th1-1ike immune responses in mice. In piglets, E2 Dna vaccine elicited moderate and more balanced immune responses. A Dna vaccine prime and protein boost vaccination strategy induced significantly higher E2-specific antibody levels and shifted the immune response towards Th2-1ike ones in piglets. CONCLUSION： A Dna vaccine expressing a secreted form of HCV E2 protein elicited E2-specific immune responses in mice and piglets. Recombinant E2 protein vaccination following Dna immunization significantly increased the antibody response in piglets. These HCV E2 vaccines may represent promising hepatitis C vaccine candidates for further investigations.

关键词： Hepatitis C virus E2, Dna vaccine Dna vaccine prime-protein boost