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nano Research 2022年第3期15卷 1934-1941页

作者： Ge Ma Na Yang Guofu Zhou Xin Wang South China Academy of Advanced Optoelectronics and International Academy of Optoelectronics at Zhaoqing South China Normal UniversityGuangzhou 510631China

The glycerol electro-oxidation reaction(GEOR)is a green and promising method for the glyceraldehyde production.In this work,Pd nanocrystals(Pd-NCs)modified ultrathin NiO nanoplates(NiO-uNPs)hybrids(Pd-NCs/NiO-uNPs)are successfully synthesized using successive cyanogel hydrolysis,chemical reduction,and calcination treatment methods.Various electrochemical measurements and physicochemical characterization results demonstrate that Pd-NCs/NiO-uNPs hybrids have excellent electrocatalytic performance for both GEOR and hydrogen evolution reaction(HER)in alkaline medium,which benefit from the large specific surface area,uniform distribution of Pd-NCs,and the modified electronic structure of Ni atoms.At Pd-NCs/NiO-uNPs hybrids,only 1.43 V is needed to obtain the current density of 100 mA∙cm^(−2) for GEOR,much lower than that for oxygen evolution reaction(1.82 V).In addition,Pd-NCs/NiO-uNPs hybrids exhibit better HER performance than commercial Pd/C electrocatalyst.As a result,the constructed Pd-NCs/NiO-uNPs||Pd-NCs/NiO-uNPs glycerol electrolyzer only requires 1.62 V electrolysis voltage to reach 10 mA∙cm^(−2) current density,showing an energy-efficient and economy-competitive synthesis for the coproduction of glyceraldehyde and hydrogen.

关键词： NiO nanoplates Pd nanocrystals synergistic effect glycerol electro-oxidation reaction hydrogen evolution reaction

Public transport inclusion and active aging: A systematic review on elderly mobility

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 312-347页

作者： na Zhang Qi yang School of Humanities Chang'an UniversityXi'an 710064China School of Transportation Engineering Chang'an UniversityXi'an 710064China School of Economics and Management Chang'an UniversityXi'an 710064China

Global aging has brought attention to addressing the elderly mobility dilemma,and a commitment to address inclusive transport in aging.Transport inclusion for older adults aims at establishing an age-friendly transport system.As a direct policy goal and promoting active aging as an indirect social goal,to help older populations gain access to transport and social opportunities.Based on the analysis of scientific knowledge mapping over the past 30 years,this study visualizes the hotspots and trends in elderly mobility research.Through a qualitative analysis of 138 papers,this paper reviews the theoretical foundations for transport inclusion and three themes of elderly mobility research,proposes a framework for public transport(PT)inclusion research as well as future research directions.The study suggests that transport inclusion can help enhance elderly health,social participation,and subjective well-being.It can improve their travel opportunities for active aging in four ways:opportunity accessibility,physical accessibility,age-friendly informationalization,and cost affordability.Future research should pay attention to examining the mechanism of perceived transport inclusion on active aging,expanding the multilevel research space of the capability approach(CA),and exploring the subjectiveobjective integrated research model for PT inclusion.This research contributes to the overall knowledge of the theoretical and empirical researches on PT inclusion for the elderly and promotes the integrated application of interdisciplinary knowledge in the field.

关键词： Transportation engineering Elderly mobility Transport-related social exclusion Transport inclusion Active aging

Mechanism and design of allosteric activators of SIRT1

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Protein & Cell 2023年第5期14卷 387-392页

作者： Fei Liu Ningning Pang Rui-Ming Xu Na Yang State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of TianjinNankai UniversityTianjin 300353China national Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China

Dear Editor,The sirtuin family Nicotinamide adenine dinucleotide-dependent deacetylases have important roles in many biological processes(Milne and Denu,2008).SIRT1 is a mammalian homolog of yeast Sir2,which is the founding member of the sirtuin family.Many SIRT1 substrates have been reported,including histones,p53,FOXOs,and PGC1α(Hsu et al.,2013).Stimulating the activity of SIRT1 has been shown to be an attractive therapeutic strategy for various physiological and pathological conditions such as aging,metabolic disorders,inflammation,and neurodegeneration(Guarente,2011).Several small molecules have been identified or developed as potential sirtuinactivating compounds(STACs).Most notably,resveratrol,a natural STAC,was shown to activate the SIRT1-catalyzed deacetylation of the Fluor de Lys(FDL)peptide,which is a p53 peptide fused to a 7-amino-4-methylcoumarin(AMC)fluorophore at the C-terminus(Table S1;Howitz et al.,2003).However,the activation of deacetylation of the p53 peptide is dependent on the presence of the AMC fluorophore(Borra et al.,2005;Wu et al.,2013).

关键词： SIRT1 PGC1α

Fixed-Time Sliding Mode Control With Varying Exponent Coefficient for Modular Reconfigurable Flight Arrays

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 514-528页

作者： Jianquan yang Chunxi yang Xiufeng Zhang Jing na Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500 Yunnan International Joint Laboratory of Intelligent Control and Aoolication of Advanced Equipment Kunming 650500China IEEE

The modular system can change its physical structure by self-assembly and self-disassembly between modules to dynamically adapt to task and environmental requirements. Recognizing the adaptive capability of modular systems, we introduce a modular reconfigurable flight array(MRFA) to pursue a multifunction aircraft fitting for diverse tasks and requirements,and investigate the attitude control and the control allocation problem by using the modular reconfigurable flight array as a platform. First, considering the variable and irregular topological configuration of the modular array, a center-of-mass-independent flight array dynamics model is proposed to allow control allocation under over-actuated situations. Secondly, in order to meet the stable, fast and accurate attitude tracking performance of the MRFA, a fixed-time convergent sliding mode controller with state-dependent variable exponent coefficients is proposed to ensure fast convergence rate both away from and near the system equilibrium point without encountering the singularity. It is shown that the controller also has fixed-time convergent characteristics even in the presence of external disturbances. Finally,simulation results are provided to demonstrate the effectiveness of the proposed modeling and control strategies.

关键词： Control allocation dynamic model fixed-time stabilization modular reconfigurable flight array(MRFA) sliding mode

Characteristics of atmospheric boundary layer structure and its influencing factors under different sea and land positions in Europe

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Earth and Planetary Physics 2023年第2期7卷 257-268页

作者： YeHui Zhang XinPeng Yong HouFu Zhou Haiyang Gao Na Yang Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China Anhui Institute of Meteorology Sciences Anhui Key Laboratory of Atmospheric Science and Satellite Remote SensingHefei 230031China School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China

This study identifies quantitatively the dominant contributions of meteorological factors on the development of the boundary layer heights(BLH)in the European region,based on 32 years(1990-2021)of radiosonde observations.The spatial variability of the BLH is further discussed by location,by classifying recording stations as inland,coastal,or bay.We find that the BLH in Europe varies considerably from day to night and with the seasons.Nighttime BLH is higher in winter and lower in summer,with the highest BLH recorded at coastal stations.Daytime BLH at coastal stations shows a bimodal structure with peaks in spring and autumn;at inland and bay stations,daytime BLH is lower in winter and higher in summer.The daily amplitudes of BLH at the inland and bay stations are stronger than those at coastal stations.Based on our multiple linear regression analysis and our decoupling analysis of temperature and specific humidity,we report that the development of the nighttime BLH at all types of stations is strongly dominated by the variations of surface wind speed(and,at coastal stations,wind directions).The main contributors to daytime BLH are the near-surface temperature variability at most coastal and inland stations,and,at most bay stations,the variation of the near-surface specific humidity.

关键词： atmospheric boundary layer height wind surface temperature specific humidity decoupling

The superhydrophobic sponge decorated with Ni-Co double layered oxides with thiol modification for continuous oil/water separation

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Chinese Journal of Chemical Engineering 2023年第2期54卷 296-305页

作者： Xiaodong yang Na Yang Ziqiang Gong Feifei Peng Bin Jiang Yongli Sun Luhong Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

In this paper, the superhydrophobic polyurethane sponge(SS-PU) was facilely fabricated by etching with Jones reagent to bind the nanoparticles of Ni-Co double layered oxides(LDOs) on the surface, and following modification with n-dodecyl mercaptan(DDT). This method provides a new strategy to fabricate superhydrophobic PU sponge with a water contact angle of 157° for absorbing oil with low cost and in large scale. It exhibits the strong absorption capacity and highly selective characteristic for various kinds of oils which can be recycled by simple squeezing. Besides, the as-prepared sponge can deal with the floating and underwater oils, indicating its application value in handling oil spills and domestic oily wastewater. The good self-cleaning ability shows the potential to clear the pollutants due to the ultralow adhesion to water. Especially, the most important point is that the superhydrophobic sponge can continuously and effectively separate the oil/water mixture against the condition of turbulent disturbance by using our designed device system, which exhibit its good superhydrophobicity, strong stability.Furthermore, the SS-PU still maintained stable absorption performance after 150 cycle tests without losing capacity obviously, showing excellent durability in long-term operation and significant potential as an efficient absorbent in large-scale dispose of oily water.

关键词： Superhydrophobic sponge Ni-Co double layered oxides Thiol modification Oil absorption Oil/water separation

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刘娜教授升阳除湿法治疗虚劳病经验

光明中医 2023年第6期38卷 1156-1158页

作者：杨心雨刘娜黑龙江省中医药科学院黑龙江哈尔滨150036 黑龙江省中医药科学院肾病九科黑龙江哈尔滨150036

黑龙江省中医医院研究生导师刘娜教授为第六批全国名老中医药专家学术经验继承人,从事中医药防治慢性肾脏病的临床科研及肾脏病理诊断工作13年,擅长运用中医临床思维以中医经典理论为切入点治疗内科相关疾病。笔者有幸随诊2年,亲睹刘娜... 详细信息

黑龙江省中医医院研究生导师刘娜教授为第六批全国名老中医药专家学术经验继承人,从事中医药防治慢性肾脏病的临床科研及肾脏病理诊断工作13年,擅长运用中医临床思维以中医经典理论为切入点治疗内科相关疾病。笔者有幸随诊2年,亲睹刘娜教授运用升阳除湿法治疗虚劳,疗效甚佳。此文从刘娜教授辨证治疗虚劳的1则典型医案着手,浅析刘娜教授对于虚劳独到的辨证思维方式以及选方用药的经验。

关键词：虚劳升阳除湿法刘娜

Diurnal variability of the planetary boundary layer height estimated from radiosonde data

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Earth and Planetary Physics 2020年第5期4卷 479-492页

作者： Jie Gu YeHui Zhang Na Yang Rui Wang School of Hydrology and Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China

Diurnal variations in the planetary boundary layer height(PBLH)at different latitudes over different surface characteristics are described,based on 45 years(1973−2017)of radiosonde observations.The PBLH is determined from the radiosonde data by the bulk Richardson number(BRN)method and verified by the parcel method and the potential temperature gradient method.In general,the BRN method is able to represent the height of the convective boundary layer(BL)and neutral residual layer cases but has relatively large uncertainty in the stable BL cases.The diurnal cycle of the PBLH over land is quite different from the cycle over ocean,as are their seasonal variations.For stations over land,the PBLH shows an apparent diurnal cycle,with a distinct maximum around 15:00 LT,and seasonal variation,with higher values in summer.Compared with the PBLH over land,over oceans the PBLH diurnal cycles are quite mild,the PBLHs are much lower,and the seasonal changes are less pronounced.The seasonal variations in the median PBLH diurnal cycle are positively correlated with the near-surface temperature and negatively correlated with the near-surface relative humidity.Finally,although at most latitudes the daytime PBLH exhibits,over these 45 years,a statistically significant increasing trend at most hours between 12:00 LT and 18:00 LT over both land and ocean,there is no significant trend over either land or ocean in the nighttime PBLH for almost all the studied latitudes.

关键词： planetary boundary layer height diurnal cycle radiosonde

Caffeine Exposure Causes Immune Dysfunction and Intrauterine Growth Restriction Retardation in Rats

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Biomedical and Environmental Sciences 2022年第2期35卷 170-173页

作者： ZHANG Wen Zhong SUN na na HU yang CAO Yu Amber Sheeks Department of Safety Engineering North China Institute of Science&TechnologySanhe 065201HebeiChina Key Laboratory of Food Risk Assessment Ministry of Health China National Center for Food Safety Risk AssessmentBeijing 100021China Center for Public Health Surveillance and Information Service Chinese Center for Disease Control and PreventionBeijing 102206China Muskingum University OH 43762USA

This study was conducted to assess the effects of caffeine on the dam and the physical development of rat offspring.Pregnant Sprague-Dawley rats(20 per dose group)were administered caffeine by gavage at 0(control),5,20,and 80 mg/kg body weight(bw)daily from gestational day 6 through lactation using caffeine dissolved in water.The developmental toxicity of caffeine was evaluated.Dams in the 80 mg/kg bw group exhibited splenic atrophy.The litter weights were significantly lower in the 20 and 80 mg/kg bw groups than the untreated control(Pnancy can cause maternal immune dysfunction and intrauterine growth restriction retardation(IUGR);the developmental toxicity of caffeine varied with gender,as females were more sensitive than males.The no observed adverse effect level was 5 mg/kg bw based on the IUGR.

关键词： Immune weights offspring

Mechanism studies of the activation of Dna methyltransferase DNMT1 triggered by histone H3 ubiquitination,revealed by multi-scale molecular dynamics simulations

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Science China(Life Sciences) 2023年第2期66卷 313-323页

作者： Jixue Sun Fei Liu Longxiao Yuan Ning-Ning Pang Bing Zhu Na Yang State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of TianjinNankai UniversityTianjin 300353China national Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China

DNMT1 is a Dna methyltransferase that catalyzes and maintains methylation in CpG dinucleotides.It blocks the entrance of Dna into the catalytic pocket via the replication foci targeting sequence(RFTS)domain.Recent studies have shown that an H3-tail-conjugated two-mono-ubiquitin mark(H3Ub2)activates DNMT1 by binding to the RFTS domain.However,the activation mechanism of DNMT1 remains unclear.In this work,we combine various sampling methods of extensive simulations,including conventional molecular dynamics,Gaussian-accelerated molecular dynamics,and coarse-grained molecular dynamics,to elucidate the activation mechanism of DNMT1.Geometric and energy analyses show that binding of H3Ub2 to the RFTS domain of DNMT1 results in the bending of theα4-helix in the RFTS domain at approximately 30°–35°,and the RFTS domain rotates~20°anti-clockwise and moves~3?away from the target recognition domain(TRD).The hydrogen-bonding network at the RFTSTRD interface is significantly disrupted,implying that the RFTS domain is dissociated from the catalytic core,which contributes to activating the auto-inhibited conformation of DNMT1.These results provide structural and dynamic evidence for the role of H3Ub2 in regulating the catalytic activity of DNMT1.

关键词： Dna methyltransferase conformational change molecular dynamics simulation activation molecular mechanism