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Highly selective photocatalytic reduction of CO_(2) to CH_(4) on electron-rich Fe species cocatalyst under visible light irradiation

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Carbon Energy 2024年第1期6卷 255-266页

作者： Qianying Lin Jiwu Zhao Pu Zhang Shuo Wang Ying Wang Zizhong Zhang na wen Zhengxin Ding Rusheng Yuan Xuxu Wang Jinlin Long State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhouChina

Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great challenges.Herein,we demonstrate unprecedented hybrid SiC photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic structure.It exhibits a superior photocatalytic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record CH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatalytic performance and selectivity.Specifically,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the CO_(2)→CH_(4) pathway.This study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts.

关键词： artificial synthesis of CH_(4) electronic structure optimization Fe species cocatalyst photocatalytic CO_(2) reduction SiC

Visual test paper based on Au/δ-MnO_(2) hollow nanosphere oxidase-like activity regulation using hexavalent chromium as a smart switch

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Rare Metals 2024年第2期43卷 711-722页

作者： wen-Chang Zhuang Hai-Yue Zhang Zhen-Yang Chen wen-Jing Cheng Wei-Dan na Zhao Li Lin Tian School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China School of Chemistry and Environmental Science Yili Normal UniversityYining835000China

Paper-based sensing platform is a point of need analytical toolkit for safety testing.However,the sensitivity,specificity,and simplicity are still challenging.Herein,we report a novel strategy(Au/δ-MnO_(2) hollow nanosphere and 3,3′,5,5′-tetramethylbenzidine(TMB)induced test strips for signal-on detection)that can be utilized for hexavalent chromium(Cr^(6+))detection.Interestingly,Cr^(6+)(CrO_(4)^(2−)) as a smart switch can remarkably enhance the oxidase-like activity of Au/δ-MnO_(2) hollow nanosphere.The presence of Cr^(6+) can regulate the surface electronic redistribution of Au/δ-MnO_(2) and adjust the geometric configuration,which leads to the improvement in oxidase-like activity of Au/δ-MnO_(2).As a proof-of-concept application,a visual paper-based sensing platform of Cr^(6+) along with quantitative analysis by the test strips was successfully constructed.This paper-based sensing platform exhibits a linear range with excellent selectivity for other interfering substances and lower limit of detection of 0.09μmol·L^(−1),providing a promising toolkit at-home Cr^(6+) measurement and environmental monitoring.

关键词： Point of need Colorimetric biosensing platform Au/δ-MnO_(2) hollow nanosphere Test strip Cr^(6+)

Numerical study of the deep removal of R134a from non-condensable gas mixture by cryogenic condensation and de-sublimation

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Chinese Journal of Chemical Engineering 2023年第9期61卷 180-191页

作者： Hongbo Tan Boshi Shao na wen Department of Refrigeration and Cryogenic Engineering School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China

Nowadays,the limits on greenhouse gas emissions are becoming increasingly stringent.In present research,a two-dimensional numerical model was established to simulate the deep removal of 1,1,1,2-tetrafluoroethane(R134a)from the non-condensable gas(NCG)mixture by cryogenic condensation and de-sublimation.The wall condensation method was compiled into the Fluent software to calculate the condensation of R134a from the gas mixture.Besides,the saturated thermodynamic properties of R134a under its triple point were extrapolated by the equation of state.The simulation of the steam condensation with NCG was conducted to verify the validity of the model,the results matched well with the experimental data.Subsequently,the condensation characteristics of R134a with NCG and the thermodynamic parameters affecting condensation were studied.The results show that the section with relatively higher removal efficiency is usually near the inlet.The cold wall temperature has a great influence on the R134a removal performance,e.g.,a 15 K reduction of the wall temperature brings a reduction in the outlet R134a molar fraction by 85.43%.The effect of changing mass flow rate on R134a removal is mainly reflected at the outlet,where an increase in mass flow rate of 12.6% can aggravate the outlet molar fraction to 210.3% of the original.The research can provide a valuable reference for the simulation of the deep removal of various low-concentration gas using condensation and de-sublimation methods.

关键词： Numerical simulation Greenhouse gas Condensation De-sublimation Vapor deep removal Non-condensable gas

Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： Hong-Xiao Wu Xiao-Yan Ding Ya-wen Xu Ming-Hua Yu Xiao-Mi Li na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment responses.AIM To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with PVTT.METHODS From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan Hospital.They were distributed to either the PTL or TACE/Lenvatinib(TL)group.The median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary endpoints.RESULTS Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)groups.For a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),res-pectively.Moreover,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)patients.There were no treatment-related deaths or differences in adverse events in either group.CONCLUSION A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-na Ye Yin-Hua Huang Yi-wen Ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of DR.METHODS:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDna gene sequencing.Sixty fecal samples from PDR,DM,and HC groups were assayed by untargeted metabolomics.Fecal metabolites were measured using liquid chromatographymass spectrometry(LC-MS)analysis.Associations between gut microbiota and fecal metabolites were analyzed.RESULTS:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were found.To be specific,the structure of gut microbiota differed in four groups.Diversity and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was observed.Functional analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC group.Arginine,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC group.Functional analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR group.Correlation analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal samples.CONCLUSION:This study elaborates the different microbiota structure in the gut from four groups.The relative abundance of Ruminococcaceae-UCG-002 and Parabacteroides are

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRna tumor vaccines

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Chinese Chemical Letters 2024年第5期35卷 314-319页

作者： wen Xiao Fazhan Wang Yangzhuo Gu Xi He na Fan Qian Zheng Shugang Qin Zhongshan He Yuquan Wei Xiangrong Song Department of Critical Care Medicine Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450000China

Dendritic cell(DC)-targeted delivery of mRna is a prominent method to boost the efficacy of mRna tumor vaccines.The targeting ligands are often modified on nanocarriers by polyethylene glycol(PEG)linker in mRna delivery systems.Whether the PEG linker length influences the targeting delivery efficiency of mRna nanocarrier in vivo remains unclear.Here,we designed and constructed DC-targeted mRna delivery systems modified by mannose via different PEG linker lengths(100/400/1000/2000)(MPn-LPX).The top candidate MP_(400)-LPX(the linker was PEG400)showed the optimal mRna expression and antigen presentation owing to the highly efficient uptake by DCs.Furthermore,MP_(400)-LPX could better inhibited tumor growth and extended survival in the E.G7-OVA lymphoma and TC-1 cervical tumor mouse model.Collectively,these results demonstrated that PEG400 was the optimal linker for the PEGylated DC-targeted mRna vaccines.Our findings provided a new platform for the rational design of targeted mRna nanovaccines with shorter-length PEG.

关键词： Cancer immunotherapy mRna vaccines DC-targeted delivery PEGylated liposomes Cellular uptake

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-wen Liu na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China national Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular membrane.However,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based therapies.We co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple myeloma.Here we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated cytotoxicity.Crystallographic analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in solution.BCMA-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived cells.Our results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

Diagnosing the Dynamic and Thermodynamic Effects for the Exceptional 2020 Summer Rainy Season in the Yangtze River Valley

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Journal of Meteorological Research 2022年第1期36卷 26-36页

作者： na wen Shujie LIU Laurent Z.X.LI College of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science&TechnologyNanjing 210044China Qingdao Engineering Technology Research Center for Meteorological Disaster Prevention Qingdao Meteorological BureauQingdao 266003China Laboratoire de Météorologie Dynamique Centre National de la Recherche ScientifiqueSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75252France

An exceptional rainy season occurred in the Yangtze River valley of eastern China in June-July 2020.The relative importance of the dynamic and thermodynamic effects on this unusual event is evaluated through the budget equations of moisture and moist static energy(MSE).The moisture budget analysis suggests that the thermodynamic effect contributes to the precipitation anomaly by 8.5%through the advection of abnormal water vapor by mean vertical motion,while the dynamic effect,related to water vapor advection by anomalous vertical motion,has the dominant contribution.The MSE budget analysis further reveals that the anomalous vertical motion is both constrained by the dynamic effect related to changes in atmospheric circulation and the thermodynamic effect related to changes of the atmospheric thermal state,with a ratio of thermodynamic versus total effects estimated at 45.3%.The dynamic effect is linked to the advection of warm and humid air by the abnormal southwesterly wind,which is related with an anomalous anticyclone over the Philippine Sea.The thermodynamic effect is partly induced by the positive advection of anomalous MSE(mainly latent energy)by the mean vertical motion.This analysis of the dynamic and thermodynamic effects is useful to understand the underlying physical mechanisms leading to the unusual rainy season in the Yangtze River valley in summer 2020.It is also helpful to put forward a few speculations on the potential role of global warming whose primary effect is,after all,to change the thermal state of the atmosphere.

关键词： exceptional rainfall Yangtze River valley global warming dynamic and thermodynamic effects

Thermodynamic theory of flotation for a complex multiphase solid -liquid system and high-entropy flotation

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1177-1197页

作者： Shuming wen State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China

The flotation of complex solid–liquid multiphase systems involve interactions among multiple components,the core problem facing flotation theory.Meanwhile,the combined use of multicomponent flotation reagents to improve mineral flotation has become an important issue in studies on the efficient use of refractory mineral resources.However,studying the flotation of complex solid–liquid systems is extremely difficult,and no systematic theory has been developed to date.In addition,the physical mechanism associated with combining reagents to improve the flotation effect has not been unified,which limits the development of flotation theory and the progress of flotation technology.In this study,we applied theoretical thermodynamics to a solid–liquid flotation system and used changes in the entropy and Gibbs free energy of the reagents adsorbed on the mineral surface to establish thermodynamic equilibrium equations that de-scribe interactions among various material components while also introducing adsorption equilibrium constants for the flotation reagents adsorbed on the mineral surface.The homogenization effect on the mineral surface in pulp solution was determined using the chemical potentials of the material components of the various mineral surfaces required to maintain balance.The flotation effect can be improved through synergy among multicomponent flotation reagents;its physical essence is the thermodynamic law that as the number of compon-ents of flotation reagents on the mineral surface increases,the surface adsorption entropy change increases,and the Gibbs free energy change of adsorption decreases.According to the results obtained using flotation thermodynamics theory,we established high-entropy flotation theory and a technical method in which increasing the types of flotation reagents adsorbed on the mineral surface,increasing the adsorption entropy change of the flotation reagents,decreasing the Gibbs free energy change,and improving the adsorption efficiency and stability of the flotation reagents improve

关键词： multicomponent flotation reagent adsorption entropy change equations of thermodynamic equilibrium adsorption equilibri-um constant high-entropy flotation