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Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp(Penaeus vannamei)proteins in BAlB/c mice

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Food Science and Human Wellness 2024年第1期13卷 339-348页

作者： Yao liu Songyi lin Kexin liu Shan wang wang li na Sun national Engineering Research center of Seafood School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China collaborative Innovation center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Shrimp(Penaeus vannamei)proteins have been shown an allergenic potential;however,l.ttle information is available on the sensitizing and eliciting capacity of shrimp protein digestion *** this study,a BAlB/c mice model was used to explore the allergenicity of shrimp protein sample(SPS)and their gastric and gastrointestinal digestion products(GDS/GIDS).As compared with the SPS groups,the GDS/GIDS groups caused lower specific immunoglobulins(Ig E/Ig G1)levels(Pt higher than the control groups,indicating that the digestion products sensitized the ***,spleen index,mouse mast cell protease-1(m McP-1)concentration and proportion of degranul.ted mast cells were significantly reduced in the GDS/GIDS groups(Pltaneously,allergic symptoms,vascular permeabil.ty and histopathological changes of tissues were ***,the allergenicity of digestion products cannot be eliminated and still cause systemic allergic reactions in *** study showed that the digestion products of shrimp still had high sensitizing and eliciting capacity.

关键词： Penaeus vannamei Allergenicity Digestion BAlB/c mice model

cage-confinement synthesis of Moc nanoclusers as efficient sulfiphilic and l.thiophilic regul.tor for superior li–S batteries

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Rare Metals 2024年第2期43卷 624-634页

作者： Xing-Yuan Zhang Mei-na lei Shan tian Jian-Gan wang State Key laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an710072China

High-energy-density li-S batteries are subjected to serious sulfur deactivation and short cycle lifetime caused by undesirable polysulfide shuttle effect and frantic l.thium dendrite *** this work,a controllable cage-confinement strategy to fabricate molybdenum carbide(Moc)nanoclusters as a high-efficient sulfiphilic and l.thiophilic regul.tor to mitigate the formidable issues of li-S batteries is *** sub-2 nm Moc nanoclusters not only guarantee robust chemisorption and fast electrocatal.tic conversion of polysulfides to enhance the sulfur electrochemistry,but also homogenize li^(+) flux to suppress the l.thium dendrite *** a consequence,the Moc-modified separator endows the batteries with boosted reaction kinetics,promoted sulfur utilization,and improved cycling stabil.ty.A reversible capacity of 701 mAh·g^(−1) at a high rate of 5.0c and a small decay rate of 0.076%per cycle at 1.0c over 600 cycles are *** study offers a rational route for design and synthesis of bifunctional nanoclusers with both sulfiphilicity and l.thiophilicity for high-performance li-S batteries.

关键词： li-S batteries nanocluster Electrocatalyst Polysulfide shuttle li dendrites

the Adjustment Analysis Method of the Active Surface Antenna Based on convol.tional Neural Network

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Research in Astronomy and Astrophysics 2024年第6期24卷 294-306页

作者： You Ban Shang Shi na wang Qian Xu Shufei Feng School of Mechanical Engineering Xinjiang UniversityUrumqi 830017China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China

Active surface technique is one of the key technologies to ensure the reflector accuracy of the millimeter/submillimeter wave large reflector *** antenna is complex,large-scale,and high-precision equipment,and its active surfaces are affected by various factors that are difficult to comprehensively deal *** this paper,based on the advantage of the deep learning method that can be improved through data learning,we propose the active adjustment value analysis method of large reflector antenna based on deep *** method constructs a neural network model for antenna active adjustment analysis in view of the fact that a large reflector antenna consists of multiple panels spliced *** on the constraint that a single actuator has to support multiple panels(usually 4),an autonomously learned neural network emphasis layer module is designed to enhance the adaptabil.ty of the active adjustment neural network *** classical 8-meter antenna is used as a case study,the actuators have a mean adjustment error of 0.00252 mm,and the corresponding antenna surface error is0.00523 *** active adjustment result shows the effectiveness of the method in this paper.

关键词： techniques:radar astronomy telescopes methods:anal.tical methods:numerical

A Scoping Review of Real-World Study in Vaccine Evaluation

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china cDc weekly 2024年第16期6卷 357-362页

作者： lei wang Hong Yang lanfang Xia Quanwei Song na liu Guomin Zhang Fuzhen wang Huaqing wang national Key laboratory of Intelligent tracking and Forecasting for Infectious Diseases(NItFID) BeijingChina national Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st century cures Act in 2016,emphasizing RWS(2).the FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data rel.ting to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).the proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facil.tating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical.trials(Rcts)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse popul.tions and are adept at identifying rare events not easily discernible in Rcts due to their infrequency.

关键词： routine gained traditionally

Striking Stabilization Effect of Spinel cobalt Oxide Oxygen Evol.tion Electrocatalysts in Neutral pH by Dual-Sites Iron Incorporation

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Energy & Environmental Materials 2024年第2期7卷 152-160页

作者： Shuairu Zhu Xue wang Jiabo le na An Jianming li Deyu liu Yongbo Kuang Key laboratory of Advanced Fuel cells and Electrolyzers technology of Zhejiang Province Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences1219 Zhongguan West RoadNingbo 315201China Zhejiang Institute of tianjin University 85 Zhongguan West RoadNingbo 315201China Research center of New Energy Research Institute of Petroleum Exploration&Development20 Xueyuan RoadBeijing 100083China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences19(A)Yuquan RoadBeijing 100049China

Developing stable and efficient nonprecious-metal-based oxygen evol.tion catalysts in the neutral electrol.te is a challenging but essential goal for various electrochemical ***,cobalt-based spinels have drawn a considerable amount of attention but most of them operate in alkali ***,the frequently studied co-Fe spinel system never exhibits appreciable stabil.ty in nonbasic conditions,not to mention attract further investigation on its key structural motif and transition states for activity ***,we report exceptional stable co-Fe spinel oxygen evol.tion catalysts(~30%Fe is optimal)in a neutral electrol.te,owing to its unique metal ion arrangements in the crystal *** introduced iron content enters both the octahedral and tetrahedral sites of the spinel as Fe^(2+)and Fe^(3+)(with co ions having mixed distribution as well).combining density functional.theory calcul.tions,we find that the introduction of Fe to co_(3)O_(4)lowers the covalency of metal-oxygen bonds and can help suppress the oxidation of co^(2+/3+)and 0^(2-).It implies that the co-Fe spinel will have minor surface reconstruction and less l.ttice oxygen loss during the oxygen evol.tion reaction process in comparison with co_(3)O_(4)and hence show much better *** findings suggest that there is still much chance for the spinel structures,especially using reasonable subl.ttices engineering via multimetal doping to develop advanced oxygen evol.tion catalysts.

关键词： dual-sites iron electrocatalyst stabil.ty neutral electrol.te oxygen evol.tion reaction spinel oxides

the role of the auxin-response genes MdGH3.1 and MdSAUR36 in bitter pit formation in apple

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Horticultural Plant Journal 2024年第5期10卷 1085-1098页

作者： Daqing Huang Wen Peng na Gong lina Qiu Yongzhang wang Haiyong Qu college of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China

Apples often exhibit bitter pits in response to metabolic disorders during ripening and storage;however, the mechanisms underlying the bitter pit(BP) development remain unclear. Here, metabolome and transcriptome analyses were performed to investigate BP pulp of 'Fuji'. two auxin-response genes, MdGH3.1 and MdSAUR36, were screened. their expression as well as the auxin content in BP pulp were found to be higher than those in healthy pulp(P the field, excess cO(NH2)2increased the incidence of BP. Moreover, the auxin content and MdGH3.1 expression increased in apples after nitrogen fertilization. On Day 30 before harvest, the two genes were transiently transferred to the fruit, and 20.69% and 23.21% of BP fruits were harvested. After 10 μmol·l-1auxin was infiltrated at low pressure into postharvest fruit, the increase in MdGH3.1 expression occurred earlier than that in MdSAUR36. MdGH3.1 increased the expression of MdSAUR36, but MdSAUR36 did not increase expression of MdGH3.1. therefore, we suggest that MdGH3.1 acts upstream of MdSAUR36 during BP formation and that these genes induce BP formation by regul.ting auxin and phenylpropanoid biosynthesis.

关键词： Apple Malusdomestica Auxin Bitter pit Flavonoids Nitrogen fertilizer Widely targeted metabolomics

toughened (ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)ta_(0.2))B_(2)–Sic composites fabricated by one-step reactive sintering with a unique SiB_(6) additive

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Journal of Advanced ceramics 2024年第1期13卷 86-100页

作者： Wei Hao Xinzhe lu ling li tao wang Guoliang Ren Huangyue cai Xiaofeng Zhao Dongyun wang na Ni Zhejiang Provincial Key laboratory of Urban Rail.transit Intelligent Operation and Maintenance technology&Equipment Zhejiang Normal UniversityZhejiang 321004China Key lab of Education Ministry for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

High-entropy diboride has been arousing considerable interest in recent ***,the low toughness and damage tolerance limit its applications as ultra-high-temperature structural *** we report that a unique SiB_(6) additive has been first incorporated as boron and silicon sources to fabricate a high-entropy boride(ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)ta_(0.2))B_(2)–Sic composite though one-step boro/carbothermal reduction reactive sintering.A synergetic effect of high-entropy sluggish diffusion and Sic secondary phase retarded the grain growth of the(ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)ta_(0.2))B_(2)–51Sic *** small grain size was beneficial.to shorten the diffusion path for mass transport,thereby enhancing the rel.tive density to~99.3%.these results in an increase of fracture toughness from~5.2 in HEBS-1900 to~7.7 MPa·m^(1/2) in HEBS-2000,which corresponded to a large improvement of 48%.the improvement was attributed to a mixed mode of intergranular and transgranular cracking for offering effective pinning in crack propagation,resulting from balanced grain boundary strength collectively affected by improved densification,solid sol.tion strengthening,and incorporation of Sic secondary phase.

关键词： high-entropy diboride silicon hexaboride boro/carbothermal reduction reactive sintering fracture toughness

Highly selective photocatal.tic reduction of cO_(2) to cH_(4) on electron-rich Fe species cocatalyst under visible light irradiation

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carbon Energy 2024年第1期6卷 255-266页

作者： Qianying lin Jiwu Zhao Pu Zhang Shuo wang Ying wang Zizhong Zhang na Wen Zhengxin Ding Rusheng Yuan Xuxu wang Jinlin long State Key laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhouChina

Efficient photocatal.tic reduction of cO_(2) to high-calorific-value cH4,an ideal.target product,is a blueprint for c_(1)industry relevance and carbon neutral.ty,but it also faces great ***,we demonstrate unprecedented hybrid Sic photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic *** exhibits a superior photocatal.tic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record cH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatal.tic performance and ***,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the cO_(2)→cH_(4) *** study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts.

关键词： artificial synthesis of cH_(4) electronic structure optimization Fe species cocatalyst photocatal.tic cO_(2) reduction Sic

DlX3(Q178R)mutation delays osteogenic differentiation via H19/miR-29c-3p/KDM5B axis in tDO-iPScs-derived MScs

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Genes & Diseases 2024年第4期11卷 49-52页

作者： liying Dong na Zhao Dongmei wang Meng wang Yixin Zhang liangjie Sun chong Ding Yixiang wang Zeyun Ma central laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China national Engineering laboratory for Digital and Material.technology of Stomatology Peking University School and Hospital of StomatologyBeijing 100081China Beijing Key laboratory of Digital Stomatology Peking University School and Hospital of StomatologyBeijing 100081China the Second clinical Division Peking University School and Hospital of StomatologyBeijing 100081China Department of VIP Service Peking University School and Hospital of StomatologyBeijing 100081China Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental MedicineBostonMA 02115USA Department of Prosthodontics Fudan UniversityShanghai 200001China Shanghai Key laboratory of craniomaxillofacial Development and Diseases Shanghai Stomatological HospitalFudan UniversityShanghai 200001China

tricho-dento-osseous(tDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DlX3)mutation.1,2 Accumul.tive bone density in alveolar bone is a clinically favorable phenotype for tDO ***... 详细信息

关键词： patients clinically alveolar