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Analysis of Bright Source Hardness Ratios in the 4 yr Insight-HXMT Galactic Plane Scanning Survey Catalog

Research in Astronomy and Astrophysics 2024年第2期24卷 154-170页

作者： Chen Wang Jin-Yuan Liao Ju Guan Yuan Liu Cheng-Kui Li na sai Jing Jin Shuang-nan Zhang Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Astronomy School of Physics and TechnologyWuhan UniversityWuhan 430072China WHU-naOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China

We conduct a statistical analysis of the hardness ratio(HR)for bright sources in the 4 yr Galactic Plane Scanning Survey catalog of Insight-HXMT.Depending on the stable(variable)flux F_(s)(F_(v))or spectrum S_(s)(S_(v))of each source,the bright sources are classified into three groups:F_(v)&S_(v),F_(v)&S_(s),and F_(s)&_(s).Our study of the HR characteristics in different types of sources reveals that accretion-powered neutron star(NS)low-mass X-ray binaries(LMXBs)exhibit softer energy spectra than NS high-mass X-ray binaries(HMXBs),but harder energy spectra than black hole binaries in most cases.This difference is probably due to their different magnetic field strengths.Additionally,Fv&Sv LMXBs tend to be harder than Fv&Ss LMXBs below 7 keV,while the opposite is true for HMXBs.Our results suggest that LMXBs may dominate unclassified sources,and NS binaries are likely to be the primary type of X-ray binaries with ambiguous compact stars.By comparing the HR of transient sources in their outburst and low-flux states,it is found that the averaged HR of four sources in the two states are roughly comparable within uncertainties.We also investigate the spatial properties of the three groups and find that Fv&Sv sources are mainly located in the longitude of-20°nantly concentrated in 19°nalyzing the HR spatial distributions shows the absorption of soft X-rays(primarily below 2 keV)in the Galactic Plane.

关键词： catalogs-surveys-methods data analysis-X-rays general

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Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss

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Neural Regeneration Research 2022年第12期17卷 2750-2754页

作者： na sai Yuan-Yuan Yang Long Ma Da Liu Qing-Qing Jiang Wei-Wei Guo Wei-Ju Han College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalBeijingChina national Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment for Prevention and Treatment BeijingChina Department of Otolaryngology Head and Neck Surgery Peking University Shenzhen HospitalShenzhenGuangdong ProvinceChina PLA Rocket Force Characteristic Medical Center Department of Stomatology China

The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system.It plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms of NLR family pyrin domain containing 3(NLRP3)inflammasome activation in NIHL have not been clearly demonstrated.In this study,miniature pigs were exposed to white noise at 120 dB(A)and auditory brainstem response measurements were used to measure their hearing function.Immunofluorescence staining,confocal laser scanning microscopy,western blot assay,and quantitative reverse transcription-polymerase chain reaction were used to analyze inflammasome-related protein distribution and expression.NLRP3,interleukin-1β,interleukin-18,and cleaved-caspase-1 were highly expressed in the cochlea after 120 dB(A)white noise exposure.Our findings suggest that NLRP3-inflammasomes in the cochlea may be activated after acoustic trauma,which may be an important mechanism of noise-induced hearing loss.

关键词： acoustic injury inflammasome interleukin-1β miniature pig NLR family pyrin domain containing 3(NLRP3) noise-induced hearing loss sensorineural hearing loss

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论民族地区治理现代化的数字化赋能

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青海民族研究 2024年第1期35卷 144-152页

作者：赛娜付梦瑶高瑞婷中国科学院大学北京100190

民族地区治理现代化是新时期全面建设中国式现代化的重要内容。鉴于近年来社会治理风险加剧,以及民族地区面临着特殊性和差异性的复杂治理需求,数字化对民族地区治理建设的赋能已成为必然趋势。数字化赋能不仅可以推动民族地区构建高效... 详细信息

民族地区治理现代化是新时期全面建设中国式现代化的重要内容。鉴于近年来社会治理风险加剧,以及民族地区面临着特殊性和差异性的复杂治理需求,数字化对民族地区治理建设的赋能已成为必然趋势。数字化赋能不仅可以推动民族地区构建高效协同的社会治理共同体和网络化治理体系,还能加强民族地区治理决策的科学性和精准性,从而提升民族地区的治理能力与治理水平。当前,民族地区在数字化赋能治理建设实践中面临治理观念、治理制度、治理资源等方面的困难与挑战。在新时期的治理建设工作中,民族地区须借鉴先进经验,针对问题精准施策,继续推动数字化赋能,从而加速推进民族地区治理现代化。

关键词：民族地区治理治理现代化数字化赋能社会治理共同体

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Localization Method for the Pointing Observation with the Collimated Telescopes of Insight-HXMT

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Research in Astronomy and Astrophysics 2023年第5期23卷 38-43页

作者： Qi Luo Jin-Yuan Liao Yi nang Cheng-Kui Li Chen Wang na sai Ju Guan Yu-Peng Chen Cheng-Cheng Guo Yuan Liu Shu Zhang Shuang-nan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Physics and Technology Wuhan UniversityWuhan 430072China WHU-naOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China

An accurate target source position is sometimes useful for the pointing observation with the collimated telescopes of the Hard X-ray Modulation Telescope(Insight-HXMT),which is determined by the reliability of the instrumental response.Insight-HXMT has the unique design that all three main payloads(LE,ME and HE)consist of detector groups with three fields of views(FOVs)whose orientations differ by 60°.As the point-spread functions are different at different positions in the FOV coordinates,the count rate ratios between the detector groups depend on the position of an X-ray source in the FOVs.Based on the multi-FOV design,we develop a localization method for an X-ray source in the pointing observation of Insight-HXMT.The accuracy of the method is investigated with the pointing observations of the Crab with different exposures.We find that the statistical error decreases with the exposure,and the systematic error is dominant for the exposure>128 s.With the exposure of1024 s,the total error is 0°.015 for the Crab.This method can effectively distinguish the Rapid Burster H 1730–333and Slow Burster GX 354–0,which are only 0°.5 apart and can both contribute to bursts in the light curve obtained by Insight-HXMT.We also apply the pointing observation localization method to locate the X-ray counterpart of FRB 200428 with high precision.The located position is consistent with SGR J1935+2154 within 1σuncertainty of 10′,which provides important evidence that fast radio bursts can originate from magnetars.

关键词： instrumentation detectors-space vehicles instruments-telescopes

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Development of Rural Tourism in Liaoning Province from the Perspective of Types

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Asian Agricultural Research 2021年第9期13卷 17-19页

作者： Siyu WANG Liang ZHAO na sai Yaning HUI School of Business Administration University of Science and Technology LiaoningAnshan 114051China

With the vigorous development of the tourism industry,the types of tourism become rich and diverse,and the development models have their own characteristics.At present,rural tourism has become a hot spot in the development of tourism,and it is also a driver of rural revitalization.However,its development type and development model are not mature yet,and there are still some fundamental problems in the process of development.Based on the development status of rural tourism in Liaoning Province,an in-depth survey was carried out on the types and development models of rural tourism in Liaoning Province,and its basic types and development models are clarified,to explore the deep-rooted problems existing in the development of rural tourism in Liaoning Province.Besides,the development models adopted in different regions of China were compared to find the universally applicable rules for the development of rural tourism.Finally,according to the distribution of rural tourism resources,the development direction was clearly defined,supporting policy recommendations were proposed,including adjusting and upgrading the existing types and development models,and implementing development strategies in a targeted manner to promote the sustainable development of rural tourism in Liaoning Province.

关键词： Rural tourism Tourism type Development strategies

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2种吻合术修复面神经缺损的疗效分析

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临床耳鼻咽喉头颈外科杂志 2024年第5期38卷 395-399页

作者：范术杭孙健斌王琴塞娜季琦朱玉华申卫东戴朴杨仕明韩东一韩维举解放军医学院北京100853 中国人民解放军总医院耳鼻咽喉头颈外科医学部、解放军总医院第六医学中心耳鼻咽喉头颈外科医学部辽宁省妇女儿童医院

目的:探讨分析2种吻合术修复面神经缺损的疗效及影响因素。方法:回顾性分析2012年1月至2021年12月在我科行面神经吻合术(直接或改道)修复面神经缺损的30例患者临床资料,其中男21例,女9例,平均年龄(37.53±11.33)岁,均为单侧发病;术前H-... 详细信息

目的:探讨分析2种吻合术修复面神经缺损的疗效及影响因素。方法:回顾性分析2012年1月至2021年12月在我科行面神经吻合术(直接或改道)修复面神经缺损的30例患者临床资料,其中男21例,女9例,平均年龄(37.53±11.33)岁,均为单侧发病;术前H-BⅣ级2例、Ⅴ级9例、Ⅵ级19例;面瘫患者术前面瘫时间6个月以内21例,6~12个月6例,1年以上3例;面瘫原因包括胆脂瘤14例、面神经肿瘤6例、外伤6例、中耳手术损伤4例。手术入路包括颅中窝入路9例,迷路-耳囊入路8例,乳突-上鼓室入路7例,耳后颈侧入路6例。结果:随访2年以上。术中采用直接吻合10例:缺损位于颞骨外段6例,水平-锥段4例;改道吻合20例:缺损位于迷路-膝状神经节11例,内听道至膝状神经节及水平段近端4例,内听道3例,水平-锥段2例。术后H-B面神经评分为Ⅱ级2例、Ⅲ级20例、Ⅳ级8例,73.3%(22/30)患者能达到H-BⅢ级或更好。结论:面神经直接吻合术和改道吻合术均可修复面神经缺损,2种术式疗效无明显差异。多数患者能达到H-BⅢ级或更好。术前面神经功能评级及术前面瘫时间是影响面神经吻合效果的主要影响因素。

关键词：面神经缺损面神经吻合术周围神经修复

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Tissue and regional expression patterns of dicistronic tRna–mRna transcripts in grapevine (Vitis vinifera) and their evolutionary co-appearance with vasculature in land plants

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Horticulture Research 2021年第1期8卷 1715-1729页

作者： Pastor Jullian Fabres Lakshay Anand na sai Stephen Pederson Fei Zheng Alexander A.Stewart Benjamin Clements Edwin R.Lampugnani James Breen Matthew Gilliham Penny Tricker Carlos M.Rodriguez Lopez Rakesh David School of Agriculture Food and WineUniversity of AdelaideAdelaideSAAustralia Environmental Epigenetics and Genetics Group Department of HorticultureCollege of AgricultureFood and EnvironmentUniversity of KentuckyLexingtonKYUSA ARC Centre of Excellence in Plant Energy Biology Waite Research Institute&School of AgricultureFood and WineUniversity of AdelaideAdelaideSAAustralia Bioinformatics Hub School of Biological SciencesUniversity of AdelaideAdelaideSAAustralia School of Biosciences University of MelbourneParkvilleVIC 3010Australia ARC Industrial Transformation Training Centre in Innovative Wine Production Waite Research Institute&School of AgricultureFood and WineUniversity of AdelaideAdelaideSAAustralia

Transfer Rnas(tRna)are crucial adaptor molecules between messenger Rna(mRna)and amino acids.Recent evidence in plants suggests that dicistronic tRna-like structures also act as mobile signals for mRna transcripts to move between distant tissues.Co-transcription is not a common feature in the plant nuclear genome and,in the few cases where polycistronic transcripts have been found,they include non-coding Rna species,such as small nucleolar Rnas and microRnas.It is not known,however,the extent to which dicistronic transcripts of tRna and mRnas are expressed in field-grown plants,or the factors contributing to their expression.We analysed tRna–mRna dicistronic transcripts in the major horticultural crop grapevine(Vitis vinifera)using a novel pipeline developed to identify dicistronic transcripts from high-throughput Rna-sequencing data.We identified dicistronic tRna–mRna in leaf and berry samples from 22 commercial vineyards.Of the 124 tRna genes that were expressed in both tissues,18 tRna were expressed forming part of 19 dicistronic tRna–mRnas.The presence and abundance of dicistronic molecules was tissue and geographic sub-region specific.In leaves,the expression patterns of dicistronic tRna–mRnas significantly correlated with tRna expression,suggesting that their transcriptional regulation might be linked.We also found evidence of syntenic genomic arrangements of tRnas and protein-coding genes between grapevine and Arabidopsis thaliana,and widespread prevalence of dicistronic tRna–mRna transcripts among vascular land plants but no evidence of these transcripts in non-vascular lineages.This suggests that the appearance of plant vasculature and tRna–mRna occurred concurrently during the evolution of land plants.

关键词： dic Vitis arrangement

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China national Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular membrane.However,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based therapies.We co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple myeloma.Here we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated cytotoxicity.Crystallographic analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in solution.BCMA-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived cells.Our results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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论“两个结合”与当代中国教育的文化使命

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民族教育研究 2023年第6期34卷 29-36页

作者：赛娜张天宸中国科学院大学公共政策与管理学院北京100190

“两个结合”指导当代中国把马克思主义基本原理与中国具体实际、与中华优秀传统文化相结合,形成中国特色社会主义的新文化形态。在全面建设社会主义现代化强国的历史新时期,中国教育须担负起新文化形态建设的重要使命。但是,现有相关... 详细信息

“两个结合”指导当代中国把马克思主义基本原理与中国具体实际、与中华优秀传统文化相结合,形成中国特色社会主义的新文化形态。在全面建设社会主义现代化强国的历史新时期,中国教育须担负起新文化形态建设的重要使命。但是,现有相关研究总量较少,且普遍成文较早,对当前而言针对性不足。本文聚焦当下,探讨中国教育履行中国特色社会主义新文化形态建设使命的重点内容与实践方法。基础教育和高等教育作为中国教育的主要阶段,应在坚持“两个结合”的同时发挥自身优势。建立和完善学科专业和课程教学体系,培养担负中华民族文化使命的时代新人;培育和弘扬社会主义核心价值观,加强中华民族现代文明教育;推动国家间的文化交流互鉴,吸收世界文明的优秀成果。用高质量的教育引领和推动中国特色社会主义文化的传承、发展和创新,推动建设社会主义文化强国。

关键词： “两个结合” 新文化形态建设教育文化使命当代中国

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公共教育对国家认同的塑造和培养——以美国为例

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中央社会主义学院学报 2022年第5期 106-120页

作者：赛娜中国科学院大学公共政策与管理学院北京100190

国家认同是支撑民族国家合法性、维系国家团结和统一的一种重要的公民意识。公共教育是塑造和培养国家认同的主要途径之一。世界各国以塑造和培养国家认同为首要任务的公共教育政策,主要遵循同化主义、多元文化主义、以政治认同为核心... 详细信息

国家认同是支撑民族国家合法性、维系国家团结和统一的一种重要的公民意识。公共教育是塑造和培养国家认同的主要途径之一。世界各国以塑造和培养国家认同为首要任务的公共教育政策,主要遵循同化主义、多元文化主义、以政治认同为核心、以国家建构为核心以及混合型等模式。美国作为社会构成复杂的移民国家,其公共教育体系受到自由同化主义、多元文化主义和以政治认同为核心等模式的影响,呈现出一种混合型的国家认同培养模式。在最近几十年中,美国的公共教育体系受到多元文化主义、教育“私有化”改革和全球化的冲击,在公民意识和国家认同的培养上遇到巨大挑战。美国的案例表明,国家认同的塑造和培养是长期的、复杂的、动态的社会任务。政府需要持续思考和不断探索,寻找和尝试适合本国社会结构且能兼顾国家认同塑造和族群文化保护的公共教育模式。

关键词：国家认同美国公共教育国家认同塑造公民意识

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