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Ti_(3)C_(2)T_(x)MXene wrapped,carbon-coated porous Si sheets for improved lithium storage performance

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Chinese Chemical Letters 2024年第2期35卷 617-621页

作者： Hui Cheng Yueming Liu Zhongling Cheng Xianying Wang na huang Haijiao Zhang Institute of nanochemistry and nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Energy Materials Research Center AG Hydrogen Materials & Devices CAS Key Laboratory of Materials for Energy ConversionShanghai Institute of CeramicsChinese Academy of Sciences (SICCAS)Shanghai 200050China

Si-based materials have shown great potential as lithium-ion batteries(LIBs)anodes due to their natural reserves and high theoretical ***,the large volume changes during cycles and poor conductivity of Si lead to rapid capacity decay and poor cycling stability,ultimately limiting their commercial ***,we have skillfully utilized the microporous MCM-22 zeolite as the unique silicon source to produce porous Si(pSi)sheets by a simple magnesiothermic reduction,followed by a carbon coating and further Ti_(3)C_(2)T_(x)MXene assembly,obtaining the ternary pSi@NC@TNSs *** the design,porous Si sheets provide more active sites and shorten Li-ion transport paths for electrochemical *** N-doped carbon(NC)layer serves as a bonding layer to couple pSi and Ti_(3)C_(2)T_(x).The conductive network formed by 2D Ti_(3)C_(2)T_(x)and medium NC layer effectively enhances the overall charge transport of the electrode material,and helps to stabilize the electrode ***,the as-made pSi@NC@TNSs anode delivers an improved lithium storage performance,exhibiting a high reversible capacity of 925 mAh/g at 0.5 A/g after 100 *** present strategy provides an effective way towards high-performance Si-based anodes for LIBs.

关键词： Si anodes Ti_(3)C_(2)Ti_(x)MXene Porous structure Interfacial assembly Lithium-ion batteries

Uterine epithelioid trophoblastic tumor with the main manifestation of increased human chorionic gonadotropin:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2876-2880页

作者： Li-na huang Xi Deng Jian Xu Department of Gynecology Ningbo Women and Children's HospitalNingbo 315012Zhejiang ProvinceChina Department of Ningbo Clinical Pathology Diagnosis Center Ningbo 315021Zhejiang ProvinceChina Department of Imaging Ningbo Women and Children's HospitalNingbo 315012Zhejiang ProvinceChina

BACKGROUND Epithelioid trophoblastic tumor(ETT)is an extremely rare malignant gestational trophoblastic neoplasm commonly presenting with abnormal vaginal bleeding,abdominal pain,and increased human chorionic gonadotropin(hCG).This study reported a case of uterine ETT with the main manifestation being increased *** SUMMARY A 39-year-old female was referred to the Ningbo Maternal and Child Hospital of China in December 2022,complaining of increased hCG levels for 1 *** resonance imaging revealed gestational trophoblastic tumor,and hysteroscopic electrotomy and curettage of intrauterine hyperplasia were *** patient was diagnosed with uterine ETT through postoperative pathological examination and immunohistochemical *** laparoscopic hysterectomy and bilateral salpingectomy were performed,and hCG levels returned to *** patient was without recurrence during the postoperative 3-month *** This study reported a case of uterine ETT with the main manifestation being increased hCG,highlighting that ETT should be considered in the presence of abnormal hCG.A total laparoscopic hysterectomy is recommended.

关键词： Uterine epithelioid trophoblastic tumor Gestational trophoblastic neoplasm Diagnosis Human chorionic gonadotropin Case report

饲料企业智造化背景下高校毕业生创新创业能力的提升路径

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中国饲料 2024年第4期 169-172页

作者：黄娜郑州科技学院河南郑州450064

专业教育有助于巩固中国制造的地位,而创新创业教育则有助于“中国制造”到“中国智造”的转型,可见将创新创业教育嵌入专业教育在当前高校教育中具有积极的现实意义。饲料企业在智造化背景下对创新创业人才的需求愈发迫切,需要高素质... 详细信息

专业教育有助于巩固中国制造的地位,而创新创业教育则有助于“中国制造”到“中国智造”的转型,可见将创新创业教育嵌入专业教育在当前高校教育中具有积极的现实意义。饲料企业在智造化背景下对创新创业人才的需求愈发迫切,需要高素质、多领域综合能力的毕业生,以推动行业的可持续发展和升级。然而,高校饲料专业毕业生在创新创业领域面临一系列挑战,包括缺乏实践经验、自信心不足等问题,同时高校在培养创新创业人才方面也需要进一步改进。基于此,本文首先分析智造化背景下饲料行业对创新创业人才的需求,然后从高校、行业层面讨论高校饲料专业毕业生在创新创业领域面临的问题,最后提出一系列饲料企业智造化背景下高校毕业生创新创业能力的提升路径,希望能培养出更多具备创新创业能力的饲料专业毕业生,推动饲料行业的智造化、可持续发展。

关键词：饲料企业智造化高校毕业生创新创业能力

The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

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Science China Life Sciences 2024年第09期 1867-1880页

作者： Weixiao Yan Xiaotong Wang Wenjing Wang Qi Guo na huang Hao Chen Xing-Jie Liang Yu Han Dandan Liu Jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education College of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei Province Hebei University CAS Key Laboratory for Biological Effects of nanomaterials and nanosafety National Center for Nanoscience and Technology

Cancer stem cells(CSCs) play an important role in metastasis development, tumor recurrence, and treatment resistance, and are essential for the eradication of cancer. Currently, therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape, which leads to enhanced aggressive behaviors compared with CSCs that have never been treated. However, the underlying mechanisms regulating the therapeutic escape remain unknown. To this end, we established a model to isolate the therapeutic escaped CSCs(TSCSCs) from breast CSCs and performed the transcription profile to reveal the mechanism. Mechanistically, we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway, resulting in TSCSCs exhibiting enhanced motility and metastasis. Notably,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo, which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and *** obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

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中医按病种付费研究进展

中国医院 2024年第4期28卷 73-76页

作者：黄娜杨土保中南大学湘雅公共卫生学院湖南省长沙市410006

中医作为中华文化的瑰宝,其医保支付方式改革已成为重要研究内容之一。按病种付费被引入医疗卫生领域后,在控制医疗成本、规范医疗行为、强化医院管理和优化资源配置等方面发挥了重要作用。随着中医医院按病种付费改革的稳步进行,学者... 详细信息

中医作为中华文化的瑰宝,其医保支付方式改革已成为重要研究内容之一。按病种付费被引入医疗卫生领域后,在控制医疗成本、规范医疗行为、强化医院管理和优化资源配置等方面发挥了重要作用。随着中医医院按病种付费改革的稳步进行,学者对中医按病种付费的研究也愈加丰富。本文回顾了中医按病种付费相关理论以及实践探索方面的文献,并在此基础上对未来相关研究方向提出建议,为后续相关理论和实证研究提供参考。

关键词：中医按病种付费支付方式中医医院

慢性阻塞性肺疾病急性加重期继发肺部真菌感染的列线图预测模型

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中国呼吸与危重监护杂志 2024年第2期23卷 77-85页

作者：林希黄娜成都医学院第一附属医院呼吸与危重症医学科四川成都610500

目的探究慢阻肺急性加重患者继发肺部真菌感染的危险因素,应用列线图构建并验证用于辅助临床预测慢阻肺急性加重患者发生肺部真菌感染概率的可视化工具。方法采用回顾性队列研究的方法,收集2021年1月—2021年12月期间,于成都医学院第一... 详细信息

目的探究慢阻肺急性加重患者继发肺部真菌感染的危险因素,应用列线图构建并验证用于辅助临床预测慢阻肺急性加重患者发生肺部真菌感染概率的可视化工具。方法采用回顾性队列研究的方法,收集2021年1月—2021年12月期间,于成都医学院第一附属医院呼吸与危重医学科住院治疗的慢阻肺急性加重患者作为训练集。并收集2020年1月—2020年12月期间的慢阻肺急性加重患者作为验证集。通过单因素、Lasso回归分析及多因素Logistic分析到独立危险因素。用独立危险因素构建列线图预测模型,并通过受试者工作特征(Receiver operating characteristic,ROC)曲线下面积(The area under ROC curve,AUC)、校准曲线和决策曲线分析(decision curve analysis,DCA)对列线图进行多方面评估。结果使用糖皮质激素、抗生素联合使用、抗生素使用时间及低蛋白血症是慢阻肺急性加重患者继发肺部真菌感染的独立危险因素(均P<0.05)。所构建预测模型的训练集和验证集的AUC值分别为0.915[95%CI:0.891~0.940]和0.830[95%CI:0.790~0.871]。训练集和验证集中的校准曲线显示,列线图预测的真菌感染概率与实际情况相符。而DCA曲线结果表明该列线图预测模型具有较好的临床实用性。结论糖皮质激素、多种抗生素联合使用、抗生素使用时间过长及低蛋白血症是慢阻肺急性加重患者继发肺部真菌感染的独立危险因素。本研究构建的慢阻肺急性加重患者继发肺部真菌感染的临床预测模型,具有较强的预测价值及实用性。

关键词：慢性阻塞性肺疾病急性加重期肺部真菌感染列线图预测模型

Janus hydrogel/electrospun-membrane dressing enhancing wound healing in rats

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Biomedical Engineering Communications 2024年第2期3卷 17-25页

作者： Zi-Rui Zhu Jia-na huang Jin-Ze Li Hao Cao Zhao-Yi Lin Yan Li School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Yat-sen UniversityGuangzhou 510006China

Background:Excessive exudate secreted from chronic wounds often leads to overhydration and *** a variety of dressings are currently available in clinical applications,they frequently fail to provide multifunction to promote chronic wound *** dressings with a Janus structure,featuring distinct properties on each side,are potential to improve wound ***:Composite dressings with a Janus structure were fabricated,comprising freeze-dried polycaprolactone(PCL)electrospun membrane and alginate-based *** PCL fibrous membrane provided air permeability,while the hydrogel loaded with Deferoxamine,composed of alginate and poly(N-isopropylacrylamide)(PNIPAM),exhibited hygroscopic *** inclusion of PNIPAM imparted ***:The hydrogel(thickness of 2.778±0.082 mm)exhibited a robust adhesion to the fiber membrane(thickness of 0.261±0.041 mm).For ANDC(Alginate-PNIPAM hydrogel with Deferoxamine/PCL membrane)samples,the water vapor transmission rate(WVTR)was measured to be 3364.80±23.23 g∙m−2∙day−1 and the swelling ratio at 2 h was determined to be 1179±125%.The thermo-responsivity of ANDC samples manifested in an increased swelling rate,escalating from 797±189%at 37°C to 1132±147%at 4°*** elastic modulus was assessed for lyophilized and rehydrated ANDC *** theωof the rheometer rotor was decreased from 10 rad/s to 0.1 rad/s,the lyophilized dressing exhibited a decrease from 2.65±0.01 MPa to 1.80±0.90 MPa,while the rehydrated dressing demonstrated an increase from 133.65±55.68 Pa to 264.23±141.71 *** pro-healing properties of the dressings were evaluated using full-thickness skin defect model on SD rats,and a circular wound of diameter 10 mm healed completely by day ***:The dressings not only protected the wound and absorbed excess exudate,but also demonstrated nondestructive peelability upon cooling,providing a novel approach for accelerating wound healing and management.

关键词： Janus structure composite dressing wound healing

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网络群体极化对大学生的影响及应对研究

现代交际 2024年第6期 101-108+124页

作者：黄娜安顺学院

群体极化是一个较为经典的社会心理学议题。网络的普遍运用出现了网络群体极化现象，其不可避免地对大学生这一庞大的网络用户群体产生影响。本文总结了网络群体极化的主要特征，并在此基础上全面审视网络群体极化对大学生思想观念、社... 详细信息

群体极化是一个较为经典的社会心理学议题。网络的普遍运用出现了网络群体极化现象，其不可避免地对大学生这一庞大的网络用户群体产生影响。本文总结了网络群体极化的主要特征，并在此基础上全面审视网络群体极化对大学生思想观念、社交行为、学习能力和心理健康产生的深刻影响，揭示其潜在的危害，探索高校应对网络群体极化的有效路径，旨在提高大学生理性思考能力，推动高校网络思政育人发展。

关键词：网络群体极化大学生高校网络思政

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基于绿色物流研究热点的物流管理专业本科实践教学改革研究

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物流科技 2024年第13期47卷 151-153页

作者：黄娜刘峥上海工程技术大学管理学院上海201620

基于“双碳”重要目标实现与物流行业发展转型的人才需要变化,通过对绿色物流,教学改革的相关研究进行前沿热点追踪与共现聚类分析。得出绿色物流研究变化特点与教学改革热点,设计了物流管理本科实践教学改革的路径分化。为改进培养高... 详细信息

基于“双碳”重要目标实现与物流行业发展转型的人才需要变化,通过对绿色物流,教学改革的相关研究进行前沿热点追踪与共现聚类分析。得出绿色物流研究变化特点与教学改革热点,设计了物流管理本科实践教学改革的路径分化。为改进培养高素质绿色物流人才的实践教学路径,优化绿色物流人才培养方案提供参考和启发,助力增强绿色物流发展内生动力。

关键词：绿色物流低碳研究热点实践教学