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Autologous transplantation with fewer fibers repairs large peripheral nerve defects

Neural Regeneration Research 2017年第12期12卷 2077-2083页

作者： Jiu-xu Deng Dian-yin Zhang Ming Li Jian Weng Yu-hui Kou Pei-xun Zhang na han Bo Chen Xiao-feng Yin Bao-guo Jiang Department of Orthopedics and Trauma Peking University People's Hospital Beijing China

Peripheral nerve injury is a serious disease and its repair is challenging. A cable-style autologous graft is the gold standard for repairing long peripheral nerve defects; however, ensuring that the minimum number of transplanted nerve attains maximum therapeutic effect remains poorly understood. In this study, a rat model of common peroneal nerve defect was established by resecting a 10-mm long right common peroneal nerve. Rats receiving transplantation of the common peroneal nerve in situ were designated as the in situ graft group. Ipsilateral sural nerves（10–30 mm long） were resected to establish the one sural nerve graft group, two sural nerves cable-style nerve graft group and three sural nerves cable-style nerve graft group. Each bundle of the peroneal nerve was 10 mm long. To reduce the barrier effect due to invasion by surrounding tissue and connective-tissue overgrowth between neural stumps, small gap sleeve suture was used in both proximal and distal terminals to allow repair of the injured common peroneal nerve. At three months postoperatively, recovery of nerve function and morphology was observed using osmium tetroxide staining and functional detection. The results showed that the number of regenerated nerve fibers, common peroneal nerve function index, motor nerve conduction velocity, recovery of myodynamia, and wet weight ratios of tibialis anterior muscle were not significantly different among the one sural nerve graft group, two sural nerves cable-style nerve graft group, and three sural nerves cable-style nerve graft group. These data suggest that the repair effect achieved using one sural nerve graft with a lower number of nerve fibers is the same as that achieved using the two sural nerves cable-style nerve graft and three sural nerves cable-style nerve graft. This indicates that according to the ‘multiple amplification＇ phenomenon, one small nerve graft can provide a good therapeutic effect for a large peripheral nerve defect.

关键词： nerve regeneration peripheral nerve injury peripheral nerve defect autologous nerve graft functional recovery nerve conductionvelocity sural nerve common peroneal nerve sleeve bridging suture neural regeneration

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Reply to “Can femoral head necrosis induced by steroid therapy in patients infected with coronaviruses be reversed?”

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Bone Research 2021年第2期9卷 249-249页

作者： Peixun Zhang Jiabao Ju na han Baoguo Jiang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina

The authors reply:We deeply appreciated your interest in our research.In our study,the conclusion that femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was partially reversible was based on the results of the volume of femoral head necrosis on MRI combined with the ARCO stage.The volume of osteonecrosis decreased significantly from 2003(38.83%±21.01%)to 2005(30.38%±20.23%)(P=0.0002),then declined slowly from 2005 to 2013(28.99%±20.59%)and plateaued in 2018(25.52%±15.51%).The ARCO stages of 17 limbs in ten patients stabilized or improved during follow-up,while the stages of six limbs in four patients reflected deterioration.

关键词： patients femoral doses

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Repair of long segmental ulnar nerve defects in rats by several different kinds of nerve transposition

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Neural Regeneration Research 2019年第4期14卷 692-698页

作者： Fei Yu You-Lai Yu Su-Ping Niu Pei-Xun Zhang Xiao-Feng Yin na han Ya-Jun Zhang Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang Peking University People's Hospital The Affiliated Hospital of Xuzhou Medical University

Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve transposition repair, the regenerated nerve fibers of motor neurons in the anterior horn of the spinal cord can effectively grow into the repaired distal nerve and target muscle tissues, which is conducive to the recovery of motor function. The aim of this study was to explore regeneration and nerve functional recovery after repairing a long-segment peripheral nerve defect by transposition of different donor nerves. A long-segment(2 mm) ulnar nerve defect in Sprague-Dawley rats was repaired by transposition of the musculocutaneous nerve, medial pectoral nerve, muscular branches of the radial nerve and anterior interosseous nerve(pronator quadratus muscle branch). In situ repair of the ulnar nerve was considered as a control. Three months later, wrist flexion function, nerve regeneration and innervation muscle recovery in rats were assessed using neuroelectrophysiological testing, osmic acid staining and hematoxylin-eosin staining, respectively. Our findings indicate that repair of a long-segment ulnar nerve defect with different donor nerve transpositions can reinnervate axonal function of motor neurons in the anterior horn of spinal cord and restore the function of affected limbs to a certain extent.

关键词： nerve regeneration nerve transposition repair conical sleeve small gap sleeve bridging ulnar nerve target organ muscle nerve reinnervation neural regeneration

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农村电商的参与意愿与影响路径研究——基于行为理论的考察

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河南财政金融学院学报（哲学社会科学版） 2024年第2期43卷 22-27页

作者：许家伟韩娜黄雅馨李峰河南财经政法大学工程管理与房地产学院河南大学黄河文明与可持续发展研究中心河南省城乡规划设计研究总院股份有限公司

课题组基于对河南省洛阳市孟津区7村516户的调查结果,采用行为理论,运用结构方程模型从农业基础、政府政策、行为态度、主观规范、知觉控制五个维度对农村电商的农户参与意愿与影响路径进行考察。研究结果表明:(1)农业基础对参与意愿有... 详细信息

课题组基于对河南省洛阳市孟津区7村516户的调查结果,采用行为理论,运用结构方程模型从农业基础、政府政策、行为态度、主观规范、知觉控制五个维度对农村电商的农户参与意愿与影响路径进行考察。研究结果表明:(1)农业基础对参与意愿有正向影响。农业基础越好,越能提升农户对电商的参与意愿。(2)政府政策对参与意愿有正向影响。政府培训、奖励补贴等均可以提升农户对电商的参与意愿。(3)行为态度对参与意愿有正向影响。农户信任与否及其对电商作用的态度将直接影响参与电商意愿。(4)主观规范对参与意愿有正向影响。周边人群对电商越认可,越能够提升农户对电商的参与意愿。(5)知觉控制对参与意愿有正向影响。农户对农村电商操作流程和相关规则越了解,越能够形成参与意愿。(6)五个维度中对农户参与农村电商的影响由强到弱依次为行为态度、政府政策、知觉控制、主观规范、农业基础。因此,建议从营造农村电商发展良好环境、完善电子商务配套服务体系、着力培养扶持新型电商人才、充分发挥政府驱动作用等方面着手提升农户对电商的参与意愿。

关键词：数字经济农村电商直播农户参与意愿高质量发展

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Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends

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Neural Regeneration Research 2019年第4期14卷 706-712页

作者： Yu-Hui Kou You-Lai Yu Ya-Jun Zhang na han Xiao-Feng Yin Yu-Song Yuan Fei Yu Dian-Ying Zhang Pei-Xun Zhang Bao-Guo Jiang Peking University People's Hospital The Affiliated Hospital of Xuzhou Medical University

During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve suture. We investigated whether a small gap bio-sleeve suture with different inner diameters at both ends can be used to repair a 2-mm tibial nerve defect by proximal transposition of the common peroneal nerve in rats and compared the results with the repair seen after epineurial neurorrhaphy. Three months after surgery, neurological function, nerve regeneration, and recovery of nerve innervation muscle were assessed using the tibial nerve function index, neuroelectrophysiological testing, muscle biomechanics and wet weight measurement, osmic acid staining, and hematoxylin-eosin staining. There was no obvious inflammatory reaction and neuroma formation in the tibial nerve after repair by the small gap bio-sleeve suture with different inner diameters at both ends. The conduction velocity, muscle strength, wet muscle weight, cross-sectional area of muscle fibers, and the number of new myelinated nerve fibers in the biosleeve suture group were similar to those in the epineurial neurorrhaphy group. Our findings indicate that small gap bio-sleeve suture with different inner diameters at both ends can achieve surgical suture between nerves of different diameters and promote regeneration and functional recovery of injured peripheral nerves.

关键词： nerve regeneration bio-sleeve small gap sleeve suture nerve transposition nerve defect nerve conduit nerve reinnervation peripheral nerve neural regeneration

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Local administration of icariin contributes to peripheral nerve regeneration and functional recovery

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Neural Regeneration Research 2015年第1期10卷 84-89页

作者： Bo Chen Su-ping Niu Zhi-yong Wang Zhen-wei Wang Jiu-xu Deng Pei-xun Zhang Xiao-feng Yin na han Yu-hui Kou Bao-guo Jiang Department of Trauma and Orthopedics Peking University People’s Hospital Beijing Shijitan Hospital Capital Medical University Health Science Center Peking University

Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the ther- apeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly（lactic-co-glycolic acid） biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local ap- plication of icariin after spinal injury can promote peripheral nerve regeneration.

关键词： nerve regeneration peripheral nerve sciatic nerve traditional Chinese medicine icariin sleeve bridging suture nerve growth factor NSFC grants neural regeneration

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Territory maximization hypothesis during peripheral nerve regeneration

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Neural Regeneration Research 2018年第2期13卷 230-231页

作者： jiu-xu deng jian weng yu-hui kou pei-xun zhang yan-hua wang na han bao-guo jiang xiao-feng yin department of orthopedics and trauma peking university people's hospitalBeijingChina

Territory awareness refers to the notion that an organism lives in a territory, considers this territory its own, and prevents entry of other organisms. Generally, an organism maximizes its territory for best survival... 详细信息

关键词： Territory maximization hypothesis during peripheral nerve regeneration

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成就动机在血液科护士完美主义和拖延行为间的中介效应

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中华现代护理杂志 2024年第8期30卷 1073-1077页

作者：王晓煜李超韩娜王瑞刘娜张小丽郑州大学第一附属医院血液内科郑州450000

目的探讨成就动机在血液科护士完美主义和拖延行为间的中介效应。方法采用分层抽样法,于2022年4月—2023年4月选取河南省14家三甲医院的280名血液科护士为研究对象,采用基本资料调查表、成就动机量表(AMS)、中文版Frost多维度完美主义量... 详细信息

目的探讨成就动机在血液科护士完美主义和拖延行为间的中介效应。方法采用分层抽样法,于2022年4月—2023年4月选取河南省14家三甲医院的280名血液科护士为研究对象,采用基本资料调查表、成就动机量表(AMS)、中文版Frost多维度完美主义量表(CFMPS)、一般拖延量表(GPS)对血液科护士进行调查,采用Pearson相关分析检验成就动机、完美主义和拖延行为的相关性,采用AMOS 26.0软件建立结构方程模型并进行中介效应验证。结果本研究共发放问卷280份,回收有效问卷271份,问卷有效回收率为96.79%。271名血液科护士AMS中追求成功得分为(51.95±10.38)分,回避失败得分为(53.11±8.91)分;CFMPS总分为(83.79±17.18)分;GPS总分为(61.71±9.50)分;完美主义与拖延行为呈负相关(P<0.01),完美主义与追求成功呈正相关(P<0.01),完美主义与回避失败呈负相关(P<0.01),拖延行为与追求成功呈负相关(P<0.01),拖延行为与回避失败呈正相关(P<0.01);成就动机在完美主义和拖延行为间起部分中介作用,中介效应占总效应的47.89%。结论血液科护士的拖延行为和完美主义均处于中等水平。追求成功和回避失败均在完美主义和拖延行为间存在部分中介效应,可从行为动机角度出发,加强血液护士的教育引导,进而避免拖延行为,对血液科护士职业规划具有一定的指导意义。

关键词：成就动机血液科护士完美主义拖延行为中介效应

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法人类学视角下的法庭语言研究

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佳木斯大学社会科学学报 2024年第3期42卷 93-97页

作者：李婉琳那梓涵昆明理工大学法学院云南昆明650500

从不同角度对法庭语言的研究进行梳理,并运用法人类学领域的先行研究得出的概念和类型作为主要框架对法庭语言进行分析。通过考察审判的主要参与者之间的互动和交流,来证实其主张在传达方式和形式上具有规律性,并会影响主张的说服力和... 详细信息

从不同角度对法庭语言的研究进行梳理,并运用法人类学领域的先行研究得出的概念和类型作为主要框架对法庭语言进行分析。通过考察审判的主要参与者之间的互动和交流,来证实其主张在传达方式和形式上具有规律性,并会影响主张的说服力和可信度。研究发现,审判参与者之间存在着发言顺序、叙述逻辑的差异,根据研究发现,这种差异在一定程度上对审判结果产生影响。

关键词：法人类学法庭语言话语分析

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儿童早期体重指数轨迹与超重风险关联的前瞻性队列研究

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北京大学学报（医学版） 2024年第3期56卷 390-396页

作者：岳芷涵韩娜鲍筝吕瑾莨周天一计岳龙王辉刘珏王海俊北京大学公共卫生学院妇幼卫生学系北京100191 北京市通州区妇幼保健院北京101101 北京大学公共卫生学院流行病与卫生统计学系北京100191

目的:基于前瞻性队列比较不同方法确定的儿童早期体重指数(body mass index,BMI)轨迹与超重风险的关联,识别在儿童早期生长发育重要窗口期具有较高肥胖风险的人群。方法:共纳入北大通州出生队列的1330名儿童,分别在儿童刚出生,1、3、6、... 详细信息

目的:基于前瞻性队列比较不同方法确定的儿童早期体重指数(body mass index,BMI)轨迹与超重风险的关联,识别在儿童早期生长发育重要窗口期具有较高肥胖风险的人群。方法:共纳入北大通州出生队列的1330名儿童,分别在儿童刚出生,1、3、6、9、12、18、24月龄和3岁进行随访,根据其身长/身高和体质量计算BMI Z评分。应用潜类别增长混合模型(growth mixture modelling,GMM)和基于纵向数据的k-means聚类方法(k-means for longitudinal data,KML)分析儿童早期(从出生至24月龄)BMI轨迹分组,采用线性回归比较不同方法确定的儿童早期BMI轨迹和儿童3岁时BMI Z评分的关联,通过五折交叉验证的平均受试者工作特征曲线下面积,比较Logistic回归模型中不同方法确定的儿童早期BMI轨迹分组对儿童3岁超重风险(BMI Z评分>1)的预测性能。结果:在纳入的研究对象中,用GMM确定的三分类轨迹分为低、中、高轨迹,分别占39.7%、54.1%、6.2%;用KML方法确定的二分类轨迹分为低轨迹和高轨迹,分别占50.3%和49.7%;用KML方法确定的三分类轨迹分为低、中、高轨迹,分别占31.1%、47.4%、21.5%。用不同方法确定的儿童早期BMI轨迹反映的生长模式存在一定差异。线性回归分析发现,在调整母亲民族、受教育水平、分娩方式、产次、分娩时年龄、分娩孕周、胎儿性别和1月龄母乳喂养等协变量后,用KML方法确定的三分类轨迹中的高轨迹组(表现为出生时BMI Z评分略高、婴儿期快速生长后持续稳定在高水平的生长模式)和儿童3岁BMI Z评分的关联最强。Logistic回归分析发现,KML三分类轨迹分组对儿童3岁超重风险具有最佳的预测效果。在额外调整儿童平衡膳食指数正端分、平均每天身体活动时间和视屏时间后,结果基本一致。结论:采用不同方法识别具有不同变化特征的儿童早期BMI轨迹,发现KML方法确定的高轨迹组能更好地发现儿童早期具有较高超重风险的人群,为选择适宜方法开展儿童早期BMI轨迹相关研究提供了依据。

关键词：儿童早期 BMI轨迹超重前瞻性队列

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