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Pathway Matters: Prefrontal Control of Negative Emotions via Distinct Downstream Regions

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Neuroscience Bulletin 2022年第2期38卷 226-228页

作者： Junqiang Zheng na Liu han Xu Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China

The infralimbic cortex(IL)is a major subregion of the medial prefrontal cortex(mPFC)that is essential for many advanced brain functions including emotions.Mounting studies have unraveled a critical role of the IL in the processing of negative emotions such as fear and anxiety.However,these studies also generate controversial data regarding the precise functions of the IL in the regulation of either fear or anxiety.On one hand,pharmacological inactivation of the IL attenuates anxiety-like behaviors and consistently,pharmacological activation of the IL produces anxiety-like behaviors[1].

关键词： inactivation precise Mount

Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration

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Neural Regeneration Research 2023年第1期18卷 200-206页

作者： Wei Zhang Xing-Xing Fang Qi-Cheng Li Wei Pi Na Han Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina national Center for Trauma Medicine BeijingChina Central Laboratory Peking University People’s HospitalBeijingChina

We previously combined reduced graphene oxide(rGO)with gelatin-methacryloyl(GelMA)and polycaprolactone(PCL)to create an rGO-GelMA-PCL nerve conduit and found that the conductivity and biocompatibility were improved.However,the rGO-GelMA-PCL nerve conduits differed greatly from autologous nerve transplants in their ability to promote the regeneration of injured peripheral nerves and axonal sprouting.Extracellular vesicles derived from bone marrow mesenchymal stem cells(BMSCs)can be loaded into rGO-GelMA-PCL nerve conduits for repair of rat sciatic nerve injury because they can promote angiogenesis at the injured site.In this study,12 weeks after surgery,sciatic nerve function was measured by electrophysiology and sciatic nerve function index,and myelin sheath and axon regeneration were observed by electron microscopy,immunohistochemistry,and immunofluorescence.The regeneration of microvessel was observed by immunofluorescence.Our results showed that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles were superior to rGO-GelMA-PCL conduits alone in their ability to increase the number of newly formed vessels and axonal sprouts at the injury site as well as the recovery of neurological function.These findings indicate that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles can promote peripheral nerve regeneration and neurological function recovery,and provide a new direction for the curation of peripheral nerve defect in the clinic.

关键词： angiogenesis axon bone mesenchymal stem cell extracellular vesicles hybrid nanofibers myelin sheath nerve conduit neurological function peripheral nerve injury reduced graphene oxide

Nogo-A aggravates oxidative damage in oligodendrocytes

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Neural Regeneration Research 2021年第1期16卷 179-185页

作者： Yang-Yang Wang Na Han Dao-Jun Hong Jun Zhang Department of Neurology Peking University People’s HospitalBeijingChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous system.It is mainly expressed by oligodendrocytes.Although previous studies have found regulatory roles for Nogo-A in neurite outgrowth inhibition,neuronal homeostasis,precursor migration,plasticity,and neurodegeneration,its functions in the process of oxidative injury are largely uncharacterized.In this study,oligodendrocytes were extracted from the cerebral cortex of newborn Sprague-Dawley rats.We used hydrogen peroxide(H2O2)to induce an in vitro oligodendrocyte oxidative damage model and found that endogenously expressed Nogo-A is significantly upregulated in oligodendrocytes.After recombinant virus Ad-ZsGreen-rat Nogo-A infection of oligodendrocytes,Nogo-A expression was increased,and the infected oligodendrocytes were more susceptible to acute oxidative insults and exhibited a markedly elevated rate of cell death.Furthermore,knockdown of Nogo-A expression in oligodendrocytes by Ad-ZsGreen-shRna-Nogo-A almost completely protected against oxidative stress induced by exogenous H2O2.Intervention with a Nogo-66 antibody,a LINGO1 blocker,or Y27632,an inhibitor in the Nogo-66-NgR/p75/LINGO-1-RhoA-ROCK pathway,did not affect the death of oligodendrocytes.Ad-ZsGreen-shRna-Nogo-A also increased the levels of phosphorylated extracellular signal-regulated kinase 1/2 and inhibited BCL2 expression in oligodendrocytes.In conclusion,Nogo-A aggravated reactive oxygen species damage in oligodendrocytes,and phosphorylated extracellular signal-regulated kinase 1/2 and BCL2 might be involved in this process.This study was approved by the Ethics Committee of Peking University People’s Hospital,China(approval No.2018PHC081)on December 18,2018.

关键词： BCL2 H2O2 LINGO1 NgR Nogo-A oligodendrocytes phosphorylated extracellular signal-regulated kinase 1/2 reactive oxygen species

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热功复合驱动热泵循环热力性能研究

工程热物理学报 2015年第11期36卷 2328-2333页

作者：王康张娜韩巍陈强中国科学院工程热物理研究所北京100190 中国科学院大学北京100049 中国华电集团科学技术研究总院北京100160

本文对LiBr-H_2O工质对的热功复合驱动热泵循环的热力性能进行了模拟分析,研究结果表明吸收式热泵循环耦合压缩过程,可以有效提高极限温升,拓宽了热泵适用范围,大幅降低发生温度,放宽了热泵对余热的要求。冷凝压力不变时,随着压缩过程... 详细信息

本文对LiBr-H_2O工质对的热功复合驱动热泵循环的热力性能进行了模拟分析,研究结果表明吸收式热泵循环耦合压缩过程,可以有效提高极限温升,拓宽了热泵适用范围,大幅降低发生温度,放宽了热泵对余热的要求。冷凝压力不变时,随着压缩过程压比的增大,复合循环的性能系数先是快速升高,达到最大值,后缓慢降低。提出一种烟气型双压热功复合驱动热泵循环,能够对余烟热能进行梯级利用,与吸收式热泵循环和复合热泵循环相比,其单位质量流量烟气的制热量分别提高了6.8%和7.0%。本文研究结果为热功复合驱动热泵循环的设计与系统集成提供了理论支撑。

关键词：复合热泵热力性能热功复合能的梯级利用

A New Cleaner Power Generation System Based on Self-Sustaining Supercritical Water Gasification of Coal

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Journal of Thermal Science 2022年第5期31卷 1380-1391页

作者： LIU Changchun han Wei WANG Zefeng ZhanG na Institute of Engineering Thermophysics Chinses Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

A new cleaner power generation system(IPGS) is proposed and investigated in this paper. Integrating combined cycle with supercritical water gasification of coal, the thermodynamic energy of the produced syngas is cascade utilized according to its temperature and pressure, both sensible and latent heat of the syngas can be recycled into the system, and thereby the net power efficiency can be about 6.4 percentage points higher than that of the traditional GE gasification based power plant(GEPP). The exergy analysis results show that the exergy efficiency of the proposed system reaches 52.45%, which is 13.94% higher than that of the GEPP, and the improvement in exergy efficiency of the proposed system mainly comes from the exergy destruction decline in the syngas energy recovery process, the condensation process and the syngas purification process. The syngas combustion process is the highest exergy destruction process with a value of 157.84 MW in the proposed system. Further performance improvement of the proposed system lies in the utilization process of syngas. Furthermore, system operation parameters have been examined on the coal mass fraction in the supercritical water gasifier(GF), the gasification temperature, and the gasification pressure. The parametric analysis shows that changes in coal concentration in the GF exert more influence on the exergy efficiency of the system compared with the other two parameters.

关键词： power generation clean production supercritical water gasification coal gasification cascade utilization combined cycle

Exercise training attenuates angiotensinⅡ-induced cardiac fibrosis by reducing POU2F1 expression

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Journal of Sport and Health Science 2023年第4期12卷 464-476页

作者： na Feng Haiyi Yu Yueshen Wang Youyi Zhang han Xiao Wei Gao Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNational Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical SciencesBeijing 100191China

Background:Exercise training protects against heart failure.However,the mechanism underlying the protective effect of exercise training on angiotensinⅡ(AngⅡ)-induced cardiac fibrosis remains unclear.Methods:An exercise model involving C57BL/6N mice and 6 weeks of treadmill training was used.AngⅡ(1.44 mg/kg/day)was administered to induce cardiac fibrosis.Rna sequencing and bioinformatic analysis were used to identify the key factors mediating the effects of exercise training on cardiac fibrosis.Primary adult mouse cardiac fibroblasts(CFs)were used in vitro.Adeno-associated virus serotype 9 was used to overexpress POU domain,class 2,transcription factor 1(POU2F1)in vivo.Results:Exercise training attenuated AngⅡ-induced cardiac fibrosis and reversed 39 gene expression changes.The transcription factor regulating the largest number of these genes was POU2F1.Compared to controls,POU2F1 was shown to be signififcantly upregulated by AngⅡ,which is itself reduced by exercise training.In vivo,POU2F1 overexpression nullified the benefits of exercise training on cardiac fibrosis.In CFs,POU2F1 promoted cardiac fibrosis.CCAAT enhancer-binding proteinβ(C/EBPβ)was predicted to be the transcription factor of POU2F1and verified using a dual-luciferase reporter assay.In vivo,exercise training activated AMP-activated protein kinase(AMPK)and alleviated the increase in C/EBPβinduced by AngⅡ.In CFs,AMPK agonist inhibited the increase in C/EBPβand POU2F1 induced by Ang II,whereas AMPK inhibitor reversed this effect.Conclusion:Exercise training attenuates AngⅡ-induced cardiac fibrosis by reducing POU2F1.Exercise training inhibits POU2F1 by activating AMPK,which is followed by the downregulation of C/EBPβ,the transcription factor of POU2F1.

关键词： AMPK C/EBPβ Cardiac fibrosis Exercise POU2F1

He-Wei Granule enhances anti-tumor activity of cyclophosphamide by changing tumor microenvironment

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Chinese Herbal Medicines 2022年第1期14卷 79-89页

作者： Jianxiu Zhai Zehai Song hang Chang Yuwei Wang Na Han Zhihui Liu Jun Yin Key Laboratory of Northeast Plant Materials Department of Pharmacognosy and UtilizationSchool of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyang 110016China

Objective:He-Wei Granule(HWKL)is a modern product derived from the modified formulation of traditional Chinese medicine Banxia Xiexin Decoction(BXD),which remarkedly enhanced the anti-proliferation activity of cyclophosphamide(CTX)on HepG2 and SGC-7901 cell lines in vitro in our previous research.The aim of the study was to investigate the synergistic effects of HWKL and CTX using a transplanted H22 hepatocellular carcinoma mouse model.Methods:The CTX-toxic-reducing efficacy of HWKL was evaluated by hematology indexes,organ indexes and marrow Dna detection.To investigate the underlying mechanisms,histopathology test,immunohistochemistry test and TUNEL staining were conducted.The efficacy of HWKL on the micro-vessel density(MVD)in tumor tissue was also evaluated by measuring CD34 level.Results:High dose HWKL(6.75 g/kg)markedly attenuated CTX-induced hepatotoxicity and myelosuppression while significantly enhanced CTX anticancer efficacy in vivo.Further mechanism investigation suggested that high dose HWKL significantly increased cleaved Caspase 3 level and promoted apoptosis in tumor tissue by up-regulating Bax expression and down-regulating Bcl-2 and FasL expressions.Compared with CTX alone group,the decrease in LC-3B and Beclin 1 levels suggested that the autophagy in H22 carcinoma was significantly inhibited with addition of high dose HWKL.ELISA assay results indicated that the autophagy inhibition was achieved by decreasing p53 expression,blocking PI3K/AKT/mTOR pathway and recovering Th1/Th2 cytokine balance.In addition,CD34 and EGFR immunohistochemistry assay suggest that high dose HWKL could significantly decrease micro-vessel density(MVD)and inhibit angiogenesis in H22 carcinoma.Conclusion:It can be concluded that high-dose HWKL enhanced CTX efficacy by promoting apoptosis,inhibiting autophagy and angiogenesis in tumor tissue while significantly alleviated CTX-induced toxicity,and could be applied along with CTX in clinical treatment as a supplement agent.

关键词： cyclophosphamide He-Wei Granule H22 carcinoma synergistic effect toxicity

Hydrogel-based composites beyond the porous architectures for electromagnetic interference shielding

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nano Research 2022年第10期15卷 9614-9630页

作者： Yunfei Yang Mingrui han Wei Liu na Wu Jiurong Liu Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials School of Materials Science and EngineeringShandong UniversityJinan 250061China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Shenzhen research institute of Shandong University Shenzhen 518052China Department of Chemistry and Applied Biosciences ETH ZurichZurich CH-8093Switzerland

With the rapid development of the electronic industry and wireless communication technology,electromagnetic interference(EMI)or pollution has been increasingly serious.This not only severely endangers the normal operation of electronic equipment but also threatens human health.Therefore,it is urgent to develop high-performance EMI shielding materials.The advent of hydrogel-based materials has given EMI shields a novel option.Hydrogels combined with conductive functional materials have good mechanical flexibility,fatigue durability,and even high stretchability,which are beneficial for a wide range of applications,especially in EMI shielding and some flexible functional devices.Herein,the current progress of hydrogel-based EMI shields was reviewed,in the meanwhile,some novel studies about pore structure design that we believe will help advance the development of hydrogel-based EMI shielding materials were also included.In the outlook,we suggested some promising development directions for the hydrogel-based EMI shields,by which we hope to provide a reference for designing hydrogels with excellent EMI shielding performance and multifunctionalities.

关键词： electromagnetic interference(EMI)shielding porous hydrogels structural design composites

Biopolymer-Based Aerogels for Electromagnetic Wave Shielding and Absorbing

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Chinese Journal of Chemistry 2023年第3期41卷 322-334页

作者： Mingrui han Runa Zhang Qilei Wu na Wu Jiurong Liu Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of Education and School of Materials Science and EngineeringShandong UniversityJinanShandong250061 China Science and Technology on Electromagnetic Compatibility Laboratory China Ship Development and Design CentreWuhanHubei430064 China Department of Chemistry and Applied Biosciences ETH ZurichCH-8093 ZurichSwitzerland

The rapid development of communication technology and electronic industry has brought unprecedented serious electromagnetic interference(EMI)and electromagnetic wave(EMW)pollution.Although EMI shields and EMW absorbers based on metal or magnetic materials were used to solve these problems,they have long been criticized for their high price,high density and easy corrosion.In order to achieve low density and efficient dissipation of electromagnetic energy,aerogels stand out among manifold materials.However,constructing aerogels with good EMI shielding or EMW absorption performance and acceptable mechanical properties is not an easy task.Burgeoning biopolymers,such as cellulose,lignin,chitin/chitosan and alginate,breathe new life into aerogels for high-efficiency EMW shielding and absorbing.Here,we reviewed the contributions of biopolymers in the fields of aerogels for EMW shielding and absorbing.At the same time,some challenges and outlook were also pointed out,aiming to promote the advance of aerogel-based EMI shields and EMW absorbers as well as the rational utilization of biopolymers.

关键词： Polymers Sustainable chemistry Electromagnetic interference(EMI)shielding Electromagnetic wave(EMW)absorbing Biomass Aerogels Biopolymers