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Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis

World Journal of Hepatology 2014年第2期6卷 98-106页

作者： Joo-Hyun Kim Hye-Jun Shin Hye-Lin Ha Young-Ho Park Tae-Ho Kwon Mi-Ra Jung Hyung-Bae Moon eun-Sang Cho Hwa-Young Son Dae-Yeul Yu Aging Research Center Korea Research Institute of Bioscience and Biotechnology College of Veterinary Medicine Chungnam National University Wonkwang University College of Medicine

AIM:To investigate the effect of methylsulfonylmethane(MSM), recently reported to have anti-cancer effects, in liver cancer cells and transgenic mice. METHODS: Three liver cancer cell lines, HepG2, Huh7-Mock and Huh7-H-rasG12V, were used. Cell growth was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly(ADP-ribose) polymerase(PARP), and B-cell lymphoma2(Bcl-2) expressions. For in vivo study, we administered MSM to H-ras12V transgenic mice for 3 mo. RESULTS: MSM decreased the growth of HepG2, Huh7-Mock and Huh7-H-rasG12V cells in a dose-dependent manner. That was correlated with significantly increased apoptosis and reduced cell numbers in MSM treated cells. Cleaved caspase-8, cleaved caspase-3 and cleaved PARP were remarkably increased in the liver cancer cells treated with 500 mmol/L of MSM; however, Bcl-2 was slightly decreased in 500 mmol/L. Liver tumor development was greatly inhibited in the H-ras12V transgenic mice treated with MSM, compared to control, by showing reduced tumor size and number. Cleaved PARP was significantly increased in non-tumor treated with MSM compared to control. CONCLUSION: Liver injury was also significantly attenuated in the mice treated with MSM. Taken together, all the results suggest that MSM has anti-cancer effects through inducing apoptosis in liver cancer.

关键词： Methylsulfonylmethane Anti-cancer effects Liver cancer cells Transgenic mice Hepatic tumorigenesis

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