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Long-term outcomes of gemcitabine and cisplatin in patients with recurrent or metastatic esophageal squamous cell carcinoma： a phase Ⅱ trial

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Chinese Medical Journal 2011年第23期124卷 4012-4017页

作者： HUANG Jing FAN Qing-xia CHEN Li LIU ai-na Cai Rui-gang HAO Xue-zhi WANG Jin-wan SUN Yan Department of Medical Oncology Cancer Institute ＆ Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100021 China

Background Esophageal cancer is the sixth most common cause of cancer-related death worldwide. Prior studies had demonstrated potential synergistic antitumor activity of gemcitabine in combination with cisplatin. Therefore, we studied the efficacy and tolerability of such combination for esophageal cancer. Methods Between October 2003 and October 2006, thirty-eight patients with metastatic or recurrent advanced squamous cell carcinoma of the esophagus were enrolled. The median number of treatment cycles per patient was 4 （range 1-7）. Gemcitabine was given at 1000 mg/m2 over 30 minutes on days 1, 8 and cisplatin 40 mg/m2 was given on days 1,2 in an every 21-day cycle. Results The median follow-up for all 38 patients was 76 months （range 11-88 months）. The overall response rate was 42.1% （95%Cl, 25.5%-56.5%）. Median progression-free survival and median survival for all patients were 4.1 months （95%C/, 3.0-5.7 months） and 10 months （95%C/, 7-12 months）, respectively. Patients with a response had significantly longer median survival compared with the patients without a response （11 months vs. 7.5 months, P=0.0069）. Overall survival at 1 year was 36.8%, at 2 years was 10.5%, and at 5 years was 5.3%. The most common grade 3-4 toxicity for all patients was leucopenia （44.7%）. Conclusions This cisplatin-gemcitabine regimen was manageable and had significant efficacy in patients with esophageal squamous cell carcinoma. Patients with a response had improved survival time. Furthermore, a small number of the Datients with metastatic esoohaaeal cancer were still alive in 5 vears with this reaimen.

关键词： chemotherapy gemcitabine cisplatin esophageal cancer

A head-mounted photoacoustic fiberscope for hemodynamic imaging in mobile mice

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Light(Science & Applications) 2024年第6期13卷 1012-1014页

作者： Xiaoyan Zheng Shuai na national Biomedical Imaging Center College of Future TechnologyPeking UniversityBeijing100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100871China

A miniaturized photoacoustic fiberscope has been developed, featuring a lateral resolution of 9 microns and a lightweight design at 4.5 grams. Engineered to capture hemodynamic processes at single-blood-vessel resolution at a rate of 0.2 Hz, this device represents an advancement in head-mounted tools for exploring intricate brain activities in mobile animals.

关键词： fiber mobile Engine

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解非线性微分方程初值问题的一种再生核方法

哈尔滨理工大学学报 2010年第3期15卷 58-60页

作者：那爱莲盘锦职业技术学院基础部辽宁盘锦124010

在再生核空间中给出了一种求解非线性常微分方程初值问题的数值解法,并证明了该方法的收敛性.

关键词：再生核非线性收敛性

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中国上市公司资本结构的行业因素分析

特区经济 2005年第6期 81-82页

作者：王爱娜上海市深水港工程建设指挥部大桥分指挥部财务科 201306

根据国外研究的结果,公司的资本结构与其所处行业是否显著相关并无确定的结论.与国外研究不同,国内的相关研究大都发现行业对资本结构有重要影响;但也有学者发现行业并不显著影响公司资本结构.国内的相关研究多数限于初步研究,他们是在... 详细信息

根据国外研究的结果,公司的资本结构与其所处行业是否显著相关并无确定的结论.与国外研究不同,国内的相关研究大都发现行业对资本结构有重要影响;但也有学者发现行业并不显著影响公司资本结构.国内的相关研究多数限于初步研究,他们是在采用多元线性回归模型对资本结构的影响因素进行研究时,仅将行业作为因素之一加以考虑;且在行业分类方法和统计检验方法上也都存在不足.即使近来有学者对资本结构与行业因素的关系作过专门研究,由于所选样本的时间跨度和数目太小,也难以对其进行全面深入的研究.本文针对前人的不足以1999～2003年的708家公司为研究样本,首先从理论上说明了不同的行业面临的行业特征有差异,从而具有不同的资产负债率,然后以单因素方差分析法检验样本公司的资产负债率是否具有显著的行业间差异,再用Scheffe法进行行业间两两比较,以考察是否由于个别行业的异常值而导致了检验结果的显著性.

关键词：中国上市公司资本结构资产负债率行业技术

Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： Li-na Cha Juan Yang Jin-ai Gao Xin Lu Xiao-Long Chang Rebecca Caroline Thuku Qi Liu Qiu-Min Lu Dong-Sheng Li Ren Lai Ming-Qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

基于边界层模糊调节的液压系统准滑模变结构控制

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湖南大学学报（自然科学版） 2006年第3期33卷 67-70页

作者：杨勇罗安覃爱娜长沙理工大学汽车与机械工程学院湖南长沙410076 湖南大学电气与信息工程学院湖南长沙410082 中南大学信息科学与工程学院湖南长沙410083

提出一种基于边界层模糊调节的准滑模变结构控制方法.基于滑模开关函数及其变化量,设计一个二维边界层模糊调节器,根据滑模开关平面状态的变化动态调整滑模边界层的宽度.应用于液压位置系统的控制实验结果表明,所提出的控制方法能保证... 详细信息

提出一种基于边界层模糊调节的准滑模变结构控制方法.基于滑模开关函数及其变化量,设计一个二维边界层模糊调节器,根据滑模开关平面状态的变化动态调整滑模边界层的宽度.应用于液压位置系统的控制实验结果表明,所提出的控制方法能保证液压系统响应速度,提高控制精度,削弱抖振,较好地协调了变结构控制鲁棒性与平滑控制抖振之间的矛盾.

关键词：准滑模变结构控制边界层模糊调节抖振削弱稳态性能液压位置系统

基于UHPLC-Q-Exactive Orbitrap MS技术的静宁方入脑、入肠及粪便成分分析

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中南药学 2024年第6期22卷 1406-1411页

作者：胡盼祥张萍芝阮意丹姚爱娜朱倩史文娟尹兴斌曲昌海董晓旭倪健北京中医药大学中药学院北京102488

目的基于UHPLC-Q-Exactive Orbitrap MS技术对静宁方给药后的大鼠入脑、入肠及粪便中的成分进行分析和鉴定。方法采用UHPLC-Q-Exactive Orbitrap MS,以0.1%甲酸-乙腈(A)和0.1%甲酸-水(B)为流动相进行梯度洗脱,流速0.2 mL·min^(-1),进样... 详细信息

目的基于UHPLC-Q-Exactive Orbitrap MS技术对静宁方给药后的大鼠入脑、入肠及粪便中的成分进行分析和鉴定。方法采用UHPLC-Q-Exactive Orbitrap MS,以0.1%甲酸-乙腈(A)和0.1%甲酸-水(B)为流动相进行梯度洗脱,流速0.2 mL·min^(-1),进样量5μL,加热电喷雾离子化源(HESI),正、负离子扫描。结合对照品比对、文献报道、数据库比对等方式对成分进行分析鉴定。结果共鉴定出42种成分,其中脑、回肠、结肠、粪便中分别鉴定出9、33、20、27种成分。结论本实验初步阐明静宁方入脑、入肠及粪便成分,为阐明其药效物质基础及作用机制提供了依据。

关键词：静宁方 UHPLC-Q-Exactive Orbitrap MS 入脑成分入肠成分粪便成分

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基于改进小波阈值函数的语音增强算法研究

湖南大学学报（自然科学版） 2015年第4期42卷 136-140页

作者：覃爱娜戴亮李飞曹卫华中南大学信息科学与工程学院湖南长沙410083

针对传统的小波阈值去噪算法中的阈值函数不足,提出一种优于非负死区阈值函数的改进的阈值函数.改进阈值函数不仅具有良好的连续性、可导性,并且克服了非负死区阈值函数没有考虑小波变换模值的衰减符合指数规律这一特点.另外在阈值的选... 详细信息

针对传统的小波阈值去噪算法中的阈值函数不足,提出一种优于非负死区阈值函数的改进的阈值函数.改进阈值函数不仅具有良好的连续性、可导性,并且克服了非负死区阈值函数没有考虑小波变换模值的衰减符合指数规律这一特点.另外在阈值的选取中,考虑了带噪语音信号的不同特性,采用谱平坦度函数修正阈值.仿真实验表明,与传统的非负死区阈值函数去噪算法相比,改进的阈值函数能更有效地消除背景噪声,在提高输出信噪比的同时,更好地保持语音质量和清晰度.

关键词：语音增强小波变换阈值去噪

Microstructure and room temperature fracture toughness of Nb-Si-based alloys with Sr addition

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Rare Metals 2024年第8期43卷 3904-3912页

作者： Yong-Lin Huang Li-na Jia Bin Kong Yue-Ling Guo na Wang School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Nb-Si-based alloys show great potential to surpass the widely used Ni-based *** element Sr is widely applied in aluminum and magnesium alloys,but reports about the effects of Sr on Nb-Si-based alloys are quite ***,Nb-Si-based alloys with nominal compositions of Nb-15Si-24Ti-4Cr-2Al-2Hf-0/0.05/0.15Sr(at%)were prepared by directional solidification and heat *** microstructural characterization and room temperature fracture toughness of Nb-Si-based alloy were systematically *** show that all these alloys consist of Nb_5Si_3 phase embedded within Nb solid solution(Nb_(ss)) *** Nb_(5)Si_(3) phase becomes refined and more discontinuous after adding minor *** for the fracture toughness,0.05 at% and 0.15 at% Sr additions do not cause significant *** discontinuous and refining mechanism of Sr element was studied,and the analysis of toughness decreasing with Sr addition reveals that the size of Nb_(ss) phase plays a crucial role in determining the fracture toughness.

关键词： Nb-Si alloy Refinement Discontinuous Fracture toughness Nb_(ss)