检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

老年人认知障碍预防产品现状及设计趋势研究

玩具世界 2024年第1期 36-38页

作者：湛金沙那成爱湖南科技大学

中国认知障碍患病人数正随着老龄化程度的日益加重呈逐年递增的趋势，认知障碍正成为老年人的一大“隐形杀手”。文章站在产品设计的角度，总结老年人认知训练产品的设计趋势。运用文献研究法、竞品分析法，首先汇总了国内认知障碍现状... 详细信息

中国认知障碍患病人数正随着老龄化程度的日益加重呈逐年递增的趋势，认知障碍正成为老年人的一大“隐形杀手”。文章站在产品设计的角度，总结老年人认知训练产品的设计趋势。运用文献研究法、竞品分析法，首先汇总了国内认知障碍现状，归纳预防方法，再结合案例对三类认知干预产品进行优缺点分析，提出了训练形式游戏化、认知负荷合理化、上肢训练产品与云端服务多领域并行三个设计趋势，为老年人认知障碍预防产品提供设计理论参考和依据。

关键词：认知障碍预防老年人产品设计设计趋势

金融集聚对高技术产业创新韧性的影响机制分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

铜陵学院学报 2024年第2期23卷 41-46页

作者：付爱娜刘家树安徽工业大学商学院安徽马鞍山243032

创新驱动发展战略实施过程中,需要创新链、产业链、资金链、人才链深度融合,进而提高创新效能。然而高技术产业创新具有高风险、高投入等特性,因此提升其持续创新能力、增强其韧性尤为重要。文章基于省份面板数据,运用动态面板广义矩阵(... 详细信息

创新驱动发展战略实施过程中,需要创新链、产业链、资金链、人才链深度融合,进而提高创新效能。然而高技术产业创新具有高风险、高投入等特性,因此提升其持续创新能力、增强其韧性尤为重要。文章基于省份面板数据,运用动态面板广义矩阵(GMM)考察金融集聚对高技术产业创新韧性的影响机制。研究结果表明:金融集聚显著提升了地区高技术产业的创新韧性;人力资本水平在金融集聚影响高技术产业创新韧性过程中发挥中介效应;创新氛围正向调节了金融集聚提升高技术产业创新韧性。

关键词：金融集聚创新韧性人力资本水平创新氛围

Protective paracrine effect of mesenchymal stem cells on cardiomyocytes

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 619-624页

作者： Mei-xiang XIANG ai-na HE Jian-an WANG Chun GUI Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective： The aim of this study was to test the protective effect of mesenchymal stem cells （MSCs） on cardiomyocytes in vitro and to investigate the anti-apoptotic signaling pathway. Methods： MSCs from Sprague-Dawley （SD） rats were separated and cultured. MSC medium was collected from MSCs （DMEM） under hypoxia. Cultured cardiomyocytes from neonatal cultured in serum-free Dulbecco＇s modified eagle medium SD rats were exposed to hypoxia/reoxygenation （H/R） and treated with MSC medium. The apoptotic cardiomyocytes were stained with Annexin-V-fluorescein isothiocyanate （FITC）, Hoechst 33342 and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling （TUNEL）. The mitochondrial transmembrane potential of cardiomyocytes was assessed using a fluorescence microscope. The expression of Bcl-2, Bax, cyto- chrome C, apoptosis-induced factor （aiF）, and caspase-3 was tested by Western blot analysis. Results： Our data demonstrated that MSC medium reduced H/R-induced cardiomyocyte apoptosis, increased the Bcl-2/Bax ratio, and reduced the release of cyto- chrome C and aiF from mitochondria into the cytosol. Conclusion： MSCs protected the cardiomyocytes from H/R-induced apoptosis through a mitochondrial pathway in a paracrine manner.

关键词： Mesenchymal stem cell (MSC) Apoptosis Mitochondrial transmembrane potential Hvpoxia/reoxygenation (H/R)

Effects of Ribbon Thickness on Structure and Soft Magnetic Properties of a High-Cu-Content FeBCuNb nanocrystalline Alloy

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2022年第2期35卷 235-242页

作者： Li-Cheng Wu Yan-Hui Li Xing-Jie Jia ai-na He Wei Zhang Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology CAS Key Laboratory of Magnetic Materials and DevicesNingbo Institute of Materials Technology&EngineeringChinese Academy of SciencesNingbo 315201China

The effects of ribbon thickness(t)on the structure and magnetic properties of a Fe_(82.3)B_(13)Cu_(1.7)Nb_(3) alloy in melt-spun and annealed states have been *** the t from 15 to 23μm changes the structure of the melt-spun ribbons from a single amorphous phase to a composite with denseα-Fe nanograins embedded in the amorphous *** grain size(D_(α-Fe))of theα-Fe near the free surface of the ribbon is about 6.7 nm,and it gradually decreases along the cross section toward the wheel-contacted *** increasing the t to 32μm coarsens the D_(α-Fe) near the free surface to 15.2 nm and aggravates the D_(α-Fe) ramp along the cross *** annealing,the ribbon with t=15μm has relatively largeα-Fe grains with D_(α-Fe)>30 nm,while the thicker ribbons possessing the pre-existing nanograins form a finer nanostructure with D_(α-Fe)nanostructure for the ribbons with suitable t has been discussed in terms of the competitive growth effect among the pre-existingα-Fe nanograins.

关键词： Fe-based nanocrystalline alloy Microstructure Pre-existingα-Fe nanograin Soft magnetic properties Ribbon thickness

Progress on direct assembly approach for in situ fabrication of electrodes of reversible solid oxide cells

在线全文

学校读者我要写书评

暂无评论

Materials Reports(Energy) 2021年第2期1卷 61-69页

作者： na ai Yuanfeng Zou Zhiyi Chen Kongfa Chen San Ping Jiang College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian350108China Testing Center Fuzhou UniversityFuzhouFujian350108China WA School of Mines:Minerals Energy&Chemical EngineeringCurtin UniversityPerthWA6102Australia

Reversible solid oxide cells(SOCs)are very efficient and clean for storage and regeneration of renewable electrical energy by switching between electrolysis and fuel cell *** of the most critical factors governing the efficiency and durability of SOCs technology is the stability of the interface between oxygen electrode and electrolyte,which is conventionally formed by sintering at a high temperature of~1000–1250℃,and which suffers from delamination problem,particularly for reversibly operated *** the other hand,our recent studies have shown that the electrode/electrolyte interface can be in situ formed by a direct assembly approach under the electrochemical polarization conditions at 800℃and *** direct assembly approach provides opportunities for significantly simplifying the cell fabrication procedures without the doped ceria barrier layer,enabling the utilization of a variety of high-performance oxygen electrode materials on barrier layer–free yttria-stabilized zirconia(YSZ)*** importantly,the in situ polarization induced interface shows a promising potential as highly active and durable interface for reversible *** objective of this progress report is to take an overview of the origin and research progress of in situ fabrication of oxygen electrodes based on the direct assembly *** prospect of direct assembly approach in the development of effective SOCs and in the fundamental studies of electrode/electrolyte interface reactions is discussed.

关键词： Reversible solid oxide cell Direct assembly Oxygen electrode Hydrogen electrode Polarization induced interface Electrode/electrolyte interface stability

消栓肠溶胶囊联合依达拉奉右莰醇注射用浓溶液治疗急性脑梗死的临床研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2024年第5期24卷 971-974,989页

作者：梁秋艳韩昱陈立新李爱娜李威娜辽宁省金秋医院药学部辽宁沈阳110016 辽宁省金秋医院神经内科三病房辽宁沈阳110016 鞍山市中心医院立山院区神经内科辽宁鞍山114034

目的:研究消栓肠溶胶囊联合依达拉奉右莰醇注射用浓溶液治疗急性脑梗死(ACI)的临床疗效。方法:选取2021年3月-2022年8月间我院诊治的132例ACI患者,按照随机数字表法将患者分为对照组(n=66,依达拉奉右莰醇注射用浓溶液治疗)和观察组(n=66... 详细信息

目的:研究消栓肠溶胶囊联合依达拉奉右莰醇注射用浓溶液治疗急性脑梗死(ACI)的临床疗效。方法:选取2021年3月-2022年8月间我院诊治的132例ACI患者,按照随机数字表法将患者分为对照组(n=66,依达拉奉右莰醇注射用浓溶液治疗)和观察组(n=66,对照组的基础上接受消栓肠溶胶囊治疗)。治疗14d后,对比两组疗效、卒中量表评分[美国国立卫生研究院卒中量表(NIHSS)、改良Rankin评分量表(mRS)]、脑血流灌注指标[平均流速(TMV)、收缩期峰值流速(PSV)、阻力指数(RI)]、炎症因子水平[正五聚蛋白3(PTX-3)、脂蛋白相关磷脂酶A2(Lp-PLA2)、淀粉样蛋白A(SAA)]水平和血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)、血浆血栓素B2(TXB2)],同时记录两组不良反应发生情况。结果:观察组的临床总有效率高于对照组(P0.05)。结论:依达拉奉右莰醇注射用浓溶液和消栓肠溶胶囊联合治疗ACI,可减轻神经损伤,抑制炎症反应,改善血管内皮功能,促进脑循环恢复,且无明显不良反应。

关键词：消栓肠溶胶囊依达拉奉右莰醇注射用浓溶液急性脑梗死疗效

艾司奥美拉唑镁肠溶片四联方案治疗老年消化性溃疡出血患者疗效及对Hp清除率、胃肠激素和不良反应的影响

在线全文

学校读者我要写书评

暂无评论

老年医学与保健 2024年第2期30卷 493-497,518页

作者：崔红霞吴美英董一韩爱娜青岛市胶州中心医院消化内科山东青岛266300 青岛市胶州中心医院中医科山东青岛266300 青岛市胶州中心医院药学部山东青岛266300

目的分析老年消化性溃疡出血(peptic ulcer bleeding,PUB)患者接受艾司奥美拉唑镁肠溶片四联方案治疗的效果。方法对2019年1月-2023年8月青岛市胶州中心医院收治的180例老年PUB患者的资料进行回顾性分析,根据治疗方法不同分为观察组(n=... 详细信息

目的分析老年消化性溃疡出血(peptic ulcer bleeding,PUB)患者接受艾司奥美拉唑镁肠溶片四联方案治疗的效果。方法对2019年1月-2023年8月青岛市胶州中心医院收治的180例老年PUB患者的资料进行回顾性分析,根据治疗方法不同分为观察组(n=92)及对照组(n=88)。对照组予以雷尼替丁四联方案,观察组予以艾司奥美拉唑镁肠溶片四联方案,疗程均为2周。观察并比较2组疗效、Hp清除率、症状改善情况、胃肠激素、炎症因子、不良反应、药物经济学。结果治疗2周后,观察组总有效率及Hp清除率均高于对照组(P0.05);观察组治疗有效率的成本-效果(C/E值)低于对照组(P<0.05)。结论艾司奥美拉唑镁肠溶片四联方案治疗老年PUB患者,效果确切,可促进Hp清除,改善患者症状及胃肠激素水平,缓解炎症反应,药物经济学价值较高,具有一定的临床应用价值。

关键词：老年消化性溃疡出血艾司奥美拉唑镁肠溶片四联方案胃肠激素不良反应

Global Phase Portraits of Uniform Isochronous Centers System of Degree Six with Polynomial Commutator

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 577-599页

作者： Li-na GUO ai-yong CHEN Shuai-feng ZHAO School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang 471023China Department of Mathematics Hunan First Normal UniversityChangsha 410205China School of Mechatronics Engineering Henan University of Science and TechnologyLuoyang 471023China

This paper studies the global phase portraits of uniform isochronous centers system of degree six with polynomial *** systems have the form x=-y+xf(x,y),y=x+yf(x,y),where f(x,y)=a_(1)x+a_(2)xy+a_(3)xy^(2)+a_(4)xy^(3)+a_(5)xy^(4)=xσ(y),and any zero of 1+a_(1)y+a_(2)y^(2)+a_(3)y^(3)+a_(4)y^(4)+a_(5)y^(5),y=y is an invariant straight *** last,all global phase portraits are drawn on the Poincare disk.

关键词： global phase portraits uniform isochronous center polynomial commutator invariant straight lines

Optimal time for mesenchymal stem cell transplantation in rats with myocardial infarction

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 630-637页

作者： Chen-yang JIANG Chun GUI ai-na HE Xin-yang HU Jie CHEN Yun JIANG Jian-an WANG Department of Cardiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Cardiology the First Affiliated Hospital Zhejiang Chinese Medical University Hangzhou 310006 China

Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of this study was to find an optimal time point for cell transplantation. Methods: MSCs were isolated and cultured from Sprague-Dawley (SD) rats. MI model was set up in SD rats by permanent ligation of left anterior descending coronary artery. MSCs were directly injected into the infarct border zone at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume of phosphate buffered saline (PBS). At 4 weeks after MI, cardiac function was assessed by echocardiography; vessel density was analyzed on hematoxylin-eosin stained slides by light microscopy; the apoptosis of cardiomyocytes was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expressions of proteins were analyzed by Western blot. Results: MSC transplantation improved cardiac function, reduced the apoptosis of cardiomyocytes and increased vessel density. These benefits were more obvious in 1-week group than in 1-h and 2-week groups. There are more obvious in-creases in the ratio of bcl-2/bax and the expression of vascular endothelial growth factor (VEGF) and more obvious decreases in the expression of cleaved-caspase-3 in 1-week group than those in other two groups. Conclusion: MSC transplantation was beneficial for the recovery of cardiac function. MSC transplantation at 1 week post-MI exerted the best effects on increases of cardiac function, anti-apoptosis and angiogenesis.

关键词： Mesenchymal stem cells (MSCs) Transplantation Myocardial infarction (MI) Apoptosis