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中国实验方剂学杂志 2012年第14期18卷 98-101页

作者：黄朋纳广州市医药职业学校广州510430

目的:建立UPLC-PDA技术快速测定穿心莲药材及制剂中主要内酯类成分含量的方法。方法:采用超高效液相色谱仪,用Acquity BEH Shield RP C18色谱柱(2.1 mm×50 mm,1.7μm);流动相甲醇(A)-水(B),梯度洗脱(0～2 min,40%A;2～4 min,40%～45%A;... 详细信息

目的:建立UPLC-PDA技术快速测定穿心莲药材及制剂中主要内酯类成分含量的方法。方法:采用超高效液相色谱仪,用Acquity BEH Shield RP C18色谱柱(2.1 mm×50 mm,1.7μm);流动相甲醇(A)-水(B),梯度洗脱(0～2 min,40%A;2～4 min,40%～45%A;4～10 min,45%～50%A;10～15 min,50%A);流速0.5 ***-1,检测波长226 nm,柱温30℃。结果:在15 min内可以完成药材和制剂中穿心莲内酯、脱水穿心莲内酯的分析,分离度良好,线性范围分别为0.028 6～0.286 g.L-1(r=0.999 6,n=6),0.094 0～0.940 g.L-1(r=0.999 3,n=6);平均加样回收率分别为97.32%,97.11%。结论:该方法快速、准确、灵敏度高,可用于穿心莲药材及制剂的质量控制。

关键词：穿心莲超高液相色谱法穿心莲内酯脱水穿心莲内酯

乌司他丁对脓毒症大鼠血清肌钙蛋白I及心肌肿瘤坏死因子-α、内皮素-1的影响

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中国危重病急救医学 2010年第6期22卷 364-366页

作者：彭娜向定成苏磊广州军区广州总医院ICU 广东510010 广州军区广州总医院心血管内科广东510010

目的探讨不同剂量乌司他丁（UTI）对脓毒症大鼠心肌损伤的保护作用及其可能机制.方法 40只雄性SD大鼠按随机数字表法均分为正常对照组、假手术组、模型组及UTI小剂量组、大剂量组5组.采用盲肠结扎穿孔术（CLP）建立脓毒症模型,24 h后... 详细信息

目的探讨不同剂量乌司他丁（UTI）对脓毒症大鼠心肌损伤的保护作用及其可能机制.方法 40只雄性SD大鼠按随机数字表法均分为正常对照组、假手术组、模型组及UTI小剂量组、大剂量组5组.采用盲肠结扎穿孔术（CLP）建立脓毒症模型,24 h后取动脉血及左室心肌,检测血清心肌肌钙蛋白Ⅰ（cTnI）及心肌组织匀浆上清液中肿瘤坏死因子-α（TNF-α）、内皮素-1（ET-1）水平,观察心肌组织病理改变.结果模型组血清cTnI及心肌TNF-α、ET-1水平较正常对照组明显升高[cTnI（μg/L）：7.58±0.53比1.05±0.21,TNF-α（pg/g）：945.6±72.0比238.2±35.2,ET-1（pg/g）：776.8±123.9比170.1±28.3,均P＜0.01].UTI小剂量组血清cTnI及心肌TNF-α、ET-1水平与模型组比较差异无统计学意义[cTnI（μg/L）：7.21±0.51比7.58±0.53,TNF-α（pg/g）：910.5±96.6比945.6±72.0,ET-1（pg/g）：714.0±66.7比776.8±123.9,均P＞0.05].UTI大剂量组血清cTnI及心肌TNF-α、ET-1较模型组明显减低[cTnI（μg/L）：4.30±0.84比7.58±0.53,TNF-α（pg/g）：430.5±75.6比945.6±72.0,ET-l（pg/g）：377.1±39.0比776.8±123.9,均P＜0.01].结论大剂量UTI对脓毒症心肌损伤具有保护作用,其机制可能通过抑制心肌TNF-α、ET-1的表达而实现;小剂量UTI可能对脓毒症心肌损伤无保护作用.

关键词：脓毒症心肌损伤乌司他丁肌钙蛋白I 肿瘤坏死因子-α 内皮素-1

Effect and Mechanism of Moxibustion on Acupoints Zusanli （ST 36） and Liangmen （ST 21） in the Prevention and Treatment of Stress Ulcer

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Journal of Acupuncture and Tuina Science 2007年第1期5卷 14-20页

作者：彭艳易受乡常小荣彭娜严洁林亚平朱忠春(Translator) Hu'nan College of Traditional Chinese Medicine Changsha 41000 P. R. China 不详

Objective： To observe the effect of moxibustion on acupoints Zusanli （ST 36） and Liangmen （ST 31） on cell proliferation and cell apoptosis of gastric mucosa in rats with stress ulcer, investigatethe mechanism of moxibustion in promoting the repair of gastric mucosal injury at cellular and molecular levels, Methods： Sixty healthy Sprague-Dawley rats were randomly divided into four groups： the restraint control group, model group, moxibustion on acupoints group and moxibustion on non-acupoints group. Water immersion and restraint stress （WRS） was used to copy the stress ulcer model of rats, radio-immunoassay was used to detect the content of transforming growth factor （TGF-α）, and S-P immunohistochemical assay was adopted to determine the HSP70 expression, the proliferating cell nuclear antigen （PCna） and cell apoptosis index in gastric mucosa. Results： For the WRS-induced gastric ulcer model of rat, the gastric mucosal injury （gastric ulcer index, UI） was increased, the content of TGF-α was decreased, PCna was also decreased, HSP70 expression and cell apoptosis index were all increased （P〈0.01）, Moxibustion on acupoints Zusanli （ST 36） and Liangmen （ST 31） could decrease UI, increase the content of TGF-α, promote the expression of PCna and HSP70, decrease cell apoptosis index in gastric mucosa, with significant differences when compared with the model group and control group （P〈0.01）. Conclusions： Moxibustion on acupoints Zusanli （ST 36） and Liangmen （ST 31） had protective effect on the gastric mucosa of stress ulcer, its mechanism may be promoting the TGF-α synthesis, stimulating cell proliferation in gastric mucosa and inhibiting cell apoptosis in gastric mucosa, and this process is related to the moxibustion-induced HSP70 expression.

关键词： Moxibustion Therapy Stress Ulcer HSP70 Cell Apoptosis

IL-17 sustains the plasma cell response via p38-mediated Bcl-xL Rna stability in lupus pathogenesis

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Cellular & Molecular Immunology 2021年第7期18卷 1739-1750页

作者： Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang na peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongChongqing International Institute for ImmunologyHong KongChina Department of Rheumatology and Immunology Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhenChina Division of Rheumatology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Rheumatology and Nephrology the Second People’s HospitalChina Three Gorges UniversityYichangChina Department of Rheumatology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina

Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely *** this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDna IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus *** a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE ***,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma *** mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus *** reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B *** mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript ***,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE.

关键词： Systemic lupus erythematosus(SLE) Plasma cell(PC) Autoantibody Interleukin-17A(IL-17)

本土产品开发能力、创新网络与后发企业逆向创新的案例研究

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研究与发展管理 2017年第5期29卷 99-112页

作者：徐娜娜彭正银天津财经大学商学院天津300222

本文聚焦后发企业的逆向创新问题,通过将企业内部创新能力与外部创新网络相结合,基于本土企业逆向创新案例研究,采用扎根理论方法总结后发企业不同发展阶段逆向创新的内在机理.研究发现:本土市场创新为后发企业创造多元化的逆向创新机会... 详细信息

本文聚焦后发企业的逆向创新问题,通过将企业内部创新能力与外部创新网络相结合,基于本土企业逆向创新案例研究,采用扎根理论方法总结后发企业不同发展阶段逆向创新的内在机理.研究发现:本土市场创新为后发企业创造多元化的逆向创新机会;作为后发企业逆向创新系统中的两个重要子系统,创新网络嵌入与基于本土的产品开发能力之间的良好互动,共同促成逆向创新的发生与实现;基于全球创新网络嵌入,促进后发企业实现逆向创新的演化升级.本研究丰富了后发企业自主创新路径的相关研究,加深了对后发企业逆向创新的认识,为本土企业逆向创新实践提供借鉴.

关键词：后发企业本土能力创新网络逆向创新

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苗族文化的群体性研究

贵州民族研究 2017年第12期38卷 47-52页

作者：彭娜娜吴秋林中山大学社会学与人类学学院广东广州510275 吉首大学历史与文化学院湖南吉首416000

在苗人的社会组织结构中表现出其"群"和"群体主义"的思想,这样的"群"和"群体主义"又是源于其"鬼"文化信仰体系中以群体形式存在的崇信对象,我们称其为"鬼群"。"鬼群"的存在影响着苗文化的方方面面,这在民族志当中有许多例证。当把苗人的... 详细信息

在苗人的社会组织结构中表现出其"群"和"群体主义"的思想,这样的"群"和"群体主义"又是源于其"鬼"文化信仰体系中以群体形式存在的崇信对象,我们称其为"鬼群"。"鬼群"的存在影响着苗文化的方方面面,这在民族志当中有许多例证。当把苗人的"鬼群"与中国古代的"井田制"群进行一番比较时,便发现了古代的"集体主义"、"儒家性集体主义"与苗人的"群体主义"的本质区别,以及苗人平权社会组织建构与中华集权社会组织所不同的文化基因建构。从而得出,平权社会与集权社会,只要与其文化相适应,都有其有效和合理性。

关键词：苗人群体主义集体主义 “井田制”群

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印尼的新发展主义实践及其效果研究

亚太经济 2019年第4期 62-70,151页

作者：林梅那文鹏厦门大学国际关系学院暨东南亚研究中心厦门361005 厦门大学国际关系学院暨南洋研究院

佐科·维多多自2014年10月正式成为印尼第七任总统后,推行了以经济发展为核心的系列政策,力图实现印尼经济复兴。在首届总统任期内,佐科通过灵活适度的货币和财政政策,维持了国民经济的稳定运行;通过发展工业和海洋经济,实现了GDP增长... 详细信息

佐科·维多多自2014年10月正式成为印尼第七任总统后,推行了以经济发展为核心的系列政策,力图实现印尼经济复兴。在首届总统任期内,佐科通过灵活适度的货币和财政政策,维持了国民经济的稳定运行;通过发展工业和海洋经济,实现了GDP增长率的逐年提升;通过推进基础设施建设与行政改革,改善了本国的营商环境;通过消除贫困和维护社会公平,促进了包容性发展。2019年4月,佐科再度在印尼大选中胜出,其所推行的新发展主义,将继续塑造印尼的政经发展。

关键词：印尼新发展主义经济政策实践

The occurrence characteristics of oil in shales matrix from organic geochemical screening data and pore structure properties:An experimental study Author links open overlay panel

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Petroleum Science 2024年第1期21卷 1-13页

作者： Zi-Zhi Lin Jun-Qian Li Shuang-Fang Lu Qin-Hong Hu peng-Fei Zhang Jun-Jie Wang Qi Zhi Hong-Sheng Huang na Yin Yue Wang Tian-Chen Ge national Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025HainanChina College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

The occurrence characteristics of shale oil are of great significance to the movability of shale *** this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin were quantitatively evaluated by organic geochemistry and microscopic pore structure characterization *** Multiple Isothermal Stages Pyrolysis(MIS)experiment results show that the content of total oil,adsorbed oil,and free oil in the shales are 3.15-11.25 mg/g,1.41-4.95 mg/g,and 1.74-6.51 mg/g,*** which the silicon-rich shale has the best *** relative content of free oil shows an increasing trend in pores with pore diameters greater than 3 *** the relative content of free oil reaches 100%,the pore size of silicon-rich shale is about 200 nm,while that of calcium-rich shale,clay-rich shale,and siliceous mixed shale is about 10 *** occurrence law of adsorbed oil is opposite to that of free oil,which indicates that shale oil will occur in the pores and fractures in a free state in a more extensive pore size range(>200 nm).This study also enables us to further understand the occurrence characteristics of shale oil under the interaction of occurrence state and occurrence space.

关键词： Shale oil Occurrence characteristics Sequential solvent extraction Low-temperature nitrogen adsorption Funing Formation Dongtai Depression

Anti-tumoractivities of calix[n]arene polyhydroxyamine derivatives

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Anti-tumoractivities of calix[n]arene polyhydroxyamine deriv...