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Journal of Oceanology and Limnology 2020年第2期38卷 503-508页

作者： Yeon Jung PARK mi nan lee Eun-mi KIM Jung Youn PARK Jae Koo NOH Tae-Jin CHOI Jung-Ha KANG Biotechnology Research Division National Institute of Fisheries ScienceBusan 46083Republic of Korea Department of microbiology Pukyoung National UniversityBusan 48513Republic of Korea

Korean freshwater snails of the genus Semisulcospira are widely distributed across East *** has been a very popular nutritional food in Korea,and is an ecologically important water quality indicator because it lives only in clean ***,no microsatellite markers have been generated to study the population genetic diversity of this *** the present study,we developed and characterized 18 novel microsatellite loci from Semisulcospira coreana genomic *** microsatellites were isolated using 454 GS-FLX titanium sequencing and 18 markers were used for genotyping in *** addition,we also tested the cross-species transferability of the microsatellite markers in four additional Semisulcospira *** identified 18 polymorphic loci and the number of alleles per loci,and their polymorphism information content values ranged from 2 to 17 and 0.203 to 0.902,*** observed and expected heterozygosities of the loci ranged from 0.063 to 0.924 and 0.226 to 0.924,*** to the analysis of the cross-species transferability of these markers,four species,***,***,***,and ***,showed a very high transferability(80%–85%).These results show that this set of nuclear markers could be useful for population genetics studies of this species and closely related species.

关键词： Semisulcospira next-generation sequencing(NGS) microsatellite markers cross-species transferability

Esophageal subepithelial lesion diagnosed as malignant gastrointestinal neuroectodermal tumor

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World Journal of Gastroenterology 2015年第18期21卷 5739-5743页

作者： Sung Bum Kim Si Hyung lee mi Jin Gu Department of Internal Medicine Yeungnam University Hospital Department of Pathology Yeungnam University Hospital

A 21-year-old male visited our hospital with a complaint of aggravating dysphagia and odynophagia for a few *** showed huge bulging mucosa with an intact surface causing luminal narrowing at 35 cm from the incisor *** ultrasonography showed an about 35 mm sized irregular margined in-homogenous hypoechoic lesion with an obscure layer of *** ultrasonography fine needle aspiration revealed spindle cell proliferation without immunoreactivity for CD117,SMA,and *** patient underwent excision of the subepithelial lesion at the distal *** pathologic examination of the specimen,the tumor was composed of short fascicles of oval to spindle cells with eosinophilic and clear cytoplasm and vesicular *** tumor cells were positive for S-100 and SOX10and negative for CD117,SMA,HMB-45,melan-A,cytokeratin,and *** split-apart signal was detected in EWSR1 on FISH,suggesting a malignant gastrointestinal neuroectodermal *** the time of writing,the patient is on radiation therapy at the operated site of esophagus and doing well,with no recurrence for three *** gastrointestinal neuroectodermal tumor is a rare gastrointestinal tumor with features of clear cell sarcoma,without melanocytic differentiation,and shows a poor *** is the first reported case of malignant gastrointestinal neuroectodermal tumor arising as subepithelial lesion in the esophagus.

关键词： Subepithelial lesion Esophagus Malignant gastrointestinal neuroectodermal tumor Ewing sarcoma break point region 1 gene Fluorescence in situ hybridization

Cortical activation pattern during shoulder simple versus vibration exercises： a functional near infrared spectroscopy study

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Neural Regeneration Research 2017年第8期12卷 1294-1298页

作者： Sung Ho Jang Sang Seok Yeo Seung Hyun lee Sang Hyun Jin mi Young lee Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Department of Physical Therapy College of Health Science Dankook University Cheonan-si Republic of Korea Robot System Research Division Daegu Gyeongbuk Institute of Science & Technology Daegu Republic of Korea Department of Physical Therapy College of Health and Therapy Daegu Haany University Gyeongsan-si Republic of Korea

To date, the cortical effect of exercise has not been fully elucidated. Using the functional near infrared spectroscopy, we attempted to compare the cortical effect between shoulder vibration exercise and shoulder simple exercise. Eight healthy subjects were recruited for this study. Two different exercise tasks（shoulder vibration exercise using the flexible pole and shoulder simple exercise） were performed using a block paradigm. We measured the values of oxygenated hemoglobin in the four regions of interest： the primary sensory-motor cortex（SM1 total, arm somatotopy, and leg and trunk somatotopy）, the premotor cortex, the supplementary motor area, and the prefrontal cortex. During shoulder vibration exercise and shoulder simple exercise, cortical activation was observed in SM1（total, arm somatotopy, and leg and trunk somatotopy）, premotor cortex, supplementary motor area, and prefrontal cortex. Higher oxygenated hemoglobin values were also observed in the areas of arm somatotopy of SM1 compared with those of other regions of interest. However, no significant difference in the arm somatotopy of SM1 was observed between the two exercises. By contrast, in the leg and trunk somatotopy of SM1, shoulder vibration exercise led to a significantly higher oxy-hemoglobin value than shoulder simple exercise. These two exercises may result in cortical activation effects for the motor areas relevant to the shoulder exercise, especially in the arm somatotopy of SM1. However, shoulder vibration exercise has an additional cortical activation effect for the leg and trunk somatotopy of SM1.

关键词： nerve regeneration functional near infrared spectroscopy cortical activation shoulder vibrationexercise flexible pole neural regeneration

Epigenetics: An emerging player in gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6433-6447页

作者： Changwon Kang Ji-Joon Song Jaeok lee mi Young Kim Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 305-701South Korea

Cancers,like other diseases,arise from gene mutations and/or altered gene expression,which eventually cause dysregulation of numerous proteins and noncoding *** in gene expression,i.e.,upregulation of oncogenes and/or downregulation of tumor suppressor genes,can be generated not only by genetic and environmental factors but also by epigenetic factors,which are inheritable but nongenetic modifications of cellular chromosome *** of the factors that contribute to individual cancers is a prerequisite to a full understanding of cancer mechanisms and the development of customized cancer *** search for genetic and environmental factors has a long history in cancer research,but epigenetic factors only recently began to be associated with cancer formation,progression,and *** alterations of chromatin include Dna methylation and histone modifications,which can affect gene-expression *** studies have revealed diverse mechanisms by which chromatin modifiers,including writers,erasers and readers of the aforementioned modifications,contribute to the formation and progression of ***,functional Rnas,such as microRnas and long noncoding Rnas,have also been identified as key players in these *** review highlights recent findings concerning the epigenetic alterations associated with cancers,especially gastric cancer.

关键词： Gastric cancer Epigenetics Dna methylation Histone modification Gene expression

Spindle-like FeySs/N-doped carbon nanohybrids for high-performance sodium ion battery anodes

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nano Research 2019年第3期12卷 695-700页

作者： Aihua Jin mi-Ju Kim Kug-Seung lee Seung-Ho Yu Yung-Eun Sung Center for nanoparticle Research Institute for Basic Science (IBS) Seoul 08826 Republic of Korea School cf Chemical and Biological Engineering Seoul National University Seoul 08826 Republic cf Korea Beamline Department Pohang Accelerator Laboratory (PAL) Pohang 790-784 Republic of Korea Department of Chemistry and Chemical Biology Cornell University Ithaca New York 14853 USA

Iron sulfides have bee n con sidered as one of the most promising can didates for sodium ion battery anode materials due to their high theoretical capacity and low cost. I n this work, spin dle-like Fe7S8 with n itroge rvdoped carb on (FeiS/N-C) nano hybrids are successfully syn thesized via a solvothermal method by sulfidation iron-based metal organic framework (FeMOF). As sodium ion battery an odes, FeySs/N-C nano hybrids exhibit high reversible capacity of 450.8 mAh g-1 at 200 mA·g^-1, and 406.7 mAh·g^-1 at 500 mA·g^-1 even after 500 cycles. They also show excellent rate properties and delivering the capacity of 327.8 mAh·g^-1 at a very high current density of 3.2 A·g^-1. These outstanding electrochemical performa nces can be attributed to the unique structure of Fe7S8/ N-C nan ohybrids. The nano scale dime nsion in their size can be ben eficial for facile ion and electro n tran sports. Furthermore, the stable n itroge n doped carb on frameworks can also improve electrical conductivity and relieve the problems related to volume expansion. X-ray absorption spectroscopy and X-ray photoelectron spectroscopy analyses have been performed to study reactions occurred in spindle-like FeySs/N-C nanohybrid electrode at both bulk and surface.

关键词： sodium ion batteries iron sulfides metal organic frameworks X-ray absorption spectroscopy X-ray photoelectron spectroscopy

Understanding protein translocation across chloroplast membranes:Translocons and motor proteins

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Journal of Integrative Plant Biology 2023年第2期65卷 408-416页

作者： Da Been Kim Changhee na Inhwan Hwang Dong Wook lee Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju 61186Korea Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Korea Department of Bioenergy Science and Technology Chonnam National UniversityGwangju 61186Korea Kumho Life Science Laboratory Chonnam National UniversityGwangju 61186Korea

Subcellular organelles in eukaryotes are surrounded by lipid *** an endomembrane system,vesicle trafficking is the primary mechanism for the delivery of organellar proteins to specific ***,organellar proteins for chloroplasts,mitochondria,the nucleus,and peroxisomes that are translated in the cytosol are directly imported into their target *** are a plant-specific organelle with outer and inner envelope membranes,a dual-membrane structure that is similar to *** chloroplast proteins translated by cytosolic ribosomes are thus translocated through TOC and TIC complexes(translocons in the outer and inner envelope of chloroplasts,respectively),with stromal ATPase motor proteins playing a critical role in pulling pre-proteins through these import *** the last three decades,the identity and function of TOC/TIC components and stromal motor proteins have been actively investigated,which has shed light on the action mechanisms at a molecular ***,there remains some disagreement over the exact composition of TIC complexes and genuine stromal motor *** this review,we discuss recent findings on the mechanisms by which proteins are translocated through TOC/TIC complexes and discuss future prospects for this field of research.

关键词： ATPase motor protein chloroplast molecular chaperone protein translocation TOC/TIC translocon

Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation

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Neural Regeneration Research 2020年第8期15卷 1483-1489页

作者： Su Hwan Bae mi Ran Yoo Ye Yeong Kim In Kyung Hong mi Hee Kim Seung Hak lee Dae Yul Kim Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Macrophage migration inhibitory factor(miF)is a chemokine that plays an essential role in immune system *** studies suggested that miF protects neurons in ischemic ***,few studies are reported on the role of miF in neurological recovery after ischemic *** purpose of this study is to identify the molecular mechanism of neuroprotection mediated by *** neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL miF recombinant(30 ng/mL)or ISO-1(miF antagonist;50μM)was administered to human neuroblastoma *** cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with miF,OGD/R with *** viability was analyzed using WST-1 *** levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic ***-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with miF group and lower in the OGD/R with ISO-1 *** blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the miF group than in the OGD/R *** levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R *** administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R *** results suggest that miF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells

关键词： apoptosis brain-derived neurotrophic factor hypoxia in vitro ischemic stroke macrophage migration inhibitory factor nerve regeneration neuroprotective effect reperfusion

Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer

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World Journal of Gastroenterology 2009年第48期15卷 6091-6095页

作者： mi-Sook Kim Chul Koo Cho Kwang Mo Yang Dong Han lee Sun mi Moon Young Joo Shin Department of RadiationOncology and Surgery Korea Institute of Radiological & Medical Sciences

AIM： To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS： From 2003 to 2009, 7 patients with paraaortic lymph node recurrence （1-3 lesions） from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS： One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION： This pilot study suggests selected paraaortic lymph node recurrence （1-3 closed lesions） that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.

关键词： Stereotactic body radiotherapy Paraaortic lymph node recurrence Colorectal cancer

Effect of infusion pressure during cataract surgery on ganglion cells measured using isolated-check visual evoked potential

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 58-65页

作者： Tong Ding Dan-na Shi Xiang Fan mi-Yun Zheng Wei Wang Wei-Qiang Qiu Peking University Third Hospital Eye Center Beijing 100191China

AIM： To detect the relationship between infusion pressure and postoperative ganglion cells ***： This prospective observational cohort study included sixty-one eyes that underwent uncomplicated cataract surgery. Patients were divided into two groups according to infusion time（IT） recorded using surgery equipment [Group A： IT〉IT_（mean）（27 eyes）; Group B： IT

关键词： isolated-check visual evoked potential optical coherence tomography ganglion cell inner plexiform layer cataract extraction

Body-centered-cubic martensite and the role on room-temperature tensile properties in Si-added SiVCrMnFeCo high-entropy alloys

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Journal of Materials Science & Technology 2021年第17期76卷 222-230页

作者： Yong Hee Jo Junha Yang Won-mi Choi Kyung-Yeon Doh Donghwa lee Hyoung Seop Kim Byeong-Joo lee Seok Su Sohn Sunghak lee Center for High Entropy Alloys Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Division of Advanced Materials SciencePohang University of Science and TechnologyPohang 37673South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea

We present a new class of metastable high-entropy alloys(HEAs),triggering deformation-induced martensitic transformation(DIMT)from face-centered-cubic(FCC)to body-centered-cubic(BCC),i.e.,*** the ab-initio calculation based on 1 st order axial interaction model and combined with the Gibbs free energy calculation,the addition of Si is considered as a critical element which enables to reduce the intrinsic stacking fault energy(ISFE)in Si_xV_((9-x))Cr_(10)Mn_5 Fe_(46)Co_(30)(x=2,4,and 7 at.%)alloy *** ISFE decreases from-30.4 to-35.5 mJ/m^(2)as the Si content increases from 2 to 7 at.%,which well corresponds to the reduced phase stability of FCC against *** BCC-DIMT occurs in all the alloys via intermediate HCP martensite,and the HCP martensite provides nucleation sites of BCC ***,the transformation rate enhances as the Si content increases in an earlier deformation ra ***,the BCC-DIMT is also affected by the phase stability of FCC against BCC,and the stability is the highest at the Si content of 7 at.%.Thus,the 7Si alloy presents the moderate transformation rate in the later deformation *** to the well-controlled transformation rate and consequent strain-ha rdening rate,the 7Si alloy possesses the superior combination of strength and ductility beyond 1 GPa of tensile strength at room *** results suggest that the Si addition can be a favorable candidate in various metastable HEAs for the further property improvement.

关键词： High-entropy alloy(HEA) Deformation-induced martensitic transformation(DIMT) Phase stability Stacking fault energy(SFE)