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Biomedical and Environmental Sciences 2014年第11期27卷 858-871页

作者： WU Jing norris jessie LIU Hui Xin LI Zheng SU Ying Ying ZHU Lin WANG Ning National Center for AIDS/STD Control and Prevention China Center for Disease and Prevention School of Agroforestry & Medicine the Open University of China

Objective To understand drug resistance prevalence among treatment-failure and treatment-nave HIV-positive individuals in *** We searched five electronic databases（Wanfang,CNKI,CQVIP,SinoMed,and Pubmed） for studies of HIV drug ***-effects models were carried out to estimate the prevalence of drug resistance among treatment-failure and treatment-nave individuals,*** The estimated nationwide rates of HIV drug resistance to any-class drugs among treatment-failure and treatment-nave individuals were 57%（95% CI：49%-65%） and 3.23%（95% CI：2.47%-4.07%）,*** the drug classes,the prevalence of resistance to PIs was low（1.45%;95% CI：0.73%-2.33%） in treatment-failure individuals,although high rates of resistance to NNRTIs（54%;95% CI：45%-63%） and NRTIs（40%;95% CI：32%-49%） were *** to any-class drugs,NNRTIs and NRTIs manifested regional differences,but resistance to PIs did *** correlations were observed between resistance to NNRTIs and NRTIs among treatment-failure and treatment-nave individuals,*** The prevalence of HIV drug resistance to NNRTIs and NRTIs among treatment-failure individuals was *** contrast,the prevalence of drug resistance among treatment-nave individuals was *** epidemics of drug resistance matched current treatment strategies and interventions in *** for HIV drug resistance is necessary to assess the sustainability and durability of current treatment regimens.

关键词： HIV Drug resistance Meta-analysis China

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Chinese Medical Journal 2012年第16期125卷 2819-2825页

作者： WANG Xiao-fang jessie L. norris LIUYingjie Kathleen H. Reilly WANG Ning National Center for AIDS/STD Control and Prev'ention Chinese Center for Disease Control and Prevention Beijing 102206 China Institute for AIDS/STD Control and Prevention Beijing Chaoyang District Center for Disease Control and Prevention Beijing 100021 China

Background Previous studies have shown evidence of health-related risk behaviors among women who have sex with women （WSW）, such as sex with men, multiple bisexual partners, and drug use. Women who have sex with women have also been known to avoid routine physical examinations and conceal their same-sex history from physicians, which can affect their ability to receive an accurate diagnosis and treatment. No previous research has targeted women who have sex with women in China. We sought to describe women who have sex with women in China and explore risk factors for their reproductive tract infections （RTI）/sexually transmitted infections （STI）. Methods Participants were recruited through outreach in venues and online for a cross-sectional study. Data were collected using interviews and laboratory tests. Results We recruited 224 women who have sex with women. In the year preceding their participation in the study, 92% （206/224） of women reported sexual relations with women. The RTI rates were： gonorrhea （15.8%）, chlamydia （3.5%）, syphilis （0.5%）, bacterial vaginosis （14.4%）, hepatitis B virus （HBV）（0.9%）, hepatitis C virus （HCV）（0.5%）, and candidiasis （6.9%）. No HIV or herpes simplex virus （HSV） positive cases were detected. Factors associated with gonorrhea infection were non-Beijing local residency （odds ratio （OR）=2.1, 95% confidence interval （C/）： 1.2-3.8） and genital-genital contact （OR=3.1, 95% CI： 1.3-7.2）; factors associated with curable STI （excluding bacterial vaginosis, candidiasis, HBV and HCV） were non-Beijing local residency （OR=1.9; 95% CI： 1.2-3.0） and bleeding during or after sex （OR=18.1; 95% CI： 5.2-62.6）; and the factor associated with RTI （including all the infections tested） was bleeding during or after sex （OR=37.8, 95% CI： 11.2-127.4）. Conclusions Behaviors that may cause RTI/STI exist among Chinese women who have sex with women. Researchers should consider these behaviors when planninq correspondin.q prevention and interventions.

关键词： women who have sex with women, lesbian, gay, bisexual, transgender HIV/AIDS sexual transmission,sexually transmitted infection

HIV prevalence and influencing factors analysis of sentinel surveillance among men who have sex with men in China, 2003-2011

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Chinese Medical Journal 2012年第11期125卷 1857-1861页

作者： WANG Lan WANG Lu jessie L.norris LI Dong-min GUO Wei DING Zheng-wei WANG Ning National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Background Men who have sex with men （MSM） have been impacted by HIV and now as an important driver of the HIV/AIDS epidemic in China. This study collected HIV sentinel surveillance system data on the MSM population to describe the characteristics and trends of the HIV epidemic among MSM in China from 2003 to 2011. Methods Data on HIV prevalence and risk behaviors from 2003 to 2011 were obtained from the national HIV sentinel surveillance database. Results MSM sentinel surveillance data for 2011 showed that proportions of MSM who consistently used condoms during anal sex in the last six months and at last anal sex encounter were 43.3% and 74.1%, respectively. Between 2005 and 2011 there were no significant changes in the proportion of consistent condom use. The proportion of MSM who had multiple male sex partners in the last six months increased. Overall HIV prevalence over the years showed a rising trend from 0.9% in 2003 to 6.3% in 2011. The syphilis antibody positive rate was 7.8% in 2011. In addition, the proportion of MSM in heterosexual marriages was rising, AIDS awareness was also increasing, and the proportion of MSM who had taken an HIV test in the last year and was aware of the results rose. The proportion who had received intervention services in the last year stabilized. Conclusions HIV prevalence in MSM populations is rapidly and widely distributed. MSM who are in heterosexual marriages may be a bridge group transmitting HIV to their heterosexual partners. The risky sexual behavior among MSM will remain a serious and important driver of China＇s AIDS epidemic over the next period of time. Intervention need to be strengthened, as does the effective implementation of measures to control AIDS and prevent it from spreading further.

关键词： MSM HIV prevalence epidemic, risk sexual behaviors

Herpes Simplex Virus Type 2 Risks in Female Sex Workers in the China-vietnam Border County of Hekou

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Biomedical and Environmental Sciences 2012年第6期25卷 706-710页

作者： WANG Jun Jie ZHU Zhi Bin YANG Xi WU Jing WANG Hai BO FENG Lin DING Guo Wei jessie L. norris WANG Ning National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206 China Hekou Center for Disease Control and Prevention Hekou 661300 Yunnan China Yunnan Center for Disease Control and Prevention Kunming 650022 China

Objective To survey the prevalence and risk factors of HSV-2 among Chinese and Vietnamese female sex workers （FSW） in the border county of Hekou, Yunnan Province, China. Methods A cross-sectional survey was conducted on demographics, sexual behavior, medical history, and drug use among FSWs. Laboratory samples were obtained to test for HSV-2 and other STIs such as HIV, Syphilis, Trichomonas vaginalis, Neisseria gonorrhoeae, Chlamydia trachomatis, Bacterial vaginosis, and Yeast infections. Cervicitis and genital warts were also diagnosed. Results Of the 345 FSWs who participated in this study, 112 （32.5%） were ethnic Chinese and 233 （67.5） were Vietnamese. Among FSWs in Hekou, the prevalence rates were 58.3% for HSV-2, 5.5% for HIV, and 4.1% for bacterial vaginosis （BV）. Age 〈21 （OR： 0.5; 95% CI： 0.3, 0.8）, duration of commercial sex work 〈3 months （OR： 0.5; 95% CI： 0.3, 0.8）, oral and vaginal sex with the last client （as opposed to only vaginal sex）（OR： 1.6; 95% CI： 1.0, 2.7）, HIV （OR： 11.4; 95% Cl： 1.5, 87.2）, and bacterial vaginosis （BV）（OR 5.6; 95% CI： 1.2, 26.9） were significantly correlated with HSV-2 infection. Conclusion Multivariate analysis showed that several factors were significantly correlated with the high prevalence of HSV-2 in FSWs in the border area between China and Vietnam. Further studies and interventions are needed for HSV-2 epidemiology in the border area.

关键词： China Vietnam Female sex workers HSV-2