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Cholangiocarcinoma, gone without the Wnt?

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World Journal of Hepatology 2016年第26期8卷 1093-1096页

作者： Anne T r noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap Department of Surgery NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Molecular Tumor Biology Department of GeneralVisceral and Transplantation SurgeryRWTH Aachen University Euregional HPB collaboration Aachen-Maastricht Aachen-Maastricht

Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human *** ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetami

关键词： Intrahepatic cholangiocarcinoma Liver neoplasms Carcinogenesis Wnt signaling pathway Wnt7B protein Wnt proteins

脑肿瘤术前Mr功能成像定位语言功能区的准确性:系统综述及Meta分析

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国际医学放射学杂志 2018年第2期 226-226页

作者： H.H.Weng K.r.noll J.M.Johnson S.S.Prabhu Y.H.Tsai S.W.Chang 孙超 Department of Diagnostic radiology Chang Gung Memorial Hospital Chiayi Chang Gung University College of Medicine

摘要目的与直接皮质刺激(DCS)对照,评估功能MrI定位脑肿瘤病人语言功能区(语言功能MrI)的准确性,并评估其相关影响因素。材料与方法于Pub Med、MEDLINE和相

关键词：语言功能区 Mr 脑肿瘤

[Y(dbm)_(3)(H_(2)O)]:Synthesis,thermal behavior and spin-coating precursor for Y_(2)O_(3)layer formation

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Journal of rare Earths 2017年第12期35卷 1248-1254页

作者： Elaheh Pousaneh Andrea Preuβ Khaybar Assim Julian noll Alexander Jakob Tobias rüffer Heinrich Lang Technische Universitat Chemnitz Faculty of Natural SciencesInstitute of ChemistryInorganic Chemistry

The synthesis,structure and thermal behavior of [Y（dbm）3（H2 O）]（3）（dbm = 1,3-diphenyl-1,3-propandionate） and its use as a spin-coating precursor for Y2 O3 deposition is reported. Complex 3 was prepared by the reaction of [Y（NO3）3·6 H2 O]（1） with 3 equiv of Hdbm（2） in presence of NaOH. The molecular structure of 3 in the solid-state was determined by single X-ray crystal diffraction. Both C1 symmetric crystallographically independent species of 3 possess a YO7 coordination setup with minor deviation from an ideal capped octahedron coordination geometry（∧ enantiomer）. Complex 3 forms a1 D chain, due to intermolecular hydrogen bonds between the coordinated H2 O molecule and the 0 atom of the dbm ligand, respectively. The thermal decomposition behavior of 3 was investigated by thermogravimetric studies in the temperature range of 40-800 ℃ and 40-1300 ℃ under an oxygen and argon atmosphere, respectively. Powder X-ray diffraction（PXrD） measurements of the residues confirmed the formation of Y2 O3. Complex 3 was applied as a spin-coating precursor for yttrium oxide film formation on either Si wafers with a continuous 100 nm thick SiO2 film, or with a native oxide *** as-deposited Y2 O3 layers are smooth, conformal, dense and transparent and are of a thickness of 27 and 30 nm, respectively.

关键词： Yttrium β-Diketonate Yttrium oxide Spin-coating Solid-state structure Vapor pressure

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Synthesis and thermal behavior of [Li(thf)3(μ-Cl)La{N(SiMe3)2}3] and its investigation as spin-coating precursor for lanthanum-based layer formation

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Journal of rare Earths 2018年第5期36卷 537-543页

作者： Andrea Preuβ Elaheh Pousaneh Julian noll Tobias rüffer Alexaner Jakob Lutz Mertens Michael Mehring Heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry 09107 Chemnitz Germany Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Coordination Chemistry 09107 Chemnitz Germany

The lanthanum（Ⅲ） complex [Li（thf）3（μ-CI）La{N（SiMe3）2}3]（3） was obtained by the reaction of LaCl3 with three equiv of Li[N（SiMe3）2]3 in a tetrahydrofuran solution. The molecular structure of 3 in the solid state was characterized by a tetracoordinated anionic lanthanide（Ⅲ） amide in form of an adduct with LiCl（thf）3 as evidenced by single crystal X-ray structure analysis. In order to study the suitability of 3 as a precursor for the deposition of La2O3/LiLaSiO4 by thin layer deposition techniques,its thermal behavior was investigated by thermogravimetry（TG） and TG-MS-coupled studies. TG studies show a two-step decomposition process, whereby volatile decomposition products can be detected during the second decomposition step. TG measurements under an atmosphere of oxygen produced La2O3, Calcination processes of 3 under ambient atmosphere for 10 h at 1000 ℃ gave La2O3 and LiLaSiO4,which was confirmed by PXrD studies. Metal-organic 3 was applied as spin-coating precursor for La2O3 thin film formation giving the as-deposited layers nearly crack-free.

关键词： Lanthanum Amide Thermogravimetry Solid state structure Spin-coating rare earths

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refrigerated and frozen storage impact aronia berry quality

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Food Production, Processing and Nutrition 2022年第1期4卷 13-24页

作者： Erica S.King Andrea noll Susan Glenn Bradley W.Bolling Department of Food Science University of Wisconsin-Madison1605 Linden Dr.MadisonWI53706USA Department of Statistics Medical Sciences CenterUniversity of Wisconsin-Madison1300 University Ave Rm 1220MadisonWI53706USA

Postharvest storage of many freshly picked berries affects polyphenol and sugar content. However, little is known about the impact of refrigerated and frozen storage on aronia berry composition. Therefore, the objective of this study was to characterize how storage at 4 ± 2 °C and − 20 ± 2 °C, and temperature cycles affect aronia berry polyphenols, total solid content, pH, titratable acidity, polyphenol oxidase (PPO) activity, sugar content, acid content, color, and cell structure. refrigerated storage reduced proanthocyanidins (21%), anthocyanins (36%), and total phenols (21%) after 12 weeks. Frozen storage increased polyphenols in the first 6 mo. of frozen storage but then decreased polyphenols at mo. 8 to levels similar to initial values. Frozen temperature cycling reduced anthocyanins 18% but did not affect total phenols or proanthocyanidins. Scanning electron microscopy analysis indicated temperature cycling induced cell damage, shrinking, and fusion. This disruption led to the release of anthocyanins inside the berry tissue. PPO activity did not significantly correlate with the decrease in polyphenol content during storage. °Brix did not significantly change during refrigeration and frozen storage but did during the 12th temperature cycle. Aronia berries’ pH and titratable acidity were affected more by refrigeration than frozen and temperature storage. The pH increased by 4% during refrigeration, and titratable acidity decreased by 17% at 12 weeks. In conclusion, refrigerated storage results in a modest reduction of aronia berry polyphenols, but absolute extractable polyphenols are stable for up to 8 months of frozen storage.

关键词： Aronia berry Polyphenols Storage refrigeration Sugars Acids Frozen

COMPArISON OF THrEE METHODS TO PrEDICT ADSOrPTION ISOTHErMS FOr OrGANIC VAPOrS FrOM SIMILAr AND NON-SIMILAr POLArITY rEFErENCE VAPOrS

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Chinese Journal of Chemical Engineering 1989年第2期 298-308页

作者：汪大翚 T.Shen Kenneth E.noll Department of Chemical Engineering Zhejiang University Hangzhou Department of Environmental Engineering Illinois Institute of Techmology Chicago IL 60616 U.S.A.

The Polanyi-Dubinin equation was used to predict adsorption isotherms for eight organic vapors at 25℃ and for two organic vapors at 25℃, 40℃ and 60℃ on activated carbon in this analysis. The theoretical affinity coefficient, β, was calculated by three methods (molar volume, molecular parachor and electronic polarization) based on nonpolar and polar reference vapors.

关键词： isotherms affinity molar Polar deviation polar monitored adsorbed maintained beads

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Gene complementation analysis indicates that parasitic dodder plants do not depend on the host FT protein for flowering

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Plant Communications 2024年第5期5卷 104-108页

作者： Sina Mackelmann Andrea Kanel Lara M.Kosters Peter Lyko Dirk Prufer Gundula A.noll Susann Wicke Institute of Plant Biology and Biotechnology University of MuensterSchlossplatz 848143 MuensterGermany Institute for Biology Humboldt-University of BerlinHaus 22Philippstr.1310115 BerlinGermany Fraunhofer Institute for Molecular Biology and Applied Ecology IME Schlossplatz 848143 MuensterGermany

Dear Editor,Cuscuta,a genus of parasitic plants,poses a significant threat to global agriculture due to its broad host range that encompasses numerous cultivated *** plants form specialized feeding organs(haustoria)that connect to the host vascular tissue and import water,nutrients,secondary metabolites,small rNAs,mrNAs,and *** such protein is FT,a peptide hormone and florigen that was recently proposed to cause the synchronization of flowering in the parasite–host system(Shen et al.,2020).

关键词： specialized organs analysis

Simulated MrI Artifacts:Testing Machine Learning Failure Modes

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Biomedical Engineering Frontiers 2022年第1期3卷 437-452页

作者： Nicholas C.Wang Douglas C.noll Ashok Srinivasan Johann Gagnon-Bartsch Michelle M.Kim Arvind rao Department of Computational Medicine and Bioinformatics University of MichiganUSA Department of Biomedical Engineering University of MichiganUSA Department of radiology University of MichiganUSA Department of radiology Division of NeuroradiologyUniversity of MichiganUSA rogel Cancer Center University of MichiganUSA Frankel Cardiovascular Center University of MichiganUSA Department of Statistics University of MichiganUSA Department of radiation Oncology University of MichiganUSA

*** types of MrI artifacts,including acquisition and preprocessing errors,were simulated to test a machine learning brain tumor segmentation model for potential failure ***-world medical deployments of machine learning algorithms are less common than the number of medical research papers using machine *** of the gap between the performance of models in research and deployment comes from a lack of hard test cases in the data used to train a *** failure modes were simulated for a pretrained brain tumor segmentation model that utilizes standard MrI and used to evaluate the performance of the model under *** simulated MrI artifacts consisted of motion,susceptibility induced signal loss,aliasing,field inhomogeneity,sequence mislabeling,sequence misalignment,and skull stripping *** artifact with the largest effect was the simplest,sequence mislabeling,though motion,field inhomogeneity,and sequence misalignment also caused significant performance *** model was most susceptible to artifacts affecting the FLAIr(fluid attenuation inversion recovery)***,these simulated artifacts could be used to test other brain MrI models,but this approach could be used across medical imaging applications.

关键词： utilize stripping susceptibility

Structural Insights into Ligand Dynamics:Correlated Oxygen and Picket Motion in Oxycobalt Picket Fence Porphyrins

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Structural Insights into Ligand Dynamics:Correlated Oxygen a...