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Unraveling the ties between irritable bowel syndrome and intestinal microbiota

World Journal of Gastroenterology 2014年第10期20卷 2470-2481页

作者： Sung noh Hong Poong-Lyul Rhee Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea

Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder. It is a multifactorial disorder. Intestinal microbiota may cause the pathogenesis of IBS by contributing to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, communication in the gut-brain axis, and so on. Previous attempts to identify the intestinal microbiota composition in IBS patients have yielded inconsistent and occasionally contradictory results. This inconsistency may be due to the differences in the molecular techniques employed, the sample collection and handling methods, use of single samples that are not linked to fluctuating symptoms, or other factors such as patients’ diets and phenotypic characterizations. Despite these difficulties, previous studies found that the intestinal microbiota in some IBS patients was completely different from that in healthy controls, and there does appear to be a consistent theme of Firmicutes enrichment and reduced abundance of Bacteroides. Based on the differences in intestinal microbiota composition, many studies have addressed the roles of microbiota-targeted treatments, such as antibiotics and probiotics, in alleviating certain symptoms of IBS. This review summarizes the current knowledge of the associations between intestinal microbiota and IBS as well as the possible modes of action of intestinal microbiota in the pathogenesis of IBS. Improving the current level of understanding of host-microbiota interactions in IBS is important not only for determining the role of intestinal microbiota in IBS pathogenesis but also for therapeutic modulation of the microbiota.

关键词： Irritable bowel syndrome Intestinal microbiota Dysbiosis Antibiotics Probiotics

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Peripheral nerve regeneration monitoring using multilayer microchannel scaffolds

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Neural Regeneration Research 2016年第3期11卷 422-423页

作者： Yoonsu Choi Hongseok(Moses)noh Department of Electrical Engineering The University of Texas Rio Grande Valley Department of Mechanical Engineering and Mechanics Drexel University

Over 200,000 Americans have peripheral nerve injuries annually that result in a loss of function and a compromised quality of *** these,a significant percent involves unsuccessful repair of peripheral nerve gaps that ... 详细信息

关键词： multilayer regeneration repair collateral Americans annually traumatic axonal nerves proximal

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Combined treatment of phacoemulsification and single-port limited pars plana vitrectomy in acute angle-closure glaucoma

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 974-979页

作者： Ha Jeong noh Seong Taeck Kim Department of Ophthalmology Chosun University Hospital

AIM: To evaluate the efficacy of combined treatment of phacoemulsification(PE) and micro-incisional single-port transconjunctival limited pars plana vitrectomy(PPV) in acute angle-closure glaucoma(AACG).METHODS: A retrospective study included 26 patients who underwent PE diagnosed with AACG. Among them, 16 patients(16 eyes) underwent PE alone, 10 patients(10 eyes) underwent combined limited vitrectomy and PE. Then we compared intraocular pressure(IOP), anterior chamber angle, anterior chamber depth, central corneal thickness and corneal endothelial cell count before and after surgery, and effective PE time during cataract ***: Effective PE time was shorter in the combined surgery group than in the single surgery group(P=0.040). There was no statistically significant difference in IOP and best-corrected visual acuity between the two groups postoperatively. At 6 mo postoperatively, there was no difference in the anterior chamber angle, anterior chamber depth, and central corneal thickness between two groups, but corneal endothelial cell count was higher in the combined surgery group than in the single surgery group(P=0.046). No complication such as vitreoretinal disease, endophthalmitis, bullous keratopathy was ***: Combined micro-incisional single-port transconjunctival limited PPV and PE are more effective and safer than PE alone because of less operation time and fewer complications for management of AACG.

关键词： limited vitrectomy phacoemulsification acute angle-closure glaucoma

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Carrier Density and Electric Field Dependent Nonlinear Transport of Chemical Vapor Deposition Graphene

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Chinese Physics Letters 2013年第3期30卷 127-130页

作者： KHALIL Hafiz M.W. KELEKCI Ozgur noh Hwayong Department of Physics and Graphene Research Institute Sejong UniversitySeoul 143-747Korea

We report on the measurements of nonlinear current-voltage characteristics of graphene fabricated by chemical vapor *** current-voltage characteristic is described by a power law with a superlinear dependence of the current on the voltage,and the nonlinearity depends on the carrier density and the excitation *** nonlinearity is strongest at the Dirac point and becomes weaker as the carrier density *** the Dirac point,we also observe a crossover to a much stronger nonlinear transport when the electric field increases above 104 V/m.

关键词： deposition. nonlinearity nonlinear

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Silicate-doped hydroxyapatite and its promotive effect on bone mineralization

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Frontiers of Materials Science 2013年第1期7卷 40-50页

作者： Zhi-Ye QIU In-Sup noh Sheng-Min ZHANG Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Wuhan 430074 China Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Chemical and Biological Engineering Seoul National University of Science and Technology Seou1139743 Korea

Bone defect is one of the most common diseases in clinic. Existing therapeutic approaches have encountered many problems, such as lack of autogenous allogeneic bone and immunological rejection to allogeneic implant. Synthetic hydroxyapatite (HA) provided solutions for bone repair, since the HA is the main inorganic component of animals’ bone. However, HA has good biocompatibility, but does not possess osteogenic capability, which is of significance for modern bone repair materials. Si is an essential trace element in bone tissue, and it has been demonstrated to be able to promote bone formation. Therefore, silicate-doped hydroxyapatite (Si-HA) may serve as a promising material for bone repair, and promote bone regeneration in the repair. The current review discusses development of Si-HA, focusing on its preparation and characterization, in vitro and in vivo evaluations of the material, positive effect of Si-HA on promoting bone formation in clinical applications, and molecular mechanism investigation of such promotive effect.

关键词： silicate-doped hydroxyapatite (Si-HA) osteogenesis collagen biosynthesis bone mineralization

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Giwa凳子设计,传统建筑之美的重新诠释

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工业设计 2024年第2期 14-14页

作者： Hyunjae noh 不详

Giwa凳子的设计灵感来自韩国传统的房子,基于现代背景重新诠释传统建筑的美感和功能。设计中追求曲线和直线的和谐平衡,体现了简单和宁静的美。此外,这一产品从制造、运输到维修的整个生命周期都考虑了生态友好和可持续性。

关键词：生态友好生命周期和谐平衡可持续性现代背景设计灵感重新诠释

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Room-temperature synthesis of ZrSnO4 nanoparticles for electron transport layer in efficient planar hetrojunction perovskite solar cells

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Journal of Materials Science & Technology 2020年第7期42卷 38-45页

作者： Young Wook noh In Su Jin Sang Hyun Park Jae Woong Jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea

The interface engineering plays a key role in controlled optoelectronic properties of perovskite photovoltaic devices,and thus the electron transport layer(ETL)material with tailored optoelectronic properties remains a challenge for achieving high photovoltaic performance of planar perovskite solar cells(PSCs).Here,the fine and crystalline zirconium stanate(ZrSnO4)nanoparticles(NPs)was synthesized at low temperature,and its optoelectronic properties are systematically *** from the favorable electronic structure of ZrSnO4 NPs for applications in ETL,efficient electron transport and extraction with suppre s sed charge recombination are achieved at the interface of perovskite *** a result,the optimized ZrSnO4 NPs synthesized at room-temperature deliver the optimized power conversion efficiency up to 16.76%with acceptable *** work opens up a new class of ternary metal oxide for the use in ETL of the planar PSCs and should pave the way toward designing new interfacial materials for practical optoelectronic devices.

关键词： ZrSnO4 Electron transport layer Nanoparticles Perovskite solar cells

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Electrochemical characteristics of phosphorus doped Si-C composite for anode active material of lithium secondary batteries

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中国有色金属学会会刊：英文版 2009年第4期19卷 1018-1022页

作者： Jae-Hyun noh Kwan-Yo ung LEE Joong-Kee LEE Battery Research Center Korea Institute of Science and Technology Department of Chemical and Biological Engineering Korea University

Phosphorus doped silicon-carbon composite particles were synthesized through a DC arc plasma ***(SiH4) and methane(CH4) were introduced into the reaction chamber as the precursor of silicon and carbon,***(PH3) was used as a phosphorus dopant *** of synthesized particles were carried out by scanning electron microscopy(SEM),X-ray diffractometry(XRD),X-ray photoelectron spectroscopy(XPS) and bulk resistivity *** properties were investigated by cyclic test and electrochemical voltage spectroscopy(EVS).In the experimental range,phosphorus doped silicon-carbon composite electrode exhibits enhanced cycle performance than intrinsic silicon and phosphorus doped *** can be explained that incorporation of carbon into silicon acts as a buffer matrix and phosphorus doping plays an important role to enhance the conductivity of the electrode,which leads to the improvement of the cycle performance of the cell.

关键词：电化学特性磷掺杂负极活性材料磷硅电池材料锂离子 X射线光电子能谱扫描电子显微镜

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The role of LIN28B in tumor progression and metastasis in solid tumor entities

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Oncology Research 2023年第2期31卷 101-115页

作者： TABEA GEWALT KA-WON noh LYDIA MEDER Department I of Internal Medicine Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne University of CologneCologneGermany Institute for Pathology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Mildred Scheel School of Oncology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and *** normal conditions,LIN28B is exclusively expressed in embryogenic stem cells,blocking differentiation and promoting *** addition,it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 *** malignancies,LIN28B is frequently overexpressed,which is associated with increased tumor aggressiveness and metastatic *** this review,we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.

关键词： Cancer Metastasis LIN28B Let-7 Stemness EMT Resistance

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Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea

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World Journal of Gastroenterology 2010年第2期16卷 256-263页

作者： Hye Won Chung Sung Hoon noh Jong-Baeck Lim Department of Gastroenterology Yonsei University College of Medicine134 Shinchon-dongSeodaemun-gu120-752 SeoulSouth Korea Department of Surgery Yonsei University College of Medicine134 Shinchon-dongSeodaemun-gu120-752 SeoulSouth Korea Department of Laboratory Medicine Yonsei University College of Medicine134 Shinchon-dong Seodaemun-gu120-752 SeoulSouth Korea

AIM:To evaluate the epidemiologic features of young age gastric cancer(GC). METHODS:Retrospectively,a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex-and age-matched controls were *** subjects were stratified into 3 groups based on age (A,18-30 years;B,31-40 years;C,41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender. RESULTS:Compared to controls,more frequent intake of high risk diet(P=0.00075),history of heavy smoking(P=0.00087),intake of heavy alcohol(P= 0.00091),lower social economic status(P=0.00083), body mass index>30(P=0.00097),urban residence(P=0.00065),and more frequent exposure to harmful occupational environments(P=0.00072)were observed in all age groups and both genders in young age *** relationships were weaker in females compared to males of the same age,and were stronger as the age of patients ***,in group C of young age GC patients,environmental factors played important roles in females and males with a similar body *** females,older age at first delivery(> 35 years),lack of lactation history,nulliparity,and poor nutritional status during pregnancy were significantly associated with an increased risk of GC(P=0.00034). In this study,252 patients(7.8%)had a family history of GC with high odds ratio(OR)(3.22-4.21).In particular, family history was more closely associated with GC in males(OR,4.21 in male vs 3.46 in female)and more advanced cases(P=0.00051). CONCLUSION:Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients.

关键词： Young age gastric cancer Epidemiology Risk factor Age Gender

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