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Fundamentals about onset and progressive disease character of type 2 diabetes mellitus

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yang ZHANG~1 Wen-Sheng HOU~(1 *) Wei-Na LI~2 Xiao-Ying WU~1 Guo-Cai WU~2 Hua FENG~2 Jun ZHENG~3 1 Department of Biomedical Engineering Chongqing University Chongqing 400044 China 2 Department of Neurosurgery Southwest Hospital Third Military Medical University Chongqing 400038 3 Department of Computer Science New Mexico Institute of Mining and Technology Socorro nm 87801 USA

＜正＞Objective The present study is to obtain correlation between spatially separated brain regions,as well as the changes in time and frequency domain through analysis of the magnetoencephalography *** By means of the theory of coherence analysis,coherence coefficient of two signals corresponding to different cortical areas is computed, which reflects synchronization of the above two signals,as well as the correlation between spatially separated brain *** frequency analysis is also used to discuss the cortical correlation changes co-vary closely with time over the course of motor task in the three frequency band-α,βand lowγ.Results（1） By computing the coherence coefficient relative to the selected reference channel,it is suggested that channels with the most significant coherence are approximately in the same area,*** contralateral primary motor cortex and premotor ***,with the increase of frequency band both the coherence coefficient and the coupled area decline.（2） Changes of coherence co-varing with time inα,βand lowγband present the following characteristic:①The coherence shows such a trend that it increases firstly and then decreases over the course of motor task.②The most significant coherence,forαband,is observed from 0 to 0.3 second,while forβand lowγit appears at -0.2 *** The changes of coherence inα,βand lowγbands suggest that there are different neuronal modulations in the contralateral primary motor *** this modulation covaries with time,which consequently reflects the changes of correlation between different brain regions in time and frequency domain.

关键词： magnetoencephalography coherence time frequency analysis

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World Journal of Diabetes 2020年第5期11卷 165-181页

作者： Rob nm Weijers Teaching Hospital Onze Lieve Vrouwe GasthuisAmsterdam 1090Netherlands

ResearchGate is a world wide web for scientists and researchers to share papers,ask and answer questions,and find *** one of the more than 15 million members,the author uploads research output and reads and responds to some of the questions raised,which are related to type 2 *** that way,he noticed a serious gap of knowledge of this disease among medical professionals over recent *** main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology,which can be helpful for the scientific understanding of the molecular nature of type 2 *** fill up the shortcomings in the curricula of medical education,and to familiarize the medical community with a new concept of the onset of type 2 diabetes,items are discussed like:Insulin resistance,glucose effectiveness,insulin sensitivity,cell membranes,membrane flexibility,unsaturation index(UI;number of carboncarbon double bonds per 100 acyl chains of membrane phospholipids),slowdown principle,effects of temperature acclimation on phospholipid membrane composition,free fatty acids,energy transport,onset of type 2 diabetes,metformin,and *** on the reviewed data,a new model is presented with proposed steps in the development of type 2 diabetes,a disease arising as a result of a hypothetical hereditary anomaly,which causes hyperthermia in and around the *** is counterbalanced by the slow-down principle,which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl *** accompanying reduction in the UI lowers membrane flexibility,promotes a redistribution of the lateral pressure in cell membranes,and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT *** events will set up a reduction in transmembrane glucose ***,a new blood glucose regulation syst

关键词： ATP Free fatty acid Glucose transporter Membrane flexibility Metformin Slow-down principle Type 2 diabetes Unsaturation index

Free fatty acids, glucose, and insulin in type 2 diabetes mellitus

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World Journal of Diabetes 2022年第3期13卷 275-277页

作者： Rob nm Weijers Teaching Hospital OLVGAmsterdam 95500Netherlands

Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin *** method is based on the assumption that the glucose-insulin axis is central for the metabolic activities,which led to type 2 ***,significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids(FFAs)into the blood circulation,which leads to a marked reduction in membrane *** data favor a FFA-glucose-insulin *** authors are invited to extend their study with the introduction of the saturation index(number of carbon-carbon double bonds per 100 fatty-acyl chains),as observed in erythrocytes.

关键词： Free fatty acids Membrane flexibility NKX2-1 gene RNA sequencing Type 2 diabetes TPD52L-3 gene Unsaturation index

Evaluation of the Effects of Cypermethrin on Female Reproductive Function by Using Rabbit Model and of the Protective Role of Chinese Propolis

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Biomedical and Environmental Sciences 2016年第10期29卷 762-766页

作者： AE Khatab nm Hashem LM El-Kodary FM Lotfy GA Hassan Department of Home Economics Department Faculty of Specific EducationAlexandria University Department of Animal Production Faculty of Agriculture(El-Shatby)Alexandria University Department of Home Economics Faculty of Agriculture(El-Shatby)Alexandria University

The prophylactic effects of Chinese propolis against cypermethrin toxicity were evaluated by performing ovary and uterus histopathology, as well as by characterizing ovarian function, embryos, and litters. Cypermethrin induced atypia in the ovary and uterus, and decreased the ovulation sites and the number of embryos. Cypermethrin-induced oxidative stress during pregnancy, decreased the parturition rate as well as the number and weight of offspring and increased the incidence of morphological malformations in the offspring. Administration of propolis to cypermethrin-treated animals mitigated cypermethrin-induced reproductive toxicity.

关键词： Evaluation of the Effects of Cypermethrin on Female Reproductive Function by Using Rabbit Model and of the Protective Role of Chinese Propolis Pro GPX

Management and outcome of hepatocellular adenoma with massive bleeding at presentation

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World Journal of Gastroenterology 2017年第25期23卷 4579-4586页

作者： Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan nm Ijzermans Department of Surgery Department of Gastroenterology and Hepatology Department of Radiology

To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma (HCA). METHODSThis retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage (grade II or III) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrast-enhanced magnetic resonance imaging (MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short- and long-term complications and patient and lesion follow-up. RESULTSAll patients were female (n = 23). Treatment in the acute phase consisted of embolization (n = 9, 39.1%), conservative therapy (n = 13, 56.5%), and other intervention (n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively (0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe short-term complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in non-surgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary (elective) treatment (i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented (4.3%). None of the patients experienced long-term complication (mean follow-up time: 36 mo). CONCLUSIONWith a 4.3% risk of rebleeding, secondary (elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm.

关键词： Hepatocellular adenoma Management Bleeding Outcome Hemorrhage

Machine perfusion in abdominal organ transplantation: Current use in the Netherlands

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World Journal of Transplantation 2020年第1期10卷 15-28页

作者： Elsaline Rijkse Jan nm IJzermans Robert C Minnee Division of HPB and Transplant Surgery Department of Surgery Erasmus MC University Medical Center

Scarcity of donor organs and the increment in patients awaiting a transplant increased the use of organs from expanded criteria donors or donation after circulatory *** to the suboptimal outcomes of these donor organs,there is an increased interest in better preservation methods,such as ex vivo machine perfusion or abdominal regional perfusion to improve *** state-ofthe-art review aims to discuss the available types of perfusion techniques,its potential benefits and the available evidence in kidney,liver and pancreas ***,translational steps from animal models towards clinical studies will be described,as well as its application to clinical practice,with the focus on the *** the lack of evidence from randomized controlled trials,currently available data suggest especially beneficial effects of normothermic regional perfusion on biliary complications and ischemic cholangiopathy after liver *** ex vivo machine perfusion in kidney transplantation,hypothermic machine perfusion has proven to be beneficial over static cold storage in a randomized controlled trial,while normothermic machine perfusion is currently under *** ex vivo machine perfusion in liver transplantation,normothermic machine perfusion has proven to reduce discard rates and early allograft *** response to clinical studies,hypothermic machine perfusion for deceased donor kidneys has already been implemented as standard of care in the Netherlands.

关键词： Machine perfusion Review Kidney transplantation Liver transplantation Pancreas transplantation

Spatio-temporal variation of cyclone intensity over the coastal region of Bangladesh using 134 years track analysis

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Tropical Cyclone Research and Review 2022年第1期11卷 16-25页

作者： nm Refat Nasher Kh Razimul Karim Md Yachin Islam Department of Geography and Environment Jagannath UniversityBangladesh Graduate School of Human Development and Environment Kobe UniversityJapan Center for Environmental and Geographic Information Services(CEGIS) DhakaBangladesh

The cyclone tracks from 1877 to 2020 were analyzed to detect the spatial and temporal *** tracks were gathered from previously published *** previous articles’tracks were digitized and converted to shape files for analysis in Arc-GIS.A total 126 cyclone tracks were used to detect monthly and seasonal cyclone intensity and spatial *** fluctuations were examined over a 30-year period,which is believed to be the climate of a particular *** cyclones hit the Bay of Bengal’s coast starting in May and lasting until *** May and October,the number of cyclones is at its peak(26 nos in each month).From June through September,the number of cyclones *** October and November,the number of cyclones increased *** number of cyclones substantially fell in December,and no cyclones were observed from January through *** 1939 through 1969,the highest number of cyclones(36)was *** the mid-and latetwentieth century,there were a higher number of *** coastal region of Bangladesh suffered the fewest cyclones in history over the recent era(2001–2020).The western shore was particularly vulnerable from 1877 to 1907,and the entire coastal region was dangerous from 1908 to *** the Post-monsoon(October to December)season,the number of cyclones is lower than in the Monsoon period(May to September).In the pre-monsoon season,71 cyclones strike,while in the Monsoon season,53 cyclones strike.

关键词： Digitize Tropical Seasonal Monthly Strike Coastal

Geastrum hyalinum(Basidiomycota,Geastraceae),a new species from Brazilian Southern Amazon

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Studies in Fungi 2019年第1期4卷 90-96页

作者： Assis nm Freitas-Neto JF Sousa JO Barbosa FR Baseia IG Programa de Pós-Graduação em Sistemática e Evolução Centro de BiociênciasUniversidade Federal do RioGrande do NorteAv.Senador Salgado Filho3000Campus Universitário59072-970NatalRNBrazil Departamento de Botânica e Zoologia Centro de BiociênciasUniversidade Federal do Rio Grande do NorteAv.Senador Salgado Filho3000Campus Universitário59072-970NatalRNBrazil Instituto de Ciências Naturais Humanas e SociaisUniversidade Federal de Mato Grosso78557-267SinopMTBrazil

The genus Geastrum *** cosmopolitan distribution and can be found in humid,arid or semi-arid *** hyalinum is a new species found in the Brazilian Southern Amazon in the Rio Ronuro Ecological *** new species can be recognized by its hyaline microscopic structures,such as peridium hyphae,capillitium and spores;indeed,this character is unusual for the genus ***,discussion and photographs of this new taxon are given.

关键词： Biodiversity Earthstar Gasteromycetes Neotropics Taxonomy

Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms

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World Journal of Methodology 2015年第2期5卷 68-87页

作者： Frank nm Twisk ME-de-pati?nten Foundation 1906 HB LimmenThe Netherlands

Although myalgic encephalomyelitis(ME) and chronic fatigue syndrome(CFS) are considered to be synonymous,the definitional criteria for ME and CFS define two distinct,partially overlapping,clinical ***,whether defined by the original criteria or by the recently proposed criteria,is not equivalent to CFS,let alone a severe variant of incapacitating chronic *** features of ME are:muscle weaknessand easy muscle fatigability,cognitive impairment,circulatory deficits,a marked variability of the symptoms in presence and severity,but above all,post-exertional "malaise":a(delayed) prolonged aggravation of symptoms after a minor *** contrast,CFS is primarily defined by(unexplained) chronic fatigue,which should be accompanied by four out of a list of 8 symptoms,e.g.,*** to the subjective nature of several symptoms of ME and CFS,researchers and clinicians have questioned the physiological origin of these symptoms and qualified ME and CFS as functional somatic ***,various characteristic symptoms,e.g.,post-exertional "malaise" and muscle weakness,can be assessed objectively using wellaccepted methods,e.g.,cardiopulmonary exercise tests and cognitive *** objective measures acquired by these methods should be used to accurately diagnose patients,to evaluate the severity and impact of the illness objectively and to assess the positive and negative effects of proposed therapies impartially.

关键词： Myalgic encephalomyelitis Chronic fatigue syndrome Symptoms Diagnosis Disability Impact