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Comparative analysis of the gut microbiota of wild adult rats from nine district areas in Hainan,China

World Journal of Gastroenterology 2023年第22期29卷 3469-3481页

作者： Li-na niu Guan-nan Zhang Duan-Duan Xuan Chong Lin Zi Lu Pei-Pei Cao Shao-Wen Chen Yong Zhang Xiu-Ji Cui Shou-Kui Hu Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikou 571199Hainan ProvinceChina The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Pathogen Biology Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Laboratory Xinxiang First People's HospitalXinxiang 453000Henan ProvinceChina Department of Laboratory The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Clinical Laboratory Peking University Shougang HospitalBeijing 100144China

BACKGROUND Wild rats have the potential to hold zoonotic infectious agents that can spread to humans and cause *** To better understand the composition of gut bacterial communities in rats is essential for preventing and treating such *** a tropical island located in the south of China,Hainan province has abundant rat ***,we examined the gut bacterial composition in wild adult rats from Hainan *** Fresh fecal samples were collected from 162 wild adult rats,including three species(Rattus norvegicus,Leopoldamys edwardsi,and Rattus losea),from nine regions of Hainan province between *** We analyzed the composition of gut microbiota using the 16S rRna gene amplicon *** identified 4903 bacterial operational taxonomic units(30 phyla,175 families,and 498 genera),which vary between samples of different rat species in various habitats at various times of the *** general,Firmicutes were the most abundant phyla,followed by Bacteroidetes(15.55%),Proteobacteria(6.13%),and Actinobacteria(4.02%).The genus Lactobacillus(20.08%),unidentified_Clostridiales(5.16%),Romboutsia(4.33%),unidentified_Ruminococcaceae(3.83%),Bacteroides(3.66%),Helicobacter(2.40%)and Streptococcus(2.37%)were *** The composition and abundance of the gut microbial communities varied between rat species and *** work provides fundamental information to identify microbial communities useful for disease control in Hainan province.

关键词： Hainan Rat Fecal microbiome Microbial community 16S rRna

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生活是艺术永恒的课堂——军艺戏剧专业“观察生活教学”的体会与思考

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解放军艺术学院学报 2010年第3期 90-93页

作者：牛娜解放军艺术学院戏剧系

生活是艺术的源泉,艺术是生活的凝练。观察生活是戏剧表演专业训练学员塑造人物诸多手段中的一种手段。艺术家不可缺少的素质之一,就是善于观察生活。未来的演员正是从这里开始掌握再体现艺术的。应该教会学员善于以艺术家敏锐的眼光在... 详细信息

生活是艺术的源泉,艺术是生活的凝练。观察生活是戏剧表演专业训练学员塑造人物诸多手段中的一种手段。艺术家不可缺少的素质之一,就是善于观察生活。未来的演员正是从这里开始掌握再体现艺术的。应该教会学员善于以艺术家敏锐的眼光在周围生活中摄取创造舞台形象所必需的素材。教会他们认知生活、扩展生活层面,感悟生活以激发创作情感,体验生活、扎根生活去创作鲜活的人物形象。

关键词：戏剧艺术观察生活体验生活学员演员

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A PTS Optimization Scheme with Superimposed Training for PAPR Reduction in OFDM System

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Communications and Network 2014年第2期6卷 97-104页

作者： Renze Luo Rui Li Xiaoqiong Wu Shuainan Hu na niu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Chengdu Sichuan China Zhongshan Branch China Telecom Co. Ltd. Zhongshan Guangdong China

Partial Transmit Sequences (PTS) is an efficient scheme for Peak-to-Average Power Ratio (PAPR) reduction in Orthogonal Frequency Division Multiplexing (OFDM) system. It does not bring any signal distortion. However, its remarkable drawback is the high computational complexity. In order to reduce the computational complexity, currently many PTS methods have been proposed but with the cost of the loss of PAPR performance of the system. In this paper, we introduce an improved PTS optimization method with superimposed training. Simulation results show that, compared with conventional PTS, improved PTS scheme can achieve better PAPR performance while be implemented with lower computation complexity of the system.

关键词： Orthogonal Frequency Division Multiplexing (OFDM) Peak-to-Average Power Ratio (PAPR) Partial Transmit Sequences (PTS) Superimposed Training

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供给侧结构性改革下我国金融发展对实体经济的推动作用

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改革与战略 2017年第10期33卷 108-110,166页

作者：牛娜商丘学院河南商丘476000

通过对供给侧结构改革下金融发展对实体经济的推动作用研究可知,金融业通过信贷支持、融资环境优化以及构建普惠金融体系,来促进我国实体经济的转型发展。但当前货币资金未能有效进入实体经济领域,低效资金供给过多而有效供给不足,普惠... 详细信息

通过对供给侧结构改革下金融发展对实体经济的推动作用研究可知,金融业通过信贷支持、融资环境优化以及构建普惠金融体系,来促进我国实体经济的转型发展。但当前货币资金未能有效进入实体经济领域,低效资金供给过多而有效供给不足,普惠金融对实体经济发展的普及面窄等问题,制约了金融业对实体经济发展的促进作用。文章建议从规范货币资金的流入领域、强化资金供给的高端有效性,以及完善中小经济体的普惠金融体系等层面进行改进。

关键词：供给侧金融业实体经济

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Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration

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Bioactive Materials 2022年第3期7卷 475-490页

作者： Yu-Xuan Ma Kai Jiao Qian-Qian Wan Jing Li Ming-Yi Liu Zi-Bin Zhang Wen Qin Kai-Yan Wang Ya-zhou Wang Franklin R.Tay Li-na niu State Key Laboratory of Military Stomatology&national Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China Department of Neurobiology The Fourth Military Medical UniversityXi’anShaanxi710032China The Graduate School Augusta UniversityAugustaGA30912USA

Sensory nerves promote osteogenesis through the release of ***,the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain *** present study identified that new bone formation was more abundantly produced after implantation of silicified collagen scaffolds into defects created in the distal femur of *** wound sites were accompanied by extensive nerve innervation and *** nerve dysfunction by capsaicin injection resulted in significant inhibition of silicon-induced osteogenesis in the aforementioned rodent *** of extracellular silicon in vitro induced axon outgrowth and increased expression of semaphorin 3 A(Sema3A)and semaphorin 4D(Sema4D)in the dorsal root ganglion(DRG),as detected by the upregulation of signaling *** medium derived from silicon-stimulated DRG cells promoted proliferation and differentiation of bone marrow mesenchymal stem cells and endothelial progenitor *** effects were inhibited by the use of Sema3A neutralizing antibodies but not by Sema4D neutralizing *** of Sema3A in DRG blocked silicon-induced osteogenesis and angiogenesis almost completely in a femoral defect rat model,whereas overexpression of Sema3A promoted the silicon-induced *** of“mechanistic target of rapamycin”(mTOR)pathway and increase of Sema3A production were identified in the DRG of rats that were implanted with silicified collagen *** findings support the role of silicon in inducing Sema3A production by sensory nerves,which,in turn,stimulates osteogenesis and *** together,silicon has therapeutic potential in orthopedic rehabilitation.

关键词： Distal femur defect Mechanistic target of rapamycin Semaphorin 3A Sensory nerve Silicified collagen scaffolds

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Prediction of T cell and B cell epitopes of the 22-, 47-, 56-, and 58-kDa proteins of Orientia tsutsugamushi

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Asian Pacific Journal of Tropical Biomedicine 2019年第10期9卷 443-448页

作者： Li-na niu Ting-Ting Fu Man-Ling Chen Yu-Ying Dong Jin-Chun Tu Zi-Hao Wang Si-Qi Wang Xuan Zhao nai-Xu Hou Qian Chen Qiang Wu Laboratory of Tropical Biomedicine and Biotechnology School of Tropical Medicine and Laboratory MedicineHainan Medical UniversityHaikou Hainan 571199China Department of Laboratory the First Affiliated Hospital of Hainan Medical UniversityHaikou Hainan 570102China Department of Gynecology the First Affiliated Hospital of Hainan Medical UniversityHaikou Hainan 570102China State Key Laboratory of Marine Resource Utilization in South China Sea College of Material science and EngineeringHainan UniversityHaikou Hainan 570228 China 5Department of Pathogen BiologySchool of Basic Medicine and Life ScienceHainan Medical UniversityHainan Medical University-University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou Hainan 571199China Key Laboratory of Emergency and Trauma of Ministry of Education&Research Unit of Island Emergency Medicine of Chinese Academy of Medical Sciences Hainan Medical UniversityHaikou Hainan 571199China

Objective:To predict B cell and T cell epitopes of 22-kDa,47-kDa,56-kDa and 58-kDa ***:The sequences of 22-kDa,47-kDa,56-kDa and 58-kDa proteins which were derived from Orientia tsutsugamushi were analyzed by SOPMA,Dnastar,Bcepred,ABCpred,NetMHC,NetMHCⅡand *** 58-kDa tertiary structure model was built by ***:The 22-kDa B-cell epitopes were located at positions 194-200,20-26 and 143-154,whereas the T-cell epitopes were located at positions 154-174,95-107,17-25 and *** 47-kD a protein B-cell epitopes were at positions 413-434,150-161 and 283-322,whereas the T-cell epitopes were located at positions 129-147,259-267,412-420 and *** 56-kDa protein B-cell epitopes were at positions 167-173,410-419 and 101-108,whereas the T-cell epitopes were located at positions 88-104,429-439,232-240 and *** 58-kDa protein B-cell epitopes were at positions 312-317,540-548 and 35-55,whereas the T-cell epitopes were located at positions 415-434,66-84 and ***:We identified candidate epitopes of 22-kDa,47-kDa,56-kDa and 58-kDa proteins from Orientia *** the case of 58-kDa,the dominant antigen is displayed on tertiary structure by homology *** findings will help target additional recombinant antigens with strong specificity,high sensitivity,and stable expression and will aid in their isolation and purification.

关键词： Orientia tsutsugamushi B cell epitopes T cell epitopes Bioinformatic prediction

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多元文化视角下欧盟外语教育政策之探究

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教育理论与实践 2015年第30期35卷 58-60页

作者：牛阿娜天津广播电视大学

欧盟是一个拥有多民族、多语言和多元文化的经济实体。欧盟外语教育政策的制定和实施必须解决"一体化与多元化"的矛盾。欧盟多语言主义政策包含的内容有:推行儿童早期学习外语、提倡终身学习外语、推广双语教学、鼓励外语教学创新等。... 详细信息

欧盟是一个拥有多民族、多语言和多元文化的经济实体。欧盟外语教育政策的制定和实施必须解决"一体化与多元化"的矛盾。欧盟多语言主义政策包含的内容有:推行儿童早期学习外语、提倡终身学习外语、推广双语教学、鼓励外语教学创新等。欧盟委员会提供多种国际交际项目,提高公民多语言能力水平和跨文化交际能力,促进欧洲成员国之间的文化了解,加深欧洲各成员国之间的友谊。

关键词：欧盟多语言主义外语教育政策多元文化双语教学跨文化交际能力

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PET显像在阿尔茨海默病的应用进展

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中国现代神经疾病杂志 2014年第3期14卷 181-185页

作者：牛娜李方中国医学科学院北京协和医学院北京协和医院核医学科 100730

阿尔茨海默病是老年期痴呆之临床常见类型,随着发病率的逐年升高,受到社会各界更多的关注。PET功能显像可通过各种显像剂敏感、特异性地反映阿尔茨海默病的病理生理学改变,笔者将重点介绍18F-FDG显像剂、淀粉样蛋白和神经原纤维缠结tau... 详细信息

阿尔茨海默病是老年期痴呆之临床常见类型,随着发病率的逐年升高,受到社会各界更多的关注。PET功能显像可通过各种显像剂敏感、特异性地反映阿尔茨海默病的病理生理学改变,笔者将重点介绍18F-FDG显像剂、淀粉样蛋白和神经原纤维缠结tau蛋白显像剂在阿尔茨海默病中的应用,详细阐述PET显像在阿尔茨海默病病因学研究、早期诊断、鉴别诊断、疾病转归和药物治疗中的作用。

关键词：正电子发射断层显像术阿尔茨海默病综述

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^(90)Y微球选择性内放射治疗在肝细胞癌中的应用及研究进展

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中国癌症杂志 2021年第5期31卷 428-434页

作者：牛娜(综述) 林岩松(审校) 中国医学科学院北京协和医学院北京协和医院核医学科北京100730

肝细胞癌(hepatocellular carcinoma,HCC)是中国癌症相关死亡第二大常见原因。中国约85%的HCC患者在确诊时已是中晚期,系统治疗(包括化疗、靶向治疗、免疫治疗)联合局部微创治疗(如介入治疗、放射治疗等)是目前主要的治疗方式。钇-90(yt... 详细信息

肝细胞癌(hepatocellular carcinoma,HCC)是中国癌症相关死亡第二大常见原因。中国约85%的HCC患者在确诊时已是中晚期,系统治疗(包括化疗、靶向治疗、免疫治疗)联合局部微创治疗(如介入治疗、放射治疗等)是目前主要的治疗方式。钇-90(yttrium-90,^(90)Y)微球选择性内放射治疗(selective internal radiation therapy,SIRT)作为主要局部微创治疗手段在国外已有近20年的临床使用经验,临床研究证明了其治疗肝脏肿瘤的疗效和安全性。相关研究证实了^(90)Y微球SIRT单用在HCC中的局部控制作用,以及其与手术、免疫药物、靶向药物联用的有效性及安全性,同时,^(90)Y微球SIRT对于肝段产生的“放射性切除”效应初步显示出其在HCC根治性治疗方面的应用前景。从HCC姑息治疗、转化治疗、放射性肝段切除等方面综述SIRT在HCC中的应用及研究进展。

关键词：钇-90微球选择性内放射治疗肝细胞癌

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Engineered extracellular vesicles:Regulating the crosstalk between the skeleton and immune system

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Engineered Regeneration 2022年第3期3卷 270-282页

作者： Wei-Wei Yu Qian-Qian Wan Yu Wei Yu-Tao Li Qi-Hong Li Tao Ye Ke-Hui Xu Jing-Han Song Chen Lei Mei-Chen Wan Kai Jiao Franklin R Tay Li-na niu State Key Laboratory of Military Stomatology&national Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of Stomatologythe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Stomatology the Fifth Medical CentreChinese PLA General HospitalDongda StreetBeijing 100071China The Dental College of Georgia Augusta UniversityAugustaGeorgiaUnited States

Osteoimmunology has gained momentum in recent years,focusing on the crosstalk between the skeleton and the immune *** vesicles(EVs)are nanoscale vesicles that are potential candidates for cell-free tissue regeneration *** may be used for repairing damaged tissues and regulating the body’s immune system and bone-related metabolic *** of the ability of EVs to deliver bioactive signals and mediate intercellular communication,they can decipher the complex mechanisms of interaction within the“osteoimmune system”at the molecular *** address the lack of targeting ability caused by vesicle heterogeneity in the clinical applications of EVs,these nanoscopical entities may be modified by bioengineering techniques to optimize the interaction between bone repair and immunomodulation for improving treatment efficacy,specificity and *** the present review,the endogenous properties that make EVs natural delivery agents are *** that may be improved by bioengineering are *** therapeutic applications of EVs in the rehabilitation of bone defects are *** opportunities and challenges that need to be addressed for translating this field of research into clinical practice are brought into perspectives.

关键词： Bone defect Crosstalk Engineered extracellular vesicles Immune regulation Osteoimmunology

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