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Chinese Journal of Natural Medicines 2021年第9期19卷 648-655页

作者： NIU Xue-Ni LUO Wen LV Chong-ning LU Jin-Cai Department of Traditional Chinese Medicine Shenyang Pharmaceutical UniversityShenyang 110016China

Ocotillol(OT)-type ginsenosides,one subtype of ginsenosides,consist of a dammarane skeleton and a tetrahydrofuran ring.Most naturally-occurring OT-type ginsenosides exist in Panax species,particularly in Panax quinquefolius,which may be attributed to the warm and humid climate of its native areas.Till now,merely 28 types of naturally-occurring OT-type ginsenosides have been isolated.In contrast,semi-synthesized OT-type ginsenosides are attracted considerable attentions.These ginsenosides can be obtained through oxidation and cyclization of side chains of dammarane-type ginsenosides,and other methods,which may change their physical and chemical properties and further improve their bioavailabilities.It is also notable that the pharmacological activities of ginsenosides are closely related to the stereoisomers caused by the configuration at C-20.Semi-synthesis of OT-type ginsenosides can facilitate our understanding of the biosynthesis,transformation and metabolism of OT-type ginsenosides in the body.This review will systematically summarize the research progress on naturally-occurring and semi-synthetic OT-type ginsenosides,which provides a theoretical basis for their bioactivity-guided research.

关键词： Ocotillol-type ginsenosides Panax species Panax quinquefolius Structure-activity relationship

Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and targeted therapy

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Journal of Interventional Medicine 2021年第3期4卷 105-113页

作者： Jian xue Hongbo ni Fan Wang Ke Xu Meng niu Department of Interventional Radiology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning110000China

Locoregional therapies(LRTs)of hepatocellular carcinoma(HCC)represented by ablation and TACE has become the main means for the clinical treatment of unresectable HCC.Among these,TACE is used throughout the stageⅠb toⅢb of HCC treatment.In recent years,immunotherapy led by immune checkpoint inhibitors has become a hot direction in clinical research.At the same time,targeted drugs such as Sorafenib and Apatinib have played an important role in the treatment and complementary therapy of advanced HCC,and their clinical application has been quite mature.HCC is the sixth most common malignant tumor in the world.When it comes to its treatment,different therapies have different indications,and their individual efficacies are not satisfactory,which makes the exploration of the use of combination therapy in HCC treatment become a new trend.In this paper,the status of the three therapies and the progress of their combined application are briefly reviewed.

关键词： Hepatocellular carcinoma Locoregional therapy Immunotherapy Targeted therapy Combination therapy

Achieving a high-strength dissimilar joint of T91 heat-resistant steel to 316L stainless steel via friction stir welding

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International Journal of Minerals,Metallurgy and Materials 2023年第1期30卷 166-176页

作者： Zhiwei Wang Min Zhang Cong Li Fenglei niu Hao Zhang Peng xue Dingrui ni Bolv Xiao Zongyi Ma CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China Shi Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The reliable welding of T91 heat-resistant steel to 316L stainless steel is a considerable issue for ensuring the safety in service of ultrasupercritical power generation unit and nuclear fusion reactor,but the high-quality dissimilar joint of these two steels was difficult to be obtained by traditional fusion welding methods.Here we improved the structure-property synergy in a dissimilar joint of T91 steel to 316L steel via friction stir welding.A defect-free joint with a large bonding interface was produced using a small-sized tool under a relatively high welding speed.The bonding interface was involved in a mixing zone with both mechanical mixing and metallurgical bonding.No obvious material softening was detected in the joint except a negligible hardness decline of only HV~10 in the heat-affected zone of the T91 steel side due to the formation of ferrite phase.The welded joint exhibited an excellent ultimate tensile strength as high as that of the 316L parent metal and a greatly enhanced yield strength on account of the dependable bonding and material renovation in the weld zone.This work recommends a promising technique for producing high-strength weldments of dissimilar nuclear steels.

关键词： heat-resistant steel stainless steel friction stir welding dissimilar welding microstructure mechanical property

Global scientific trends on portal hypertension and cirrhosis in the 21st century: A bibliometric and visualized analysis

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Portal Hypertension & Cirrhosis 2023年第1期2卷 46-48页

作者： Haozhuo Guo Hongbo ni Jian xue Fan Wang Xiaohan Sun Zhongqing Wang Meng niu Department of Interventional Radiology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Information Center The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina

To the Editor,Cirrhosis develops histologically as regenerative nodules surrounded by fibrous bands because of chronic liver injury,resulting in portal hypertension and end‐stage liver failure.Liver cirrhosis imposes a heavy health and economic burden on many countries.In 2014,Mokdad et al.1 reported the results of the 2010 Global Burden of Disease Study(GBD).Global deaths from cirrhosis increased monotonically from just over 676,000 deaths in 1980(1.54%of global deaths)to more than 1 million deaths in 2010,or 1.95%.Portal hypertension is a group of disorders characterized by symptoms,such as hepatic encephalopathy.Cirrhosis is the main cause of portal hypertension,accounting for 80%–90%of cases.In addition,cirrhosis has fatal complications that greatly affect the quality of life of patients.

关键词： cirrhosis hypertension portal

Paired formate and H_(2) productions via efficient bifunctional ni-Mo nitride nanowire electrocatalysts

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Journal of Energy Chemistry 2022年第9期31卷 432-441,I0012页

作者： Xuan Liu Zhongying Fang xue Teng Yanli niu Shuaiqi Gong Wei Chen Thomas JMeyer Zuofeng Chen Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina Department of Chemistry University of North Carolina at Chapel HillChapel HillNC 27599United States

Electrocatalytic water splitting provides a potentially sustainable approach for hydrogen production,but is typically restrained by kinetically slow anodic oxygen evolution reaction(OER)which is of lesser value.Here,free-standing,hetero-structured ni_(3)N-ni_(0.2)Mo_(0.8)N nanowire arrays are prepared on carbon cloth(CC)electrodes for hydrogen evolution reaction(HER)and glycerol oxidation reaction(GOR)to formate with a remarkably high Faradaic efficiency of 96%.A two-electrode electrolyzer for GOR-assisted hydrogen production operates with a current density of 10 mA cm^(-2)at an applied cell voltage of 1.40 V,220 mV lower than for alkaline water splitting.In-situ Raman measurements identify ni(Ⅲ)as the active form of the catalyst for GOR rather than ni(IV)and in-situ Fourier transform infrared(FTIR)spectroscopy measurements reveal pathways for GOR to formate.From density functional theory(DFT)calculations,the ni_(3)N-ni_(0.2)Mo_(0.8)N heterostructure is beneficial for optimizing adsorption energies of reagents and intermediates and for promoting HER and GOR activities by charge redistribution across the heterointerface.The same electrode also catalyzes conversion of ethylene glycol from polyethylene terephthalate(PET)plastic hydrolysate into formate.The combined results show that electrolytic H_(2) and formate production from alkaline glycerol and ethylene glycol solutions provide a promising strategy as a cost-effective energy supply.

关键词： Transition metal nitrides Heterostructures Hydrogen evolution reaction Glycerol and ethylene glycol oxidation Formic acid

Synthesis,structure and properties of three novel transition-metal-containing tantalum-phosphate clusters

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Chinese Chemical Letters 2022年第10期33卷 4675-4678页

作者： xue Li Hui Zhao Yuyan Li Yuanyuan Yang Mingyang Zhang Suyi Liu Pengtao Ma Jingping Wang Jingyang niu Henan Key Laboratory of Polyxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China

Peroxide ligation of aqueous metal-oxo clusters provides rich speciation and structural diversity.Here,three novel transition-metal derivatives of polyoxometalate anions,[ni_(2)(H_(2)O)_(10){P_(4)Ta_(6)(O_(2))_(6)O_(24)}]^(6-)(1a),[Zn(H_(2)O)_(4){P_(4)Ta_(6)(O_(2))_(6)O_(24)}]^(8-)(2a)and[Cd(H_(2)O)_(4){P_(4)Ta_(6)(O_(2))_(6)O_(24)}]^(8-)(3a),have been successfully synthesized by adopting a one-pot reaction strategy.All of these hexatantalates are built from a new-type phosphorus-incorporated hexatantalates.We investigated the solution behaviors,and the peak assignments of the MS spectra indicated some degree of stability of them in water.Furthermore,the proton-conducting ability of compound 1a was also explored and it has shown well conductivity at high relative humidities,with conductivity achieved 1.22×10^(-3) S/cm(85℃,90%RH).

关键词： Polyoxotantalates Transition-metal Synthesize Structure Proton-conduction

基于累积量标准差的超分辨光学涨落成像解卷积优化

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物理学报 2016年第19期65卷 279-285页

作者：王雪花陈丹妮于斌牛憨笨深圳大学光电工程学院光电子器件与系统教育部/广东省重点实验室深圳生物医学工程重点实验室深圳518060

超分辨光学涨落成像方法通过计算一组随机闪烁图像序列的累积量来提高空间分辨率.在实际实验中,由于计算的图像序列帧数有限,每个像素上累积量估计的误差将显著影响重构图像的均匀性和连续性.传统超分辨光学涨落成像技术由于缺乏对累积... 详细信息

超分辨光学涨落成像方法通过计算一组随机闪烁图像序列的累积量来提高空间分辨率.在实际实验中,由于计算的图像序列帧数有限,每个像素上累积量估计的误差将显著影响重构图像的均匀性和连续性.传统超分辨光学涨落成像技术由于缺乏对累积量估计的误差分析,在其后续的Lucy-Richardson解卷积算法中,没有对累积量重构图像的噪声添加约束条件.本文利用基于单组有限长数据的累积量标准差公式,计算了超分辨光学涨落显微图像每个像素上的累积量标准差,并将结果引入Lucy-Richardson解卷积算法中作为迭代优化的偏差阈值.模拟和实验结果表明,在相同图像序列长度下,该优化方法显著提高了超分辨重构图像的均匀性和连续性;在同等图像质量下,该方法可缩短图像序列帧数至原来的一半以下,有望用于活细胞动态超分辨成像.

关键词：超分辨显微累积量解卷积

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野山参中1个新的聚炔类化合物

中草药 2021年第1期52卷 23-27页

作者：牛雪妮罗文吕重宁路金才沈阳药科大学中药学院辽宁沈阳110016

目的研究野山参Panax ginseng根与根茎的化学成分。方法利用HPD-400大孔吸附树脂和反相硅胶柱色谱以及半制备高效液相色谱等方法进行分离纯化,通过质谱、核磁共振波谱(^(1)H-和^(13)C-NMR以及HSQC、HMBC实验)等手段鉴定化合物结构。结... 详细信息

目的研究野山参Panax ginseng根与根茎的化学成分。方法利用HPD-400大孔吸附树脂和反相硅胶柱色谱以及半制备高效液相色谱等方法进行分离纯化,通过质谱、核磁共振波谱(^(1)H-和^(13)C-NMR以及HSQC、HMBC实验)等手段鉴定化合物结构。结果从野山参70%乙醇提取物经HPD-400大孔吸附树脂90%乙醇洗脱部位分离得到5个化合物,分别鉴定为8Z-癸烷-4,6-二炔-1-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖苷(1)、三七皂苷Rt(2)、20(E)-人参皂苷F_(4)(3)、人参皂苷Rg_(6)(4)、20(E)-人参皂苷Rg_(9)(5)。结论化合物1为新的聚炔类化合物,命名为人参炔氧苷A;化合物2~5为首次从野山参中分离得到。

关键词：野山参人参人参炔氧苷A 聚炔类化合物人参皂苷三七皂苷Rt 20(E)-人参皂苷F_(4) 人参皂苷Rg_(6)

Multiple structural defects in ultrathin niFe-LDH nanosheets synergistically and remarkably boost water oxidation reaction

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Nano Research 2022年第1期15卷 310-316页

作者： Zhongyin Zhao Qi Shao Jiangyan xue Bolong Huang Zheng niu Hongwei Gu Xiaoqing Huang Jianping Lang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HornKowloonHong Kong SARChina

Modifying electrocatalysts nanostructures and tuning their electronic properties through defects-oriented synthetic strategies are:essential to improve the oxygen evolution reaction(OER)performance of electrocatalysts.Current synthetic strategies about.electrocatalysts mainly target the single or double structural defects,while the researches about the synergistic effect of multiple'structural defects are rare.In this work,the ultrathin niFe layered double hydroxide nanosheets with a holey structure,oxygen;vacancies and ni^(3+)defects on nickel foam(niFe-LDH-NSs/NF)are prepared by employing a simple and green H202-assisted etching 1 method.The synergistic effect ofthe above three defects leads to the exposure of.more active sites and significant improvement of:the intrinsic activity.The optimized catalyst exhibits an excellent OER performance with an extraordinarily low overpotential of 170 mV;at to mA·cm^(-2) and a small Tafel slope of 39.3 mV·dec^(-1) in 1 M KOH solution.Density functional theory calculations reveal this OER;performance arises from pseudo re-oxidized metal-stable ni^(3+)near oxygen vacancies(O_(vac)),which suppresses 3d-e_(g) of ni-site and!elevates d-band center towards the competitively low electron-transferbarrier.This work provides a new insight to fabricate advanced electrocatalysts for renewable energy conversion technologies.

关键词： layered double hydroxide holey structures oxygen vacancies ni3+defects oxygen evolution reaction

Diabetes mellitus and adverse outcomes after carotid endarterectomy:A systematic review and meta-analysis

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Chinese Medical Journal 2023年第12期136卷 1401-1409页

作者： Fengshi Li Rui Zhang Xiao Di Shuai niu Zhihua Rong Changwei Liu Leng ni Department of Vascular Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Breast Oncoplastic Surgery Hunan Cancer Hospital&The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunan 410031China

Background:There is still uncertainty regarding whether diabetes mellitus(DM)can adversely affect patients undergoing carotid endarterectomy(CEA)for carotid stenosis.The aim of the study was to assess the adverse impact of DM on patients with carotid stenosis treated by CEA.Methods:Eligible studies published between 1 January 2000 and 30 March 2023 were selected from the PubMed,EMBASE,Web of Science,CENTRAL,and ClinicalTrials databases.The short-term and long-term outcomes of major adverse events(MAEs),death,stroke,the composite outcomes of death/stroke,and myocardial infarction(MI)were collected to calculate the pooled effect sizes(ESs),95%confidence intervals(CIs),and prevalence of adverse outcomes.Subgroup analysis by asymptomatic/symptomatic carotid stenosis and insulin/noninsulin-dependent DM was performed.Results:A total of 19 studies(n=122,003)were included.Regarding the short-term outcomes,DM was associated with increased risks of MAEs(ES=1.52,95%CI:[1.15-2.01],prevalence=5.1%),death/stroke(ES=1.61,95%CI:[1.13-2.28],prevalence=2.3%),stroke(ES=1.55,95%CI:[1.16-1.55],prevalence=3.5%),death(ES=1.70,95%CI:[1.25-2.31],prevalence=1.2%),and MI(ES=1.52,95%CI:[1.15-2.01],prevalence=1.4%).DM was associated with increased risks of long-term MAEs(ES=1.24,95%CI:[1.04-1.49],prevalence=12.2%).In the subgroup analysis,DM was associated with an increased risk of short-term MAEs,death/stroke,stroke,and MI in asymptomatic patients undergoing CEA and with only short-term MAEs in the symptomatic patients.Both insulin-and noninsulin-dependent DM patients had an increased risk of short-term and long-term MAEs,and insulin-dependent DM was also associated with the short-term risk of death/stroke,death,and MI.Conclusions:In patients with carotid stenosis treated by CEA,DM is associated with short-term and long-term MAEs.DM may have a greater impact on adverse outcomes in asymptomatic patients after CEA.Insulin-dependent DM may have a more significant impact on post-CEA adverse outcomes than noninsulin-dependent DM.Whether DM manag

关键词： Carotid artery stenosis Carotid endarterectomy Diabetes mellitus Meta-analysis