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超声引导下射频消融术与手术切除治疗小肝癌患者的对比研究

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医药论坛杂志 2024年第17期45卷 1807-1811页

作者：李雯杨柳牛卫丽宗红张艺冰郑州大学第一附属医院肿瘤科郑州450052

目的观察超声引导下射频消融术与手术切除对小肝癌患者疗心理状态、并发症及复发率的影响。方法纳入郑州大学第一附属医院治疗的小肝癌患者126例,病例选取时间2019年1月—2021年12月,应用随机数字表法分为两组,射频消融组60例患者采取... 详细信息

目的观察超声引导下射频消融术与手术切除对小肝癌患者疗心理状态、并发症及复发率的影响。方法纳入郑州大学第一附属医院治疗的小肝癌患者126例,病例选取时间2019年1月—2021年12月,应用随机数字表法分为两组,射频消融组60例患者采取超声引导下经皮穿刺射频消融术治疗,手术切除组66例患者采取外科手术切除,比较两组患者的心理状态、并发症、疗效及术后不同时间的复发率。结果术后,射频消融组SAS评分、SDS评分明显较手术切除组降低[分别为(34.58±3.26)vs(41.84±3.87),(30.06±3.01)vs(41.21±3.58),P0.05),射频消融组并发症总发生率(16.67%)明显较手术切除组(34.85%)低,差异有统计学意义(P0.05)。射频消融组患者术后半年、1年、2年总生存率(分别为96.67%、90.00%、86.67%)与手术切除组(分别为100.00%、93.94%、86.36%)比较差异无统计学意义(P>0.05)。结论超声引导下射频消融治疗效果、术后半年、1年、2年复发率和生存率与手术切除相当,但其在减少并发症、缩短手术时间和住院时间、减轻患者负性心理状态上更具有优势,射频消融治疗可作为治疗小肝癌的主要治疗方法。

关键词：小肝癌射频消融术手术切除心理状态

Characterization of Domeless receptors and the role of Bd Domeless3 in anti-symbiont-like virus defense in Bactrocera dorsalis

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Journal of Integrative Agriculture 2024年第4期23卷 1274-1284页

作者： wei Zhang Shaoyang li Rong li Jinzhi niu Jinjun Wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River Ministry of Education/International Joint Laboratory of China-Belgium on Sustainable Crop Pest ControlAcademy of Agricultural SciencesSouthwest UniversityChongqing 400715China

The Janus kinase/signal transducers and activators of transcription(JAK/STAT)signaling pathway play a pivotal role in innate *** invertebrates,Domeless receptors serve as the key upstream regulators of this *** our study on Bactrocera dorsalis,we identified three cytokine receptors:BdDomeless1,BdDomeless2,and *** receptor encompasses five fibronectin-type-III-like(FN III)extracellular domains and a transmembrane ***,these receptors exhibit the increased responsiveness to diverse pathogenic ***,only BdDomeless3 is upregulated during symbiont-like viral ***,silencing BdDomeless3 enhanced the infectivity of Bactrocera dorsalis cripavirus(BdCV)and *** picorna-like virus(BdPLV),underscoring BdDomeless3’s crucial role in antiviral defense of *** the suppression of Domeless3 expression,six antimicrobial peptide genes displayed decreased expression,potentially correlating with the rise in viral *** our knowledge,this is the first study identifying cytokine receptors associated with the JAK/STAT pathway in tephritid flies,shedding light on the immune mechanisms of ***.

关键词： Bactrocera dorsalis JAK/STAT pathway Domeless receptors antiviral immunity symbiont-like virus

On traceable iterated line graph and hamiltonian path index

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 239-252页

作者： niu Zhao-hong XIONG li-ming YANG wei-hua School of Mathematical Sciences Shanxi UniversityTaiyuan 030006China School of Mathematics and Statistics Beijing Key Laboratory on MCAACIBeijing Institute of TechnologyBeijing 100081China Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China

Xiong and liu[21]gave a characterization of the graphs G for which the n-iterated line graph L^(n)(G)is hamiltonian,for n≥*** this paper,we study the existence of a hamiltonian path in L^(n)(G),and give a characterization of G for which L^(n)(G)has a hamiltonian *** applications,we use this characterization to give several upper bounds on the hamiltonian path index of a graph.

关键词： iterated line graph traceable hamiltonian index hamiltonian path index

Phase-field modeling of epitaxial growth with the Ehrlich-Schwoebel barrier: Model validation and application

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Science China(Technological Sciences) 2015年第4期58卷 753-762页

作者： DONG Xiang Lei XING Hui SHA Sha CHEN Chang Le niu li wei WANG Jian Yuan JIN Ke Xin Shanxi Key Laboratory for Condensed Matter Structure and Properties Department of Applied Physics Northwestern Polytechnical University

In this paper,we introduce different forms of mobility into a quantitative phase-field model to produce arbitrary Ehrlich-Schwoebel(ES)*** studies were carried out in the one-side step-flow model,which showed that the original mobility not only induces the ES effect,but also leads to larger numerical instability with increase of the step ***,another modified form of the ES barrier is proposed,and is found to be more suitable for large-scale *** applications were performed on the wedding-cake structure,coarsening and coalescence of islands and spiral *** results show that the ES barrier exhibits more significant kinetic effects at the larger deposition rates by limiting motions of atoms on upper steps,leading to aggregation on the top layers,as well as the roughening of growing surfaces.

关键词： epitaxial growth phase-field method Ehrlich-Schwoebel barrier kinetics interfacial

Factors influencing the functional significance in intermediate coronary stenosis

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Journal of Geriatric Cardiology 2015年第2期12卷 107-112页

作者： li-Jie SUN Gui-Song WANG Ming CUI li-Jun GUO Yong-Zhen ZHANG Fu-Chun ZHANG Jie niu Jiang-li HAN wei-Xian XU Dan ZHU wei GAO Department of Cardiology Peking University Third Hospital 49 North Huayuan Road Haidian D&trict Beijingl O0191 China

Objective To analyze the influencing factors of the functional significance determined by fractional flow reserve （FFR） in interme- diate coronary artery stenosis. Methods The study enrolled 143 patients with 203 intermediate coronary lesions. Pressure-derived FFR of these lesions was gained at maximal hyperemia induced by intravenous adenosine infusion. An FFR 〈 0.80 was considered as abnormal functional significance. Anatomic parameters at the lesion sites were obtained by off-line quantitative coronary angiography analysis （QCA）. The predictive value of the demographic characteristics and anatomic parameters for FFR in these intermediate lesions was assessed using multiple linear and binary logistic regression analysis. Results Overall, FFR 〈 0.8 was found in 70 （34%） of the total 203 intermediate coronary lesions. FFR values were positively correlated with QCA-measured minimum lumen diameters （MLD, r = 0.372, P = 0.000） and the reference vessel diameters （RVD, r = 0.217, P〈 0.002） were negatively correlated with percent area stenosis （AS, r = -0.251, P = 0.000） and percent diameter stenosis （DS, r = -0.210, P = 0.000）. Age, MLD and the lesion location in different coronary arteries were the inde- pendent determinants of FFR 〈 0.8. Conclusions MLD can predict the functional significance of intermediate coronary stenosis, while age and the lesion location in different coronary arteries should be taken into account as important influencing factors of FFR values.

关键词： Fractional flow reserve Influencing factors Intermediate coronary lesion Quantitative coronary angiography

pH-sensitive KHA/CMC-Fe^(3+)@CS hydrogel loading and the drug release properties of riboflavin

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Particuology 2024年第3期86卷 13-23页

作者： Jie Song Xi li Yuhua niu lijun Chen Zhiqiang wei Yidan li Youqian Wang Shaanxi University of Science&Technology Xi'an710021China

To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball *** tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal *** stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were *** results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

关键词： Potassium humate Hydrogel spheres pH-sensitive Drugsustained-release Drug release model

纳米氧化铈亚急性暴露对小鼠学习记忆能力的影响

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毒理学杂志 2024年第3期38卷 221-226页

作者：刘艳张存辉方鑫徐肖倩施贝贝陈嘉威武瑞婷牛丽薇牛玉杰内蒙古医科大学公共卫生学院内蒙古呼和浩特010010 河北医科大学公共卫生学院河北石家庄050000

目的探究纳米氧化铈亚急性暴露对小鼠学习记忆能力的影响。方法鼻腔滴注染毒昆明小鼠30 d后进行Morris水迷宫实验,取海马组织进行尼氏染色,测定海马中超氧化物歧化酶(SOD)、丙二醛(MDA)、γ-氨基丁酸(GABA)和谷氨酸(Glu)含量,并采用West... 详细信息

目的探究纳米氧化铈亚急性暴露对小鼠学习记忆能力的影响。方法鼻腔滴注染毒昆明小鼠30 d后进行Morris水迷宫实验,取海马组织进行尼氏染色,测定海马中超氧化物歧化酶(SOD)、丙二醛(MDA)、γ-氨基丁酸(GABA)和谷氨酸(Glu)含量,并采用Western blot检测炎性蛋白NF-κB和NLRP3表达量。结果相对于对照组,中和高染毒组小鼠行为学检测出现学习记忆能力障碍,中和高剂量组尼氏染色阳性细胞数减少,差异有统计学意义(F=9.246,P<0.05);高剂量组SOD活性降低,差异有统计学意义(F=3.969,P<0.05),中和高剂量组MDA含量升高,差异有统计学意义(F=9.368,P<0.05);各剂量组的GABA含量呈降低趋势,差异有统计学意义(F=59.81,P<0.05),中和高剂量组Glu含量升高差异有统计学意义(F=10.64,P<0.05);高剂量组NF-κB、NLRP3表达量增加,差异有统计学差异(F=10.97,F=7.443,P<0.05)。结论本试验条件下,一定剂量的纳米氧化铈亚急性染毒可影响小鼠空间学习能力,损伤海马神经元,影响其抗氧化能力并产生炎症反应。

关键词：纳米氧化铈学习记忆能力亚急性暴露

Time-dependent deviation of bridge pile foundations caused by adjacent large-area surcharge loads in soft soils and its preventive measures

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 184-201页

作者： Shuanglong li limin wei Jingtai niu Zhiping DENG Bangbin WU Wuwen QIAN Feifei HE School of Hydraulic Engineering Nanchang Institute of TechnologyNanchang 330099China School of Civil Engineering Central South UniversityChangsha 410075China

Time-dependent characteristics(TDCs)have been neglected in most previous studies investigating the deviation mechanisms of bridge pile foundations and evaluating the effectiveness of preventive *** this study,the stress-strain-time characteristics of soft soils were illustrated by consolidation-creep tests based on a typical engineering *** extended Koppejan model was developed and then embedded in a finite element(FE)model via a user-material subroutine(UMAT).Based on the validated FE model,the time-dependent deformation mechanism of the pile foundation was revealed,and the preventive effect of applying micropiles and stress-release holes to control the deviation was *** results show that the calculated maximum lateral displacement of the cap differs from the measured one by 6.5%,indicating that the derived extended Koppejan model reproduced the deviation process of the bridge cap-pile foundation with *** additional load acting on the pile side caused by soil lateral deformation was mainly concentrated within the soft soil layer and increased with the increase in load *** with t=3 d(where t is surcharge time),the maximum lateral additional pressure acting on Pile 2#increased by approximately 47.0%at t=224 *** bridge pile foundation deviation in deep soft soils,stress-release holes can provide better prevention compared to micropiles and are therefore recommended.

关键词： bridge pile foundation surcharge load soft soil time-dependent deformation interaction mechanism preventive measure

Sedimentary systems of the Oligocene Huagang Formation in the central anticline zone of the Xihu Depression,East China Sea Shelf Basin

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Energy Geoscience 2024年第1期5卷 275-282页

作者： Wenbo Zheng Guofeng Yin li Sun Shuijian wei Xiuping wei Bo niu Petroleum Exploration and Production Research Institute of SINOPEC Beijing100083China Shanghai Offshore Oil&Gas Branch SINOPECShanghai200120China

The Xihu Depression is the largest hydrocarbon-bearing depression of the East China Sea Shelf Basin(also referred to as the ECSSB).However,the depositional systems and reservoir distribution of the Oligocene Huagang Formation in the Xihu Depression are still *** the guidance of sedimentology and stratigraphy,this study documented a marine-terrestrial transitional environment in the restricted bay setting of the Oligocene Huagang Formation through core description,well logging,and seismic data *** study also revealed that the Oligocene Huagang Formation is dominated by tidal delta,estuary,and gravity flow deposits in the central anticline zone of the Xihu *** new understanding of the sedimentary systems and the discovery of the transgressive gap in the eastern Diaoyu Islands uplift explain the origin of fine-grained sediments and the EW-trending sand bodies in the central depression and the sand bodies parallel to shoreline in the west slope belt,which cannot be explained by previous study results,such as southern transgression or fluvial deltas and even lacustrine ***,the tidal channels,tidal sand flats,and gravity flow sand bodies formed by the transgressive tides are high-quality *** study will provide a basis for well placement and serve as guidance for the selection of favorable hydrocarbon exploration areas in the Xihu Depression.

关键词： Estuary Sedimentary system Oligocene Huagang Formation Central anticline Xihu Depression East China Sea Shelf Basin