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Green Energy and Intelligent Transportation 2024年第1期3卷 55-69页

作者： Senwei Xiang Anhuan Xie Minxiang Ye Xufei Yan Xiaojia Han hongjiao niu Qiang Li Haishan Huang Research Center for Intelligent Robotics Zhejiang LabHangzhou 311121China TianMuShan Laboratory Hangzhou 310023China

Due to the rising concept of advanced air mobility(AAM),electric vertical take-off and landing(eVTOL)aircraft has become the hotspot for academic research and commercial *** paper provides a comprehensive review of latest researches related to autonomous *** examines key technologies involved in autonomous eVTOL,including automated flight control,sensing&perception,safety&reliability,and decision *** also addresses the technical,regulatory,and societal challenges associated with the wholesale adoption of autonomous eVTOL into *** paper concludes with a discussion of future trends and recommendations,including the importance of integration with air traffic management,urban infrastructure and human–machine *** aims to be a useful resource for those involved in the research,policy,and industry of autonomous eVTOL technology.

关键词： eVTOL AAM Autonomy Key technology Challenge

Robust stabilization of an AUV within pre-specified finite-time

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Robust stabilization of an AUV within pre-specified finite-t...

Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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作者： hongjiao niu Yixiong Wei Tao Zhen Haiping Wang Xiuhui Peng Qi Wang Xufei Yan ZheJiang Lab College of Automation Engineering Nanjing University of Aeronautics and Astronautics Beijing National Railway Research & Design Institute of Signal & Communication

This study addresses the robust stabilization control of an autonomous underwater vehicle(AUV) within pre-specified *** AUV is represented as a solid body submerged in *** to hydrodynamic interaction,the AUV's system encounters uncertain inherent dynamics,encompassing gyroscopic forces and physical *** direct compensation of the system's inherent dynamics,a common approach in control design,proves ineffective for AUVs affected by ***,a robust control technique that does not rely on compensating unknown dynamics is ***,a time rescaling technique is introduced to transform pre-specified finite-time stabilization into asymptotic ***,a PD controller designed through potential energy shaping and damping injection is proposed to achieve exponential stabilization of the time rescaling *** artificial potential energy defined on the AUV's configuration space SE(3)(a Special Euclidean group) is introduced,utilizing its gradient as the proportional control *** damping leads to asymptotically stabilization,which serves as the differential control ***,the pre-specified finite-time controller is proposed by the time rescaling method,which also enhances robustness against uncertain dynamics in the *** simulations are conducted to validate the obtained results.

关键词： robust stabilization pre-specified finite-time control time rescaling method potential energy shaping damping injecting

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei niu Guo-Chao Zhang Wu Ning Hai-Bin Liu Hua Yang Chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Genome-Wide Analysis of the KANADI Gene Family and Its Expression Patterns under Different Nitrogen Concentrations Treatments in Populus trichocarpa

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2001-2015页

作者： Minghui niu Heng Zhang Xiangyang Li Zhibao Hu hongjiao Zhang Zhiru Xu Chunpu Qu Guanjun Liu State Key Laboratory of Tree Genetics and Breeding(Northeast Forestry University) School of ForestryNortheast Forestry UniversityHarbin150040China Key Laboratory of Saline-Alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationHarbin150040China College of Life Science Northeast Forestry UniversityHarbin150040China College of Forestry Guizhou UniversityGuiyang550025China

KANADI(KAN)is a plant-specific gene that controlled the polarity development of lateral *** mainly acted on the abaxial characteristics of plants to make the lateral organs ***,it had been less identified in woody *** this study,the members of the KAN gene family in Populus trichocarpa were identified and analyzed using the bioinformatics *** results showed that a total of 8 KAN family members were screened out,and each member contained the unique GARP domain and conserved region of the family *** analysis and their gene structures revealed that all KAN genes from ***,Arabidopsis thaliana,and Nicotiana benthamiana could be divided into four subgroups,while the eight genes in *** were classified into three subgroups,*** analysis of tissue-specific expression indicated that PtKAN1 was highly expressed in young leaves,PtKAN6 was highly expressed in young leaves and mature leaves,PtKAN2,PtKAN5,and PtKAN7 were highly expressed in nodes and internodes,PtKAN8 was highly expressed in roots,and PtKAN3 and PtKAN4 showed low expression levels in all *** them,PtKAN2 and PtKAN6,and PtKAN4 and PtKAN5 might have functional *** high nitrogen concentrations,PtKAN2 and PtKAN8 were highly expressed in mature stems and leaves,respectively,while PtKAN4,PtKAN5,and PtKAN7 were highly expressed in *** study laid a theoretical foundation for further study of the KAN genemediated nitrogen effect on root development.

关键词： Bioinformatics analysis KANADI gene family nitrogen Populus trichocarpa

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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面向工业互联网的语义编码传输方法及应用

中山大学学报（自然科学版）（中英文） 2025年第1期64卷 51-60页

作者：牛凯鲁延鹏董超北京邮电大学人工智能学院北京100876 泛网无线通信教育部重点实验室北京100876 鹏城实验室广东深圳518055

通过将语义通信技术引入工业网络,构建了一个面向工业互联网的语义编码传输系统。系统中设计了语义编解码器以提取信源中的语义信息,相对于传统通信系统,基于语义信息的通信有更高的信息压缩效率与更高的符号差错容忍能力。同时引入信... 详细信息

通过将语义通信技术引入工业网络,构建了一个面向工业互联网的语义编码传输系统。系统中设计了语义编解码器以提取信源中的语义信息,相对于传统通信系统,基于语义信息的通信有更高的信息压缩效率与更高的符号差错容忍能力。同时引入信源信道联合编解码器,以信源信道联合编码的方式将语义信息转化为信道符号传输,进一步提升系统对工业网络通信资源的利用效率。所有编解码器均构建在深度神经网络架构Transformer上,确保了编解码器对语义信息的理解能力及系统的泛化能力。在工业药品生产场景中,对该系统进行测试,结果显示:相较于传统通信方案,该语义编码传输系统在图像重建质量和传输处理速度方面均有显著提升。且系统对下游任务的性能影响极小,保证了工业生产中如缺陷检测等关键任务的准确性。

关键词：工业互联网数据压缩与传输语义通信深度学习