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Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

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Zoological Research 2024年第2期45卷 341-354页

作者： Yu-Han niu Li-hong Guan Cheng Wang Hai-Feng Jiang Guo-Gang Li Lian-Dong Yang Shun-Ping He State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Life Sciences Qinghai Normal UniversityXiningQinghai 810008China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXiningQinghai 810016China Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province Qinghai Normal UniversityXiningQinghai 810008China College of Life Sciences and Technology Xinxiang Medical UniversityXinxiangHenan 453003China College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving *** a period of dormancy,organisms often exhibit exceptional *** period is typically divided into hibernation and aestivation based on seasonal ***,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further ***,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,*** on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across *** analyses revealed noteworthy disparities between the two dormant species in their responses to extreme ***,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and *** further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available *** comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent *** conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.

关键词： Hibernation Aestivation Multi-organs Convergent evolution

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Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson’s Disease

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Neuroscience Bulletin 2024年第6期40卷 743-758页

作者： Jiaqi niu Yan Zhong Chentao Jin Peili Cen Jing Wang Chunyi Cui Le Xue Xingyue Cui Mei Tian hong Zhang Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Institute of Nuclear Medicine and Molecular Imaging Zhejiang UniversityHangzhou310009China Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou310009China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310014China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou310014China Huashan Hospital and Human Phenome Institute Fudan UniversityShanghai200040China

Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex *** formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine *** loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological *** emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular *** synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical *** this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.

关键词： Parkinson’s disease Positron emission tomography Synapse dysfunction Alpha-synuclein Dopamine system Non-dopamine system

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Event-triggered sliding mode control of linear repetitive processes and its application in metal rolling process

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Science China(Information Sciences) 2024年第3期67卷 167-181页

作者： Xinyu LV Yugang niu James LAM Key Laboratory of Smart Manufacturing in Energy Chemical Process (East China University of Science and Technology) Ministry of Education Department of Mechanical Engineering The University of Hong Kong

This paper investigates the design problem of a sliding mode controller for linear repetitive processes(LRPs) with a finite pass length on each pass. Under limited communication resources, an eventtriggered mechanism is implemented from the sensors to the controller, whose triggered sequence is consistent with the evolution direction of LRPs. To periodically orchestrate communication between the controller and actuator, a round-robin scheduling mechanism is established based on the pass length. A sliding function involving the state and pass profile is constructed, and the sliding mode controller is designed using triggered states and pass profile signals. Feasible controller gains are attained to ensure the stability of the resultant closed-loop system. Finally, the proposed strategy is implemented for a multi-roll metal rolling process.

关键词： event-triggered mechanism linear repetitive processes metal rolling process round-robin scheduling sliding mode control

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Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

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Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin Yang hong-Yong xiang Ming niu Jia-Cheng Deng Xue-Yuan Li Wen-Jie Hao hong-Sheng Ou-Yang Tong-Yu Liu xiao-Chun Tang Da-Xin Pang hong-Ming Yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

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Constructed Mott-Schottky Heterostructure Catalyst to Trigger Interface Disturbance and Manipulate Redox Kinetics in Li-O_(2) Battery

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Nano-Micro Letters 2024年第12期16卷 42-58页

作者： Yongji xia Le Wang Guiyang Gao Tianle Mao Zhenjia Wang Xuefeng Jin Zheyu hong Jiajia Han Dong-Liang Peng Guanghui Yue State Key Lab of Physical Chemistry of Solid Surface Fujian Key Laboratory of Surface and Interface Engineering for High Performance MaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China

Lithium-oxygen batteries(LOBs)with high energy density are a promising advanced energy storage ***,the slow cathodic redox kinetics during cycling causes the discharge products to fail to decompose in time,resulting in large polarization and battery failure in a short ***,a self-supporting interconnected nanosheet array network NiCo_(2)O_(4)/MnO_(2)with a Mott-Schottky heterostructure on titanium paper(TP-NCO/MO)is ingeniously designed as an efficient cathode catalyst material for *** heterostructure can accelerate electron transfer and influence the charge transfer process during adsorption of intermediate by triggering the interface disturbance at the heterogeneous interface,thus accelerating oxygen reduction and oxygen evolution kinetics and regulating product decomposition,which is expected to solve the above *** meticulously designed unique structural advantages enable the TP-NCO/MO cathode catalyst to exhibit an astounding ultra-long cycle life of 800 cycles and an extraordinarily low overpotential of 0.73 *** study utilizes a simple method to cleverly regulate the morphology of the discharge products by constructing a Mott-Schottky heterostructure,providing important reference for the design of efficient catalysts aimed at optimizing the adsorption of reaction intermediates.

关键词： Mott-Schottky heterostructure Lithium-oxygen batteries Electrocatalysts Electrodeposition

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Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： Ling-xia Kong Yan-hong Zhao Zhi-Lin Feng Ting-Ting Liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

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大数据网络安全态势感知中数据融合技术研究

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信息技术与信息化 2020年第3期 101-103页

作者：牛霞红甘肃工业职业技术学院电信学院甘肃天水741025

网络的飞速发展给人们的生活带来了便捷,同时网络的安全问题也在威胁着数字经济的健康发展。数据融合技术的出现为构建完备的网络安全机制带来了生机。文章以数据融合技术作为切入点,多维度分析数据融合技术的概念、特性以及应用方法,... 详细信息

网络的飞速发展给人们的生活带来了便捷,同时网络的安全问题也在威胁着数字经济的健康发展。数据融合技术的出现为构建完备的网络安全机制带来了生机。文章以数据融合技术作为切入点,多维度分析数据融合技术的概念、特性以及应用方法,旨在发掘数据融合技术的优势,促进大数据网络安全态势感知平台的高效设置。

关键词：大数据网络安全态势感知数据融合

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数据加密技术在计算机网络安全中的应用

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通信电源技术 2020年第6期37卷 186-187,191页

作者：牛霞红甘肃工业职业技术学院甘肃天水741025

目前,在计算机网络领域普遍使用数据加密技术对计算机网络进行防护,通过对数据系统化的加密处理,最大程度地避免数据丢失、泄漏或者损毁情况的出现。为进一步提升计算机网络安全,有效防范网络攻击行为对于数据存储、使用产生的影响,需... 详细信息

目前,在计算机网络领域普遍使用数据加密技术对计算机网络进行防护,通过对数据系统化的加密处理,最大程度地避免数据丢失、泄漏或者损毁情况的出现。为进一步提升计算机网络安全,有效防范网络攻击行为对于数据存储、使用产生的影响,需营造出高效、稳定的计算机网络运行机制。本文以数据加密技术作为研究对象,全面探讨数据加密技术在计算机网络安全中应用的方式方法,旨在形成完备的安全防护体系,提升计算机网络安全等级。

关键词：计算机网络安全数据加密技术应用

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3ds max课程中引入项目式教学的探讨

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佳木斯教育学院学报 2012年第6期 198-,217页

作者：牛霞红甘肃工业职业技术学院电信学院甘肃天水741025

结合当前职业教育的现状分析了职业教育的重要性,职业教育的教学方式急需改革,讨论了引入项目式教学的必要性,探讨了项目式教学的实施条件,并结合3ds max这门课程详细的分析了项目式教学的具体过程,项目的选取、分组、点评、完善作品、... 详细信息

结合当前职业教育的现状分析了职业教育的重要性,职业教育的教学方式急需改革,讨论了引入项目式教学的必要性,探讨了项目式教学的实施条件,并结合3ds max这门课程详细的分析了项目式教学的具体过程,项目的选取、分组、点评、完善作品、考试等五个方面进行了说明。和以往的传统教学相比较,项目式教学显示出更多的优势,是适合当前高职教育的教学方法。

关键词：教学项目 3ds max 应用职业教育

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车辆安全检测和管理系统的设计与实现

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铁路计算机应用 2005年第6期14卷 28-30页

作者：牛红霞郑州铁路职业技术学院信息工程系郑州450052

分析海量数据传输和管理系统的功能,并针对系统特点提出了基于C/S和B/S混合结构的解决方案,最后介绍了系统的设计与实现。

关键词：海量数据传输和管理系统 C/S结构 B/S结构面向对象

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