检索结果-南通市图书馆

Intratumor heterogeneity,microenvironment,and mechanisms of drug resistance in glioma recurrence and evolution

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2021年第4期15卷 551-561页

作者： Zhaoshi Bao Yongzhi Wang Qiangwei Wang Shengyu Fang xia Shan Jiguang Wang Tao Jiang Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Divison of Life Science Department of Chemical and Biological EngineeringCenter for Systems Biology and Human Healthand State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyHong KongChina China National Clinical Research Center for Neurological Diseases Beijing 100050China Division of Life Science Hong Kong University of Science and TechnologyHong KongChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijing 100069China Department of Radiotherapy Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Glioma is the most common lethal tumor of the human *** median survival of patients with primary World Health Organization grade IV glioma is only 14.6 *** World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and *** primary glioblastoma that usually develop de novo in the elderly,secondary glioblastoma enriched with an isocitrate dehydrogenase mutant typically progresses from lower-grade glioma within 5-10 years from the time of *** on various evolutional trajectories brought on by clonal and subclonal alterations,the evolution patterns of glioma vary according to different *** important features distinguish the normal brain from other tissues,e.g.,the composition of the microenvironment around the tumor cells,the presence of the blood-brain barrier,and *** underlying mechanism of glioma recurrence and evolution patterns of glioma are different from those of other types of *** studies correlated tumor recurrence with tumor heterogeneity and the immune ***,the detailed reasons for the progression and recurrence of glioma remain *** this review,we introduce the different mechanisms involved in glioma progression,including tumor heterogeneity,the tumor microenvironment and drug resistance,and their pre-clinical implements in clinical *** review aimed to provide new insights into further clinical strategies for the treatment of patients with recurrent and secondary glioma.

关键词： glioma evolution mechanism strategies tumor heterogeneity secondary glioma

Turbiscan多重光散射法研究纳米银溶胶的分散稳定性

在线全文

学校读者我要写书评

暂无评论

光谱学与光谱分析 2015年第7期35卷 1992-1996页

作者：夏朝辉吕丽云王虹天津大学化工学院绿色合成与转化教育部重点实验室天津300072

以硝酸银为银源、间苯二酚为还原剂、聚乙烯吡咯烷酮为保护剂通过化学还原法制得纳米银颗粒,通过离心洗涤等操作洗掉多余的反应物,将其分别超声分散于水、无水乙醇和乙二醇中获得0.2 Wt%不同体系的纳米银溶胶。利用激光粒度分析仪、透... 详细信息

以硝酸银为银源、间苯二酚为还原剂、聚乙烯吡咯烷酮为保护剂通过化学还原法制得纳米银颗粒,通过离心洗涤等操作洗掉多余的反应物,将其分别超声分散于水、无水乙醇和乙二醇中获得0.2 Wt%不同体系的纳米银溶胶。利用激光粒度分析仪、透射电子显微镜、扫描电子显微镜和同步热分析仪对纳米银颗粒进行表征并测定纳米银溶胶中的银含量。激光粒度分析仪的粒度分析结果表明,实验制得的纳米银颗粒的粒径在100nm左右,且粒径分布均一。透射电子显微镜和扫描电子显微镜的结果进一步证实纳米银颗粒的粒径在纳米尺度范围且粒径均匀。采用Turbiscan多重光散射法研究了不同体系纳米银溶胶的分散稳定性,分析了导致纳米银溶胶不稳定的主要因素。研究发现:影响纳米银溶胶分散稳定性的主要因素包括颗粒粒径的变化和颗粒的迁移。对于水相体系,样品池中间部分背散射光强度随时间变化不大,样品池底部和顶部背散射光强度有较大变化,说明其稳定性的主要影响因素是纳米银颗粒的迁移,颗粒粒径变化影响不大;对于乙醇和乙二醇体系,样品池中间部分、底部和顶部的背散射光强度均有明显变化,说明颗粒粒径的变化和颗粒的迁移对体系稳定性均有一定程度的影响;最后通过比较三个体系的稳定性动力学指数,得到体系稳定性由高到低依次为乙二醇、水和乙醇。

关键词：纳米银溶胶稳定性 Turbiscan Lab

在线全文

学校读者我要写书评

暂无评论

承压热冲击对核压力容器强度的影响

核动力工程 2001年第3期22卷 242-247页

作者：牛莉莎叶红光施惠基清华大学工程力学系北京100084

主要研究核压力容器承压热冲击(PTS)的瞬态过程，对热应力和机械应力产生的耦合效应进行分析，评价承压热冲击事件对容器强度的影响。利用有限元方法，建立合理的三维计算模型，模拟核压力容器进出口水管附近的承压热冲击的过程和特性... 详细信息

主要研究核压力容器承压热冲击(PTS)的瞬态过程，对热应力和机械应力产生的耦合效应进行分析，评价承压热冲击事件对容器强度的影响。利用有限元方法，建立合理的三维计算模型，模拟核压力容器进出口水管附近的承压热冲击的过程和特性。承压热冲击的历程大体在几百秒量级。热冲击产生的应力大于压力变化产生的应力，最大应力出现在接管和容器的接口附近，在这些区域产生局部塑性区。

关键词：承压热冲击压力容器有限元方法热应力强度核反应堆热冲击

Beneficial effects of a novel shark-skin collagen dressing for the promotion of seawater immersion wound healing

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2018年第2期5卷 117-128页

作者： xian-Rong Shen Xiu-Li Chen Hai-xia Xie Ying He Wei Chen Qun Luo Wei-hong Yuan Xue Tang Deng-Yong Hou Ding-Wen Jiang Qing-Rong Wang The PLA Key Laboratory of Biological Effect and Medical Protection on Naval Vessel Special Environment Naval Medical Research InstituteShanghai 200433China College of Food Science and Technology Shanghai Ocean UniversityShanghai 201306China Research Center of TCM Processing Technology Zhejiang Chinese Medical UniversityHang Zhou 311401China

Background: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing which should be suitable to prevent the wound from seawater immersion and to promote the wound ***: Shark skin collagen(SSC) was purified via ethanol de-sugaring and de-pigmentation and adjusted for p H. A shark skin collagen sponge(SSCS) was prepared by freeze-drying. SSCS was attached to an anti-seawater immersion polyurethane(PU) film(SSCS+PU) to compose a new dressing. The biochemical properties of SSC and physicochemical properties of SSCS were assessed by standard methods. The effects of SSCS and SSCS+PU on the healing of seawaterimmersed wounds were studied using a seawater immersion rat model. For the detection of SSCS effects on seawaterimmersed wounds, 12 SD rats, with four wounds created in each rat, were divided into four groups: the 3 rd day group, 5 th day group, 7 th day group and 12 th day group. In each group, six wounds were treated with SSCS, three wounds treated with chitosan served as the positive control, and three wounds treated with gauze served as the negative control. For the detection of the SSCS+PU effects on seawater-immersed wounds, 36 SD rats were divided into three groups: the gauze(GZ)+PU group, chitosan(CS)+PU group and SSCS+PU group, with 12 rats in each group, and two wounds in each rat. The wound sizes were measured to calculate the healing rate, and histomorphology and the immunohistochemistry of the CD31 and TGF-β expression levels in the wounded tissues were measured by standard ***: The results of Ultraviolet-visible(UV-vis) spectrum, Fourier-transform infrared(FTIR) spectrum, circular dichroism(CD) spectra, sodium

关键词： Anti-seawater immersion dressing Shark skin collagen Seawater immersion wound Wound healing

Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第6期16卷 1011-1016页

作者： Hui-Ling Wang Fei-Lai Liu Rui-Qing Li Ming-Yue Wan Jie-Ying Li Jing Shi Ming-Li Wu Jun-Hua Chen Wei-Juan Sun hong-xia Feng Wei Zhao Jin Huang Ren-Chao Liu Wen-Xue Hao xiao-Dong Feng Rehabilitation Center the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhouHenan ProvinceChina Department of Rehabilitation Medicine Fujian University of Chinese MedicineFuzhouFujian ProvinceChina Department of Rehabilitation Medicine Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia,but the underlying mechanism has not yet been fully *** have shown that autophagy plays an important role in the formation and development of cognitive impairment,and the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway plays an important role in autophagy *** investigate the role played by the PI3K/Akt signaling pathway in the electroacupuncture treatment of cerebral ischemia/reperfusion rat models,we first established a rat model of cerebral ischemia/reperfusion through the occlusion of the middle cerebral artery using the suture *** at 2 hours after modeling,electroacupuncture was delivered at the Shenting(GV24)and Baihui(GV20)acupoints,with a dilatational wave(1-20 Hz frequency,2 mA intensity,6 V peak voltage),for 30 minutes/day over 8 consecutive *** results showed that electroacupuncture reduced the infarct volume in a rat model of cerebral ischemia/reperfusion injury,increased the mRNA expression levels of the PI3K/Akt signaling pathwayrelated factors Beclin-1,mammalian target of rapamycin(mTOR),and PI3K,increased the protein expression levels of phosphorylated Akt,Beclin-1,PI3K,and mTOR in the ischemic cerebral cortex,and simultaneously reduced p53 mRNA and protein expression *** the Morris water maze test,the latency to find the hidden platform was significantly shortened among rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** the spatial probe test,the number of times that a rat crossed the target quadrant was increased in rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** stimulation applied to the Shenting(GV24)and Baihui(GV20)acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory *** study was approved by the Animal Ethics Committee

关键词： acupuncture brain central nervous system factor neurological function pathways protein stroke

在线全文

学校读者我要写书评

暂无评论

高功率微波在电离层中传播的折射率研究

强激光与粒子束 2006年第10期18卷 1673-1676页

作者：邹伟侯德亭王芊牛忠霞周东方信息工程大学理学院郑州450001

高功率微波在电离层中的传播特性主要由其折射率的变化决定,而高功率微波的大气折射率与相应传输层面的电子浓度有关。结合电离层电子浓度分布模型对电子浓度和大气折射率进行了数值模拟,对电离层折射率以及折射率垂直梯度相对于高度的... 详细信息

高功率微波在电离层中的传播特性主要由其折射率的变化决定,而高功率微波的大气折射率与相应传输层面的电子浓度有关。结合电离层电子浓度分布模型对电子浓度和大气折射率进行了数值模拟,对电离层折射率以及折射率垂直梯度相对于高度的变化特性进行了分析。结合射线描迹法对高功率微波波束传播高度、仰角和距离进行了修正,并在低功率微波下进行实验验证,证实修正值更接近实际值。

关键词：高功率微波电离层电子浓度折射率

不同频率一指禅推法对脾虚家兔胃黏膜形态学改变的影响

在线全文

学校读者我要写书评

暂无评论

中华中医药杂志 2018年第8期33卷 3593-3596页

作者：沈夏虹王继红广州中医药大学针灸康复临床医学院广州510405

目的:通过观察不同频率一指禅推法对脾虚家兔胃黏膜形态学改变,探讨手法频率与效应之间的关系。方法:48只新西兰家兔随机抽取8只为空白对照组(K组),其余接受灌胃造脾虚模型,将造模家兔随机分为A、B、C、D和模型对照组(P组),每组8只。A、... 详细信息

目的:通过观察不同频率一指禅推法对脾虚家兔胃黏膜形态学改变,探讨手法频率与效应之间的关系。方法:48只新西兰家兔随机抽取8只为空白对照组(K组),其余接受灌胃造脾虚模型,将造模家兔随机分为A、B、C、D和模型对照组(P组),每组8只。A、B、C、D组分别在中脘、天枢(双)给予50~100、101~150、151~200和201~250次/min频率段的一指禅推法。实验结束后取各组胃黏膜制成标本,通过比较各组光镜以分析手法治疗效应。结果:一指禅推法干预后,B组101~150次/min脾虚家兔其胃黏膜厚度均值、主细胞数均值、壁细胞数均值、炎细胞数均值与P组比较均明显改善(P<0.01,P<0.05)。结论:一指禅推法101~150次/min对脾虚型家兔的胃黏膜形态学改善作用较优。

关键词：一指禅推法脾虚家兔手法频率形态学

Increased Endogenous Sulfur Dioxide Involved in the Pathogenesis of Postural Tachycardia Syndrome in Children： A Case-Control Study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第4期131卷 435-439页

作者： hong-xia Li xiao-Chun Zheng Si-Yao Chen Ying Liao Zhen-Hui Han Pan Huang Chu-Fan Sun Jia Liu Jing-Yuan Song Chao-Shu Tang Jun-Bao Du Yong-hong Chen hong-Fang Jin Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Cardiac Surgery Guangdong General Hospital Guangzhou Guangdong 510000 China Department of Intensive Care Kaifeng Children's Hospital Kaifeng Henan 475000 China Department of Physiology and Pathophysiology Peking University Health Science Center and Key Laboratory of Molecular Cardiology of Ministry of Education Beijing 100191 China

Background： The pathogenesis of postural tachycardia syndrome （POTS） remains unclear. This study aimed to explore the changes and significance of sulfur dioxide （SO2） in patients with POTS. Methods： The study included 31 children with POTS and 27 healthy children from Peking University First Hospital between December 2013 and October 2015. A detailed medical history, physical examination results, and demographic characteristics were collected. Hemodynamics was recorded and the plasma SO2was determined. Results： The plasma SO2was significantly higher in POTS children compared to healthy children （64.0 ± 20.8 μmol/L vs. 27.2 ± 9.6 μmol/L, respectively, P 〈 0.05）. The symptom scores in POTS were positively correlated with plasma SO2levels （r = 0.398, P 〈 0.05）. In all the study participants, the maximum heart rate （HR） was positively correlated with plasma levels of SO2（r = 0.679, P 〈 0.01）. The change in systolic blood pressure from the supine to upright （ΔSBP） in POTS group was smaller than that in the control group （P 〈 0.05）. The ΔSBP was negatively correlated with baseline plasma SO2levels in all participants （r = ？0.28, P 〈 0.05）. In the control group, ΔSBP was positively correlated with the plasma levels of SO2（r = 0.487, P 〈 0.01）. The change in HR from the supine to upright in POTS was obvious compared to that of the control group. The area under curve was 0.967 （95% confidence interval： 0.928–1.000）, and the cutoff value of plasma SO2level 〉38.17 μmol/L yielded a sensitivity of 90.3% and a specificity of 92.6% for predicting the diagnosis of POTS. Conclusions： Increased endogenous SO2levels might be involved in the pathogenesis of POTS.

关键词： Blood Pressure Children: Pathogenesis Postural Tachycardia Syndrome Sulfur Dioxide

在线全文

学校读者我要写书评

暂无评论

Bom表管理系统的设计与开发

机械设计与制造 2006年第5期 174-176页

作者：夏欣徐宏华东理工大学机械工程学院上海200237

这里以某研究所为背景,从目前企业产品设计中计算机应用现状和数据管理现状入手,分析了企业实施BOM(BillofMaterial)表管理系统的迫切性和意义,并由此提出了系统实现的目标与应达到的性能。结合面向对象的系统建模,设计BOM表管理系统的... 详细信息

这里以某研究所为背景,从目前企业产品设计中计算机应用现状和数据管理现状入手,分析了企业实施BOM(BillofMaterial)表管理系统的迫切性和意义,并由此提出了系统实现的目标与应达到的性能。结合面向对象的系统建模,设计BOM表管理系统的数据库,具体介绍了数据库的创建过程及其最终的实现。

关键词：物料清单面向对象体系结构数据库