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Oncology Research 2024年第11期32卷 1765-1776页

作者： YONGJIAN HUANG JINZHOU WANG JIUHUA XU ning ruan Department of Gastrointestinal Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhou350005China

Background:Despite significant advancements in the development of anticancer therapies over the past few decades,the clinical management of colorectal cancer remains a challenging *** study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal *** and Methods:Liposomes consisting of 3β-[N-(N′,N′-dimethylamino ethane)carbamoyl]-cholesterol(DC-CHOL),cholesterol(CHOL),and dioleoylphosphatidylethanolamine(DOPE)at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand(pTRAIL)gene,along with the toll-like receptor(TLR7)agonist Rsiquimod(R848).The rationale behind this design is that pTRAIL can trigger cancer cell apoptosis by activating the DR4/5 receptor,while R848 can stimulate the immune ***:Experimental results demonstrated the synergistic effects of R848 and pTRAIL encapsulated by liposomes(RTL)in suppressing the proliferation of colorectal cancer ***,further in vivo investigations revealed the strong anti-tumor efficacy of RTL in xenograft and orthotropic in situ models of colorectal ***:These findings collectively highlight the therapeutic potential of R848/pTRAIL-loaded liposomes in the treatment of colorectal cancer.

关键词： Colorectal cancer Plasmid TRAIL(pTRAIL) R848 Tumor-associated macrophages

A novel cylindrical sandwich plate inspired by beetle elytra and its compressive properties

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Science China Technological Sciences 2024年第11期67卷 3465-3476页

作者： SONG YiHeng ruan SiHan HAO ning OKABE YoJi School of Engineering The University of Tokyo School of Civil Engineering Southeast University School of Engineering RMIT University Institute of Industrial Science The University of Tokyo

The design and experimental analysis of a semi-cylindrical structure known as the cylindrical beetle elytron plate(CBEP) were presented. Radial compression tests and finite element simulation were performed on CBEPs under 30° and 45° inclined sliding support constraints, with a comparison made to cylindrical honeycomb plate(CHP). The study aims to investigate the superior compression performance and enhancement mechanisms of CBEPs. The results demonstrate that CBEPs exhibit a 14%–26% increase in specific load-bearing capacity and a 20% increase in specific energy absorption compared with CHPs with equal core wall thickness. Distinct “Z-shaped” tearing failures were observed, with honeycomb plates showing tearing at the center of the honeycomb walls, while beetle elytron plates exhibited tearing along the midline of the trabeculae. Three different stress patterns,including elastic-plastic development stage of arch, plastic hinge node stage, and rigid node stage, were identified and analyzed to explain the mechanical performance improvements and failure characteristics. Considering that structural damage to trabeculae mostly occurs at its junction with the skin, it is recommended to add chamfers to the junctions of CBEP. Therefore, this paper lays the groundwork for the engineering application of CBEP.

关键词： beetle elytron cylindrical beetle elytron plate compression performance failure characteristics enhancement mechanism

Complete Solutions to Mixed Integer Programming

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American Journal of Computational Mathematics 2013年第3期3卷 27-30页

作者： ning ruan School of Science Information Technology and Engineering University of Ballarat Ballarat Australia

This paper considers a new canonical duality theory for solving mixed integer quadratic programming problem. It shows that this well-known NP-hard problem can be converted into concave maximization dual problems witho... 详细信息

关键词： Duality Theory Double Well Global Optimization Canonical Dual Transformation Combinatorial Optimization NP-hard Problems

An Exact A lgorithm for Optimal Redundancy in Series Systems with Multiple Component Choices

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An Exact A lgorithm for Optimal Redundancy in Series Systems...

带组约束可靠性网络最优化问题的精确算法(英文)

2006年中国运筹学会数学规划分会代表会议暨第六届学术会议

作者： ruan ning (Department of Mathematics,Shanghai University)

In this report we present an exact algorithm for optimal redundancy in series systems with multiple component choices. A reformulation of the nonseparable reliability function is approximated by a sep

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运筹学学报 2007年第4期11卷 33-40页

作者：阮宁孙小玲上海理工大学管理学院上海200093 复旦大学管理学院上海200433

本文提出了一种求解带组约束串-并网络系统最优冗余问题的精确算法.该算法利用拉格朗日松驰和Dantzig-Wolfe分解法得到问题的上界,并结合动态规划求解子问题.算法采用一种有效的切割和剖分方法,以逐步缩小对偶间隙和保证收敛性.数值结... 详细信息

本文提出了一种求解带组约束串-并网络系统最优冗余问题的精确算法.该算法利用拉格朗日松驰和Dantzig-Wolfe分解法得到问题的上界,并结合动态规划求解子问题.算法采用一种有效的切割和剖分方法,以逐步缩小对偶间隙和保证收敛性.数值结果表明该算法对于求解带组约束可靠性最优化问题是很有效的.

关键词：运筹学可靠性网络最优化非线性整数规划 Dantzig-Wolfe分解分枝定界法区域分割

2种方法在下颌水平阻生第三磨牙拔除中的比较

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华西口腔医学杂志 2010年第1期28卷 71-73页

作者：李文超阮宁内蒙古赤峰学院附属医院口腔颌面外科内蒙古赤峰024000

目的比较舌侧骨板劈开法与高速手机裂钻去骨法拔除下颌低位水平阻生第三磨牙的效果。方法将150颗下颌低位水平阻生第三磨牙随机分成2组,每组75颗,分别采用舌侧骨板劈开法和高速手机裂钻去骨法拔除,记录手术时间及并发症情况并进行统计... 详细信息

目的比较舌侧骨板劈开法与高速手机裂钻去骨法拔除下颌低位水平阻生第三磨牙的效果。方法将150颗下颌低位水平阻生第三磨牙随机分成2组,每组75颗,分别采用舌侧骨板劈开法和高速手机裂钻去骨法拔除,记录手术时间及并发症情况并进行统计学分析。结果舌侧骨板劈开法和高速手机裂钻去骨法拔除下颌阻生第三磨牙的手术时间分别为(35.85±6.05)min和(43.52±7.70)min(P0.05)。2种手术方法术后均未出现舌神经损伤及下唇麻木,高速手机裂钻去骨法发生干槽症1例。结论采用舌侧骨板劈开法拔除下颌低位水平阻生第三磨牙的手术时间短,且术中、术后并发症较少。

关键词：舌侧骨板劈开法高速手机裂钻去骨法下颌骨阻生第三磨牙

An exact algorithm for optimal redundancy in a series system with multiple component choices

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Journal of Shanghai University(English Edition) 2006年第1期10卷 15-19页

作者：孙小玲阮宁 Department of Mathematics College of Sciences Shanghai University Shanghai 200444 P.R. China

In this paper, an exact algorithm was proposed for optimal redundancy in a series system with multiple component choices. A reformulation of the nonseparable reliability function was approximated by a separable integer programming problem. The resulting separable nonlinear integer programming problem is used to compute upper bounds by Lagrangian relaxation and dual search. A special partition scheme was derived to reduce the duality gap in a branch-and-bound process, thus ensure the convergence of the algorithm. Computational results show that the algorithm is efficient for solving this class of reliability optimization problems.

关键词： reliability optimization multiple component choices Lagrangian relaxation and dual search partition scheme numerical results.

dPPH手术与TST STARR+术治疗直肠黏膜脱垂的临床对比研究

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福建医科大学学报 2016年第4期50卷 256-259页

作者：阮宁徐卓荦福建医科大学附属第一医院胃肠外科2区福州350005

目的比较双吻合器痔上黏膜环切钉合术(dPPH手术)与选择性吻合器经肛门直肠黏膜部分切除术(TST STARR+手术)治疗直肠黏膜脱垂的可行性、有效性、安全性及术后并发症发生情况。方法直肠黏膜脱垂患者89例,经术前评估随机分为2组,分别进行d... 详细信息

目的比较双吻合器痔上黏膜环切钉合术(dPPH手术)与选择性吻合器经肛门直肠黏膜部分切除术(TST STARR+手术)治疗直肠黏膜脱垂的可行性、有效性、安全性及术后并发症发生情况。方法直肠黏膜脱垂患者89例,经术前评估随机分为2组,分别进行dPPH手术(A组)和TST STARR+手术(B组)治疗,记录术中情况,并观察和评估2组的手术疗效和并发症发生情况。结果所有患者均成功施行了手术。2组术中情况比较,在手术时间、追加手工缝合次数及标本体积方面差别均有统计学意义(P0.05);并发症方面,A组的吻合口狭窄和慢性疼痛发生率均高于B组(P0.05)。结论 dPPH手术和TST STARR+手术治疗直肠黏膜脱垂的疗效相当,但后者术后并发症更少,安全性较好。

关键词：脱垂,直肠,黏膜手术后并发症手术后期间

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长江航运转型升级的战略思考

科技和产业 2010年第10期10卷 19-22,93页

作者：阮宁华中科技大学管理学院武汉430074

通过对长江航运发展现状的研究,分析了产业优势、转型升级所面临的问题以及发展机遇。进行了产业转型战略的SWOT分析。从创新产业发展理念、发展模式、发展路径等方面提出了长江航运转型升级的战略措施。

关键词：长江航运转型升级战略

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相关集的数据关联描述及实例讨论

计算机科学 2017年第1期44卷 283-288,299页

作者：闫林阮宁闫硕高伟河南师范大学计算机与信息工程学院新乡453007 北京交通大学计算机与信息技术学院北京100044

为了讨论数据关联问题,按层次对数据集进行了粒化,引入了每一粒的相关集,产生了与相关集类关联的分层粒化结构,并称之为粒化树。进而以同一数据集上的两棵粒化树为结构支撑,完成了对数据关联的定义,使相关集之间数据的关联得以数值化表... 详细信息

为了讨论数据关联问题,按层次对数据集进行了粒化,引入了每一粒的相关集,产生了与相关集类关联的分层粒化结构,并称之为粒化树。进而以同一数据集上的两棵粒化树为结构支撑,完成了对数据关联的定义,使相关集之间数据的关联得以数值化表示,形成了数据关联的数值描述方法。对此的研究确定了数据关联的等价条件,以此为依托并通过实例探究了数据关联的相关性质,讨论了关联的紧密程度、数据的粒化等同、关联的相互比较等数值化的处理方法。同时为实例的讨论提供了算法编程的基础,表明了数据关联研究的实际意义。

关键词：划分粒化树数据关联粒相关集