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Ultrahigh power factors in P-type 1T-ZrX_2(X=S, Se)single layers

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Science Bulletin 2017年第22期62卷 1530-1537页

作者： Ying-Xiang zhen Ming Yang Hang zhang guang-Sheng Fu Jiang-Long Wang shu-fang Wang Rui-ning Wang Hebei Key Laboratory of Optic-Electronic Information and Materials College of Physics Science and TechnologyHebei University Institute of Engineering Thermophysics Chinese Academy of Sciences

The thermoelectric performances of 1 T-ZrX_2(X=S and Se) single layers were investigated using a combination of density functional calculations and semi-classical Boltzmann transport theory. Because of the high hole mobilities at 300 K, ultrahigh power factors(PF = S^2σ) were found in the P-type compounds;these values were ~ 11.95 and ~13.58 mWK ~2 m^1 for 1T-ZrS_2 and 1T-ZrSe_2 single layers, ***, because of the Lorenz relation between the electrical conductivity(σ) and an electron's thermal conductivity(K_(el)) given by the Wiedemann-Franz law, the electronic figures of merit(Z_(el)T = PF T/K_(el)) at 300 K were approximately 0.67 and 0.75 for the N-and P-type 1T-ZrSe_2, respectively. In addition, the lattice thermal conductivities(K_(Ph)) were calculated, giving values of ~1.43 and ~0.97 W K ~1 m^1 for 1T-ZrS_2 and 1T-ZrSe_2 single layers, respectively. Therefore, because of the lower K_(Ph)/K_(el) ratio, the P-type 1T-ZrX_2 single layers possess higher fngure-of-merits(ZT = Z_(el)T/(1+(K_(Ph)/K_(el))) than their counterparts. This signifies that the P-type samples demonstrate better thermoelectric performance than the N-type ones. The thermoelectric properties of metastable 2H-ZrX_2(X = S and Se) single layers were also investigated.

关键词： Thermoelectric property Zirconium dichalcogenides Density functional theory Boltzmann-transport theory

可重复使用航天器基于状态估计的再入飞行滑模控制器设计研究(英文)

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宇航学报 2007年第1期28卷 69-76页

作者：宁国栋张曙光方振平北京航空航天大学航空科学与工程学院北京100083

给出了一种可重复使用航天器再入飞行鲁棒控制方法。在给定可用制导指令和干扰、不确定性的上界条件下,综合利用快慢双回路连续滑模控制方法,生成包括气动舵面和反推力控制系统(RCS)发动机的控制指令,得到了在建模误差和外界干扰存在的... 详细信息

给出了一种可重复使用航天器再入飞行鲁棒控制方法。在给定可用制导指令和干扰、不确定性的上界条件下,综合利用快慢双回路连续滑模控制方法,生成包括气动舵面和反推力控制系统(RCS)发动机的控制指令,得到了在建模误差和外界干扰存在的情况下拥有高精度、鲁棒性和解耦特性的气动角和姿态角速率跟踪结果。滑模控制抖振抑制逻辑利用李亚普诺夫方法,构筑滑模干扰观测器,并依据自适应增益调节思想,有效消除了控制抖振,保证了工程实际应用的能力。以某型可重复使用航天器为例,在考虑到模型不确定性、风扰以及测量噪声的情况下,通过不同的控制律设计结果对比表明,该方法高效、可靠。

关键词：飞行控制滑模控制状态观测器鲁棒性再入双回路

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可重复使用航天器再入飞行综合仿真模型研究

系统仿真学报 2007年第9期19卷 1905-1908页

作者：宁国栋张曙光方振平北京航空航天大学航空科学与工程学院北京100083

提出并建立了一种可重复使用航天器(RLV)再入飞行综合制导/控制仿真模型。在精确的RLV非线性飞行动力学模型的基础上,综合考虑任务限制条件和舵面完好状况,建立飞行管理模块,实现了标称条件下飞行任务的管理、非标称条件下对制导/控制... 详细信息

提出并建立了一种可重复使用航天器(RLV)再入飞行综合制导/控制仿真模型。在精确的RLV非线性飞行动力学模型的基础上,综合考虑任务限制条件和舵面完好状况,建立飞行管理模块,实现了标称条件下飞行任务的管理、非标称条件下对制导/控制律的重构以及严重事故时任务中断策略的实施。仿真程序利用Stateflow技术,构筑状态转换器和算法公用接口,保证了便捷应用的能力。以某型RLV为例,在考虑到不同舵面故障的情况下,通过仿真结果表明,该方法便捷、有效。

关键词：再入飞行制导控制建模仿真重构中止

Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase- B/mechanistic target of rapamycin pathway

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 872-886页

作者： Yong-Jie Teng Zhe Deng Zhao-guang Ouyang Qing Zhou Si Mei Xing-Xing Fan Yong-Rong Wu Hong-ping Long Le-Yao fang dong-Liang Yin Bo-Yu zhang Yin-Mei guo Wen-Hao Zhu zhen Huang Piao zheng Di-Min ning Xue-Fei Tian The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Integrated Chinese and Western Medicine Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Preventive Dentistry Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhou Medical UniversityGuangzhou 510132Guangdong ProvinceChina Department of Physiology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Macao Institute For Applied Research in Medicine and HealthMacao University of Science and TechnologyMacaoChina School of Pharmacy Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Acupuncture and Massage Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND The phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin(PI3K/Akt/mTOR) signalling pathway is crucial for cell survival, differentiation, apoptosis and metabolism. Xihuang pills(XHP) are a traditional Chinese preparation with antitumour properties. They inhibit the growth of breast cancer, glioma, and other tumours by regulating the PI3K/Akt/mTOR signalling pathway. However, the effects and mechanisms of action of XHP in hepatocellular carcinoma(HCC) remain unclear. Regulation of the PI3K/Akt/mTOR signalling pathway effectively inhibits the progression of HCC. However, no study has focused on the XHPassociated PI3K/Akt/mTOR signalling pathway. Therefore, we hypothesized that XHP might play a role in inhibiting HCC through the PI3K/Akt/mTOR signalling *** To confirm the effect of XHP on HCC and the possible mechanisms *** The chemical constituents and active components of XHP were analysed using ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry(UPLC-Q-TOF-MS). Cellbased experiments and in vivo xenograft tumour experiments were utilized to evaluate the effect of XHP on HCC tumorigenesis. First, SMMC-7721 cells were incubated with different concentrations of XHP(0, 0.3125, 0.625, 1.25, and 2.5 mg/mL) for 12 h, 24 h and 48 h. Cell viability was assessed using the CCK-8 assay, followed by an assessment of cell migration using a wound healing ***, the effect of XHP on the apoptosis of SMMC-7721 cells was evaluated. SMMC-7721 cells were stained with fluorescein isothiocyanate and annexin V/propidium iodide. The number of apoptotic cells and cell cycle distribution were measured using flow cytometry. The cleaved protein and mRNA expression levels of caspase-3 and caspase-9 were detected using Western blotting and quantitative reverse-transcription polymerase chain reaction(RT-qPCR), ***, Western blotting and RT–qPCR were performed to confirm the effects of XHP on

关键词： Hepatocellular carcinoma Xihuang pills Apoptosis Antitumour Phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway

RLV再入初期连续滑模姿态控制律设计及仿真

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系统仿真学报 2007年第22期19卷 5272-5276页

作者：宁国栋张曙光方振平北京机电工程研究所北京100074 北京航空航天大学航空科学与工程学院北京100083

给出了一种可重复使用航天器(RLV)再入初期鲁棒姿态控制方法。在给定可用姿态指令和摄动、干扰的上界条件下,基于内外双回路连续滑模控制方法,得到了在系统摄动和干扰存在的情况下拥有高精度、鲁棒性和良好动态响应品质的姿态角跟踪结... 详细信息

给出了一种可重复使用航天器(RLV)再入初期鲁棒姿态控制方法。在给定可用姿态指令和摄动、干扰的上界条件下,基于内外双回路连续滑模控制方法,得到了在系统摄动和干扰存在的情况下拥有高精度、鲁棒性和良好动态响应品质的姿态角跟踪结果。滑模控制抖振抑制利用李亚普诺夫方法,构造滑模状态观测器,并依据自适应增益调节思想,有效地抑制了控制抖振,减少了推进器的开关次数,保证了工程实际应用的能力。以某型RLV为例,在精确的仿真模型基础上,通过不同的控制律设计方法仿真结果对比表明,该方法有效、可靠。

关键词：滑模控制状态观测鲁棒性再入仿真

Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China

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Biomedical and Environmental Sciences 2014年第5期27卷 353-359页

作者： HOU Xin guo WANG Chuan MA Ze Qiang YANG Wei fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU shu Min Hu Xiu ping zhang Xiu ping JIANG Mei WANG Wei Qing ning guang zhenG Hui zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji dong YAN Fei YANG Jun Peng WANG Ling shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li Department of Endocrinology Qilu Hospital and Institute of Endocrinology and Metabolism Shandong University China National Heavy Duty Truck Group Corporation Hospital Jining Lukang Hospital Department of Endocrinology Jining Second People's Hospital Shantui Community Health Center Department of Endocrine and Metabolic Diseases Ruijin HospitalShanghai Jiaotong University Medical School

Objective To study the optimal waist circumference （WC） cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome （MetS） was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China.

关键词： Waist circumference Metabolic syndrome Central obesity

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跨大气层飞行器再入段RCS控制特性

飞行力学 2005年第3期23卷 16-20页

作者：宁国栋张曙光方振平北京航空航天大学航空科学与工程学院北京100083

以航天飞机为例,论述了跨大气层飞行器反推力控制系统(R eaction Con trol System,RCS)的工作原理,并给出了RCS推进器的控制模型。同时分析了RCS在回路中的各种工作模式和多推进器的系统冗余及其组合方式。最后在对RCS系统操作的基础上... 详细信息

以航天飞机为例,论述了跨大气层飞行器反推力控制系统(R eaction Con trol System,RCS)的工作原理,并给出了RCS推进器的控制模型。同时分析了RCS在回路中的各种工作模式和多推进器的系统冗余及其组合方式。最后在对RCS系统操作的基础上,研究了航天飞机在再入段飞行时的RCS控制问题。

关键词：反推力控制系统飞行控制系统冗余再入段飞行

Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine

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Chinese Journal of Integrative Medicine 2023年第4期29卷 308-315页

作者： QU Yi-lun dong Zhe-yi CHENG Hai-mei LIU Qian WANG Qian YANG Hong-tao MAO Yong-hui LI Ji-jun LIU Hong-fang GENG Yan-qiu HUANG Wen LIU Wen-hu XIE Hui-di PENG Fei LI shuang JIANG shuang-shuang LI Wei-zhen DUAN shu-wei FENG Zhe zhang Wei-guang LIU Yu-ning TIAN Jin-zhou CHEN Xiang-mei Department of Nephrology First Medical Center of Chinese People's Liberation Army General HospitalNephrology Institute of the Chinese People's Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaInstitute of Chinese MedicineGuangdong Pharmaceutical UniversityGuangdong Traditional Chinese Medicine Key Laboratory for Metabolic DiseasesGuangzhou 510006China Department of Nephrology The First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Nephrology Beijing HospitalBeijing 100730China Department of Nephrology The Forth Medical Center of People's Liberation Army General HospitalBejing 100039China Department of Endocrinology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBejing 100700China Department of Nephrology The Third Medical Center of PLA General HospitalBeijing 100039China Department of Nephrology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Nephrology Beijing Friendship HospitalFaculty of Kidney DiseasesCapital Medical UniversityBeijing 100050China Department of Nephrology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Three Departments of Encephalopathy Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China

Objective:To investigate the factors related to renal impairment in patients with diabetic kidney disease(DKD)from the perspective of integrated Chinese and Western ***:Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were *** to Kidney Disease Improving Global Outcomes(KDIGO)staging guidelines,patients were divided into a chronic kidney disease(CKD)1-3 group and a CKD 4-5 *** data were collected,and logistic regression was used to analyze the factors related to different CKD stages in DKD ***:Demographically,male was a factor related to increased CKD staging in patients with DKD(OR=3.100,P=0.002).In clinical characteristics,course of diabetes>60 months(OR=3.562,P=0.010),anemia(OR=4.176,P60 months,anemia,hyperuricemia,massive proteinuria,atherosclerosis,and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD.(Registration ***03865914).

关键词： diabetickidney disease integrated Chinese and Western medicine Chinese medicine syndrome

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao ping Cao Qi-ping Chen zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu shu-Bin Liu guang-Yuan Luan Chang-Jun ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu guo-Hui zhang Lin-Hao zhang Mo-Han zhang Qi-Wei zhang Xian-Peng zhang Yu-Liang zhang Yue zhang Zhi-Yong zhang Mao-Yuan Zhao Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method