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LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： Xian-hui ning Bing Han Ye Peng Shao-Wu Yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

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Bimetallic In_(2)O_(3)/Bi_(2)O_(3) Catalysts Enable Highly Selective CO_(2) Electroreduction to Formate within Ultra-Broad Potential Windows

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Energy & Environmental Materials 2024年第1期7卷 257-264页

作者： Zhongxue Yang Hongzhi Wang Xinze Bi Xiaojie Tan Yuezhu Zhao Wenhang Wang Yecheng Zou Huai ping Wang hui ning Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringCollege of New EnergyChina University of Petroleum(East China)Qingdao 266580China Shandong Dongyue Future Hydrogen Energy Material Co. Ltd.Zibo 255000China

CO_(2)electrochemical reduction reaction(CO_(2)RR)to formate is a hopeful pathway for reducing CO_(2)and producing high-value chemicals,which needs highly selective catalysts with ultra-broad potential windows to meet the industrial ***,the nanorod-like bimetallic ln_(2)O_(3)/Bi_(2)O_(3)catalysts were successfully synthesized by pyrolysis of bimetallic InBi-MOF *** abundant oxygen vacancies generated from the lattice mismatch of Bi_(2)O_(3)and ln_(2)O_(3)reduced the activation energy of CO_(2)to*CO_(2)·^(-)and improved the selectivity of*CO_(2)·^(-)to formate ***,the carbon skeleton derived from the pyrolysis of organic framework of InBi-MOF provided a conductive network to accelerate the electrons *** catalyst exhibited an ultra-broad applied potential window of 1200 mV(from-0.4 to-1.6 V vs RHE),relativistic high Faradaic efficiency of formate(99.92%)and satisfactory stability after 30 *** in situ FT-IR experiment and DFT calculation verified that the abundant oxygen vacancies on the surface of catalysts can easily absorb CO_(2)molecules,and oxygen vacancy path is dominant *** work provides a convenient method to construct high-performance bimetallic catalysts for the industrial application of CO_(2)RR.

关键词： bimetallic catalyst CO_(2)electrochemical reduction reaction formate oxygen vacancy wide potential window

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Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases:A prospective,blind clinical study

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World Journal of Gastroenterology 2024年第9期30卷 1121-1131页

作者： Yan-Ling Yang Huang-Wen Qin Zhao-Yu Chen hui-ning Fan Yi Yu Wei Da Jin-Shui Zhu Jing Zhang Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Traditional esophagogastroduodenoscopy(EGD),an invasive examination method,can cause discomfort and pain in *** contrast,magnetically controlled capsule endoscopy(MCE),a noninvasive method,is being applied for the detection of stomach and small intestinal diseases,but its application in treating esophageal diseases is not *** To evaluate the safety and efficacy of detachable string MCE(ds-MCE)for the diagnosis of esophageal *** Fifty patients who had been diagnosed with esophageal diseases were pros-pectively recruited for this clinical study and underwent ds-MCE and conven-tional *** primary endpoints included the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for patients with esophageal *** secondary endpoints consisted of visualizing the esophageal and dentate lines,as well as the subjects'tolerance of the *** Using EGD as the gold standard,the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for esophageal disease detection were 85.71%,86.21%,81.82%,89.29%,and 86%,***-MCE was more comfortable and convenient than EGD was,with 80%of patients feeling that ds-MCE examination was very comfortable or comfortable and 50%of patients believing that detachable string v examination was very *** This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD,providing a novel noninvasive method for treating esophageal diseases.

关键词： Clinical trial Detachable string magnetically controlled capsule endoscopy Esophagogastroduodenoscopy Noninvasive diagnosis Esophageal diseases

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Progress in the evaluation tool of Character Strengths and its application in nursing staff

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Nursing Communications 2024年第16期8卷 1-6页

作者： Ming-hui ning Gui-Hong Yan Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Spine Surgery Tianjin HospitalTianjin 300211China

Character Strengths is a group of positive personality traits reflected through cognition,behavior,and emotion,which play a positive role in improving happiness,alleviating negative emotions,and maintaining physical and mental *** article reviews the concept,content,methods,evaluation tools,and application progress of Character Strengths in nurses,so as to provide a reference for clinical managers and improve the quality of life,mental health,and professional satisfaction of n urses.

关键词： character strengths nurses review

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Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures

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Chinese Chemical Letters 2024年第3期35卷 316-320页

作者： Wei Yuan Gui-Zhi Dong hui ning Xiang-Xiang Guan Jia-Feng Cheng Zi-Wei Shi Xiu-Ji Du Si-Wen Meng Dong-Sheng Liu Yuan-Chen Dong CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dandong Bettersize Instruments Ltd. Dandong 118000China Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry Renmin University of ChinaBeijing 100872China

Understanding the dynamic assembly process of DNA nanostructures is important for developing novel strategy to design and construct functional *** this work,temperature-controlled dynamic light scattering(DLS)strategy has been applied to study the global assembly process of DNA origami and DNA *** the temperature dependent size and intensity profiles,the self-assembly process of various DNA nanostructures with different morphologies have been well-studied and the temperature transition ranges could be *** advantage of the DLS information,rapid preparation of the DNA origami and the brick assembly has been realized through a constant temperature *** results demonstrate that the DLS-based strategy provides a convenient and robust tool to study the dynamic process of forming hieratical DNA structures,which will benefit understanding the mechanism of self-assembly of DNA nanostructures.

关键词： Dynamic light scattering Self-assembly process DNA nanostructures Temperature transition ranges Rapid preparation

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活性浴中惰性粒子形状对有效作用力的影响

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物理学报 2024年第15期73卷 235-242页

作者：宁鲁慧张雪杨明成郑宁刘鹏彭毅中国石油大学(北京) 油气光学探测技术北京市重点实验室北京102249 中国石油大学(北京)理学院能源交叉学科基础研究中心北京102249 北京理工大学物理学院北京100081 中国科学院物理研究所北京凝聚态物理国家研究中心软物质物理实验室北京100190 中国科学院大学物理科学学院北京100049 松山湖材料实验室东莞523808

活性物质是典型的非平衡态系统,其组成单元能够利用自身存储的能量或者周围环境的能量实现自驱动.在活性系统中,物体间的受力情况直接影响其结构和动力学行为,因此深入了解物体间的有效作用力是理解活性物质一切复杂现象的基础.本文通... 详细信息

活性物质是典型的非平衡态系统,其组成单元能够利用自身存储的能量或者周围环境的能量实现自驱动.在活性系统中,物体间的受力情况直接影响其结构和动力学行为,因此深入了解物体间的有效作用力是理解活性物质一切复杂现象的基础.本文通过光镊显微镜实验分别研究了活性大肠杆菌溶液中惰性球形聚苯乙烯胶体粒子间和板状粒子间的有效作用力,发现球形粒子间有效作用力的性质一直是短程排斥力,而板状粒子间的有效作用力则为长程吸引力,这说明惰性粒子间的有效作用力受粒子形状的影响.惰性粒子间的有效作用力主要来源于两部分的贡献,即细菌-惰性粒子间的直接碰撞,以及细菌运动产生的流场.在实验上通过对比粒子之间、粒子外侧细菌的浓度和取向有序性发现,球形粒子间的有效排斥力主要来源于细菌-粒子的直接碰撞,而板状粒子间的长程吸引力则主要源于细菌流场的贡献.本文通过光镊显微镜实验证明了惰性粒子间的有效作用力与惰性粒子的几何构型有关,为调控活性物质中的动态自组装提供了实验支撑.

关键词：活性物质光镊有效作用力粒子形状

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数字金融何以释放产业结构红利:理论机制与实证检验

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统计与决策 2024年第19期40卷 134-139页

作者：许潇丹惠宁西北大学经济管理学院西安710027

文章基于2011—2020年中国省级层面和企业层面的面板数据,多维考察了数字金融的发展对产业结构的赋能效果和影响机制,并进一步探究了数字金融和绿色金融在释放产业结构红利方面的协同效应。结果显示:数字金融的发展通过推动产业结构高... 详细信息

文章基于2011—2020年中国省级层面和企业层面的面板数据,多维考察了数字金融的发展对产业结构的赋能效果和影响机制,并进一步探究了数字金融和绿色金融在释放产业结构红利方面的协同效应。结果显示:数字金融的发展通过推动产业结构高级化和合理化从而释放产业结构红利,在考虑内生性偏误并经过稳健性检验后,该结论仍然成立。机制分析结果表明,数字金融能够从供需两端发力,在需求端拉动居民消费,在供给端缓解融资约束进而推动企业创新,最终打通内循环堵点,促进产业结构优化升级。进一步地,从联动共生性和耦合协调性两个角度探究数字金融与绿色金融的协同关系,发现二者协同发展更有利于产业结构红利的释放。

关键词：数字金融产业结构红利绿色金融协同效应

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税收激励政策对制造业企业绩效的影响——基于增值税税负的视角

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当代财经 2024年第10期 44-58页

作者：惠宁杨金璇西北大学经济管理学院陕西西安710127

制造业是立国之本、兴国之器、强国之基,税收激励政策是支撑制造业高质量发展的关键。为此,在加快建设制造强国的背景下,从税收激励政策的视域探究制造业企业绩效问题具有重要的意义。基于2010—2021年我国制造业上市公司的微观数据,实... 详细信息

制造业是立国之本、兴国之器、强国之基,税收激励政策是支撑制造业高质量发展的关键。为此,在加快建设制造强国的背景下,从税收激励政策的视域探究制造业企业绩效问题具有重要的意义。基于2010—2021年我国制造业上市公司的微观数据,实证分析服务业“营改增”扩围和增值税税率下调对制造业企业绩效的影响及其作用机制,结果表明:服务业“营改增”扩围通过减轻制造业企业增值税税负,能够有效地提升制造业企业绩效,因而对制造业企业的发展具有间接激励作用;增值税税率下调能够直接提升制造业企业绩效,因而对制造业企业的发展具有直接激励作用。同时,服务业“营改增”扩围和增值税税率下调对不同年龄企业、不同产权性质企业的影响均存在差异。因此,我国应适当降低企业税费负担,提升制造业企业绩效;进一步完善增值税制度,畅通增值税抵扣链条;继续下调增值税税率,全面释放市场主体活力;实施差异化的税收优惠政策,营造良好的经营和投资环境。

关键词：税收激励政策增值税税负制造业企业绩效服务业“营改增”扩围增值税税率下调

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Effects of comprehensive nursing with cognitive behavioral therapy in orthodontic osteodilated arch treatment

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World Journal of Clinical Cases 2024年第22期12卷 5051-5058页

作者： Xin Yang Zeng-Xiang Wang Yu-Xing Tian Chao Peng hui-ning Yang Ying Wu Department of Nursing Nanjing Stomatological HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Orthodontics Nanjing Stomatological HospitalNanjing 210008Jiangsu ProvinceChina

BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore the application effect of CBT-based CNI model in orthodontic expansion arch *** Using convenient sampling method,81 patients with OOA were selected and rolled into a control group(Ctrl group,40 cases)and an observation group(Obs group,41 cases).During the treatment,patients in the Ctrl group received routine nursing intervention mode,and the those in the Obs group received CBT mode on the basis of *** and after intervention,the incidence of oral mucositis,the mastery rate of correct arch expansion method,self-rating anxiety scale score,soft scale index,and plaque index were compared for patients in different *** addition,satisfaction and complications were comparatively *** Incidence of oral mucositis in the Obs group was lower(14.6%vs 38.5%),and the mastery rate of correct arch expansion method was obviously higher(90.2%vs 55.0%)was obviously higher(all P<0.05).Meanwhile,the soft scale index and plaque index in the Obs group were much lower(P<0.05).The compliance(90.24%)and satisfaction(95.12%)in the Obs group were greatly higher(P<0.05).CONCLUSION The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients,improving the patient compliance.

关键词： Orthodontic osteodilated arch Cognitive behavior therapy Comprehensive nursing intervention mode Nursing effect Pain management Oral care

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数字经济驱动与文化产业高质量发展

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北京工业大学学报（社会科学版） 2024年第2期24卷 31-47页

作者：惠宁张林玉西北大学经济管理学院陕西西安710127

基于产业链的研究脉络,立足“价值链—技术链—企业链—空间链”的研究框架,利用2013—2020年省级面板数据,实证考察数字赋能文化产业高质量发展的效果、规律与路径,分析数字经济对文化产业高质量发展的影响效应。研究发现,数字经济能... 详细信息

基于产业链的研究脉络,立足“价值链—技术链—企业链—空间链”的研究框架,利用2013—2020年省级面板数据,实证考察数字赋能文化产业高质量发展的效果、规律与路径,分析数字经济对文化产业高质量发展的影响效应。研究发现,数字经济能显著提升文化产业的高质量发展水平,且具有边际报酬递减的非线性特征;机制分析表明,数字经济对文化产业高质量发展的促进作用主要通过提高知识产权保护力度、促进创新要素流动和降低交易成本来实现;进一步区分“宽带中国”试点地区、大数据综合试验园区和智慧城市分析发现,政策工具试点地区数字经济对文化产业高质量发展的驱动作用更强。中国未来文化产业的发展应抓住数字化转型的重大时代机遇,推动文化科技融合创新,以高质量文化供给实现文化繁荣和经济增长的双重目标。

关键词：数字经济文化产业高质量发展

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