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初始pH值对产氢产乙酸/耗氢产乙酸两段耦合工艺定向生产乙酸的影响

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生物工程学报 2007年第4期23卷 686-691页

作者：聂艳秋刘和堵国成陈坚江南大学生物工程学院环境生物技术研究室

以葡萄糖为底物，以经加热预处理并活化过的厌氧污泥为种泥，研究了初始pH值对产氢产乙酸，耗氢产乙酸两段耦合工艺厌氧发酵定向生产乙酸的影响。实验考察了7个初始pH值（5、6、7、8、9、10、11）条件下的底物降解、产物产生和发酵过程p... 详细信息

以葡萄糖为底物，以经加热预处理并活化过的厌氧污泥为种泥，研究了初始pH值对产氢产乙酸，耗氢产乙酸两段耦合工艺厌氧发酵定向生产乙酸的影响。实验考察了7个初始pH值（5、6、7、8、9、10、11）条件下的底物降解、产物产生和发酵过程pH值的变化。结果表明：产氢产乙酸段初始pH值的变化不仅影响本阶段产酸，而且影响耗氢产乙酸段产酸。初始pH=5时主要进行乙醇型发酵；pH：6和7时主要进行丁酸型发酵；pH=8时混合酸型发酵类型逐渐占优势，pH=8～11时均以乙酸为主要产物，耦合系统生产乙酸最优初始pH值为10。在初始pH=8-11范围内，产氢产乙酸段初期的乙醇浓度一般较高，但到后期因乙醇被微生物进一步代谢转化成乙酸而使其含量下降。

关键词：产氢产乙酸同型产乙酸 pH 耦合工艺厌氧发酵

活性污泥中微生物种群特性及对底物降解的影响研究

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中国生态农业学报 2005年第4期13卷 25-28页

作者：聂艳秋周青湖南工学院建工系衡阳421101 江南大学工业生物技术教育部重点实验室无锡214036

简介了分离微生物培养基的选择以及PCR、ERIC、DGGE、TGGE、FISH、T-RFLP等种群特性测定方法,阐述了活性污泥微生物的种群多样性、结构稳定性和功能稳定性等特性,指出活性污泥微生物种群多样性是结构稳定性的基础,而结构稳定性是功能稳... 详细信息

简介了分离微生物培养基的选择以及PCR、ERIC、DGGE、TGGE、FISH、T-RFLP等种群特性测定方法,阐述了活性污泥微生物的种群多样性、结构稳定性和功能稳定性等特性,指出活性污泥微生物种群多样性是结构稳定性的基础,而结构稳定性是功能稳定性的前提,功能稳定性又是底物有效降解的保证;同时底物及环境因子的变化也影响活性污泥群落结构及功能的稳定,并可能使种群多样性发生变化,结构稳定性与功能稳定性二者变化并不同步。

关键词：污水处理种群特性测定方法活性污泥微生物微生物培养基底物降解结构稳定性种群多样性能稳定性

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产乙酸耦合系统产酸及其微生物种群动态分析

中国环境科学 2008年第4期28卷 319-323页

作者：刘和聂艳秋许科伟堵国成陈坚江南大学生物工程学院江苏无锡214122 湖南工学院安全环境工程系湖南衡阳421008

研究了产氢产酸／同型产乙酸耦合系统在不同底物负荷条件下运行的产酸效率及其不同运行阶段的微生物种群变化．结果表明，系统在底物负荷为4～6g／（L．d）、水力停留时间（HRT）为20d的状态下稳定运行时，乙酸在产氢产酸相达到25-32g／... 详细信息

研究了产氢产酸／同型产乙酸耦合系统在不同底物负荷条件下运行的产酸效率及其不同运行阶段的微生物种群变化．结果表明，系统在底物负荷为4～6g／（L．d）、水力停留时间（HRT）为20d的状态下稳定运行时，乙酸在产氢产酸相达到25-32g／L；在同型产乙酸相达到14g／L左右；系统乙酸产率为0．40～0．48g／g．底物负荷不同时，微生物多样性发生相应变化．同型产乙酸相的Shannon指数远低于产氢产酸相．耦合系统两相中始终有Clostridium和Fusobacterium的存在，而且为优势种群．

关键词：产氢产酸/同型产乙酸耦合系统微生物种群乙酸

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li yan-yan qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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一种组合式除油设备的设计

工业用水与废水 2005年第2期36卷 69-71页

作者：邹芝芳罗魁元聂艳秋湖南大学衡阳分校湖南衡阳421101

在传统方法的基础上,采用集成方法设计了一种组合式除油设备,它综合了竖向隔板分油法、蜂窝斜管分油法、磁性颗粒吸附过滤法的特点,结合了废油循环处理,实现了清洁生产工艺。运行结果表明:在进水水质油,CODCr,BOD5的质量浓度分别为1041,... 详细信息

在传统方法的基础上,采用集成方法设计了一种组合式除油设备,它综合了竖向隔板分油法、蜂窝斜管分油法、磁性颗粒吸附过滤法的特点,结合了废油循环处理,实现了清洁生产工艺。运行结果表明:在进水水质油,CODCr,BOD5的质量浓度分别为1041,158,86.7mg/L,出水水质油,CODCr,BOD5的质量浓度分别为0.4～0.6,26.2,21.5mg/L。该系统在环保和经济上都达到了满意的效果。

关键词：组合式除油综合隔板

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负压封闭技术治疗软组织缺损的效果观察

护理研究 2002年第12期16卷 702-703页

作者：聂智容邱金玉颜婕中国人民解放军第三军医大学大坪医院野战外科研究所

目的 :探讨负压封闭技术 (VS)治疗软组织缺损的疗效。方法 :46例病人 (5 2个创面 )接受VS治疗 ,清创后将负压封闭引流材料覆盖在创面上或创腔内 ,维持负压在 5 0kPa～ 60kPa ,5d～ 7d后行二期缝合、植皮或皮瓣转移。结果 :42例病人(48... 详细信息

目的 :探讨负压封闭技术 (VS)治疗软组织缺损的疗效。方法 :46例病人 (5 2个创面 )接受VS治疗 ,清创后将负压封闭引流材料覆盖在创面上或创腔内 ,维持负压在 5 0kPa～ 60kPa ,5d～ 7d后行二期缝合、植皮或皮瓣转移。结果 :42例病人(48个创面 )完全治愈 ,无一例发生全身和局部并发症。与对照组比较 ,二期缝合时间、换药次数、创面缩小程度及总体治疗费用等方面均有统计学意义(P <0 .0 1)。结论 :VS能防止创面污染。

关键词：负压封闭技术治疗软组织缺损疗效

Uncover the myths of voltage-gated sodium channels: cryo-EM structure of the EeNa_v1.4-β1 complex

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Science Bulletin 2017年第19期62卷 1291-1292页

作者： yan nie Shanghai Institute for Advanced Immunochemical Studies Shanghai Tech University

Ion channels are membrane-embedded macromolecular pores,which allow charged ions flow through the insulating lipid bilayer when channel pores are *** opening and closing(termed gating)of ion channels are modulated by various stimuli,such as changes of membrane potential and binding of ligands(neurotransmitters,toxins,etc.).Some ion channels are classified as‘‘voltage-gated ion channels',as they can be gated by altering

关键词：钠离子通道电压门控冷冻电镜结构神话带电离子神经递质膜电位

Synergistic Flame-retardant Effect of Epoxy Resin Combined with Phenethyl-bridged DOPO Derivative and Graphene Nanosheets

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Chinese Journal of Polymer Science 2019年第1期37卷 79-88页

作者： Wei yan Ming-qiu Zhang Jie Yu Sheng-Qiang nie Dai-Qin Zhang Shu-Hao Qin School of Chemistry Sun Yat-sen University School of Chemistry and Materials Engineering Guiyang University National Engineering Research Center for Compounding and Modification of Polymer Materials

Phenethyl-bridged DOPO derivative(DiDOPO)was combined with graphene nanosheets(GNSs)in epoxy resin(EP)to improve its flame *** results indicated that the introduction of only 1.5 wt%DiDOPO/1.5 wt%GNS in EP increased the limited oxygen index(LOI)from 21.8%to 32.2%,hence meeting UL 94 V-0 *** thermogravimetric analyses revealed that char yield rose in presence of GNSs to form thermally stable carbonaceous *** decomposition and pyrolysis products in gas phase were characterized by thermogravimetry-Fourier transform infrared spectroscopy(TG-FTIR),and the release of large amounts of phosphorus was detected in the gas *** evaluation of flame-retardant effect by cone calorimetry demonstrated that GNSs improved the protective-barrier effect of fire residue of EP/DiDOPO/*** latter was further confirmed by digital photography and scanning electron microscopy(SEM).Also,Raman spectroscopy showed that GNSs enhanced graphitization degree of the resin during ***,the combination of DiDOPO with GNSs provides an effective way for developing high-performance resins with improved flame retardancy.

关键词： Epoxyresin DOPO derivative GNS Flame retardancy