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Chinese Medicine for Menopausal Syndrome： Current Status, Problems and Strategies

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Chinese Journal of Integrative Medicine 2011年第12期17卷 889-892页

作者： WANG Xiao-yun nie guang-ning YANG Hong-yan ZONG Li-li The Second Affiliated Hospital of guangzhou University of Traditional Chinese Medicine Guangzhou （510120） China Integrative Medicine Hospital Southern Medical University Guangzhou （501515） China

The use of Chinese medicine （CM） for the management of menopausal syndrome is considered effective both at home and abroad, and more and more clinical studies are confirming its efficacy. However, many problems still exit in current studies, such as the standard of CM syndrome differentiation, the design methodology and criteria to assess the quality of clinical trials and the efficacy of interventions. In this paper, the authors present the CM research and treatment strategies for menopausal syndrome with concepts explaining the CM understanding of the mechanism of the disorder. It is concluded that CM is effective for menopausal syndrome, but improvement in both study methodology and treatment strategy is needed. In detail, it is firstly necessary to conduct clinical studies to evaluate the difference of various CM treatments for menopausal syndrome manifesting different symptoms, so as to establish a comprehensive treatment protocol of CM. Secondly,an acknowledged evaluation system needs to be founded, which embodies the characteristics of CM, and covers appropriate endpoint indices and parameters to objectively evaluate the effect and study quality of CM. Finally, an epidemiological survey with large sample size should be implemented with robust statistical design and CM expertise to collect data for establishing diagnostic criteria for menopause in different stages and with different symptoms.

关键词： menopausal syndrome Chinese medicine complementary and alternative medicine herbalmedicine

Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1690-1704页

作者： Shu-Chang nie Yan-Hua Jing Lu Lu Si-Si Ren guang Ji Han-Chen Xu Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation Shanghai 200032China State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine(Shanghai University of Traditional Chinese Medicine) Shanghai 200032China

Severe immunosuppression is a hallmark of colorectal cancer(CRC).Myeloid-derived suppressor cells(MDSCs),one of the most abundant components of the tumor stroma,play an important role in the invasion,metastasis,and immune escape of *** create an immunosuppressive microenvironment by inhibiting the proliferation and activation of immunoreactive cells,including T and natural killer cells,as well as by inducing the proliferation of immunosuppressive cells,such as regulatory T cells and tumor-associated macrophages,which,in turn,promote the growth of cancer ***,MDSCs are key contributors to the emergence of an immunosup-pressive microenvironment in CRC and play an important role in the breakdown of antitumor *** this narrative review,we explore the mechanisms through which MDSCs contribute to the immunosuppressive microenvironment,the current therapeutic approaches and technologies targeting MDSCs,and the therapeutic potential of modulating MDSCs in CRC *** study provides ideas and methods to enhance survival rates in patients with CRC.

关键词： Myeloid-derived suppressor cells Tumor microenvironment Colorectal cancer Therapy Immunosuppression

Simulation and evaluation study of atmospheric aerosol nonsphericity as a function of particle size

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Particuology 2024年第7期90卷 281-291页

作者： Qianjun Mao Xin nie School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China College of New Energy and Materials Northeast Petroleum UniversityDaqing163318China

Aerosol nonsphericity causes great uncertainty in radiative forcing assessments and climate *** considerable studies have attempted to quantify this uncertainty,the relationship between aerosol nonsphericity and particle size is usually not considered,thus reducing the accuracy of the *** this study,a coupled inversion algorithm combining an improved stochastic particle swarm optimization algorithm and angular light scattering is used for the nonparametric estimation of aerosol nonsphericity variation with particle size,and the optimal sample selection method is employed to screen the *** on the verification of inversion accuracy,the variation of aerosol aspect ratio with particle size based on the ellipsoidal model in global regions has been obtained from Aerosol Robotic Network(AERONET)data,and the effect of nonsphericity on radiative forcing and dry deposition has been *** results show that the aspect ratio increases with particle size in all regions,with the maximum ranging from 1.4 to 1.8 in the desert,reflecting the differences in aerosol composition at different particle *** radiation calculations,considering aerosol nonsphericity makes the aerosol cooling effect weaker and surface radiative fluxes increase,but hardly changes the aerosol absorption,with maximum differences of 9.22%and 22.12%at the bottom and top of the atmosphere,***,the differences in radiative forcing between aspect ratios as a function of particle size and not varying with particle size are not significant,averaging less than 2%.Besides,the aspect ratio not varying with particle size underestimates the deposition velocity of small particles and overestimates that of large particles compared to that as a function of particle size,with maximum differences of 7%and 4%,respectively.

关键词： Aerosol nonsphericity Inversion Aspect ratio Radiative forcing Dry deposition velocity

Speed limit effect during lane change in a two-lane lattice model under V2X environment

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Chinese Physics B 2024年第3期33卷 718-722页

作者：金灿彭光含聂方彦 College of Physical Science and Technology Guangxi Normal UniversityGuilin 541004China guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China Information and Modern Education Technology Center Hunan University of Arts and ScienceChangde 415000China Computer and Information Engineering College Guizhou University of CommerceGuiyang 550014China

Speed limit measures are ubiquitous due to the complexity of the road environment,which can be supplied with the help of vehicle to everything(V2X)communication ***,the influence of speed limit on traffic system will be investigated to construct a two-lane lattice model accounting for the speed limit effect during the lane change process under V2X ***,the stability condition and the mKdV equation are closely associated with the speed limit effect through theory ***,the evolution of density and hysteresis loop is simulated to demonstrate the positive role of the speed limit effect on traffic stability in the cases of strong reaction intensity and high limited speed.

关键词： traffic flow lattice model speed limit

Comprehensive insights:unraveling the mechanisms of gut commensals in glucose metabolism regulation

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Science China(Life Sciences) 2024年第2期67卷 414-417页

作者： Zhipeng Li Qixing nie Shao-Ping nie State Key Laboratory of Food Science and Resources China-Canada Joint Lab of Food Science and Technology(Nanchang)Key Laboratory of Bioactive Polysaccharides of Jiangxi ProvinceNanchang UniversityNanchang 330047China

The prevalence of type 2 diabetes(T2D)has escalated to a global epidemic,garnering widespread *** research utilizing germ-free(GF)mice,antibiotic treatments,and fecal microbiota transplantation approaches has established the critical role of gut microbiota in modulating glucose *** microbiota interacts with diets and the mucosal immune system,influencing intestinal permeability and the penetration of microbial products.

关键词： metabolism utilizing insight

Recent advances in small-scale hydrogel-based robots for adaptive biomedical applications

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Nano Research 2024年第2期17卷 649-662页

作者： Mingzhe nie Qilong Zhao Xuemin Du Institute of Biomedical&Health Engineering Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of Sciences(CAS)Shenzhen 518055China

Small-scale robots,ranging in size from micrometers to centimeters,have gained significant attention in the biomedical ***,conventional small-scale robots made of rigid materials encounter challenges in adapting themselves to the soft tissues and complicated environments of human *** to the rigid counterpart,small-scale hydrogel-based robots hold great promises due to their tissue-like low modulus,outstanding biocompatibility and accessible stimuli-responsive *** attributes offer small-scale hydrogel-based robots with multimodal locomotion and reinforced functions,further enhancing the adaptability in manipulation and tasks execution for various biomedical *** this review,we present recent advances in small-scale hydrogel-based *** first summarize the design principles of small-scale hydrogel-based robots including materials,fabrication techniques and manipulation strategies,then highlighting their upgraded functions and adaptive biomedical ***,we discuss existing challenges and future perspectives for small-scale hydrogel-based robots.

关键词： small-scale robot hydrogel locomotion multi-function adaptability

Matched Volterra reduced-order model for an airfoil undergoing periodic translation

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Chinese Journal of Aeronautics 2024年第1期37卷 19-23页

作者： Lianrui nie Ziniu WU Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China

This paper is devoted to application of the Reduced-Order Model(ROM)based on Volterra series to prediction of lift and drag forces due to airfoil periodic translation in transonic flow *** there is large amplitude oscillation of the relative Mach number,as appeared in helicopter rotor movement in forward flight,the conventional Volterra ROM is found to be *** cover such applications,a matched Volterra ROM,inspired from previous multistep nonlinear indicial response method based on Duhamel integration,is thus considered,in which the step motions are defined inside a number of equal intervals with both positive and negative step motions to match the airfoil forward and backward movement,and the kernel functions are constructed independently at each *** shows that,at least for the translation movement considered,this matched Volterra ROM greatly improves the accuracy of ***,the matched Volterra ROM,with the total number of step motions and thus the computational cost close to those of the conventional Volterra ROM method,has the additional advantage that the same set of kernels can match various translation motions with different starting conditions so the kernels can be predesigned without knowing the specific motion of airfoil.

关键词： Airfoil periodic translation Lift and drag Reduced-order model Transonic flow Unsteady flow

Collectively induced transparency and absorption in waveguide quantum electrodynamics with Bragg atom arrays

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Communications in Theoretical Physics 2024年第08期76卷 21-30页

作者： Haolei Cheng Wei nie Center for Joint Quantum Studies and Department of Physics School of Science Tianjin University Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology Tianjin University

Collective quantum states, such as subradiant and superradiant states, are useful for controlling optical responses in many-body quantum systems. In this work, we study novel collective quantum phenomena in waveguide-coupled Bragg atom arrays with inhomogeneous *** atoms without free-space dissipation, collectively induced transparency is produced by destructive quantum interference between subradiant and superradiant states. In a large Bragg atom array, multi-frequency photon transparency can be obtained by considering atoms with different frequencies. Interestingly, we find collectively induced absorption(CIA) by studying the influence of free-space dissipation on photon transport. Tunable atomic frequencies nontrivially modify decay rates of subradiant states. When the decay rate of a subradiant state equals to the free-space dissipation, photon absorption can reach a limit at a certain frequency. In other words, photon absorption is enhanced with low free-space dissipation, distinct from previous photon detection schemes. We also show multi-frequency CIA by properly adjusting atomic frequencies. Our work presents a way to manipulate collective quantum states and exotic optical properties in waveguide quantum electrodynamics(QED) systems.

关键词： Bragg atom array collective quantum states photon absorption waveguide quantum electrodynamics

A Tri-mode of Mock-Walker Cells

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Advances in Atmospheric Sciences 2024年第4期41卷 671-679页

作者： Han QIN Ji nie Zhiyong MENG Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China China Meteorological Administration Tornado Key Laboratory Foshan 528061China

This work uses cloud-resolving simulations to study mock-Walker cells driven by a specified sea surface temperature(SST).The associated precipitation in the mock-Walker cells exhibits three different modes,including a single peak of precipitation over the SST maximum(mode 1),symmetric double peaks of precipitation straddling the SST maximum(mode 2),and a single peak of precipitation on one side of the SST maximum(mode 3).The three modes are caused by three distinct convective activity center migration *** indicate that the virtual effect of water vapor plays an important role in differentiating the three *** the SST gradient is large,the virtual effect may be strong enough to overcome the temperature effect,generating a low-level low-pressure anomaly below the ascending branch of the Walker cell off the *** results here highlight the importance of the virtual effect of water vapor and its interaction with convection and large-scale circulation in the Walker circulation.

关键词： Walker circulation cloud-resolving simulation virtual effect