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Delineating the role of phytocompounds against anti-bacterial drug resistance–An update

BIOCELL 2021年第6期45卷 1465-1477页

作者： REKHA GAHTORI MOSLEH MOHAMMAD ABOMUGHAID nidhi NEGI SARAVANAN KRISHNAN SUGAPRIYA DHANASEKARAN SOUMYA PANDIT KANU PRIYA DILLIP KUMAR BISHI RAM PRASAD PIYUSH KUMAR gupta Department of Biotechnology Sir J.C.Bose Technical CampusKumaun UniversityNainitalIndia Department of Medical Laboratory Sciences University of BishaBishaSaudi Arabia Department of Chemistry Kumaun UniversityNainitalIndia Dhanvantari Nano Ayushadi Pvt. Ltd.ChennaiIndia Department of Medical Laboratory Sciences(Pathology) College of Applied Medical SciencesPrince Sattam Bin Abdulaziz UniversityRiyadhSaudi Arabia Department of Life Sciences School of Basic Sciences and ResearchSharda UniversityGreater NoidaIndia Department of Biotechnology Rama Devi Women’s UniversityBhubaneswarIndia Department of Botany Mahatma Gandhi Central UniversityMotihariIndia

Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human *** kind of problem is not limited to India only,but it is a global ***,many treatments and medicines for bacterial diseases have been ***,they possess some ***,the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming *** products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in *** recent years,researchers have also focused on new drug discovery from plant-based *** have looked on various phytocompounds as antibacterial *** the current review,we report various classes of secondary metabolites such as phenolic compounds,flavonoids,alkaloids,saponins,terpenes,quinones,and some essential oils that have been used as an antibacterial *** addition,we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.

关键词： Drug-resistance Phytocompounds Antibacterial Mechanisms Medicinal plants Natural products

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Co-positivity of anti-dengue virus and anti-Japanese encephalitis virus IgM in endemic area:co-infection or cross reactivity?

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 124-129页

作者： Kaleshwar Prasad Singh Gitika Mishra Parul Jain nidhi Pandey Rachna Nagar Shikha gupta Shantanu Prakash Om Prakash Danish Nasar Khan Sakshi Shrivastav Desh Deepak Singh Amita Jain Department of Microbiology K.G.Medical University

Objective:To report high co-positivity of anti-dengue virus(DV)and anti-Japanese encephalitis virus(JEV)IgM in an area endemic for both the viruses and to discuss the possibilities of ***:Serum samples from the patients who presented with fever,suspected central nervous system infection and thrombocytopenia,were tested for anti-DV IgM and antiJEV IgM *** reverse transcriptase polymerase chain reaction was done for detection of DV RNA and JEV ***:Of 1 410 patient sera tested for anti-DV and antiJEV antibodies,129(9.14%)were co-positive for *** co-positivity was observed only in those months when anli-JEV IgM positivily was *** of both anli-DV IgM and anti-JEV IgM were high in most of the co-positive *** these 129 co-positive cases,76 were lesled by conventional reverse Iranscriplase polymerase chain reaction for both flaviviruses,of which eight cases were co-positive for DV and ***:Co-infection with more than one fluvivirus species can occur in hyperendemic areas.

关键词： Co-infection Co-circulation Dengue virus IgM Japanese encephalitis virus Reverse transcriptase polymerase chain reaction

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从漂白浆的生产成本探讨麦草浆蒸煮的脱木素程度

从漂白浆的生产成本探讨麦草浆蒸煮的脱木素程度

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第二届国际非木材纤维制浆造纸学术会议

作者： gupta Hari Kishore nidhi Rawat Brijesh Kumar R.Pant 刘仁庆印度中央制浆造纸研究所印度中央制浆造纸研究所印度中央制浆造纸研究所印度中央制浆造纸研究所

麦草制浆的条件是:氢氧化钠用量11～18％,液比1:5,在170℃下保温2小时。以未漂浆的卡伯值作为衡量脱木素程度的标准。再把不同卡伯值的未漂浆分别进行CEH三段漂和 H——H两段漂。在不降低漂白浆强度的前提下,比较了不同卡伯值的未漂浆...

麦草制浆的条件是:氢氧化钠用量11～18％,液比1:5,在170℃下保温2小时。以未漂浆的卡伯值作为衡量脱木素程度的标准。再把不同卡伯值的未漂浆分别进行CEH三段漂和 H——H两段漂。在不降低漂白浆强度的前提下,比较了不同卡伯值的未漂浆在蒸煮和漂白过程中耗用化学品的费用,以及漂白浆的物理性能。结果表明,当未漂浆的卡伯值在26-29之间时,采取 CEH三段漂;而当卡伯值在25—27之间时,采取H—H两段漂,其每吨漂白浆耗用纤维原料, 以及蒸煮和漂白化学品的总费用均较低。

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Plasma cathepsin L:A prognostic marker for pancreatic cancer

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World Journal of Gastroenterology 2014年第46期20卷 17532-17540页

作者： nidhi Singh Prasenjit Das Surabhi gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029India Deparment of Pathology All India Institute of Medical SciencesNew Delhi 110029India Department of Biostatistics All India Institute of Medical SciencesNew Delhi 110029India Department of GI Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Biochemistry All India Institute of Medical SciencesNew Delhi110029India

AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic ***:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by *** of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by *** of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical ***:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival *** plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate *** plasma levels of the protease decreased after *** no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in ***:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease.

关键词： Cathepsin L Pancreatic cancer Overall median survi

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