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Multimode vibrational strong coupling in direct laser written mid-IR plasmonic MIM nano-patch antennas

Photonics Research 2023年第12期11卷 2136-2148页

作者： nicholas v.proscia MICHAEL A.MEEKER nicholas SHARAC FRANK K.PERKINS CHASE T.ELLIS PAUL D.CUNNINGHAM JOSEPH G.TISCHLER NRC Postdoc residing at U.S.Naval Research Laboratory WashingtonD.C.20375USA U.S.Naval Research Laboratory WashingtonD.C.20375USA Current address:Rigetti Computing FreemontCalifornia 94538USA Current address:Homer L.Dodge Department of Physics and Astronomy The University of OklahomaNormanOklahoma 73019USA

Strong coupling of mid-infrared(mid-IR)vibrational transitions to optical cavities provides a means to modify and control a material’s chemical reactivity and offers a foundation for novel chemical detection ***,the relatively large volumes of the mid-IR photonic cavities and weak oscillator strengths of vibrational transitions restrict vibrational strong coupling(vSC)studies and devices to large ensembles of molecules,thus representing a potential limitation of this nascent ***,we experimentally and theoretically investigate the mid-IR optical properties of 3D-printed multimode metal-insulator-metal(MIM)plasmonic nanoscale cavities for enabling strong light-matter interactions at a deep subwavelength *** observe strong vibration-plasmon coupling between the two dipolar modes of the L-shaped cavity and the carbonyl stretch vibrational transition of the polymer *** cavity mode volume is half the size of a typical square-shaped MIM geometry,thus enabling a reduction in the number of vibrational oscillators to achieve strong *** resulting three polariton modes are well described by a fully coupled multimode oscillator model where all coupling potentials are *** 3D printing technique of the cavities is a highly accessible and versatile means of printing arbitrarily shaped submicron-sized mid-IR plasmonic cavities capable of producing strong light–matter interactions for a variety of photonic or photochemical ***,similar MIM structures fabricated with nanoscopic voids within the insulator region could constitute a promising microfluidic plasmonic cavity device platform for applications in chemical sensing or photochemistry.

关键词： coupling vibrational shaped

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Clinical implications of the molecular characterization of intraductal papillary mucinous neoplasms of the pancreas

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 430-447页

作者： nicholas v.Peters John W.Kunstman Department of Surgery Yale University School of MedicineNew Haven 06510CTUSA.

Intraductal papillary mucinous neoplasm(IPMN)is a pre-malignant,mucin-producing epithelial lesion arising from pancreatic *** reports define IPMN behavior as ranging from indolent,asymptomatic lesions to dysplasia that sometimes degenerate into pancreatic *** goal of IPMN management is risk-reducing surgery for high-risk cysts and observation of the *** high-from low-risk IPMN disease still relies on imaging and clinical cyst ***,we review the accepted classification of IPMN including the most common histological subtypes,their clinical features,and currently-accepted high-risk *** then deeply examine the known molecular landscape of IPMN,which has largely been derived from post-resection *** includes those gene variants unique to IPMN,chiefly GNAS and RNF43,but also examines the overlap between IPMN and conventional pancreatic *** molecular markers in the clinical setting relies on endoscopically-obtained cyst fluid and presumes that it accurately represents the molecular characteristics of the cystic *** synthesize existing data on mutational analysis from IPMN cyst fluid and consider the benefits and proper role of current commercially-available cyst fluid molecular analysis *** conclude that carefully interpreted molecular analysis of resected IPMN tissue reveals insights into its biology and natural history while cyst fluid analysis offers prognostication and data to guide treatment ***,knowledge gaps remain,especially in characterizing IPMN molecular heterogeneity,time to progression,and correlating cyst fluid genotype data with surveillance *** such,substantial additional research is required before the promise of true molecular guidance of IPMN management can be realized.

关键词： Intraductal papillary mucinous neoplasm pancreatic cancer molecular analysis GNAS KRAS RNF43

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Identifying the occurrence time of an impending major earthquake:a review

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Earthquake Science 2017年第4期30卷 209-218页

作者： Panayiotis A.varotsos nicholas v.Sarlis Efthimios S.Skordas Department of Physics Section of Solid State Physics and Solid Earth Physics InstituteNational and Kapodistrian University of AthensPanepistimiopolisZografos157 84 AthensGreece

The procedure through which the occurrence time of an impending major earthquake can be determined is reviewed in the light of the recent advances. This can be achieved by analyzing in natural time the seismicity in the candidate area. To apply this general procedure, we need two important elements： first, to know when we should start the analysis, i.e., set the natural time equal to zero. This is the time at which the system enters the critical stage. Second a reliable estimation of the candidate epicentral area. If geoelectrical measurements are taken and the vAN method （after the initials of the three researchers varotsos, Alexopoulos and Nomicos）is applied, both these elements become available upon the recording of a precursory Seismic Electric Signals （SES） activity, because its initiation marks the time when the system enters the critical stage, and in addition the SES data enable the determination of the epicentral area of the impending mainshock. On the other hand, if geoelectrical data are lacking, we make use of the following two recent findings by means of natural time analysis： First, the fluctuations of the order parameter of seismicity in a large area exhibit a minimum a few months before a major earthquake almost simultaneously with the initiation of an SES activity. Second, a spatiotemporal study of this minimum unveils an estimate of the epicentral area of the impending major earthquake. Two examples are given that refer to the strongest earthquakes that occurred in Greece and Japan during the last 3 decades, i.e., the Mw6.9 earthquake in southwestern Greece on 14 February 2008 and the Mw9.0 Tohoku earthquake in Japan on 11 March 2011.

关键词： Seismic Electric Signals vAN method Natural time analysis Earthquake prediction

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A tentative model for the explanation of B?th law using the order parameter of seismicity in natural time

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Earthquake Science 2016年第6期29卷 311-319页

作者： Konstantina A. Papadopoulou Efthimios S. Skordas nicholas v. Sarlis Section of Solid State Physics Department of Physics School of Science National and Kapodistrian University of Athens Panepistirniopolis Zografos 157 84 Athens Greece Solid Earth Physics Institute Department of Physics School of Science National and Kapodistrian University of Athens Panepistimiopolis Zografos 157 84 Athens Greece

Using the order parameter of seismicity defined in natural time, we suggest a simple model for the expla- nation of Bath law, according to which a mainshock differs in magnitude from its largest aftershock by approximately 1.2 regardless of the mainshock magnitude. In addition, the validity of Bath law is studied in the Global Centroid Moment Tensor catalogue by using two different aftershock definitions. It is found that the mean of this difference, when considering all the pairs mainshock-largest aftershock, does not markedly differ from 1.2 and the corresponding distributions do not depend on the mainshock＇s magnitude threshold in a statistically significant manner. Finally, the analysis of the cumulative distribution functions provides evidence in favour of the proposed model.

关键词： Bath law . Aftershocks .Order parameter .Natural time

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Animal personalities and their implications for complex signaling

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Current Zoology 2014年第3期60卷 381-386页

作者： nicholas DIRIENZO Ann v HEDRICK Department of Neurobiology Physiology & Behavior Animal Behavior Graduate Group University of California Davis CA 95616 USA Department of Neurobiology Physiology & Behavior University of California Davis CA 95616 USA

Animal personalities have been a major focus of behavioral ecology over the past decade. Consistent individual dif ferences in behavior have been found across taxa, and have been shown to influence a range of ecological processes. The role of personalities in sexual selection has been considered, and examples exist that show selection for personality traits with both assortative and disassortative mating patterns between personality types. One overlooked aspect of the personality and sexual se lection literature is the potential for personalitysignaling interactions, specifically with complex signaling. Complex signaling is a diverse topic in itself, and in short, consists of multiple signals within one or more modalities that interact to elicit a receiver response. Research into complex signaling has been thorough, although at times studies discover complex signaling systems that fail to fit into one of the existing hypotheses in the literature. Here, we argue that personalities may interact with complex signal ing, which should be considered by researchers of both personality and sexual selection and communication. We describe several ways in which personalitycomplex signaling interactions could affect both the signaler and receiver, and the way in which they may drive personalityspecific signals as well as receiver preferences. Finally, we discuss how considering personality in com plex signaling studies may inform theory as well as improve the ability of researchers to accurately describe its function.

关键词： Animal Personalities Sexual Selection Complex Signaling Multimodal Communication Communication

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The Realization Problem for Discrete Morse Functions on Trees

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Algebra Colloquium 2020年第3期27卷 455-468页

作者： Yuqing Liu nicholas A.Scoville Department of Mathematics and Computer Science Ursinus College CollegevillePA 19426USA

We introduce a new notion of equivalence of discrete Morse functions on graphs called persistence *** functions are considered persistence equivalent if and only if they induce the same persistence *** compare this notion of equivalence to other notions of equivalent discrete Morse *** we compute an upper bound for the number of persistence equivalent discrete Morse functions on a fixed graph and show that this upper bound is sharp in the case where our graph is a *** is a version of the"realization problem"of the persistence *** conclude with an example illustrating our construction.

关键词： persistent homology barcode discrete Morse theory tree

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Design and synthesis of synthetic promoters for consistency of gene expression across growth phases and scale in ***

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Synthetic and Systems Biotechnology 2024年第2期9卷 330-339页

作者： Kristin v.Presnell Omar Melhem Sarah M.Coleman nicholas J.Morse Hal S.Alper McKetta Department of Chemical Engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute for Cellular and Molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

Metabolic engineering and synthetic biology endeavors benefit from promoters that perform consistently(or robustly)with respect to cellular growth phase(exponential and stationary)and fermentation scale(microtiter plates,tubes,flasks,and bioreactors).However,nearly all endogenous promoters(especially in Saccharomyces cerevisiae)do not perform in this *** this work,a hybrid promoter engineering strategy is leveraged to create novel synthetic promoters with robustness across these *** a multi-dimensional RNA-seq dataset,promoters with specific phase dependencies were *** enriched with functional transcription factors were identified using MEME *** motif-containing fragments could impart activity dependence in the opposing ***,we obtain two new promoters with high and consistent expression across both phases by increasing the exponential phase activity of the starting stationary-phase scaffold by 38 and 23-fold ***,we show that these promoters function consistently across various laboratory growth scales over time in a microtiter plate and in ***,this work presents and validates a new strategy for engineering promoters in *** with high levels of expression that are robust to cellular growth phase and the scale of the culture.

关键词： endogenous synthetic stationary

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Neoadjuvant treatment of esophageal cancer

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World Journal of Gastroenterology 2010年第30期16卷 3793-3803页

作者： nicholas P Campbell victoria M villaflor Section of Hematology/Oncology Department of MedicineThe University of Chicago Pritzker School of MedicineChicagoIL 60637United States

The management of esophageal cancer has been evolving over the past 30 years. In the United States, multimodality treatment combining chemotherapy and radiotherapy (RT) prior to surgical resection has come to be accepted by many as the standard of care, although debate about its overall effect on survival still exists, and rightfully so. Despite recent improvements in detection and treatment, the overall survival of patients with esophageal cancer remains lower than most solid tumors, which highlights why further advances are so desperately needed. The aim of this article is to provide a complete review of the history of esophageal cancer treatment with the addition of chemotherapy, RT, and more recently, targeted agents to the surgical management of resectable disease.

关键词： Esophageal cancer Multimodality therapy Neoadjuvant therapy Chemotherapy Radiotherapy Targeted agents Disease management

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Mw9 Tohoku earthquake in 2011 in Japan:precursors uncovered by natural time analysis

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Earthquake Science 2017年第4期30卷 183-191页

作者： Panayiotis A.varotsos nicholas v.Sarlis Efthimios S.Skordas Mary S.Lazaridou-varotsos Department of Physics Section of Solid State Physics and Solid Earth Physics InstituteNational and Kapodistrian University of AthensPanepistimiopolisZografos 157 84AthensGreece Department of Physics Solid Earth Physics InstituteNational and Kapodistrian University of AthensPanepistimiopolisZografos 157 84AthensGreece

This paper reviews the precursory phenomena of the 2011 Mw9 Tohoku earthquake in Japan that emerge solely when we analyze the seismicity data in a new time domain termed natural time. If we do not consider this analysis, important precursory changes cannot be identified and hence are missed. Natural time analysis has the privilege that enables the introduction of an order parameter of seismicity. In this frame, we find that the fluctuations of this parameter exhibit an unprecedented characteristic change, i.e., an evident minimum, approximately two months before Tohoku earthquake, which strikingly is almost simultaneous with unique anomalous geomagnetic field variations recorded mainly on the z component. This is consistent with our finding that such a characteristic change in seismicity appears when a seismic electric signal （SES） activity of the vAN method （from the initials of varotsos, Alexopoulos, Nomicos） initiates, and provides a direct confirmation of the physical interconnection between SES and seismicity.

关键词： Seismic electric signals vAN method Natural time analysis Earthquake prediction

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Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

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World Journal of Gastroenterology 2015年第14期21卷 4126-4135页

作者： nicholas G Theodorakis Yining N Wang vyacheslav A Korshunov Mary A Maluccio nicholas J Skill Division of Transplant Surgery Department of SurgerySchool of MedicineIndiana University School of Medicine University of Rochester

AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and *** reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully *** hypothesis is that thalidomide destabilizes tumor necrosis factor α(TNFα) mR NA and therefore diminishes TNFα induction of nitric oxide synthase(NOS) and the production of nitric oxide(NO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PvL) PHT model in combination with endothelial or inducible NOS isoform gene knockout ***: Wild type, inducible nitric oxide synthase(i NOS)-/- and endothelial nitric oxide synthase(e NOS)-/-mice received either PvL or sham surgery and were given either thalidomide or *** nitrate(total nitrate, NOx) was measured daily for 7 d as a surrogate of NO *** TNFα level was quantified by enzyme-linked immunosorbent ***α m RNA was quantified in liver and aorta tissue by reverse transcription-polymerase chain *** was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 *** to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma NOx were increased in wild type and i NOS-/-PvL mice when compared to sham operated control *** contrast, SPP, Qao and plasma NOx were not increased in e NOS-/- PvL mice when compared to sham *** TNFα level in both sham and PvL mice was below the detection limit of the commercial ELISA ***, the effect of thalidomide on serum TNFα levels was undetermined in wild type, e NOS-/-or i NOS-/- *** acutely increased plasma NOx in wild type and e NOS-/- mice but not i NOS-/-***, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e NOS-/- and i NOS-/- PvL mice, aft

关键词： Portal hypertension Thalidomide Nitric oxide Knock

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