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Glymphatic function and its influencing factors in different glucose metabolism states

World Journal of Diabetes 2024年第7期15卷 1537-1550页

作者： Bin Tian Chen Zhao Jia-Li Liang Hui-Ting Zhang Yi-Fan Xu Hui-Lei Zheng Jia Zhou jiang-nian Gong Shu-Ting Lu Zi-San Zeng Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Magnetic Resonance Research Collaboration Siemens HealthineersGuangzhou 510620Guangdong ProvinceChina Magnetic Resonance Research Collaboration Siemens Healthineers Ltd.Wuhan 430071Hubei ProvinceChina Department of Health Management The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well *** To investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states,the present study employed diffusion tensor imaging along the perivascular space(DTI-ALPS)*** Sample size was calculated using the pwr package in R *** crosssectional study enrolled 22 patients with normal glucose metabolism(NGM),20 patients with prediabetes,and 22 patients with type 2 diabetes mellitus(T2DM).A 3.0T magnetic resonance imaging was used to evaluate the function of the glymphatic *** mini-mental state examination(MMSE)was used to assess general cognitive *** DTI-ALPS index of bilateral basal ganglia and the mean DTI-ALPS index was ***,the correlation between DTI-ALPS and clinical features was *** The left-side,right-side,and mean DTI-ALPS index in the T2DM group were significantly lower than that in the NGM *** right-side DTI-ALPS and mean DTI-ALPS index in the T2DM group were significantly lower than those in the prediabetes ***-ALPS index lateralization was not *** MMSE score in the T2DM group was significantly lower than that in the NGM and prediabetes *** controlling for sex,the left-side DTI-ALPS and mean DTI-ALPS index in the prediabetes group were positively correlated with 2-hour postprandial blood glucose level;the left-side DTI-ALPS index was negatively correlated with total cholesterol and low-density lipoprotein *** right-side DTI-ALPS and mean DTI-ALPS index were negatively correlated with the glycosylated hemoglobin level and waist-to-hip ratio in the prediabetes *** left-side,right-side,and mean DTI-ALPS index in the T2DM group were positively correlated with *** left-side and mean DTIALPS index in the T2DM group were negatively

关键词： Glymphatic system Prediabetes Type 2 diabetes mellitus Magnetic resonance imaging Diffusion tensor imaging along the perivascular space

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基于FPGA的“低慢小”目标检测系统实现

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光电子技术 2024年第1期44卷 29-33页

作者：王朝洋樊昌元蒋念成都信息工程大学电子工程学院成都610225

为解决“低慢小”目标检测困难的问题,实现了一种基于FPGA(Field Programmable Gate Array,现场可编程逻辑门阵列)的“低慢小”目标检测系统。该系统采取COMS相机获取图像,DDR3 SDRAM缓存视频帧,使用FPGA处理帧间差分法和光流法结合的算... 详细信息

为解决“低慢小”目标检测困难的问题,实现了一种基于FPGA(Field Programmable Gate Array,现场可编程逻辑门阵列)的“低慢小”目标检测系统。该系统采取COMS相机获取图像,DDR3 SDRAM缓存视频帧,使用FPGA处理帧间差分法和光流法结合的算法,目标检测结果使用VGA标准显示。测试结果表明,该系统能够检测出在悬停和低速飞行姿态下的低慢小无人机目标并实时显示。

关键词： “低慢小”目标现场可编程逻辑门阵列帧间差分光流法目标检测

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Does burning fat make tumor immune hot? Discovery of cD47 overexpression by radiation induced fatty acid oxidation

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Genes & Diseases 2023年第1期10卷 7-9页

作者： nian jiang Bowen Xie Ming Fan Jian Jian Li Department of Radiation Oncology University of California Davis School of MedicineSacramentoCA 95817USA Department of Neurosurgery National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangshaHunan 410008China Institute for Immunology and School of Medicine Tsinghua UniversityBeijing 100084China NCl-Designated Comprehensive Cancer Center University of California DavisSacramentoCA 95817USA

Although extensively studied,it is unknown what is the major cellular energy driving tumor metastasis after anti-cancer *** reprogramming is one of the fundamental hallmarks in carcinogenesis and tumor progression featured with the increased glycolysis in solid ***,accumulating evidence indicates that in addition to the rudimentary glycolytic pathway,tumor cells are capable of reactivating mitochondrial OxPHOS under genotoxic stress condition to meet the increasing cellular fuel demand for repairing and surviving anti-cancer *** dynamic metabolic rewiring may play a key role in cancer therapy resistance and ***,data from our group and others have demonstrated that cancer cells can re-activate mitochondrial oxidative respiration to boost an annexing energy to meet the increasing cellular fuel demand for tumor cells surviving genotoxic anti-cancer therapy with metastatic potential.

关键词： CD47 Immunecheckpoint Immunotherapy Metabolic rewiring Radiation therapy Tumor acquired resistance

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Implementing 1 → M Economical Phase-Covariant Telecloning in Cavity QED

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Communications in Theoretical Physics 2011年第3期55卷 441-444页

作者： XUE Li jiang nian-Quan College of Physics and Electric Information Wenzhou University Wenzhou 325035 China

我们建议一个试验性地可行的计划实现节俭 1 M phase-covariant telecloning 基于洞证完。由有在原子之间的一个 high-Q 洞和不同联合力量的洞地和洞地的原子的反响的相互作用，计划能在一步产生量纠纷隧道。而且，操作时间和步不随原... 详细信息

我们建议一个试验性地可行的计划实现节俭 1 M phase-covariant telecloning 基于洞证完。由有在原子之间的一个 high-Q 洞和不同联合力量的洞地和洞地的原子的反响的相互作用，计划能在一步产生量纠纷隧道。而且，操作时间和步不随原子的增加增加。

关键词：腔量子电动力学克隆远程协变相位经济共振相互作用实验计划

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3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway

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BIOCELL 2022年第11期46卷 2425-2432页

作者： SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU nian jiang JING HUI LINGJIE MENG YUN LIU Guizhou Provincial College–Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi563000China Life Science Institute of Zunyi Medical University Zunyi563000China School of Preclinical Medicine of Zunyi Medical University Zunyi563000China

Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor ***,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well *** present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in ***,3-epi-bufotalin inhibited the JAK1/STAT3 signaling *** results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells.

关键词： 3-epi-bufotalin Colorectal cancer JAK1/STAT3 signaling pathway Apoptosis

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脑室及脑实质内神经鞘瘤临床特点分析

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国际神经病学神经外科学杂志 2024年第3期51卷 45-54页

作者：蒋念潘舟洋陈银华廖宇翔廖新斌张治平中南大学湘雅医院神经外科湖南长沙410008

目的总结脑室及脑实质内神经鞘瘤的临床特点。方法收集2010年6月—2020年6月中南大学湘雅医院诊治的13例脑室及脑实质内神经鞘瘤病例,并分析患者的一般资料、症状、体征、影像学资料、手术记录以及住院治疗经过。结果13例非颅神经起源... 详细信息

目的总结脑室及脑实质内神经鞘瘤的临床特点。方法收集2010年6月—2020年6月中南大学湘雅医院诊治的13例脑室及脑实质内神经鞘瘤病例,并分析患者的一般资料、症状、体征、影像学资料、手术记录以及住院治疗经过。结果13例非颅神经起源的脑实质内或脑室神经鞘瘤,占同期神经鞘瘤的0.45%。患者年龄1~71岁,平均35.7岁;男性9例,女性4例(男∶女=2.25∶1.00)。患者症状出现时间从4 d到3年不等,最常见的首发症状是头痛,其次是癫痫发作。肿瘤位于额叶最常见,其次为小脑半球和颞叶。囊变、瘤周水肿是该肿瘤常见影像学特征,1例病例出现钙化。该13例术前均误诊为其他类型肿瘤,多数诊断为胶质瘤或脑膜瘤。结论脑室及脑实质内神经鞘瘤是一种罕见的肿瘤,术前难以与实质性肿瘤鉴别。该肿瘤起因不明,手术为首选治疗方式,除恶性神经鞘瘤外预后均较好。

关键词：神经鞘瘤脑实质脑室临床特点神经影像组织病理

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New Three-Mode Squeezing Operators Gained via Tripartite Entangled State Representation

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Communications in Theoretical Physics 2008年第1期49卷 225-228页

作者： jiang nian-Quan FAN Hong-Yi College of Physics and Electric Information Wenzhou University Wenzhou 325035 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

我们证明单个模式的挤压的状态的阿加瓦尔·西蒙表示能被概括发现三模式的挤压的状态的新形式。我们使用分成三部分的纠缠的州的代表 | p， y， z 〉和 | x， u，实现这个目标的 v 〉。

关键词：三重纠结状态 IWOP 三位模式操作方法

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Programmable quantum processor implemented with superconducting circuit

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Communications in Theoretical Physics 2021年第5期73卷 33-37页

作者： nian-Quan jiang Xi Liang Ming-Feng Wang College of Mathematics and Physics Wenzhou UniversityWenzhou 325035China

A quantum processor might execute certain computational tasks exponentially faster than a classical ***,using superconducting quantum circuits we design a powerful universal quantum processor with the structure of symmetric all-to-all capacitive *** present the Hamiltonian and use it to demonstrate a full set of qubit operations needed in the programmable universal quantum *** the device the unwanted crosstalk and ZZ-type couplings between qubits can be effectively suppressed by tuning gate voltages,and the design allows efficient and high-quality couplings of *** available technology,the scheme may enable a practical programmable universal quantum computer.

关键词： programmable quantum processor universal quantum gate superconducting qubit

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Development of sympathetic ophthalmia following globe injury

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Chinese Medical Journal 2009年第24期122卷 2961-2966页

作者： ZHANG Ying ZHANG Mao-nian jiang Cai-hui YAO Yi Department of Ophthalmology Chinese PLA General HospitalBeijing 100853 China

Background Sympathetic ophthalmia （SO）, a rare, bilateral, diffuse granulomatous uveitis, usually occurs after open globe injury or intraocular surgery. We sought to identify the risk factors for the development of SO after open globe injury and describe their demographic and clinical features and outcomes of treatments. Methods A retrospective study of inpatients with globe injury in 15 tertiary referral hospitals of China from January 2001 to December 2005 was conducted. The information of demography, nature and mechanism of injury, time and ways of treatments and outcomes was reviewed. Diagnosis of SO was made based on a history of ocular trauma or surgery and subsequent development of bilateral or contralateral uveitis consistent with SO. Any association between related parameters and development of SO was analyzed. Results Among 9103 patients （9776 eyes） of globe injury, SO occurred after open globe injury in 18 cases with an occurrence rate of 0.37%, vitrectomy of closed globe injury in 2 （0.37%） and perforation of burned eyes in another 2. For open globe injury, the median age （（36.72±13.59） years, P=0.01） was higher in patients with SO; there were no significant effects of sexes, injury type, uvea proplaps, once or multi-intraocular surgery, once or multi-vitrectomy and endophthalmitis on incidence of SO; 0.70% endophthalmitis concurred with SO; 83.33% of SO occurred within 1 year after injury or last ocular surgery. SO developed in a fellow eye one week after evisceration of the perforating burned eye. Good final visual acuity was obtained in sympathizing eyes with prompt treatment. Conclusions For open globe injuries, SO sufferers were relatively older and any injury type could induce SO with equal possibility. The initial open globe injury was more likely to be the trigger of SO than subsequent intraocular surgeries including vitrectomy. Prophylactic enucleation after injury is not recommended.

关键词： sympathetic ophthalmia eye injury intraocular sugery risk factors

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富硒绞股蓝功能性茶冻的研制

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现代农业科技 2024年第10期 135-140,150页

作者：孙喆田媛张钊李鹏江年孙前进夏曾润王少可李建科张玉环陕西师范大学食品工程与营养科学学院陕西西安710119 陕西女娲神草农业科技有限公司陕西安康725000 东京大学生命科学院日本东京日本陕西联谊会日本东京农业农村部富硒产品开发与质量控制重点实验室/安康市富硒产品研发中心陕西安康725000

绞股蓝是一种药食同源的草本植物,兼具较高的营养价值与药用价值。目前,绞股蓝相关产品以绞股蓝茶为主,存在味苦、浮沫多的弊端,制约了绞股蓝茶推广销售。本文以富硒超微绞股蓝茶粉为主要原料,以黄原胶、甜菊糖苷(甜味剂)、水等为辅料,... 详细信息

绞股蓝是一种药食同源的草本植物,兼具较高的营养价值与药用价值。目前,绞股蓝相关产品以绞股蓝茶为主,存在味苦、浮沫多的弊端,制约了绞股蓝茶推广销售。本文以富硒超微绞股蓝茶粉为主要原料,以黄原胶、甜菊糖苷(甜味剂)、水等为辅料,以感官评分为主要指标,利用正交试验与Box-Behnken设计-响应面法筛选出最优的富硒绞股蓝功能性茶冻配方工艺,即富硒超微绞股蓝茶粉0.65 g、水1.00 L、甜菊糖苷0.10 g、黄原胶0.20 g,同时添加魔芋葡甘聚糖60 g。相较于传统绞股蓝茶,所得产品克服了绞股蓝茶味苦、浮沫多的弊端,丰富了绞股蓝茶产品形式;茶冻状态突破了传统茶冲泡形式下功能成分利用率低的限制,极大地提高了硒等功能活性物质的摄取率;以膳食纤维魔芋葡甘聚糖为成胶成分,既使产品具有细腻弹爽的口感、透明均匀的色泽,又赋予其调节肠道菌群、缓解便秘的功能特性,增强了产品的功能活性;以甜菊糖苷甜味剂代替传统茶冻中的蔗糖,更适宜控糖人群食用。该研究结果为绞股蓝基功能性产品的研制与推广提供了技术和理论借鉴。

关键词：绞股蓝富硒茶冻功能性食品工艺优化感官评定

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