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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Tourism Route Recommendation Based on A Multi-Objective Evolutionary Algorithm Using Two-Stage Decomposition and Pareto Layering

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 486-500页

作者： Xiaoyao zheng Baoting Han zhen ni IEEE the School of Computer and Information Anhui Normal UniversityWuhu 241002China the Department of Electrical Engineering and Computer Science Florida Atlantic UniversityBoca Raton FL33431 USA

Tourism route planning is widely applied in the smart tourism *** Pareto-optimal front obtained by the traditional multi-objective evolutionary algorithm exhibits long tails,sharp peaks and disconnected regions problems,which leads to uneven distribution and weak diversity of optimization solutions of tourism *** by these limitations,we propose a multi-objective evolutionary algorithm for tourism route recommendation(MOTRR)with two-stage and Pareto layering based on *** method decomposes the multiobjective problem into several subproblems,and improves the distribution of solutions through a two-stage *** crowding degree mechanism between extreme and intermediate populations is used in the two-stage *** neighborhood is determined according to the weight of the subproblem for crossover ***,Pareto layering is used to improve the updating efficiency and population diversity of the *** two-stage method is combined with the Pareto layering structure,which not only maintains the distribution and diversity of the algorithm,but also avoids the same *** with several classical benchmark algorithms,the experimental results demonstrate competitive advantages on five test functions,hypervolume(HV)and inverted generational distance(IGD)*** the experimental results of real scenic spot datasets from two famous tourism social networking sites with vast amounts of users and large-scale online comments in Beijing,our proposed algorithm shows better *** proves that the tourism routes recommended by our proposed algorithm have better distribution and diversity,so that the recommended routes can better meet the personalized needs of tourists.

关键词： Evolutionary algorithm multi-objective optimization Pareto optimization tourism route recommendation two-stage decomposition

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Transcranial magnetic stimulation to understand pathophysiology and as potential treatment for neurodegenerative diseases

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Translational Neurodegeneration 2015年第1期4卷 184-195页

作者： zhen ni Robert Chen Division of Neurology Krembil Neuroscience Centre and Toronto Western Research InstituteUniversity Health NetworkUniversity of TorontoTorontoONCanada MC-411 Toronto Western Hospital399 Bathurst StreetTorontoON M5T 2S8Canada

Common neurodegenerative diseases include Parkinson’s disease(PD),Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS)and Huntington’s disease(HD).Transcranial magnetic stimulation(TMS)is a noninvasive and painless method to stimulate the human ***-and paired-pulse TMS paradigms are powerful ways to study the pathophysiological mechanisms of neurodegenerative *** evoked potential studied with single-pulse TMS is increased in PD,AD and ALS,but is decreased in *** in motor cortical excitability in neurodegenerative diseases may be related to functional deficits in cortical circuits or to compensatory *** or even absence of short interval intracortical inhibition induced by paired-pulse TMS is common in neurodegenerative diseases,suggesting that there are functional impairments of inhibitory cortical *** short latency afferent inhibition in AD,PD and HD may be related to the cortical cholinergic deficits in these *** plasticity tested by paired associative stimulation or theta burst stimulation is impaired in PD,AD and *** TMS(rTMS)refers to the application of trains of regularly repeating TMS ***-frequency facilitatory rTMS may improve motor symptoms in PD patients whereas low-frequency inhibitory stimulation is a potential treatment for levodopa induced *** delivered both to the left and right dorsolateral prefrontal cortex improves memory in AD *** motor cortical stimulation in low frequency may be useful for HD ***,the effects of treatment with multiple sessions of rTMS for neurodegenerative diseases need to be tested in large,sham-controlled studies in the future before they can be adopted for routine clinical practice.

关键词： Alzheimer’s disease Amyotrophic lateral sclerosis Huntington’s disease Parkinson’s disease Transcranial magnetic stimulation

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Synthesis of Octapod Cu-Au Bimetallic Nanocrystal with Concave Structure through Galvanic Replacement Reaction

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Journal of Electronic Science and Technology 2020年第2期18卷 151-158页

作者： zhen-ni Wang Qiang Li zhen-Huan Zhao Xiao-Mei Tong School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710126

We synthesized octapod Cu-Au bimetallic alloy with a concave structure by employing a replacement reaction between Au PPh3Cl and Cu nanocubes. Using the Cu nanocube as sacrificial templates, we have successfully generated high-active sites on alloy nanocrystals by carefully tuning the replacement reaction and growth. The key is to afford the proper concentration of Au PPh3Cl-TOP to the reaction solution. When the Au precursor with high concentration is injected into the galvanic replacement reaction, the growth dominated the process and hollowed octapod Cu-Au alloy was obtained. In contrast, when the concentration of the Au precursor is low, the replacement reaction can only take place at the nanocrystals, leading to generate Cu-Au nanocages. This work provides an effective strategy for the preparation of hollow bimetallic nanocrystals with high-active sites.

关键词： solution. crystal concave

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RETHINKING INCLUSION： IS THERE A RIGHT TO INCLUSIVE EDUCATION？

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Frontiers of Law in China-Selected Publications from Chinese Universities 2016年第3期11卷 486-514页

作者： ni zhen Faculty of Law The University of Hong Kong Researcher Beijing China

By combining theories of education, human rights law, and political philosophy, the author provides lenses to understanding inclusive education, thereby establishing consensus on the new, cognitive grounds over the description of a better inclusive education system for all children. The investigation is guided by two research questions. The first question concerns what description we should hold for a better education system inclusive of disabled children. The second addresses how to arrive at a consensus over that better system among stakeholders and within the whole society. To answer these questions, the investigation is conducted through both transcendental and comparative routes. Firstly, to contextualize this research, a brief review of theoretical disagreements on inclusive education is provided, and a case study of China＇s struggles towards inclusion is presented. The theoretical review and the case study provide concrete information for later assessment and comparison between reality and the ideal plan. Meanwhile, the author discusses ways to go beyond binary thoughts and disorganized practice. To achieve the goal, transcendental thought experiments are employed to generate new grounds for a more comprehensive, inclusive project; the idea of a right to inclusive education is elaborated.

关键词： inclusive education consensus justice disability CRPD China

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Chinese Journal of Electronics 2021年第1期30卷 55-63页

作者： BO Lili ZHU Xuanrui SUN Xiaobing ni zhen LI Bin School of Information Engineering Yangzhou University Jiangsu Engineering Research Center of Knowledge Management and Intelligent Service State Key Laboratory for Novel Software Technology Nanjing University

Fine-grained change operations can help software developers fix software bugs more accurately and efficiently. However, the current fine-grained change operations are only used in specific fixing process, such as fixing of If statement. In this paper, we conducted an empirical study to explore the fine-grained change operations for bug fixing. Based on the Mozilla bug data,we examined whether similar bugs are fixed with similar change operations. The results show that: First, for bug reports with similar descriptions or bug-fix commits with similar descriptions, their corresponding fine-grained change operations are not related; Second, in the case where the descriptions of both bug reports and bug-fix commits are similar, the fine-grained change operations in patch code are not related; Third, by classifying bug reports, we find that the change operations in the same bug report category are similar; Finally, by analyzing the fine-grained change operations for each bug, we present some combined patterns that are often used together.

关键词： bug reports bug fixing If statement Mozilla bug data bug-fix commits similar descriptions program debugging fine-grained change operations

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Variable selection in near infrared spectroscopy for quantitative models of homologous analogs of cephalosporins

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Journal of Innovative Optical Health Sciences 2014年第4期7卷 91-100页

作者： Yan-Chun Feng zhen ni Chang-Qin Hu National Institutes for Food and Drug Control(niFDC)Beijing 100050 P.R.China Tibet Institute for the Control of Food and Pharmaceutical Products Lhasa 850000 P.R.China

Two universal spectral ranges(4550-4100 cm^(-1) and 6190-5510 cm^(-1))for construction of quantitative models of homologous analogs of cephalosporins were proposed by evaluating theperformance of five spectral ranges and their combinations,using three data sets of cephalos-porins for injection,ie.,cefuroxime sodium,cetriaxone sodium and cefoperazone ***,the proposed ranges were validated by using eight calibration sets of otherhomologous analogs of cephalosporins for injection,namely cefmenoxime hydrochloride,ceftezole sodium,cefmetazole,cefoxitin sodium,cefotaxime sodium,cefradine,cephazolin sodium and ceftizoxime *** the constructed quantitative models for the eight kinds of cephalosporinsusing these universal ranges could fulill the requirements for quick *** that,competitive adaptive reweighted sampling(CARS)algorithm and infrared(IR)-near infrared(niR)two-dimensional(2D)correlation spectral analysis were used to determine the scientific basis of these two spectral ranges as the universal regions for the construction of quantitativemodels of *** CAR.S algorithm demonstrated that the ranges of 4550-4100 cm^(-1) and 6190-5510 cm^(-1) included some key wavenumbers which could be attributed to content changes of *** IR-niR 2D spectral analysis showed that certain wavenumbersin these two regions have strong correlations to the structures of those cephalosporins that wereeasy to degrade.

关键词： Near infrared spectroscopy cephalosporins quantitation spectral range selection

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Online Learning Control for Harmonics Reduction Based on Current Controlled Voltage Source Power Inverters

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 447-457页

作者： Naresh Malla Ujjwol Tamrakar Dipesh Shrestha zhen ni Reinaldo Tonkoski Electrical Engineering and Computer Science Department South Dakota State University IEEE

Nonlinear loads in the power distribution system cause non-sinusoidal currents and voltages with harmonic *** active filters(SAF) with current controlled voltage source inverters(CCVSI) are usually used to obtain balanced and sinusoidal source currents by injecting compensation ***,CCVSI with traditional controllers have a limited transient and steady state *** this paper,we propose an adaptive dynamic programming(ADP) controller with online learning capability to improve transient response and *** proposed controller works alongside existing proportional integral(PI) controllers to efficiently track the reference currents in the d-q *** can generate adaptive control actions to compensate the PI *** proposed system was simulated under different nonlinear(three-phase full wave rectifier) load *** performance of the proposed approach was compared with the traditional *** have also included the simulation results without connecting the traditional PI control based power inverter for reference *** online learning based ADP controller not only reduced average total harmonic distortion by 18.41%,but also outperformed traditional PI controllers during transients.

关键词： Adaptive dynamic programming(ADP) current controlled voltage source power inverter(CCVSI) online learning based controller neural networks shunt active filter(SAF) total harmonic distortion(THD)

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Time and Location Aware Points of Interest Recommendation inLocation-Based Social Networks

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Journal of Computer Science & Technology 2018年第6期33卷 1219-1230页

作者： Tie-Yun Qian Bei Liu Liang Hong zhen-ni You School of Computer Science Wuhan University Wuhan 430072 China SchooI of Information Management Wuhan University Wuhan 430072 China

The wide spread of location-based social networks brings about a huge volume of user check-in data, whichfacilitates the recommendation of points of interest （POIs）. Recent advances on distributed representation shed light onlearning low dimensional dense vectors to alleviate the data sparsity problem. Current studies on representation learningfor POI recommendation embed both users and POIs in a common latent space, and users＇ preference is inferred basedon the distance/similarity between a user and a POI. Such an approach is not in accordance with the semantics of usersand POIs as they are inherently different objects. In this paper, we present a novel translation-based, time and locationaware （TransTL） representation, which models the spatial and temporal information as a relationship connecting users andPOIs. Our model generalizes the recent advances in knowledge graph embedding. The basic idea is that the embedding ofa 〈time, location〉 pair corresponds to a translation from embeddings of users to POIs. Since the POI embedding shouldbe close to the user embedding plus the relationship vector, the recommendation can be performed by selecting the top-kPOIs similar to the translated POI, which are all of the same type of objects. We conduct extensive experiments on tworeal-world ***. The results demonstrate that our TransTL model achieves the state-of-the-art performance. It is alsomuch more robust to data sparsity than the baselines.

关键词： point of interest (POI) recommendation, location-based social network (LBSN), time and location aware

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Adaptive composite frequency control of power systems using reinforcement learning

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CAAI Transactions on Intelligence Technology 2022年第4期7卷 671-684页

作者： Chaoxu Mu Ke Wang Shiqian Ma Zhiqiang Chong zhen ni School of Electrical and Information Engineering Tianjin UniversityTianjinChina State Grid Tianjin Electric Power Company Electric Power Research Institute TianjinChina Department of Electrical Engineering and Computer Science Florida Atlantic UniversityBoca RatonFLUSA

With the incorporation of renewable energy,load frequency control(LFC)becomes more challenging due to uncertain power generation and changeable load *** electric vehicle(EV)has been a popular transportation and can also provide flexible options to play a role in frequency *** this paper,a novel adaptive composite controller is designed to solve the LFC problem for the interconnected power system with electric vehicles and wind *** are used as regulation resources to effectively compensate the power ***,the sliding mode controller is developed to reduce the random influences caused by the wind turbine generation ***,an auxiliary controller with reinforcement learning is proposed to produce adaptive control signals,which will be attached to the primary proportion-integration-differentiation control signal in a realtime ***,by considering random wind power,load disturbances and output constraints,the proposed scheme is verified on a two-area power system under four different *** results demonstrate that the proposed adaptive composite frequency control scheme has a competitive performance with regard to dynamic performance.

关键词： power composite attached

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