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Comparison of anti-inflammatory effects of intense pulsed light with tobramycin/dexamethasone plus warm compress on dry eye associated meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1708-1713页

作者： Yu-fei Gao rong-jun Liu ya-Xin Li Chenmilu Huang Yi-Yun Liu Chen-Xi Hu Hong qi Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third HospitalBeijing 100191China The First Hospital of fangshan District Beijing 102400China Beijing No.6 Hospital Beijing 100007China

AIM: To compare the anti-inflammatory effects of intense pulsed light(IPL) with tobramycin/dexamethasone plus warm compress through clinical signs and cytokines in ***: Eighty-two patients with dry eye disease(DED) associated meibomian gland dysfunction(MGD) were divided into two groups. Group A was treated with IPL, and Group B was treated with tobramycin/dexamethasone plus warm compress. Ocular Surface Disease Index(OSDI), tear film breakup time(TBUT), corneal fluorescein staining(CFS), meibomian gland expressibility(MGE), meibum quality, gland dropout and tear cytokine levels were evaluated before treatment, 1 wk and 1 mo after treatment. RESULTS: TBUT in Group A was higher(P=0.035), and MGE score was lower than Group B at 1 mo(P=0.001). The changes of interleukin(IL)-17 A and IL-1β levels in tears were lower in Group A compared with that in Group B at 1 wk after treatment(P=0.05, P=0.005).CONCLUSION: Treatment with IPL can improve TBUT and MGE and downregulate levels of IL-17 A and IL-1β in tears of patients with DED associated MGD better than treatment with tobramycin/dexamethasone plus warm compress in one-month treatment period.

关键词： intense pulsed light meibomian gland dysfunction dry eye disease interleukin-17A interleukin-1β

The clinicopathological and prognostic significance of PD-L1 expression in pancreatic cancer:A meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 95-100页

作者： He-Li Gaoa Liang Liua Zi-Hao qi Hua-Xiang Xu wen-Quan Wang Chun-Tao Wu Shi-rong Zhang jin-Zhi Xu Quan-Xing ni Xian-jun Yua Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China

Background: Immunotherapy has shown promise against solid tumors. However, the clinical significance of programmed cell death 1(PD-1) and programmed cell death ligand 1(PD-L1) in pancreatic ductal adenocarcinoma(PDAC) remains unclear. This meta-analysis aimed to analyze the prognostic effect of PD-L1 in *** sources: Electronic search of the Pub Med, Cochrane Library and Web of Science was performed until December 2016. Through database searches, we identified articles describing the relationship between PD-L1 status and PDAC patient prognosis. Meta-analysis was performed to investigate the relationship between PD-1 and overall survival(OS).Results: nine studies with 989 PDAC patients were included for PD-L1 expression analysis. And 5 studies with 688 PDAC patients were included in the prognostic analysis. The PD-L1 positive rate measured by immunohistochemistry(IHC) was higher than that measured by polymerase chain reaction(PCR)(P nificantly reduced OS(HR = 2.34;95% CI: 1.78–3.08). Subgroup analysis showed that the prognostic effect of PD-L1 levels was similar between the IHC and PCR methods. The PD-L1 positive rate was associated with PDAC T stages; the PD-L1 positive rate in the T3–4 group was higher than that in the T1-2 group(OR = 0.37; P = 0.001).Conclusions: High PD-L1 expression levels predicted a poor prognosis in PDAC patients. Thus, PD-L1 status helps determine treatment in PDAC patients.

关键词： Pancreatic ductal adenocarcinoma Programmed cell death ligand 1 Prognosis Meta-analysis

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薄壁水槽拉深变形规律研究及工艺优化

塑性工程学报 2024年第8期31卷 26-36页

作者：洪熠豪吴菲韩建霖章争荣陈宇麒李建平莫炳俊广东工业大学材料与能源学院广东广州510000 广东省金属成形加工与锻压装备技术重点实验室广东广州510000 广东樱奥厨具有限公司广东佛山528000 广东锻压机床厂有限公司广东佛山528000

为解决几何形状复杂且不对称及采用3次拉深工艺成形的薄壁水槽模具制造及试模难度大和成本高的问题,研究了该水槽采用多道次拉深工艺时板料的变形规律,同时对其拉深工艺进行了优化。利用Dynaform有限元分析软件对薄壁水槽拉深一序、拉... 详细信息

为解决几何形状复杂且不对称及采用3次拉深工艺成形的薄壁水槽模具制造及试模难度大和成本高的问题,研究了该水槽采用多道次拉深工艺时板料的变形规律,同时对其拉深工艺进行了优化。利用Dynaform有限元分析软件对薄壁水槽拉深一序、拉深二序和拉深三序进行数值模拟分析,研究了关键工艺参数对成形结果的影响规律并得出最优的工艺参数,最后通过拉深实验对该工艺方案进行了验证。根据工艺优化方案,得出了最优工艺参数。拉深一序:从0 s至0.01 s,压边力恒定40 kN,从0.01 s至拉深结束,压边力从40 kN线性增长至500 kN;凸模、凹模、压边圈与板料之间的摩擦因数分别为0.2、0.05、0.05;模具间隙为0.66 mm。拉深二序:凸模、凹模、压边圈与板料之间的摩擦因数分别为0.15、0.1、0.1;压边力为500 kN。拉深三序:采用合适的拉深筋布置方式及阻力值。实验结果表明,在不同拉深工序中分别侧重调控不同拉深工艺参数可以有效控制薄壁水槽的减薄量。

关键词：数值模拟拉深薄壁结构工艺优化

基础隔震-外挂墙板减震钢筋混凝土框架振动台试验研究

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工程力学 2024年第7期41卷 176-185页

作者：种迅郭宇菲沙慧玲黄俊旗乐腾胜魏建鹏合肥工业大学土木与水利工程学院安徽合肥230009 安徽土木工程材料与结构省级重点实验室安徽合肥230009 安徽省建筑科学研究设计院绿色建筑与装配式建造安徽省重点实验室安徽合肥230031

该文提出一种新型的基础隔震-外挂墙板减震混合控制结构(简称“隔震-减震结构”)。该结构采用铅芯橡胶隔震支座作为基础隔震装置,上部结构则采用外挂墙板与U型金属消能器联合构成减震系统。通过减震与隔震混合控制,实现主体结构和围护... 详细信息

该文提出一种新型的基础隔震-外挂墙板减震混合控制结构(简称“隔震-减震结构”)。该结构采用铅芯橡胶隔震支座作为基础隔震装置,上部结构则采用外挂墙板与U型金属消能器联合构成减震系统。通过减震与隔震混合控制,实现主体结构和围护墙体在罕遇地震下不发生损伤,可用于对韧性性能要求较高的生命线工程中。为对比研究隔震-减震结构与传统隔震结构的抗震性能,设计制作了一个在两方向上完全一致的1/2缩尺基础隔震钢筋混凝土框架结构,并在Y方向附加外挂墙板和U型金属消能器,形成隔震-减震结构,X方向不含外挂墙板,为隔震结构。分别在两个方向输入单向地震动进行振动台试验,试验结果表明:相比隔震结构,隔震-减震结构能进一步降低结构在设防和罕遇地震下的位移响应;隔震-减震结构在罕遇地震下最大层间位移角小于或接近钢筋混凝土框架结构弹性层间位移角限值,主体结构保持弹性,外挂墙板未出现损伤,可以实现预期的性能目标。

关键词：基础隔震外挂墙板减震混合控制 U型金属消能器振动台试验抗震性能

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Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke

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Science China(Life Sciences) 2021年第9期64卷 1473-1480页

作者： fei Han Ding-Ding Zhang fei-fei Zhai jun Xue jiang-Tao Zhang Shuang yan Li-Xin Zhou jun ni Ming yao Meng yang Ming-Li Li Zheng-Yu jin qing Dai Shu-yang Zhang Li-Ying Cui Yi-Cheng Zhu Department of Neurology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Echocardiography China Emergency General HospitalBeijing 100730China Department of Ultrasound Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China

We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined *** the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were *** were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD ***-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid *** estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression *** a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic *** LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk *** multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke.

关键词： large artery stenosis cerebral small vessel disease ischemic stroke cohort study

Sudden sensorineural hearing loss(SSHL) following a local anesthetic dental procedure

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Journal of Otology 2019年第2期14卷 67-72页

作者： Yi Wang jun-Kai Cao Hui-Xin yang jin Feng qi-you Zhou fei ji Department of Stomotology General Hospital of the PLABeijing100853China Department of Otolaryngology General Hospital of the PLABeijing100853China Key Laboratory of Hearing Impairment Science(Chinese PLA Medical School) Ministry of EducationBeijing100853China Beijing Key Laboratory of Hearing Impairment Prevention and Treatment Laboratory of Military Acoustic Trauma ProtectionBeijing100853China

Acute sensorineural hearing loss is an uncommon phenomenon in *** describe the case of a 79-year-old male who presented with acute sensorineural hearing loss occurring 2 days after a tooth extraction procedure under local *** mechanisms are *** was treated with vasodilators(Ginaton and Alprostadil Injection)and Mecobalamin injection with *** dose oral steroids(1 mg/kg)and low molecular weight dextran were used.

关键词： Sudden sensorineural hearing loss Dental procedure Acute hearing loss

强化地板VOCs/VVOCs吸附管采样参数的优化

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中南林业科技大学学报 2024年第1期44卷 202-210页

作者：马郡鸿沈隽周萍齐飞郑德宗王晓东东北林业大学材料科学与工程学院黑龙江哈尔滨150040 哈尔滨国营松江胶合板厂有限公司黑龙江哈尔滨150300

【目的】为提高吸附管对挥发性有机化合物(VOCs)和易挥发性有机化合物(VVOCs)采样检测的准确性,对其采样条件和老化条件进行优化。【方法】试验将强化木质地板放入国产试验微舱中循环8 h,设置温度(23±1)℃、相对湿度(40±5)%的标准环境... 详细信息

【目的】为提高吸附管对挥发性有机化合物(VOCs)和易挥发性有机化合物(VVOCs)采样检测的准确性,对其采样条件和老化条件进行优化。【方法】试验将强化木质地板放入国产试验微舱中循环8 h,设置温度(23±1)℃、相对湿度(40±5)%的标准环境,分别使用Tenax TA吸附管和内填Carbopack C、Carbopack B、Carboxen 1000混合吸附剂的吸附管(简称CB-1000吸附管),控制不同的采样流量和采样体积,对舱内强化木质地板释放的气体进行采样,将采样后的吸附管放入气相色谱质谱联用仪(GC/MS)中进行检测。此外,对强化木质地板以150 mL·min^(-1)的采样流量采集2 L气体,用正交试验设计9种老化条件,对采样后的吸附管进行老化处理,使用GC/MS进行检测。【结果】两种吸附管采集到的气体成分中芳香族类占比最大,酯类占比最小。Tenax TA吸附管和CB-1000混合吸附管中总挥发性有机物(TVOC)与总易挥发性有机化合物(TVVOC)的采样质量浓度分别占总采样质量浓度的91.1%、8.9%和59.5%、40.5%。Tenax TA吸附管在老化时间为45 min、老化流量为100 mL·min^(-1)、老化温度为310℃时化合物的残留质量浓度为22.89μg·m^(-3),CB-1000混合吸附管在老化时间为45 min、老化流量为150 mL·min^(-1)、老化温度为350℃时化合物的残留质量浓度为27.16μg·m^(-3)。【结论】两种吸附管的建议采样条件为采样流量150 mL·min^(-1),采样体积2 L。Tenax TA吸附管适合检测VOCs,其采样浓度主要受采样体积影响。内填Carbopack C、Carbopack B、Carboxen 1000混合吸附剂的吸附管更适合检测VVOCs,其采样浓度主要受采样流量影响。Tenax TA吸附管建议的老化条件为老化时间45 min、老化流量100 mL·min^(-1)、老化温度310℃;CB-1000混合吸附管建议的老化条件为老化时间45 min、老化流量150 mL·min^(-1)、老化温度350℃。

关键词：采样条件老化条件挥发性有机化合物易挥发性有机化合物吸附管

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带孔扰流片核废液浓缩器强化换热数值研究

机械研究与应用 2024年第1期37卷 26-31页

作者：郭俊飞卿德藩倪浪白建军向立平南华大学机械工程学院湖南衡阳421001 南华大学核科学技术学院湖南衡阳421001

为提高核废液浓缩器的换热性能,并研究带孔扰流片螺旋板式换热器在核废液浓缩中的应用。文章采用周期流模型进行数值模拟,分析了不同带孔扰流片结构参数对换热器流动阻力和换热性能的影响。结果表明:增加扰流片长度或减小间距会增强流... 详细信息

为提高核废液浓缩器的换热性能,并研究带孔扰流片螺旋板式换热器在核废液浓缩中的应用。文章采用周期流模型进行数值模拟,分析了不同带孔扰流片结构参数对换热器流动阻力和换热性能的影响。结果表明:增加扰流片长度或减小间距会增强流道内的传热性能,带孔扰流片强化传热综合性能受扰流片长度变化的影响较小,扰流片间距对综合性能影响大;大孔结构会减小压降和换热系数,但综合换热性能更高。在片长60 mm、间距为100 mm、开孔直径13 mm的条件下,Re值为33238时综合性能评价系数达最大值E=0.89,Re大于49858时未开孔扰流片的综合性能更好。

关键词：带孔扰流片强化换热数值模拟周期流模型

经外侧裂-岛叶切除岛叶胶质瘤手术入路的显微解剖学研究

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局解手术学杂志 2024年第4期33卷 301-305页

作者：程进超王其福李陈荣军李廷政倪红斌南京医科大学鼓楼临床医学院南京鼓楼医院神经外科江苏南京210000 皖南医学院第一附属医院/弋矶山医院神经外科安徽芜湖241000 皖南医学院神经系统疾病转化医学中心安徽芜湖241000 安徽省马鞍山市人民医院神经外科安徽马鞍山243000 安徽省宣城市中心医院神经外科安徽宣城242000

目的通过尸头标本模拟经外侧裂-岛叶入路的相关解剖结构,为临床医师进行岛叶胶质瘤手术提供参考,从而在提高肿瘤全切率的同时能最大程度保护脑组织功能。方法在10例尸头标本上进行外侧裂、岛叶、大脑中动脉区域的解剖研究,拍照并观察... 详细信息

目的通过尸头标本模拟经外侧裂-岛叶入路的相关解剖结构,为临床医师进行岛叶胶质瘤手术提供参考,从而在提高肿瘤全切率的同时能最大程度保护脑组织功能。方法在10例尸头标本上进行外侧裂、岛叶、大脑中动脉区域的解剖研究,拍照并观察各重要结构的关系及测量相关参数。结果岛中央沟与大脑表面的中央沟相齐平,将岛叶分为前半部分和后半部分,前半部分为3~5个岛短回,后半部分由2个岛长回构成。岛叶前半部分被额下回三角部、盖部和中央前回覆盖;岛叶后半部分的上方被中央后回、缘上回覆盖,下方被赫氏勒回覆盖。岛叶被上纵束环绕,上纵束联系额颞顶枕叶,钩束在岛叶下方连接额叶和颞叶。经侧裂暴露到达上界沟区域、前岛点,额眶部至少需要牵拉2.0 cm,牵拉时要避免对Broca区的损伤。暴露岛叶下界沟则需要牵拉颞叶2.5 cm,牵拉压迫过程中应注意避免损伤颞横回。结论经外侧颞-岛叶入路可充分暴露岛叶,适合切除纯岛叶胶质瘤。对于其他类型岛叶胶质瘤,前岛点和前界沟位置容易暴露,后岛点及下界沟暴露更为困难。

关键词：岛叶岛盖外侧裂胶质瘤显微解剖

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