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Modern phenomics to empower holistic crop science, agronomy, and breeding research

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Journal of Genetics and Genomics 2024年第8期51卷 790-800页

作者： ni Jiang xin-Guang Zhu Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Center of Excellence for Molecular Plant Sciences Chinese Academy of SciencesShanghai 200032China

Crop phenomics enables the collection of diverse plant traits for a large number of samples along different time scales,representing a greater data collection throughput compared with traditional *** modern crop phenomics use different sensors to collect reflective,emitted,and fluorescence signals,etc.,from plant organs at different spatial and temporal *** multi-modal,high-dimensional data not only accelerates basic research on crop physiology,genetics,and whole plant systems modeling,but also supports the optimization of field agronomic practices,internal environments of plant factories,and ultimately crop *** challenges and opportunities facing the current crop phenomics research community include developing community consensus or standards for data collection,management,sharing,and processing,developing capabilities to measure physiological parameters,and enabling farmers and breeders to effectively use phenomics in the field to directly support agricultural production.

关键词： Crop phenomics High-throughput phenotyping Traits Crop designer breeding Agronomy

Adsorption Site and State of nitrogen Atom on Ru(0001),(1010) Low-index and (1120),(1121) Stepped Surfaces

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Chemical Research in Chinese Universities 2009年第5期25卷 705-710页

作者： DIAO Zhao-yu YU hai-yan WANG Zhong-ni ZHANG Xue-na WANG Ze-xin Department of Chemistry Shandong Normal University Jinan 250014 P. R. China

The adsorptions of nitrogen atoms on Ru（0001）, （1010） low index surfaces and （1120）, （1121） stepped surfaces were investigated by the five-parameter Morse potential（5-MP） method in details, Calculated results demonstrate that N atoms show a tendency to be adsorbed at threefold sites. No subsurface state was found for N atoms on Ru（1010） surface. There exist 6 stable adsorption sites for N atoms on Ru（1121） stepped surface which can be classified into 3 types： the on-surface adsorption state, the facet adsorption state and the subsurface state. Moreover, two new perpendicular vibrations at 97 and 98 meV are predicted. All calculated results are in good accord with HR-EELS experiments.

关键词： N-Ru system 5-MP Surface adsorption

The Evolution of Photospheric Current Density During an X9.3-Class Solar Flare

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Research in Astronomy and Astrophysics 2024年第10期24卷 189-200页

作者： hai-Li Li Hong-Fei Liang xin-Ping Zhou Yu Liu ni Meng Yu-Long Feng Department of Physics Yunnan Normal UniversityKunming 650500China State Key Laboratory of Space Weather Chinese Academy of SciencesBeijing 100190China College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610068China School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610068China

This paper deduced the temporal evolution of the magnetic field through a series of high-resolution vector magnetograms and calculated the fine distribution map of current density during an X9.3-class flare eruptions using Ampère's *** results show that a pair of conjugate current ribbons exist on both sides of the magnetic neutral line in this active region,and these conjugate current ribbons persist before,during,and after the *** was observed that the X9.3-class flare brightened in the form of a bright core and evolved into a double-ribbon flare over ***,the position of the double-ribbon flare matches the position of the current ribbons with high accuracy,and their morphologies are very *** investigating the complexity of current density and flare morphology,we discovered a potential connection between the eruption of major flares and the characteristics of current density.

关键词： Sun:activity Sun:magnetic fields Sun:flares methods:data analysis

The Challenge and promise of rare disease diagnosis in China

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Science China(Life Sciences) 2017年第7期60卷 681-685页

作者： xin ni Tieliu Shi Otolaryngology Head and Neck Surgery Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China The Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biology the Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai 200241 China

Rare diseases are chronic and serious,featuring early onset at birth or in childhood,rapid deterioration and high mortality rate,which creates a burden on society and public health *** the known rare diseases,80 percent are genetic in origin,and half of those affected worldwide are *** China,the rare disease patients are over 10 million,and70 percent of the patients are children(Song et al.,2012;Liu et al.,2010).

关键词： deterioration childhood burden children featuring promise birth mortality pediatric distinguished

New adaptive time step symplectic integrator:an application to the elliptic restricted three-body problem

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Research in Astronomy and Astrophysics 2014年第10期14卷 1329-1342页

作者： Xiao-Ting ni xin Wu Department of Physics Nanchang University

The time-transformed leapfrog scheme of Mikkola ＆ Aarseth was specifi- cally designed for a second-order differential equation with two individually separable forms of positions and velocities. It can have good numerical accuracy for extremely close two-body encounters in gravitating few-body systems with large mass ratios, but the non-time-transformed one does not work well. Following this idea, we develop a new explicit symplectic integrator with an adaptive time step that can be applied to a time-dependent Hamiltonian. Our method relies on a time step function having two distinct but equivalent forms and on the inclusion of two pairs of new canonical con- jugate variables in the extended phase space. In addition, the Hamiltonian must be modified to be a new time-transformed Hamiltonian with three integrable parts. When this method is applied to the elliptic restricted three-body problem, its numerical pre- cision is explicitly higher by several orders of magnitude than the nonadaptive one＇s, and its numerical stability is also better. In particular, it can eliminate the overestima- tion of Lyapunov exponents and suppress the spurious rapid growth of fast Lyapunov indicators for high-eccentricity orbits of a massless third body. The present technique will be useful for conservative systems including N-body problems in the Jacobian coordinates in the the field of solar system dynamics, and nonconservative systems such as a time-dependent barred galaxy model in a rotating coordinate system.

关键词： celestial mechanics -- methods numerical -- planetary systems --chaos

大内皮素-1评价特发性肺动脉高压严重程度和预后的研究

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中国分子心脏病学杂志 2009年第1期9卷 31-33页

作者：陶新曹倪新海柳志红何建国熊长明张健强刘峻豪北京协和医学院中国医学科学院阜外心血管病医院肺血管病诊治中心 100037

目的研究特发性肺动脉高压(IPAH)患者血浆大内皮素-1水平与肺动脉高压严重程度和预后的关系。方法回顾性分析2005年6月到2007年6月在阜外心血管病医院住院并诊断为IPAH的82名患者,并进行随访,统计采用SPSS13.0软件包。结果82名IPAH患者... 详细信息

目的研究特发性肺动脉高压(IPAH)患者血浆大内皮素-1水平与肺动脉高压严重程度和预后的关系。方法回顾性分析2005年6月到2007年6月在阜外心血管病医院住院并诊断为IPAH的82名患者,并进行随访,统计采用SPSS13.0软件包。结果82名IPAH患者平均随访(17.51±7.66)个月,随访到71例(86.6%),11例失访(13.4%),随访期间有21人(25.6%)死于右心衰竭,男性IPAH患者血浆大内皮素-1水平(1.77±1.76 fmol/ml)较女性(1.52±1.79fmol/ml)没有显著性差异(P=0.666)。以性别和年龄作为控制因素,偏相关分析结果显示IPAH患者血浆大内皮素-1水平与平均肺动脉压呈正相关(R=0.354,P=0.037),与动脉血氧分压不相关(R=0.058,P= 0.694)。单因素COX分析显示动脉血氧分压(P=0.015,RR=0.950)、血浆大内皮素-1(P=0.022,RR=1.281)和平均肺动脉压(P=0.004,RR=1.054)是影响IPAH患者生存的危险因素。多因素COX分析显示仅血浆大内皮素-1(P=0.037,RR=1.450)能预测IPAH患者的预后。结论男性和女性IPAH患者血浆大内皮素-1水平没有显著差异。血浆大内皮素-1与平均肺动脉压呈正相关,与动脉血氧分压不相关。血浆大内皮素-1是特发性肺动脉高压患者预后的独立预测因子,浓度越高,预后越差。

关键词：特发性肺动脉高压大内皮素-1 预后研究

冠心病患者血浆N-末端脑钠肽浓度与体重指数关系研究

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中国分子心脏病学杂志 2009年第6期9卷 353-356页

作者：冯莉浦介麟倪新海赵兴山孙华毅杨跃进中国医学科学院协和医科大学阜外心血管病医院心律失常诊治中心北京100037 北京积水潭医院北北京大学第四临床医学院心内科

目的肥胖是冠心病和心力衰竭发生的危险因素之一,近来有研究发现肥胖状态会影响血浆BNP和NT-proBNP浓度。本研究旨在探究N-末端脑钠肽(NT-proBNP)与体重指数(BMI)之间的关系;明确在冠心病人群中肥胖状态对NT-proBNP预测心力衰竭的影响... 详细信息

目的肥胖是冠心病和心力衰竭发生的危险因素之一,近来有研究发现肥胖状态会影响血浆BNP和NT-proBNP浓度。本研究旨在探究N-末端脑钠肽(NT-proBNP)与体重指数(BMI)之间的关系;明确在冠心病人群中肥胖状态对NT-proBNP预测心力衰竭的影响。方法选取2005年4月～2006年1月我院住院冠心病患者310例。记录一般临床情况,测量患者身高、体重。超声心动图测定左室射血分数(LVEF);ELISA法测定血浆和Nt-proBNP浓度。以BMI值将患者分为肥胖组(BMI≥28kg/m2)和非肥胖组(BMI<28kg/m2)。比较两组间Nt-proBNP浓度差异,描记LogNT-proBNP与BMI相关曲线。比较不同年龄性别亚组内肥胖对Nt-proBNP浓度的影响。结果肥胖组(210例)患者血浆NT-proBNP浓度明显低于非肥胖组(100例),分别为:627.42±418fmol/ml和1951.71±614fmol/ml(P=0.021)。且在不同年龄组、男性患者、合并高血压组和糖尿病组中肥胖者血浆NT-proB-NP浓度均低于非肥胖者(P<0.05)。BMI与LogNT-proBNP之间存在负相关关系(r=-0.327,P<0.001),两组患者血浆NT-proBNP浓度均随心功能下降而升高,组间差异有统计学意义。结论冠心病肥胖患者中血浆NT-proBNP浓度随BMI增加而降低。在应用NT-proBNP对冠心病患者进行心功能评价时应同时考虑肥胖因素对其产生的影响。

关键词：冠心病心力衰竭脑钠肽体重指数

Multi-verse optimizer based parameters decision with considering tool life in dry hobbing process

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Advances in Manufacturing 2021年第2期9卷 216-234页

作者： Heng-xin ni Chun-Ping Yan Shen-Fu ni Huan Shu Yu Zhang State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400030People’s Republic of China Hefei Meiya Photoelectric Technology Co.Ltd Hefei 230088People’s Republic of China

Dry hobbing has received extensive attention for its environmentally friendly processing *** to the absence of lubricants,hobbing process is highly dependent on process parameters combination since using unreasonable parameters tends to affect the machining ***,the consideration of tool life is frequently ignored in gear ***,to settle the above issues,a multiobjective parameters decision approach considering tool life is ***,detailed quantitative analysis between process parameters and hobbing performance,i.e.,machining time,production cost and tool life is ***,a multi-objective parameters decision-making model is constructed in search for optimum cutting parameters(cutting velocity v,axial feed rate f_(a))and hob parameters(hob diameter d_(0),threads z_(0)).Thirdly,a novel algorithm named multi-objective multi-verse optimizer(MOMVO)is utilized to solve the presented model.A case study is exhibited to show the feasibility and reliability of the proposed *** results reveal that(i)a balance can be achieved among machining time,production cost and tool life via appropriate process parameters determination;(ii)optimizing cutting parameters and hob parameters simultaneously contributes to optimal objectives;(iii)considering tool life provides usage precautions support and process parameters guidance for practical machining.

关键词： Process parameters Decision-making Tool life Dry hobbing Multi-objective multi-verse optimizer(MOMVO)

Offline Reinforcement Learning with Constrained Hybrid Action Implicit Representation Towards Wargaming Decision-Making

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Tsinghua Science and Technology 2024年第5期29卷 1422-1440页

作者： Liwei Dong ni Li Guanghong Gong xin Lin School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191ChinaState Key Laboratory of Virtual Reality Technology and SystemsBeihang UniversityBeijing 100191Chinaand also with Zhongguancun LaboratoryBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191Chinaand also with State Key Laboratory of Virtual Reality Technology and SystemsBeihang UniversityBeijing 100191China

Reinforcement Learning(RL)has emerged as a promising data-driven solution for wargaming ***,two domain challenges still exist:(1)dealing with discrete-continuous hybrid wargaming control and(2)accelerating RL deployment with rich offline *** RL methods fail to handle these two issues simultaneously,thereby we propose a novel offline RL method targeting hybrid action space.A new constrained action representation technique is developed to build a bidirectional mapping between the original hybrid action space and a latent space in a semantically consistent *** allows learning a continuous latent policy with offline RL with better exploration feasibility and scalability and reconstructing it back to a needed hybrid ***,a novel offline RL optimization objective with adaptively adjusted constraints is designed to balance the alleviation and generalization of out-of-distribution *** method demonstrates superior performance and generality across different tasks,particularly in typical realistic wargaming scenarios.

关键词： offline Reinforcement Learning(RL) wargaming decision-making hybrid action space