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Mechanotransduction of stem cells for tendon repair

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World Journal of Stem Cells 2020年第9期12卷 952-965页

作者： Hao-Nan Wang Yong-Can Huang Guo-xin ni School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina National and Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

Tendon is a mechanosensitive tissue that transmits force from muscle to *** loading contributes to maintaining the homeostasis and adaptation of tendon,but aberrant loading may lead to injury or failed *** is shown that stem cells respond to mechanical loading and play an essential role in both acute and chronic injuries,as well as in tendon *** the process of mechanotransduction,mechanical loading is detected by mechanosensors that regulate cell differentiation and proliferation via several signaling *** order to better understand the stem-cell response to mechanical stimulation and the potential mechanism of the tendon repair process,in this review,we summarize the source and role of endogenous and exogenous stem cells active in tendon repair,describe the mechanical response of stem cells,and finally,highlight the mechanotransduction process and underlying signaling pathways.

关键词： Stem cells Mechanical loading Tendon repair Mechanotransduction

Shaping polyploid wheat for success:Origins,domestication,and the genetic improvement of agronomic traits

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Journal of Integrative Plant Biology 2022年第2期64卷 536-563页

作者： Jie Liu Yingyin Yao Mingming xin Huiru Peng Zhongfu ni Qixin Sun State Key Laboratory for Agrobiotechnology Key Laboratory of Crop Heterosis and Utilizationthe Ministry of EducationKey Laboratory of Crop Genetic ImprovementNational Plant Gene Research CentreChina Agricultural UniversityBeijing100193 China

Bread wheat(Triticum aestivum L.,AABBDD,2 n=6 x=42),which accounts for most of the cultivated wheat crop worldwide,is a typical allohexaploid with a genome derived from three diploid wild *** wheat arose and evolved via two sequential allopolyploidization events and was further polished through multiple steps of ***,cultivated allohexaploid bread wheat has numerous advantageous traits,including adaptive plasticity,favorable yield traits,and extended end-use quality,which have enabled its cultivation well beyond the ranges of its tetraploid and diploid progenitors to become a global staple food *** the past decade,rapid advances in wheat genomic research have considerably accelerated our understanding of the bases for the shaping of complex agronomic traits in this polyploid ***,we summarize recent advances in characterizing major genetic factors underlying the origin,evolution,and improvement of polyploid *** end with a brief discussion of the future prospects for the design of gene cloning strategies and modern wheat breeding.

关键词： adaptation bread wheat domestication end-use quality photoperiod response polyploid semi-dwarfing breeding vernalization

Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui ni Chuan-xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

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钙磷生物陶瓷支架的常温自强式3D打印技术与工艺研究

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陕西科技大学学报 2025年第1期43卷 126-135页

作者：贾倩倩赵雪妮袁海泉李玲娜石国文朱智鹏刘朝阳谷泽鑫陕西科技大学机电工程学院陕西西安710021

在常温不添加高分子聚合物粘接剂的情况下,首次研发了自强式钙磷生物陶瓷的无需高温后处理的3D打印成型技术与工艺.通过材料表征、孔隙率、力学性能测试和降解性测试对不同配比和不同打印间距的支架进行研究.结果表明,随着HA含量从70 w... 详细信息

在常温不添加高分子聚合物粘接剂的情况下,首次研发了自强式钙磷生物陶瓷的无需高温后处理的3D打印成型技术与工艺.通过材料表征、孔隙率、力学性能测试和降解性测试对不同配比和不同打印间距的支架进行研究.结果表明,随着HA含量从70 wt.%减小至50 wt.%,浆料粘度与打印成型性变差,孔隙尺寸减小,而60 wt.%HA含量浆料具有良好的打印成型性,所打印的支架结构稳定、均匀.压缩强度随着HA含量的减少而增大,60 wt.%和50 wt.%含量的HA打印的钙磷生物陶瓷支架压缩强度分别为3.61±0.194 MPa(0.6-HTC)和5.28±0.629 MPa(0.5-HTC),能够匹配松质骨的要求.此外,随着打印间距(1 mm、2 mm和4 mm)的增加,支架的压缩强度也随之降低.随着HA含量的增加,钙磷生物陶瓷支架的孔隙率先增大后减小.60 wt.%HA含量的支架孔隙率最大(51.4%),降解性能优异,且降解后能保持完整性.此创新的3D打印技术能够根据临床手术现场患者实际植入部位结构尺寸要求直接打印并调整支架结构和形状,具有极大的应用前景.

关键词： 3D打印钙磷生物陶瓷支架力学性能生物降解性

Partial Order in Potts Models on the Generalized Decorated Square Lattice

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Chinese Physics Letters 2013年第7期30卷 152-156页

作者： QIN Ming-Pu CHEN Jing CHEN Qiao-ni XIE Zhi-Yuan KONG xin ZHAO Hui-hai Bruce Normand XIANG Tao Institute of Physics Chinese Academy of SciencesBeijing 100190 Department of Chemistry Frick LaboratoryPrinceton UniversityPrincetonNew Jersey 08544USA Department of Physics Renmin University of ChinaBeijing 100872

We explore the Potts model on the generalized decorated square lattice,with both nearest(J1)and next-nearest(J2)neighbor *** the tensor renormalization-group method augmented by higher order singular value decompositions,we calculate the spontaneous magnetization of the Potts model with q=2,3,and *** results for q=2 allow us to benchmark our numerics using the exact *** q=3,we find a highly degenerate ground state with partial order on a single sublattice,but with vanishing entropy per site,and we obtain the phase diagram as a function of the ratio J2/*** is no finite-temperature transition for the q=4 case when J1=J2,whereas the magnetic susceptibility diverges as the temperature goes to zero,showing that the model is critical at T=0.

关键词： solution. degenerate magnetization

Tunable Metamorphic Resonant Cavity Enhanced InGaAs Photodetectors Grown on GaAs Substrates

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Chinese Physics Letters 2012年第3期29卷 251-254页

作者： LIU Shao-Qing HAN Qin ZHU Bin YANG Xiao-Hong ni hai-Qiao HE Ji-Fang WANG xin niU Zhi-Chuan State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesP.O.Box 912Beijing 100083 State Key Laboratory for Superlattices and microstructures Institute of SemiconductorsChinese Academy of SciencesP.O.Box 912Beijing 100083

Tunable metamorphic InGaAs partially depleted absorber photodiodes with resonant cavity enhanced structure are fabricated on GaAs ***-current densities of 7.2×10^(-7)A/cm^(2) at 0 V and 3.6×10^(-4)A/cm^(2) at-5 V,a high quantum efficiency of 74.4%at 1546nm,and a 3-dB bandwidth up to 12GHz are *** full width at half maximum of the detector is about ***,through thermal tuning,the peak wavelength red shifts from 1527nm to 1544 nm,and a tuning range of 17nm is realized without fabricating extra tuning electrodes.

关键词： tuning Tunable absorber

A statistical analysis of the Kappa-type energy spectrum distribution of radiation belt electrons observed by Van Allen Probes

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Earth and Planetary Physics 2024年第2期8卷 368-374页

作者： LuHuai Jiao xin Ma YuanNong Zhang TaiFeng Jin Song Fu BinBin ni Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072China

The energy spectrum of energetic electrons is a key factor representing the dynamic variations of Earth’s Van Allen radiation *** measurements have indicated that the commonly used Maxwellian and Kappa distributions are inadequate for capturing the realistic spectral distributions of radiation belt *** we adopt the Kappa-type(KT)distribution as the fitting function and perform a statistical analysis to investigate the radiation belt electron flux spectra observed by the Van Allen *** calculating the optimal values of the key KT distribution parameters(i.e.,κandθ2)from the observed spectral shapes,we fit the radiation belt electron fluxes at different L-shells under different geomagnetic *** this manner,we obtain typical values of the KT distribution parameters,which are statistically feasible for modeling the radiation belt electron flux profiles during either geomagnetically quiet or active periods.A comparison of the KT distribution model results with those using the Maxwellian or Kappa distribution reveals the advantage of the KT distribution for studying the overall properties of the radiation belt electron spectral distribution,which has important implications for deepening the current understanding of the radiation belt electron dynamics under evolving geomagnetic conditions.

关键词： radiation belt electron Kappa-type distribution fitting geomagnetic storm

Artificial modification of Earth's radiation belts by ground-based very-low-frequency(VLF)transmitters

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Science China Earth Sciences 2022年第3期65卷 391-413页

作者： Binbin ni Man HUA Xudong GU Song FU Zheng XIANG xing CAO xin MA Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China

Wave-particle interactions play a fundamental role in the dynamic variability of Earth’s donut-shaped radiation belts that are highly populated by magnetically trapped energetic particles and characteristically separated by the slot devoid of high energetic *** to the continuous accumulation of high-quality wave and particle measurements from multiple satellites in geospace,the important contribution of ground-based very-low-frequency(VLF)transmitter waves to the electron dynamics in the near-Earth space has been unprecedently advanced,in addition to those established findings of the significant effects of a variety of naturally occurring magnetospheric *** paper focuses on the artificial modification of Earth’s inner radiation belt and slot by artificial VLF transmitter *** review the global distributions of VLF transmitter waves in geospace,their scattering effects on radiation belt electrons in terms of both theoretical and observational analyses,and diffusion simulation results of wave-particle interactions along with data-model *** start with a brief review of the radiation belt electron dynamics and an introduction of anthropogenic VLF transmitter ***,we review the global morphology of in situ VLF transmitter waves corresponding to different transmitter locations,including their day-night asymmetry,geographic distributions,seasonal and geomagnetic activity dependence,and wave propagation *** theoretical and observational analyses of electron scattering effects by VLF transmitter waves are then reviewed to approach the underlying physics that can modulate the spatio-temporal variations of the electron radiation *** Fokker-Planck electron diffusion simulations and their comparisons with realistic satellite observations clearly indicate that VLF transmitter emissions can effectively remove energetic electrons to produce a radially bifurcated electron belt,thereby quantitatively confirmin

关键词： VLF transmitters Wave-particle interactions Electron precipitation Earth’s radiation belts Flux bifurcation

Mechanisms of Electroacupuncture on Alzheimer's Disease: A Review of Animal Studies

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Chinese Journal of Integrative Medicine 2020年第6期26卷 473-480页

作者： SONG Yang-yang XU Wen-tao ZHANG xin-chang ni Guang-xia College of Acupuncture and Massage College of Regimen and RehabilitationNanjing University of Traditional Chinese MedicineNanjing(210023)China

Alzheimer's disease(AD)is the main type of dementia affecting elderly *** medicines used for treating AD have limits in their ability to alleviate cognitive and functional ***(EA),an economical alternative and complementary therapeutic measure used in Chinese medicine,has strong clinical applicability,and its treatment effects are more reliable as its stimulation factors can be *** has been effectively used for ameliorating spatial learning and memory impairment in AD patients and rodent AD ***,we summarized the mechanisms of EA on rodent AD models,aiming to provide a theoretical basis for identifying new targets and research directions,and exploring appropriate EA stimulation parameters,then provide a detailed methodology to optimize the effects of EA,ultimately reducing the heavy burden of treating AD patients on families and *** review showed that 8 acupoints were used when treating AD animals;Baihui(GV 20)was the most frequently *** mechanisms of EA were studied:(1)protection of cerebral neurons from oxidative stress,apoptosis,neuroinflammation,synaptic plasticity and hormone levels;(2)regulation of metabolism,including glucose metabolism and plasma metabolism;(3)regulation of brain derived neurotrophic factor;and(4)regulation of β-amyloid peptide protein deposition.

关键词： mechanism electroacupuncture Alzheimer's disease Chinese medicine