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Hybrid magnetic resonance and optoacoustic tomography(MROT) for preclinical neuroimaging

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Light(Science & Applications) 2022年第12期11卷 2961-2971页

作者： Zhenyue Chen Irmak Gezginer Mark-Aurel Augath Wuwei Ren Yu-Hang Liu ruiqing ni Xose Luis Dean-Ben Daniel Razansky Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology Faculty of MedicineUniversity of ZurichZurichSwitzerland Institute for Biomedical Engineering Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland Zurich Neuroscience Center(ZNZ) ZurichSwitzerland

Multi-modal imaging is essential for advancing our understanding of brain function and unraveling pathophysiological processes underlying neurological and psychiatric *** resonance(MR)and optoacoustic(OA)imaging have been shown to provide highly complementary contrasts and capabilities for preclinical *** integration between these modalities can thus offer unprecedented capabilities for studying the rodent brain in *** report on a hybrid magnetic resonance and optoacoustic tomography(MROT)system for concurrent noninvasive structural and functional imaging of the mouse *** OA tomography was designed as an insert into a high-field MR scanner by integrating a customized MR-compatible spherical transducer array,an illumination module,and a dedicated radiofrequency coil.A tailored data processing pipeline has been developed to mitigate signal crosstalk and accurately register image volumes acquired with T1-weighted,angiography,and blood oxygenation level-dependent(BOLD)sequences onto the corresponding vascular and oxygenation data recorded with the OA *** demonstrate the concurrent acquisition of dual-mode anatomical and angiographic brain images with the scanner,as well as real-time functional readings of multiple hemodynamic parameters from animals subjected to oxygenation *** approach combines the functional and molecular imaging advantages of OA with the superb soft-tissue contrast of MR,further providing an excellent platform for cross-validation of functional readings by the two modalities.

关键词： scanner resonance illumination

Quercetin exhibits neuroprotective effect by reducing amyloid precursor protein expression and oxidative stress in Neuro2a/APPswe cell model

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中国药理学与毒理学杂志 2023年第7期37卷 520-520页

作者： TANG Zhi GUO Min PENG Yaqian ZHANG Ting XIAO Yan ni ruiqing QI Xiaolan Key Laboratory of Endemic and Ethnic Diseases Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province Guizhou Medical University Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry Institute for Regenerative Medicine University of Zurich Institute for Biomedical Engineering ETH Zurich and University of Zurich

OBJECTIVE The abnormal amyloid-β(Aβ)and oxidative stress assiociated with the progression of Alzheimer disease(AD). Quercetin has been reported to possess antioxidant and anti-inflammatory properties in neurodegenerative disorders. In this present study, we designed to characterize the mechanisms by which quercetin exerts neuroprotective effects in murine neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein(N2a/APP). METHODS N2a/APP cells were treated with quercetin at concentrations of 10, 20 and 50 μmol · L-1for 24 h. Cell viability was examined with CCK-8 assays. The protein levels of ERK1/2 and Akt were detected by Western blotting. Intracellular reactive oxygen species(ROS) was detected by a fluorescent probe 2, 7-dichlorofluorescein diacetate(DCFH-DA). The mitochondrial membrane potential( Δψ m) in N2a/APP cells was detected by using JC-1staining method. Immunofluorescence was used to detect the generation of 8-hydroxy-2′-deoxyguanosine(8-OHdG)and 4-hydroxynonenal(4-HNE). RESULTS Quercetin attenuated the enhancement of p-ERK1/2, reductions of p-Akt, and decreased levels of APP expression. Moreover, quercetin alleviated loss of mitochondria membrane potential(MMP) since it attenuates these oxidative stress, as reflected in the levels of ROS, 4-HNE and 8-OHdG, was elevated in N2a/APP cells and these effects were again ameliorated by quercetin. CONCLUSION Neuroprotection by quercetin in N2a/APP cells involves normalizing the impaired mitochondrial function and reducing oxidative stress via inactivation of the ERK1/2and activation of the Akt pathways.

关键词：

人参内生可培养细菌16S rDNA-RFLP分析

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东北林业大学学报 2012年第8期40卷 34-39页

作者：姜云尹望陈长卿倪瑞卿吉林农业大学长春130118

以我国吉林省5个不同地区来源的健康人参植株为实验材料,分别从根茎叶不同器官分离获得了152株内生细菌,利用HhaⅠ、HinfⅠ和HaeⅢ3种限制性内切酶对所有供试菌株的16 S rDNA片段进行了RFLP分析。聚类分析结果表明,供试菌株在相似性为83... 详细信息

以我国吉林省5个不同地区来源的健康人参植株为实验材料,分别从根茎叶不同器官分离获得了152株内生细菌,利用HhaⅠ、HinfⅠ和HaeⅢ3种限制性内切酶对所有供试菌株的16 S rDNA片段进行了RFLP分析。聚类分析结果表明,供试菌株在相似性为83%水平上可分为18个类群,不同地区内生细菌的遗传多样性存在差异,其中抚松县和吉林农业大学的菌株多样性较高;不同器官蕴含的菌株数目也存在差异,茎部和根部蕴含菌株较为丰富。研究结果期望为了解人参内生细菌的种群结构,明确菌株种类奠定基础。

关键词：人参内生细菌 16 S rDNA—RFLP 多样性

基于PCA-APCS-MLR模型的西藏扎西岗湿地土壤重金属风险评价及来源解析

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生态学杂志 2024年第6期43卷 1807-1816页

作者：杨崛园熊健李伟黄瑞卿杨博谢鹏程西藏大学生态环境学院拉萨850000

扎西岗湿地是典型的高原草甸沼泽湿地,也是拉萨市重要的生态功能保护区。西藏特殊的气候与地形造成湿地生态环境极其脆弱,因此对西藏湿地的研究尤为重要。为准确评估扎西岗湿地土壤中重金属的污染现状及解析污染源,采集扎西岗湿地18个... 详细信息

扎西岗湿地是典型的高原草甸沼泽湿地,也是拉萨市重要的生态功能保护区。西藏特殊的气候与地形造成湿地生态环境极其脆弱,因此对西藏湿地的研究尤为重要。为准确评估扎西岗湿地土壤中重金属的污染现状及解析污染源,采集扎西岗湿地18个表层土壤样品,分析Cr、ni、Zn、Pb、Cd、As和Hg 7种重金属元素的含量,利用地累积指数(Igeo)和污染负荷指数(PLI)法评价污染情况,基于PCA分析,结合APCS-MLR模型,解析重金属的污染来源。结果表明:(1)扎西岗湿地表层土壤中Cr和ni含量均低于西藏土壤背景值,其余5种重金属含量都存在不同程度的累积;与《土壤环境质量农用地土壤污染风险管控标准(GB 15618—2018)》的风险筛选值相比,除Cd和As有一定程度超标外,其他5种元素的测定值均未超标。(2)地累积指数表明,除Cd和Hg外,其他5种元素污染等级均为清洁(Igeoni、Zn、Pb、Cd和As主要来源于工业-交通混合源,Cr主要来源为自然源,Hg的来源主要受农业和燃煤等人类活动的影响。

关键词：扎西岗湿地沉积物重金属污染评价绝对主成分得分-多元线性回归模型

矮砧密植红富士苹果树体矿质营养动态及需求特征

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中国果树 2024年第7期 47-57页

作者：王双王琛倪玉雪李艳杰杨睿晴张丽娟河北农业大学资源与环境科学学院河北省城市森林健康技术创新中心保定071000 邢台市信都区农业农村局土肥站北京绿氮生物科技有限公司

2021年,在河北省保定市唐县丹凤山苹果种植基地,动态监测矮砧密植苹果不同器官各时期N、P、K、Ca、Mg、Fe、Mn、Cu、Zn、B元素的变化和累积规律,分析矮砧密植苹果营养元素需求特性。结果表明:整个生长季内,叶片中的氮、磷、钾呈不同程... 详细信息

2021年,在河北省保定市唐县丹凤山苹果种植基地,动态监测矮砧密植苹果不同器官各时期N、P、K、Ca、Mg、Fe、Mn、Cu、Zn、B元素的变化和累积规律,分析矮砧密植苹果营养元素需求特性。结果表明:整个生长季内,叶片中的氮、磷、钾呈不同程度的降低趋势,钙和镁含量增加,其中镁波动较大但整体呈增加趋势;铁、锰、铜、锌和硼在叶、枝、干和根中均在前期含量高,铁、铜和硼在后期低,锰和锌则是在中期含量低;果实中氮、磷、铁、锰、锌和硼均呈现前期高、后期低,铜和钙在中期含量较高,镁变化较平稳,钾则呈逐渐升高的趋势。单位产量常量元素N、P、K、Ca、Mg需求比例是1.00∶0.17∶1.88∶0.75∶0.25,微量元素Fe、Mn、Cu、Zn、B需求比例为1.00∶0.66∶0.44∶0.20∶0.46。生产1000 kg果实,盛果期矮砧密植富士苹果营养元素需求为氮1.32 kg、磷0.23 kg、钾2.48 kg、钙0.99 kg、镁0.33 kg、铁14.44 g、锰9.56 g、铜6.40 g、锌2.82 g、硼6.59 g。研究认为,苹果树生长前期对氮需求较高,磷、钾累积量逐渐上升,微量元素利用树体贮存的营养且消耗较少,中期对氮需求量相对减少而对磷、钾和微量元素的需求增强;基施应以氮肥为主,追施磷、钾肥,中后期补充钙、镁肥,适时适量补充微量元素。

关键词：苹果红富士矮砧密植矿质营养变化规律需求

Highly sensitive hybrid nanofiber-based room-temperature CO sensors： Experiments and density functional theory simulations

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Nano Research 2018年第2期11卷 1029-1037页

作者： Lili Wang ruiqing Chai Zheng Lou Guozhen Shen State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun China State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing China College of Materials Science and Opto-electronic Technology University of Chinese Academy of Sciences Beijing China

Chemical sensors （CSs） are an emerging area in nanoscience research, which focuses on the highly sensitive detection of toxic and hazardous gases and disease- related volatile organics. While the field has advanced rapidly in recent years, it lacks the theoretical support required for the rational design of innovative materials with tunable measurement responses. Herein, we present a one-dimensional （1D） hybrid nanofiber decorated with ultrafine niO nanoparticles （niO NPs） as an efficient active component for CSs. Highly dispersed （110）-facet niO NPs with a high percentage of ni2~ active sites with unsaturated coordination were confined in a TiO2 nanofiber （TiO2 NF） matrix that is favorable for surface catalytic reactions. The CSs constructed using the 1D heterostructure niO/TiO2 nanofibers （niOdrio2 HNFs） exhibited a highly selective response to trace CO gas molecules （1 ppm） with high sensitivity （AR/Ro = 1.02）, ultrafast response/ recovery time （T 〈 20 s）, and remarkable reproducibility at room tem- perature. The density functional theory （DFT） simulations and experimental results confirmed that the selective response could be attributed to the high molecular adsorption energy of the niO nanoparticles with （110） facets and abundant interfaces, which act synergistically to promote CO adsorption and facilitate charge transfer.

关键词： hybrid nanofiber high active facet gas sensor selectivity highly sensitive density functional theory

PanGu Drug Model: learn a molecule like a human

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Science China(Life Sciences) 2023年第4期66卷 879-882页

作者： Xinyuan Lin Chi Xu Zhaoping Xiong Xinfeng Zhang ningxi ni Bolin ni Jianlong Chang ruiqing Pan Zidong Wang Fan Yu Qi Tian Hualiang Jiang Mingyue Zheng Nan Qiao Laboratory of Health Intelligence Huawei Cloud Computing Technologies Co.LtdGuizhou 550025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Dear Editor,Recent achievements in large-scale pre-trained models like GPT-3 and PanGu-α have demonstrated astounding performances in many downstream tasks of natural language processing (NLP),confirming AI to be user-oriented for even industrial *** learning has been recognized as the most promising technology for pharmaceuticals,a powerful molecule pre-trained model that could economize researchers’tons of *** the strategic application of AI capabilities to the drug discovery field,we pre-trained a model called PanGu Drug Model with 1.7 billion small molecules from ZINC20 (Irwin et al.,2020),DrugSpaceX(Yang et al.,2021),and UniChem (Chambers et al.,2013).

关键词： fir trained strategic

基于蒙特卡罗模拟的拉萨城区土壤重金属健康风险评价

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环境化学 2024年第4期43卷 1339-1352页

作者：杨博熊健李伟谢鹏程杨崛园黄瑞卿吕学斌西藏大学生态环境学院拉萨850000 天津大学环境科学与工程学院天津300000

由于城市化的快速发展,城区土壤中重金属(HMs)的污染问题,目前已成为环境和人类健康风险的主要问题之一.为科学地评价城区土壤重金属的健康风险,降低评价结果的不确定性,研究以拉萨城区土壤为研究对象,将蒙特卡罗模拟引入USEPA模型,构... 详细信息

由于城市化的快速发展,城区土壤中重金属(HMs)的污染问题,目前已成为环境和人类健康风险的主要问题之一.为科学地评价城区土壤重金属的健康风险,降低评价结果的不确定性,研究以拉萨城区土壤为研究对象,将蒙特卡罗模拟引入USEPA模型,构建了土壤重金属不确定性健康风险评价模型.研究表明,拉萨城区表层土壤中Cu、Zn、Cr、ni、Pb、Cd、As、Hg的含量均值分别为20.25、66.07、35.90、17.35、22.70、0.10、25.64、0.07 mg·kg^(−1).除As和Zn外,均未超过拉萨市土壤背景值,污染负荷指数(PLI_(zone))为0.83,整体为无污染水平.健康风险评价结果表明,拉萨城区表层土壤中,HMs对儿童和成人的总致癌风险(TCR)分别为1.30×10^(−5)—7.60×10^(−5)和1.03×10^(−5)—8.15×10^(−5),处于可接受水平;总非致癌风险(HI)分别为1.82×10^(−1)—1.27和3.91×10^(−2)—3.57×10^(−1),成人均处于可接受水平,但儿童可能存在3.61%的概率高于风险阈值;其中As是最主要的风险元素,皮肤接触和经口摄入分别是成人和儿童的主要暴露途径,皮肤黏附系数和体重分别是成人和儿童的主要影响参数.该模型可有效的降低健康风险评价中的不确定性,更加精确地反映区域健康风险状况,并能获取优先控制因子和暴露途径等信息.

关键词：蒙特卡罗模拟拉萨城区土壤重金属健康风险评价

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特提斯喜马拉雅中新世煌斑岩的成因及构造意义

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地质科学 2024年第4期59卷 853-869页

作者：孙敏佳魏震刘晓强刘桂萍宫相宽郭瑞清新疆大学地质与矿业工程学院乌鲁木齐830017 新疆中亚造山带大陆动力学与成矿预测自治区重点实验室乌鲁木齐830017 南京大学内生金属矿床成矿机制研究国家重点实验室南京210046

后碰撞幔源岩浆是示踪深部地球动力学和地幔动力学过程的最直接指针。印度-亚洲碰撞缝合带南侧特提斯喜马拉雅中-新生代地层中发现了规模可观的煌斑岩岩墙群,锆石U-Pb定年结果显示其整体侵位时代介于15~10 Ma。煌斑岩具有中等的SiO_(2)... 详细信息

后碰撞幔源岩浆是示踪深部地球动力学和地幔动力学过程的最直接指针。印度-亚洲碰撞缝合带南侧特提斯喜马拉雅中-新生代地层中发现了规模可观的煌斑岩岩墙群,锆石U-Pb定年结果显示其整体侵位时代介于15~10 Ma。煌斑岩具有中等的SiO_(2)含量(50.0%~52.9%),较高的K_(2)O(2.30%~4.77%)和Na_(2)O含量(3.04%~4.23%),属于钙碱性煌斑岩。其高MgO含量(5.64%~7.63%)和Mg^(#)值(70~74)以及高Cr(363×10^(-6)~465×10^(-6))、Co(24.7×10^(-6)~31.2×10^(-6))、ni(128×10^(-6)~269×10^(-6))等过渡族元素丰度,显示显著的幔源岩石特征,未受明显地壳混染。煌斑岩富含大离子亲石元素、轻稀土元素(Th、U、Ba、Pb、Nd),贫高场强元素和重稀土元素(Nb、Ta、Ti),来源于与俯冲作用有关的富集岩石圈地幔,是在石榴石稳定域含金云母二辉橄榄岩低程度部分熔融的产物。岩墙群呈东西向平行展布,指示该区域中新世处于南北向伸展背景,可能是撕裂的印度大陆岩石圈板片局部地区发生断离,软流圈上涌,导致富集印度岩石圈地幔源区部分熔融的产物。

关键词：特提斯喜马拉雅中新世煌斑岩地球化学