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High-throughput and simultaneous inertial separation of tumor cells and clusters from malignant effusions using spiral-contraction-expansion channels

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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui ren Dan Wu Zhonghua ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-2.1} tumor cells were recovered at a high flow rate of 3.00µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

Multi-Fidelity Simulation of Gas Turbine Overall Performance by Directly Coupling High-Fidelity Models of Multiple Rotating Components

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Journal of Thermal Science 2024年第4期33卷 1357-1378页

作者： DENG Weimin XU Yibing ni Ming WEI Zuojun GAN Xiaohua ren Guangming department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055China School of Aerospace Engineering Tsinghua UniversityBeijing100084China Shenzhen Key Laboratory of Wide-Speed-Range and Variable-Density Continuous Wind Tunnel Shenzhen Science and Technology Innovation CommitteeShenzhen518000China

Multi-fidelity simulations incorporate computational fluid dynamics(CFD) models into a thermodynamic model,enabling the simulation of the overall performance of an entire gas turbine with high-fidelity *** iterative coupled methods rely on characteristic maps,while fully coupled methods directly incorporate high-fidelity ***,fully coupled methods face challenges in simulating rotating components,including weak convergence and complex *** address these challenges,a fully coupled method with logarithmic transformations was developed to directly integrate high-fidelity CFD models of multiple rotating *** developed fully coupled method was then applied to evaluate the overall performance of a KJ66 micro gas turbine across various off-design *** developed fully coupled method was also compared with the traditional iterative coupled ***,experimental data from ground tests were conducted to verify its *** convergence history indicated that the proposed fully coupled method exhibited stable convergence,even under far-off-design *** experimental verification demonstrated that the multi-fidelity simulation with the fully coupled method achieved high accuracy in off-design *** analysis revealed inherent differences in the coupling methods of CFD models between the developed fully coupled and traditional iterative coupled *** inherent differences provide valuable insights for reducing errors between the component-level model and CFD models in different coupling *** developed fully coupled method,introducing logarithmic transformations,offers more realistic support for the detailed and optimal design of high-fidelity rotating components within the overall performance platform of gas turbines.

关键词： multi-fidelity fully coupled method iterative coupled method gas turbine component-level model

Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro

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World Journal of Stem Cells 2024年第2期16卷 163-175页

作者： Yan ren Yan-ni Cui Hong-Wei Wang The Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina department of Hematology Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital ***(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD{2.^(+)CD{2.)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD{2.^(+)CD{2.CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD{2.^(+)CD{2.CD45RACD49f^(+)CD90^(+))is not yet *** a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and ***,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or *** propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of *** To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and *** CD{2.^(+)cells were purified from umbilical cord blood using MacsCD{2. beads,and cultured for 10-12.d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental *** cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured ***-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant ***-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead *** Compared with the control group,the proportion and expansion folds of HSPCs(CD{2.^(+)CD{2.)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all Pnificantly

关键词： Hematopoietic stem cells nicotinamide Concentration Proliferation Differentiation Sirtuin 1

Half-lives and fine structure for the α decay of deformed even-even nuclei

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 24-31页

作者： ni dongdong1,2.& ren zhongzhou1,{2. of Physics,{3., nanjing 2.0093. China 2.avli Institute for Theoretical Physics China, Beijing 100190, China 3.enter of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator, Lanzhou 73.000, China nanjing Univ Dept Phys Nanjing 210093 Jiangsu Peoples R China Kavli Inst Theoret Phys China Beijing 100190 Peoples R China Ctr Theoret Nucl Phys Natl Lab Heavy Ion Accelerator Lanzhou 730000 Peoples R China

The α-decay properties of well-deformed even-even nuclei are systematically calculated within the multichannel cluster model (MCCM). Instead of working in the WKB framework, the quasibound solution to the coupled Schro¨dinger equation is presented with outgoing wave boundary conditions, and the coupling potential is taken into full account in terms of the general quantum theories. The calculated α-decay half-lives are found to agree well with the experimental data with a mean factor of less than 2. The fine structure observed in α decay is also well reproduced by the four-channel microscopic calculation. Very strikingly, the MCCM can give relatively precise descriptions of the branching ratio to excited 4+ states, which is often overestimated in the usual WKB calculations. We expect it to be a significant development of theoretical models toward quantitative descriptions of α transitions to high-spin daughter states.

关键词： α decay half-lives cluster model coupled channel approach

Probing proton halo of the exotic nucleus ^(2.)S by elastic electron scattering

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Science China(Physics,Mechanics & Astronomy) 2004年第1期47卷 42-51页

作者： WANG Zaijun1 & ren zhongzhou1’2.1. {2. of Physics,{3., nanjing 2.0008, China 2. Center of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator at Lanzhou, Lanzhou 73.000, China Correspondence should be addressed to ren zhongzhou (email: zren@*** zren99@***) Received June 16, 2.03 1. department of Physics Nanjing University 210008 Nanjing China 2. Center of Theoretical Nuclear Physics National Laboratory of Heavy-Ion Accelerator at Lanzhou 730000 Lanzhou China

Elastic electron scattering on the exotic light nucleus 2.S is investigated in the plane wave Born approximation. The variation of the squared form factors of 2.S with momentum transfer is compared with that of 3.S. It is found that the behavior of the form factors near the second minimum (with a moderate momentum transfer) is sensitive to the alteration of the charge density distribution of halo protons in 2.S. This indicates that elastic electron scattering can be a good probe of the structure of proton-halo nuclei.

关键词： elastic electron scattering, cross section, form factor, proton-halo nucleus.

Semitransparent organic solar cells with high light utilization efficiency and color rendering index

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Science China Chemistry 2024年第7期67卷 2248-2256页

作者： ni Gao Haijun Bin Shangrong Wu renéA.J.Janssen Yongfang Li Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123China Molecular Materials and Nanosystems&Institute for Complex Molecular Systems Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands

Semitransparent organic solar cells(ST-OSCs)have garnered considerable attention as promising renewable energy technology for integrating photovoltaics into ***,there is a trade-off between power conversion efficiency(PCE)and average visible transmittance(AVT),which hinders the achievement of a high light utilization efficiency(LUE).In this study,we propose a valuable method to address this challenge by replacing the transparent top electrode,Ag,with a 2. nm layer of *** ST-OSCs based on the 2. nm Au electrode demonstrate superior exciton extraction,more efficient charge collection,and higher color-rendering index(CRI)due to their smoother surface,higher conductivity,and enhanced visible light transmittance,resulting in a significantly higher PCE of 13.67%and an enhanced AVT of 3..17%,contributing to a high LUE of 4.15%.Additionally,optically transparent dielectric layers,applied on the front and back sides of the ST-OSCs to further boost performance,delivered an impressive LUE of 4.93.,with PCE and AVT values reaching 14.44%and 3..12.,***,the champion ST-OSCs also exhibited a favorable CRI value of *** achievements represent the bestperforming ST-OSCs to date with both high LUE and CRI and hold significant implications for the prospective commercialization of ST-OSCs.

关键词： semitransparent organic solar cells power conversion efficiency average visible transmittance light utilization efficiency color-rendering index

Recent progress in MnBi2.Te3.+1 intrinsic magnetic topological insulators: crystal growth, magnetism and chemical disorder

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National Science Review 2024年第2期11卷 65-80页

作者： Chaowei Hu Tiema Qian ni ni department of Physics and Astronomy and California Nano Systems Institute University of California-Los Angeles

The search for magnetic topological materials has been at the forefront of condensed matter research for their potential to host exotic states such as axion insulators, magnetic Weyl semimetals, Chern insulators,etc. To date, the MnBi2.Te3.+1family is the only group of materials showcasing van der Waals-layered structures, intrinsic magnetism and non-trivial band topology without trivial bands at the Fermi level. The interplay between magnetism and band topology in this family has led to the proposal of various topological phenomena, including the quantum anomalous Hall effect, quantum spin Hall effect and quantum magnetoelectric effect. Among these, the quantum anomalous Hall effect has been experimentally observed at record-high temperatures, highlighting the unprecedented potential of this family of materials in fundamental science and technological innovation. In this paper, we provide a comprehensive review of the research progress in this intrinsic magnetic topological insulator family, with a focus on single-crystal growth, characterization of chemical disorder, manipulation of magnetism through chemical substitution and external pressure, and important questions that remain to be conclusively answered.

关键词： MnBi2.e4 magnetic topological insulator magnetism tuning antiferromagnetism ferromagnetism pressure chemical doping

Toughened (Ti_(0.2.Zr_(0.2.Hf_(0.2.Nb_(0.2.Ta_(0.2.)B_(2.–SiC composites fabricated by one-step reactive sintering with a unique SiB_(6) additive

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Journal of Advanced Ceramics 2024年第1期13卷 86-100页

作者： Wei Hao Xinzhe Lu Ling Li Tao Wang Guoliang ren Huangyue Cai Xiaofeng Zhao Dongyun Wang Na ni Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and Maintenance Technology&Equipment Zhejiang Normal UniversityZhejiang 321004China Key Lab of Education Ministry for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

High-entropy diboride has been arousing considerable interest in recent ***,the low toughness and damage tolerance limit its applications as ultra-high-temperature structural *** we report that a unique SiB_(6) additive has been first incorporated as boron and silicon sources to fabricate a high-entropy boride(Ti_(0.2.Zr_(0.2.Hf_(0.2.Nb_(0.2.Ta_(0.2.)B_(2.–SiC composite though one-step boro/carbothermal reduction reactive sintering.A synergetic effect of high-entropy sluggish diffusion and SiC secondary phase retarded the grain growth of the(Ti_(0.2.Zr_(0.2.Hf_(0.2.Nb_(0.2.Ta_(0.2.)B_(2.–51SiC *** small grain size was beneficial to shorten the diffusion path for mass transport,thereby enhancing the relative density to~99.3..These results in an increase of fracture toughness from~5.2.in HEBS-1900 to~7.7 MPa·m^(1/2. in HEBS-2.00,which corresponded to a large improvement of 48%.The improvement was attributed to a mixed mode of intergranular and transgranular cracking for offering effective pinning in crack propagation,resulting from balanced grain boundary strength collectively affected by improved densification,solid solution strengthening,and incorporation of SiC secondary phase.

关键词： high-entropy diboride silicon hexaboride boro/carbothermal reduction reactive sintering fracture toughness

Magnetic mineralogy of the Hongqiling Cu-ni sulphide deposit: Implications for ore genesis

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Progress in Natural Science:Materials International 2007年第10期17卷 1192-1198页

作者： Xi Aihua1,2. Ge Yuhui1, Cai Yuanfeng2.and Zhang Xuefeng3.1. Faculty of Resources & Environment, Southwest Petroleum university, Chengdu 610500, China 2. State Key Laboratory for Endoge{2.c Metal Deposit Research, nanjing university, {3. 2.0093. China 3. department of Natural Resources & Technology Information, China university of Petroleum, Beijing 102.49, China) Faculty of Resources & Environment Southwest Petroleum University Chengdu 610500 China State Key Laboratory for Endogenic Metal Deposit Research Nanjing University Nanjing 210093 China department of Natural Resources & Technology Information China University of Petroleum Beijing 102249 China

Pyrrhotite is one of the common ore minerals in Cu-ni sulphide deposits, but only monoclinic pyrrhotite is ferromagnetic at room temperature. X-ray and EPA analyses reveal that most pyrrhotite forming sideronitic texture in the Hongqiling Cu-ni sulphide deposit is monoclinic, but that in the massive ore is a mixture of monoclinic and hexagonal pyrrhotites. Differential thermal and magnetic- thermogravimetric analyses of massive ore indicate a magnetic transition and heat absorption at 3.3., suggesting that this temperature is the thermomagnetic and phase transition point of pyrrhotite. For massive pyrrhotite ores heated at 400oC for 3. h and then quenched by cool water, the monoclinic pyrrhotite (mpo) transforms completely into the hexagonal pyrrhotite (hpo). However, all the pyrrhotites resulting from slow cooling of the sample in air are mpo. These results indicate that transformation between hpo and mpo depends upon the cooling rate. Therefore, massive ores in this deposit might have been formed via rapid cooling of ore melts. On the other hand, it is significant to study the effect of the ratio of the magnetite in total ores on the genesis of magmatic Cu-ni suphide deposits.

关键词： pyrrhotite magnetite genesis of Cu-ni sulphide deposit Hongqiling.