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Spinocerebellar ataxia type 3 with dopamine-responsive dystonia:A case report

World Journal of Clinical Cases 2021年第28期9卷 8552-8556页

作者： Xiao-Le Zhang Xiao-Bo Li fa-Feng Cheng Shu-Ling Liu Wen-Chao ni Fei-Fei Tang Qing-Guo Wang Xue-Qian Wang School of Basic Medical Sciences Beijing University of Chinese MedicineBeijing 100029China Internal Medicine-Neurology Xi'an Third HospitalXi'an 710000Shaanxi ProvinceChina

BACKGROUND Spinocerebellar ataxia type 3(SCA3)is a rare neurodegenerative disease with high genetic heterogeneity.SCA3 mainly manifests as progressive cerebellar ataxia accompanied by paralysis of extraocular muscles,dysphagia,lingual fibrillation,pyramidal tract sign,and extrapyramidal system sign.However,it rarely has clinical manifestations similar to Parkinson-like symptoms,and is even rarer in patients sensitive to dopamine.We report a patient initially diagnosed with dopamine-responsive dystonia who was ultimately diagnosed with SCA3 by genetic testing,which was completely different from the initial diagnosis.CASE SUMMARY A 40-year-old Chinese woman was admitted to hospital due to severe inflexibility.At the beginning of the disease,she presented with anxiety and sleep disorder.At the later stage,she presented with gait disorder,which was similar to Parkinson's disease.Her medical history was unremarkable,but her mother,grandmother,and uncle all had similar illnesses and died due to inability to take care of themselves and related complications.Laboratory and imaging examinations showed no abnormalities,but electromyography and electroencephalography revealed delayed somatosensory evoked potentials and slow background rhythm,respectively.Her symptoms fluctuated during the daytime,and we initially diagnosed her with dopamine-responsive dystonia.After treatment with lowdose levodopa,the patient’s symptoms were significantly improved,but the final genetic diagnosis was SCA3.CONCLUSION SCA3 has various clinical phenotypes and needs to be differentiated from Parkinson's syndrome and dopamine-responsive dystonia.

关键词： Spinocerebellar ataxia type 3 Dopamine-responsive dystonia Gene phenotype Clinical phenotype Differential diagnosis Case report

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In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum

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Biomedical and Environmental Sciences 2006年第5期19卷 367-370页

作者： faNG HUANG LIN-HUA TANG LIN-QIAN YU YI-CHANG ni QIN-MEI WANG fa-JUN NAN National Institute of Parasite Diseases Chinese Center for Disease Control and Prevention Shanghai 200025 China Chinese National Center for Drug Screening Shanghai Institute of Materia Medica Shanghai Institute for Biological Sciences Graduate School of the Chinese Academy of Sciences Shanghai 201203 China

Objective To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Method Plasmodium faciparum （FCC1） was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. Results DA79 and DA78 showed potent antimalarial activity against Plasmodiumfalciparum cultured in vitro. Conclusion Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.

关键词： Daphnetin Antimalarial Drug screening

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油松人工林土壤微生物对结构调整的响应研究

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林业科学研究 2024年第3期37卷 193-202页

作者：法蕾裴顺祥杜满义马淑敏吴莎吴迪王海霞李佳林许基煌中国林业科学研究院华北林业实验中心北京九龙山暖温带森林国家长期科研基地北京102300 中国林业科学研究院热带林业实验中心广西凭祥532600

[目的]为评估结构调整对油松人工林生态系统的影响,探索土壤微生物群落结构动态对结构调整干扰的响应机制。[方法]利用高通量测序技术,对结构调整后山西省中条山油松人工林林下土壤微生物的类群组成及多样性进行探究,分析土壤微生物群... 详细信息

[目的]为评估结构调整对油松人工林生态系统的影响,探索土壤微生物群落结构动态对结构调整干扰的响应机制。[方法]利用高通量测序技术,对结构调整后山西省中条山油松人工林林下土壤微生物的类群组成及多样性进行探究,分析土壤微生物群落的组成结构、多样性及其与环境因素的相互关系。[结果]油松人工林结构调整能够降低土壤的pH值,土壤养分含量显著低于对照样地。土壤微生物的优势菌群未发生较大的变化,土壤的优势细菌类群是变形菌门、放线菌门、酸杆菌门,而优势真菌类群为子囊菌门、担子菌门和被孢菌门。结构调整后油松人工林土壤微生物的丰富度显著增加,多样性较对照样地略有增加,但差异不显著。对结构调整前后的油松人工林微生物类群与土壤理化性质进行RDA分析,pH、总氮、土壤有机质和速效氮是驱动土壤微生物类群变化的主要因子。[结论]结构调整后的油松人工林样地仍处于恢复期,微生物类群结构与未调整样地相比具有相似性,但调整后的土壤微生物类群更为丰富,变形菌门和担子菌门的增加使得土壤中固氮菌的比例提高,土壤微生物类群向有助于有机质分解的方向转换。

关键词：油松人工林结构调整目标树经营土壤微生物微生物群落结构

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Irregular Characteristics of Bond Interface Formation in Ultrasonic Wire Wedge Bonding

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Journal of Materials Science & Technology 2006年第4期22卷 483-486页

作者： Mingyu LI Hongjun JI Chunqing WANG Au Tai KUNG Han Sur bang Hee Seon bang Shenzhen Graduate School of Harbin Institute of Technology Shenzhen 518055 China Microjoining Lab School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Sun East Technology （Holdings） Ltd. Shenzhen 518103 China Department of Naval Architecture and Ocean Engineering Chosun University 375 Seosek Dong Donggu Guangju 501-759 Korea

The mechanism of ultrasonic wire wedge bonding, one of the die/chip interconnection methods, was investigated based on the characteristics of the ultrasonic wire bonding joints. The Al-1%Si wire of 25 μm in diameter was bonded on Au/ni/Cu pad and the joint cross-section was analyzed by scanning electron microscopy （SEM） and energy-dispersive X-ray spectroscopy （EDX）. The results indicated that it is irregular for the ultrasonic bond formation, non-welded at the centre but joining well at the periphery, especially at the heel and toe of the joint. Furthermore, the diffusion and/or reaction at the cross-section interface are not clear at C-zone, while there exists a strip layer microstructure at P-zone, and the composition is 78.96 at. pct Al and 14.88 at. pct ni, close to the Al3ni intermetallic compound. All these observations are tentatively ascribed to the plastic flow enhanced by ultrasonic vibration and repeated cold deformation driving interdiffusion between AI and ni at bond interface.

关键词： Ultrasonic bonding Irregular joint Interface diffusion Repeated cold deformation

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Identifying the Risk of SARS-CoV-2 Infection and Environmental Monitoring in Airborne Infectious Isolation Rooms(AIIRs)

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Virologica Sinica 2020年第6期35卷 785-792页

作者： Zhi-Gang Song Yan-Mei Chen fan Wu Lin Xu bang-fang Wang Lei Shi Xiao Chen fa-Hui Dai Jia-Lei She Jian-Min Chen Edward CHolmes Tong-Yu Zhu Yong-Zhen Zhang Shanghai Public Health Clinical Center State Key Laboratory of Genetic EngineeringSchool of Life SciencesFudan UniversityShanghai 201508China College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China Department of Environmental Science and Engineering Fudan UniversityShanghai 200438China Marie Bashir Institute for Infectious Diseases and Biosecurity School of Life and Environmental Sciences and School of Medical SciencesThe University of SydneySydneyNSW 2006Australia

Healthcare workers(HCWs)are at high risk of occupational exposure to the new pandemic human coronavirus,SARSCoV-2,and are a source of nosocomial transmission in airborne infectious isolation rooms(AIIRs).Here,we performed comprehensive environmental contamination surveillance to evaluate the risk of viral transmission in AIIRs with 115 rooms in three buildings at the Shanghai Public Health Clinical Center,Shanghai,during the treatment of 334 patients infected with SARS-CoV-2.The results showed that the risk of airborne transmission of SARS-CoV-2 in AIIRs was low(1.62%,25/1544)due to the directional airflow and strong environmental hygiene procedures.However,we detected viral RNA on the surface of foot-operated openers and bathroom sinks in AIIRs(viral load:55.00–3154.50 copies/mL).This might be a source of contamination to connecting corridors and object surfaces through the footwear and gloves used by HCWs.The risk of infection was eliminated by the use of disposable footwear covers and the application of more effective environmental and personal hygiene measures.With the help of effective infection control procedures,none of 290 HCWs was infected when working in the AIIRs at this hospital.This study has provided information pertinent for infection control in AIIRs during the treatment of COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Nosocomial transmission AIIRs Environmental sampling

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细胞自噬在甲酸致PC12细胞损伤中的作用研究

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环境与健康杂志 2024年第2期 95-99,92页

作者：刘贺荣郝乐乐严姣李亚妮陈楠宁夏医科大学公共卫生学院宁夏银川750004 宁夏环境因素与慢性病控制重点实验室

目的探讨甲酸(fa)染毒对PC12细胞的损伤效应,阐明细胞自噬在其中的关键作用及机制。方法采用CCK-8法检测并确定自噬抑制剂3-甲基腺嘌呤(3-Methyladenine,3-MA)、自噬溶酶体抑制剂巴弗洛霉素A1(Bafilomycin A1,BA)染毒PC12细胞的浓度。将... 详细信息

目的探讨甲酸(fa)染毒对PC12细胞的损伤效应,阐明细胞自噬在其中的关键作用及机制。方法采用CCK-8法检测并确定自噬抑制剂3-甲基腺嘌呤(3-Methyladenine,3-MA)、自噬溶酶体抑制剂巴弗洛霉素A1(Bafilomycin A1,BA)染毒PC12细胞的浓度。将PC12细胞分为对照组(0 mmol/L)、3-MA组(1.25 mmol/L)、BA组(1 nmol/L)、fa组(16.64mmol/L)、fa+3-MA组(16.64 mmol/L+1.25 mmol/L)、fa+BA组(16.64 mmol/L+1 nmol/L),染毒24 h。采用3-MA、BA调控自噬水平后,用透射电镜观察各组凋亡及自噬情况;采用单丹磺酰尸胺(MDC)染色检测PC12细胞自噬情况;采用Western blotting法检测自噬相关蛋白LC3Ⅱ/LC3Ⅰ、Beclin1、P62的表达;采用流式细胞仪检测各组PC12细胞的凋亡情况。结果透射电镜观察结果显示,对照组、3-MA组、BA组可见大量的正常线粒体,核膜光滑,染色质均匀;fa组线粒体嵴溶解、断裂、消失,部分存在空泡,自噬现象明显;fa+3-MA组大量线粒体空泡,线粒体呈局灶性,染色质聚集,溶酶体增多,细胞核固缩明显,少见自噬小体形成;fa+BA组大量线粒体空泡,线粒体嵴溶解、断裂甚至消失,染色质边集明显,溶酶体增多,但未形成自噬溶酶体。MDC染色结果显示,对照组、3-MA组、BA组可见极少量的蓝色荧光,fa组、fa+3-MA组、fa+BA组可见大量的蓝色荧光。Western blot检测法结果显示,与对照组相比,fa组LC3Ⅱ/LC3Ⅰ、Beclin1蛋白表达量增加,P62蛋白表达量降低,差异有统计学意义(Pfa+3-MA组LC3Ⅱ/LC3Ⅰ、Beclin1蛋白表达量与fa组相比明显降低,P62蛋白表达量明显增加,差异有统计学意义(Pfa+BA组的LC3Ⅱ/LC3Ⅰ、P62蛋白表达量高于fa组,Beclin1蛋白表达量明显降低,差异有统计学意义(P0.05);fa组3种类型的凋亡率均高于对照组,差异有统计学意义(Pfa组比较,fa+3-MA组晚期凋亡和总凋亡率增加,fa+BA组3种类型凋亡率均增加,差异有统计学意义(P<0.05)。结论甲酸能够诱导PC12细胞自噬水平升高,用自噬抑制剂干预后可促进甲酸引起的PC12细胞凋亡,提示自噬对甲酸引起的PC12细胞毒性损伤可能有保护作用。

关键词：甲酸 PC12细胞凋亡自噬

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Effect of temperature on formation and evolution of solid electrolyte in terphase on Si@Graphite@C anodes

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Journal of Energy Chemistry 2022年第1期31卷 190-200,I0006页

作者： Hong Dong Jie Wang Peng Wang Hao Ding Ru Song ning-Shuang Zhang Dong-ni Zhao Li-Juan Zhang Shi-You Li College of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Gansu Key Laboratory of Low-Carbon Energy and Chemical Engineering Lanzhou 730050GansuChina College of Chemistry and Chemical Engineering Qinghai University for NationalitiesXining 810007QinghaiChina

Studies on the formati on and evolutio n of the solid electrolyte in terface(SEI)film under different ambient temperatures are important to understand the failure behavior of lithium-ion batteries(LIBs).Herein,in-situ electrochemical impedance spectroscopy(EIS)test is performed on the whole discharge process of Si@Graphite@C/Li cell at 0,25 and 55℃,respectively.Combining with scanning electron microscopy,transmission electron microscopy and X-ray photoelectron spectroscopy characterizations,it is found that the SEI film undergoes a complicated evolution process of pre-formation,self-improvement and gradual decay in succession at 25℃.Besides,due to the dissolution of organo-alkyl lithium at high temperature,the formed film is mainly composed of LiF,Li_(2)CO_(3) and other in organic salts,which helps to decrease the impedance.However,the electrolyte is consumed continuously on the new exposed in terface,leading to the degraded performance of the cell.Moreover,the dyn amic properties of Li^(+) ions are poor at low temperature,though the migration ability of Li^(+) ions in the solid phase can be improved as the cycle goes on.Therefore,the development and application of in-situ EIS tech no logy are expected to become an important means to explain the electrochemical performance of batteries.

关键词： In-situ EIS Solid electrolyte in terphase Formation Evolution Si@Graphite@C anodes

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Study on ZnO Nanowire Prepared by Nuclear Track Technique

Study on ZnO Nanowire Prepared by Nuclear Track Technique

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作者： LIU Chao LIU Cun-xiong GAO Si-ze ni bang-fa TIAN Wei-zhi XIAO Cai-jin niE Peng ZHAO Chang-jun WANG Ping-sheng QIN Ya-li CHEN Zhe ZHANG Gui-ying HUANG Dong-hui SUN Hong-chao ZHANG Hai-qing College of Physics Science and Engineering Technology Guangxi University

As aⅡ-Ⅵcompound semiconductor with a wide and direct band gap of 3.37 eV,bound excition binding energy of 60 MeV,zinc oxide(ZnO) has been shown to be a candidate for electronic and

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Total Fractionation and Analysis of Polysaccharides from Leaves of Panax ginseng C.A. Meyer

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Chemical Research in Chinese Universities 2010年第2期26卷 230-234页

作者： ni Xiu-zhen WANG Bing-qing ZHI Yuan WEI ning-ning ZHANG Xu LI Shan-shan TAI Gui-hua ZHOU Yi-fa ZHAO Ji-ming School of Life Sciences Northeast Normal University Changchun 130024 P. R. China School of Life Sciences Changchun Normal University Changchun 130032 P. R. China

The water-soluble polysaccharides isolated from the leaves of Panax ginseng C. A. Meyer were totally fractionated into one neutral fraction（GLPN-1）, six acidic fractions（GLPN-2, GLPA-1a, GLPA-1b, GLPA-1c, GLPA-2 and GLPA-3） by a combination of ethanol precipitation, ion-exchange and gel permeation chromatography. All the fractions were analyzed by determining monosaccharide composition, molecular weight distribution. The resuits show that GLPN-1 was mainly composed of Gal（38.1%） and Ara（33.6%） and presumed to be an arabinogalactan. GLPA-1a, GLPA-1b and GLPA-2 mainly contained Gal, Ara, Rha and GalA. The amount of Gal and Ara acounted for over 50% of total sugar and the amount of Rha was more than 10%. The molar ratios of Rha/GalA in GLPA-1a, GLPA-1b and GLPA-2 were 1：1, 1：2 and 1：2.7, respectively, indicating that they belong to type-1 rhamnogalacturonan （RG-1）-rich pectin. GLPA-1c was mainly composed of GalA（78%）, belonging to homogalacturonan（HG）-rich pectin. GLPA-3 might be a glycoprotein.

关键词： Ginseng leave Polysaccharide Fractionation RG-I domain

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Preparation and properties of the ni-Al/Fe-Al intermetallics composite coating produced by plasma cladding

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International Journal of Minerals,Metallurgy and Materials 2011年第6期18卷 725-730页

作者： Li-min Zhang bang-wu liu Dong-bai Sun National Center of Analysis and Testing for Non-ferrous Metals ＆ Electronic Materials General Research Institute for Nonferrous Metals Beijing 100088 China Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China Corrosion and Protection Center University of Science and Technology Beijing Beijing 100083 China

A novel approach to produce an intermetallic composite coating was put forward.The microstructure,microhardness,and dry-sliding wear behavior of the composite coating were investigated using X-ray diffraction （XRD）,scanning electron microscopy （SEM）,energy dispersive spectrum （EDS） analysis,microhardness test,and ball-on-disc wear experiment.XRD results indicate that some new phases FeAl,Fe0.23ni0.77Al,and ni3Al exit in the composite coating with the Al2O3 addition.SEM results show that the coating is bonded with carbon steel metallurgically and exhibits typical rapid directional solidification structures.The Cr7C3 carbide and intermetallic compounds co-reinforced composite coating has a high average hardness and exhibits an excellent wear resistance under dry-sliding wear test compared with the Cr7C3 carbide-reinforced composite coating.The formation mechanism of the intermetallic compounds was also investigated.

关键词： composite coatings plasma cladding intermetallics microhardness wear resistance

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