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北京创意园区整体规划

建筑技艺 2011年第6期17卷 94-99页

作者： Ben van Berkel Caroline Bos Markus van Aalderen Yi Cheng Pan Mieneke Dijkema Ren yee Clarissa Alfrink Megan ng Maudvan Hees Wendy van der Knijff Jae Young Lee 吴春花 UNStudio

客户北京市延庆区人民政府规划与建筑设计UNStudio:Ben van Berkel,Caroline Bos with Markus van Aalderen,Yi Cheng Pan and Mieneke Dijkema,Ren yee,Clarissa Alfrink,Megan ng,Maud van Hees,Wendy van der Knijff,Jae Young Lee 基地面积210 152m2建筑面积145 119m2城市发展顾问dcu,Pablo Vaggione可持续设计顾问Arup工程顾问(上海)有限公司'于自然中的都市'这一主题旨在保护延庆当地的自然特征,同时容纳一定的城市生活,整个设计将绿带与城市肌理两个尺度结合起来.通过对城市肌理的浓缩,创造出一个高度编织和紧密的城市环境,从而在城市与自然之间既形成清晰的界限又具有紧凑性.两个不同但相互联系的创意产业带和基础设施带相互编织成边缘地带的城市组织,同时营造了从街道到庭院到公共广场的一系列连续的开放空间.浓缩景观最大限度地扩展了绿带,增加的绿带和公园为创意人士工作、组织活动以及画室和亭、阁的娱乐活动提供了绿色环境.

关键词：城市肌理创意园区公园园林广场绿带设计者 Nature

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

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选择外科导航系统的参考要素

中华创伤骨科杂志 2005年第7期7卷 651-656页

作者：吕宝仪邓宁苏伟权梁国穗王文吕红斌香港特别行政区香港中文大学矫形外科及创伤学系

外科导航系统可提供外科手术过程中的实时指导,是一种极具应用前景的互动式工具。它可以在术中为外科医生提供实时信息,从而有利于手术的进程,改善手术效果,减少并发症。该系统的运用可降低手术创伤。该系统中计算机的运用有助于术前计... 详细信息

外科导航系统可提供外科手术过程中的实时指导,是一种极具应用前景的互动式工具。它可以在术中为外科医生提供实时信息,从而有利于手术的进程,改善手术效果,减少并发症。该系统的运用可降低手术创伤。该系统中计算机的运用有助于术前计划的制定和术后资料的收集。计算机辅助外科手术导航系统的应用已有十多年历史。随着近年来技术的发展,该技术得以进一步改良,并精确化了手术程序。虽然外科导航系统是一门相对较新的技术,但由于其显著的优点,将会在临床上越来越广泛地应用。我们调研了五个外科导航系统的生产商,旨在介绍目前临床上可选择的外科导航系统和注意事项。

关键词：外科导航系统生产商选择要素

Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection

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World Journal of Hepatology 2019年第6期11卷 553-561页

作者： En Xian Sarah Low Edhel Tripon Kieron Lim Poh Seng Tan How Cheng Low Yock Young Dan Yin Mei Lee Mark Muthiah wai Mun Loo Calvin Jianyi Koh Wah Wah Phyo JunXiong Pang Seng Gee Lim Guan-Huei Lee Department of Medicine Ng Teng Fong General HospitalNational University Health SystemSingapore 609606Singapore Centre for Liver Disease Management and Transplant of Medical City Manila 1605Philippines Mount Elizabeth Medical Centre Singapore 228510Singapore Division of Gastroenterology and Hepatology National University Health SystemSingapore 119228Singapore Department of Medicine National University of SingaporeSingapore 119077Singapore Centre for Infectious Disease Epidemiology and Research National University of SingaporeSingapore 117549Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

BACKGROUND Hepatitis E virus(HEV)infection is a cause of chronic hepatitis in immunosuppressed *** virologic response rates to a 12-wk course of ribavirin therapy were reported to be>70%in the *** study describes the outcome of HEV treatment in a transplant center in *** To study the outcome of ribavirin treatment in a series of chronic HEV patients,and the cause of treatment *** We studied all of the transplant recipients who were diagnosed with HEV infection between 2012 to *** outcome of therapy and virologic relapse are monitored for three years after the end of *** Ten transplant recipients(4 liver,5 kidney,and 1 bone marrow transplantation)with positive HEV RNA were *** patients received at least 12 wk of ribavirin therapy,and the remaining patient resolved after reducing immunosuppression *** subjects had prolonged viremia that lasted more than one year,despite continuous ribavirin *** ribavirin-treated patients(44.4%)had HEV RNA relapse after achieving a virologic response by the end of *** overall failure rate is 66.7%.Being a kidney transplant recipient is the strongest risk factor for not achieving an initial sustained virologic response(0/5 treated,Chi-Square test,P<0.05).The most common side effect of ribavirin is anemia(100%)(haemoglobin reduction of 3-6.2 g/dL).Seven patients required either a blood transfusion or erythropoietin *** The sustained virologic response rate of 12-wk ribavirin therapy for HEV infection in this Asian series was lower than *** transplant recipients had a higher rate of treatment failure due to higher immunosuppression requirements and adverse effects.

关键词： Toxicity Antiviral agents Hepatitis E virus Virus classification Systemic immunity Immune responses Persistent infection

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戊型病毒性肝炎研究进展

厦门大学学报（自然科学版） 2011年第2期50卷 431-436页

作者：夏宁邵张军李少伟葛胜祥吴婷郑子峥吴文翰史维国厦门大学国家传染病诊断试剂与疫苗工程技术研究中心福建厦门361005

戊型病毒性肝炎是全球最主要的病毒性肝炎之一,近半个世纪多次发生大规模暴发,孕妇感染戊型肝炎后病死率高达20%.近年随着基于构象型表位多肽E2的戊型肝炎诊断试剂的出现,戊型肝炎的病原学诊断及流行病学调查均获得了较大的发展,越来越... 详细信息

戊型病毒性肝炎是全球最主要的病毒性肝炎之一,近半个世纪多次发生大规模暴发,孕妇感染戊型肝炎后病死率高达20%.近年随着基于构象型表位多肽E2的戊型肝炎诊断试剂的出现,戊型肝炎的病原学诊断及流行病学调查均获得了较大的发展,越来越引起人们的重视.由我国自主创新研制的重组戊型肝炎疫苗现已在中国完成世界上首个Ⅲ期临床试验,其预防戊型肝炎的保护率达到100%（95%CI,72.1%~100.0%）.

关键词：戊型病毒性肝炎戊型肝炎病毒 E2 诊断试剂重组戊型肝炎疫苗

以三苯三戊并烯或窗茚满为核心的非平面纳米石墨烯

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有机化学 2020年第10期40卷 3017-3025页

作者：吴振辉王伟丞叶皓宏刘永华孙晓庆谢浩荣何丽思张以诺 Dietmar Kuck 周克勋香港中文大学化学系中国香港比勒费尔德大学化学系及分子材料中心(CM2) 德国比勒费尔德33615

总结了我们近年合成的以三苯三戊并烯或窗茚满为骨架的非平面纳米石墨烯之研究成果.巫师帽形或鞍形的纳米石墨烯可由非经典的Scholl环庚三烯环化或19元环大环化反应制备.这些反应成功的关键是在这些分子的湾区区域引入恰当的富电子芳香... 详细信息

总结了我们近年合成的以三苯三戊并烯或窗茚满为骨架的非平面纳米石墨烯之研究成果.巫师帽形或鞍形的纳米石墨烯可由非经典的Scholl环庚三烯环化或19元环大环化反应制备.这些反应成功的关键是在这些分子的湾区区域引入恰当的富电子芳香官能团,通过X射线晶体学,一些纳米石墨烯的三维结构可以得到确定.此外,这些富含碳的π-共轭分子还显示出有趣的光物理、自缔合和主-客体络合的特性.

关键词：非平面芳香族纳米石墨烯三苯三戊并烯窗茚满

In the Spotlight Esther Eng——Chinese Cinema's First Major Female Director

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Women of China 2006年第6期 32-35页

作者：宾法兰 SALLY ng 伍锦屏

On June 4, 1936, The President Hoover, a luxurious ocean liner, berthed in Hong Kong. One of its passengers was wai Kim-fong, a successful stage actress who was well-known in Southern China. wai disembarked with her close friend, ng Kam-ha, who had also traveled from San Francisco, the United States, to arrange the overseas premiere of a new Chinese-American movie, entitled Sum Hun, or "Heartache." It was the first Cantonese talkie ever produced in Hollywood. It was produced by 21 -year-old ng Kam-ha, under...

关键词：女导演好莱坞聚光灯

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高棉瓷器制作工艺初探

文物保护与考古科学 2011年第1期23卷 19-24页

作者：潘国平孙秀萍胡立敏朱铁权黄慧怡厦门大学历史系福建厦门361005 中山大学社会学与人类学学院广东广州510275 新加坡国立大学新加坡117570

为揭示高棉古代瓷器的制作工艺及其特征,用体视显微镜、微聚焦能量色散X射线荧光光谱仪、X射线衍射仪等,对柬埔寨Thnal Mrech窑与Bang Kong窑出土的陶瓷器进行系统的分析测试。结果表明,两个窑口使用了不同种类的制瓷原料。Thnal Mrech... 详细信息

为揭示高棉古代瓷器的制作工艺及其特征,用体视显微镜、微聚焦能量色散X射线荧光光谱仪、X射线衍射仪等,对柬埔寨Thnal Mrech窑与Bang Kong窑出土的陶瓷器进行系统的分析测试。结果表明,两个窑口使用了不同种类的制瓷原料。Thnal Mrech窑的青釉瓷原料具有高硅低铝的特征,对原料的处理比较精细;瓷胎、釉颜色的差异,与其铁、钛等致色元素的含量有关;两个窑口的瓷釉中,均添加了草木灰作为主要助熔剂,从瓷釉的配方来说,Thnal Mrech窑与Bang Kong青釉瓷均属钙釉,而Bang Kang窑的酱釉瓷中既有钙碱釉,也有碱钙釉;柬埔寨吴哥时期陶瓷器的烧制温度可达1200℃,同时,两个窑口的瓷器烧成温度还没有一个严格的标准。分析结果对探讨柬埔寨古陶瓷发展史及中柬之间的文化交流史有重要参考价值。

关键词：高棉瓷器 Thnal Mrech窑 Bang Kong窑柬埔寨

Defining minimal invasive surgical therapy for benign prostatic obstruction surgery: Perspectives from a global knowledge, attitude, and practice survey

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Asian Journal of Urology 2024年第1期11卷 55-64页

作者： Bryan Kwun-Chung Cheng Steffi Kar-Kei Yuen Daniele Castellani Marcelo Langer Wroclawski Hongda Zhao Mallikarjuna Chiruvella Wei-Jin Chua Ho-yee Tiong Yiloren Tanidir Jean de la Rosette Enrique Rijo Vincent Misrai Amy Krambeck Dean S.Elterman Bhaskar K.Somani Jeremy Yuen-Chun Teoh Vineet Gauhar Department of Surgery United Christian HospitalHong KongChina S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Urology University Hospital“Ospedali Riuniti”and Polytechnic University of Marche RegionAnconaItaly Hospital Israelita Albert Einstein Sao PauloSPBrazil BP—A Beneficencia Portuguesa de Sao Paulo Sao PauloSPBrazil Faculdade de Medicina do ABC Santo AndreSPBrazil Department of Urology Asian Institute of Nephrology and UrologyHyderabadTGIndia Department of Urology National University HospitalSingapore Department of Urology Marmara University School of MedicineIstanbulTurkey Department of Urology Medipol Mega University HospitalIstanbul Medipol UniversityIstanbulTurkey Department of Urology Hospital Quiron BarcelonaBarcelonaSpain Department of Urology Clinique PasteurToulouseFrance Department of Urology Indiana University School of MedicineIndianapolisINUSA Division of Urology Department of SurgeryUniversity Health NetworkUniversity of TorontoTorontoCanada Department of Urology University Hospital Southampton NHS TrustSouthamptonUK Department of Urology Ng Teng Fong General HospitalNUHSSingapore

Objective:To scrutinize the definitions of minimal invasive surgical therapy(MIST)and to investigate urologists’knowledge,attitudes,and practices for benign prostatic obstruction ***:A 36-item survey was developed with a Delphi *** on definitions of MIST and attitudes and practices of benign prostatic obstruction surgeries were *** were invited globally to complete the online *** was achieved when more than or equal to 70%responses were“agree or strongly agree”and less than or equal to 15%responses were“disagree or strongly disagree”(consensus agree),or when more than or equal to 70%responses were“disagree or strongly disagree”and less than or equal to 15%responses were“agree or strongly agree”(consensus disagree).Results:The top three qualities for defining MIST were minimal blood loss(n=466,80.3%),fast post-operative recovery(n=431,74.3%),and short hospital stay(n=425,73.3%).The top three surgeries that were regarded as MIST were Urolift®(n=361,62.2%),Rezum®(n=351,60.5%),and endoscopic enucleation of the prostate(EEP)(n=332,57.2%).Consensus in the knowledge section was achieved for the superiority of Urolift®,Rezum®,and iTIND®over transurethral resection of the prostate with regard to blood loss,recovery,day surgery feasibility,and post-operative *** in the attitudes section was achieved for the superiority of Urolift®,Rezum®,and iTIND®over transurethral resection of the prostate with regard to blood loss,recovery,and day surgery *** on both sections was achieved for EEP as the option with the better symptoms and flow improvement,lower retreatment rate,and better suitable for prostate more than 80 ***:Minimal blood loss,fast post-operative recovery,and short hospital stay were the most important qualities for defining ***®,Rezum®,and EEP were regarded as MIST by most urologists.

关键词： Benignprostate hyperplasia Minimalinvasive surgical therapy Surgery Bladderoutlet obstruction