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Color Fusion of Magnetic Resonance Images Improves Intracranial Volume Measurement in studies of Aging

Open journal of Radiology 2012年第1期2卷 1-9页

作者： Maria del C.Valdes Hernandez natalie A.Royle Michael R.jackson susana Munoz Maniega Lars Penke Mark E.Bastin Ian j.Deary joanna M.Wardlaw Brain Research Imaging Centre University of EdinburghEdinburghUK Department of Psychology University of EdinburghEdinburghUK Department of Medical and Radiological sciences University of EdinburghEdinburghUK

Background: Comparison of intracranial volume (ICV) measurements in different subpopulations offers insight into age-related atrophic change and pathological loss of neuronal tissue. For such comparisons to be meaningful the accuracy of ICV measurement is paramount. Color magnetic resonance images (MRI) have been utilised in several research applications and are reported to show promise in the clinical arena. Methods: We selected a sample of 150 older community-dwelling individuals (age 71 to 72 years) representing a wide range of ICV, white matter lesions and atrophy. We compared the extraction of ICV by thresholding on T2*-weighted MR images followed by manual editing (reference standard) done by an analyst trained in brain anatomy, with thresholding plus computational morphological operations followed by manual editing on a framework of a color fusion technique (MCMxxxVI) and two automatic brain segmentation methods widely used, these last three done by two image analysts. Results: The range of ICV was 1074 to 1921 cm3 for the reference standard. The mean difference between the reference standard and the ICV measured using the technique that involved the color fusion was 2.7%, while it was 5.4% compared with any fully automatic technique. However, the 95% confidence interval of the difference between the reference standard and each method was similar: it was 7% for the segmentation aided by the color fusion and was 7% and 8.3% for the two fully automatic methods tested. Conclusion: For studies of aging, the use of color fusion MRI in ICV segmentation in a semi-automatic framework delivered best results compared with a reference standard manual method. Fully automated methods, while fast, all require manual editing to avoid significant errors and, in this post-processing step color fusion MRI is recommended.

关键词： Intracranial Volume segmentation Brain Volume Aging Color MRI

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Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor

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World journal of Gastroenterology 2016年第16期22卷 4201-4210页

作者： Mireen Friedrich-Rust Beate Wanger Florian Heupel natalie Filmann Reinhard Brodt Volkhard Aj Kempf johanna Kessel Thomas A Wichelhaus Eva Herrmann stefan Zeuzem joerg Bojunga Department of Internal Medicine I (Gastroenterology Pulmonology Endocrinology) J.W. Goethe-University Hospital Institute of Biostatistics and Mathematical Modeling Faculty of Medicine J.W. Goethe-University Department of Internal Medicine II (Infectious Disease Oncology Hematology) J.W. Goethe-University Hospital Institute of Medical Microbiology and Infection Control J.W. Goethe-University Hospital

AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). special focus was drawn on patients with liver ***: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on ***: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p s with infection had significantly increased in-hospital-mortality(34% vs 17%, p s with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial ***: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-b

关键词： Intensive care unit sepsis-bundle Early goal-directed therapy Liver cirrhosis Mortality

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Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng john P.Hamilton sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger joseph j.Coombs Danny Esselink natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel shereda Heather K.Tuttle Brieanne Vaillancourt joshua C.Wood jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman jvan Eck Dave Ellis Max j.Feldman Kyle M.Gardner johannes C.P.Hopman jiming jiang Walter s.De jong joseph C.Kuhl Richard G.Novy stan Oome Vidyasagar sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem jeffrey B.Endelman Laura M.shannon Martina V.stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural science University of MinnesotaSt.PaulMN 55108USA Department of Plant science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop science WoodlandCA 95695USA Averis seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru UsDA-ARs ProsserWA 99350USA Agriculture and Agri-Food Canada Fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada school of Integrative Plant science Cornell UniversityIthacaNY 14853-1901USA Department of Plant sciences University of IdahoMoscowID 83844USA UsDA-ARs Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and soil science Oregon State UniversityHermistonOR 97838USA school of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** stCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of stCDF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

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Using electronic medical record data to assess chronic kidney disease,type 2 diabetes and cardiovascular disease testing,recognition and management as documented in Australian general practice:a cross-sectional analysis

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Family Medicine and Community Health 2022年第1期10卷 25-35页

作者： julia L jones natalie G Lumsden Koen simons Anis Ta'eed Maximilian P de Courten Tissa Wijeratne Nicholas Cox Christopher j A Neil jo-Anne Manski-Nankervis Peter shane Hamblin Edward D janus Craig L Nelson Nephrology Western HealthMelbourneVictoriaAustralia Medicine University of MelbourneMelbourneVictoriaAustralia Western Health Chronic Disease Alliance MelbourneVictoriaAustralia General Practice University of MelbourneMelbourneVictoriaAustralia Epidemiology and Biostatistics University of MelbourneMelbourneVictoriaAustralia Mitchell Institute for Education and Health Policy MelbourneVictoriaAustralia Chronic Disease Prevention and Management Victoria UniversityMelbourneVictoria3011 La Trobe University MelbourneVictoriaAustralia Neurology Western HealthMelbourneVictoriaAustralia Cardiology Western HealthMelbourneVictoriaAustralia Endocrinology and Diabetes Western HealthMelbourneVictoriaAustralia Medicine Western HealthMelbourneVictoriaAustralia

Objectives To evaluate the capacity of general practice(GP)electronic medical record(EMR)data to assess risk factor detection,disease diagnostic testing,diagnosis,monitoring and pharmacotherapy for the interrelated chronic vascular diseases-chronic kidney disease(CKD),type 2 diabetes(T2D)and cardiovascular *** Cross-sectional analysis of data extracted on a single date for each practice between 12 April 2017 and 18 April 2017 incorporating data from any time on or before data extraction,using baseline data from the Chronic Disease early detection and Improved Management in PrimAry Care *** data were extracted from GP EMRs using the Pen Computer systems Clinical Audit Tool and descriptive statistics used to describe the study *** Eight GPs in Victoria,*** Patients were≥18 years and attended GP≥3 times within 24 months.37946 patients were *** Risk factor and disease testing/monitoring/treatment were assessed as per Australian guidelines(or Us guidelines if none available),with guidelines simplified due to limitations in data availability where *** factor assessment in those requiring it:30%of patients had body mass index and 46%blood pressure within guideline recommended *** testing in at-risk population:17%had diagnostic testing as per recommendations for CKD and 37%for *** undiagnosed disease:Pathology tests indicating possible disease with no diagnosis already coded were present in 6.7%for CKD,1.6%for T2D and 0.33%familial *** prevalence:Coded diagnoses were recorded in 3.8%for CKD,6.6%for T2D,4.2%for ischaemic heart disease,1%for heart failure,1.7%for ischaemic stroke,0.46%for peripheral vascular disease,0.06%for familial hypercholesterolaemia and 2%for atrial *** prescriptions:the proportion of patients prescribed guideline-recommended medications ranged from 44%(beta blockers for patients for some condi

关键词： diagnosis testing record

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***直接锁定拉美裔

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现代广告 2014年第13期 184-184页

作者： natalie Zmuda

***再次颠覆其营销策划，将重点受众锁定在拉美裔。

关键词：拉美裔锁定营销策划

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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： stanley W. K. Ng Foad j. Rouhani simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. sanders Nicholas Williams Tim H. H. Coorens jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson natalie Birtchnell Michael R. stratton Iñigo Martincorena Raheleh Rahbari Peter j. Campbell Foad j. Rouhani & Huw Naylor sarah j. Aitken & Matthew Hoare sarah j. Aitken & susan E. Davies sarah j. Aitken Ming Yang Efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands stem Cell Institute University of Cambridge Cambridge UK Department of surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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