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Intestinal barrier in inflammatory bowel disease:A bibliometric and knowledge-map analysis

世界胃肠病学杂志:英文版 2023年第36期29卷 5254-5267页

作者： Feng Zhou nan-zhen wu Yong Xie Xiao-Jiang Zhou Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Gastrointestinal Surgery Fengcheng People's HospitalFengcheng 331100Jiangxi ProvinceChina

BACKGROUND Barrier surfaces composed of specialized epithelial cells separate the host body from the external environment,and are essential for maintaining proper intestinal physiologic and immune *** To explore the development trends and research hotspots of intestinal barrier research in inflammatory bowel disease(IBD).METHODS The publications related to the intestinal barrier in IBD were obtained from the Web of Science Core Collection *** analysis and visualization were conducted using VOSviewer,CiteSpace and R *** A total of 4482 articles published between 2002 and 2022 were *** United States is dominant in intestinal barrier research,whereas the University of Chicago is the most active *** from Harvard Medical School was the most productive authors with the most *** journals Inflammatory Bowel Disease and Gastroenterology have made significant contributions in this *** keywords appearing at high frequency related to the intestinal barrier in IBD were detected,including nuclear factor kappa B,tumor necrosis factor-α,apoptosis,oxidative stress and *** them,antioxidants,Akkermansia muciniphila,nanoparticles,short-chain fatty acids and extracellular vesicles have received growing interest in recent *** The intestinal barrier field is developing rapidly with extensive *** the gut microbiota and dietary metabolism to regulate the intestinal barrier has shown promising prospective applications and has generated broad *** importance of the intestinal barrier in IBD is gradually being fully recognized,providing a new therapeutic perspective for improving inflammation and prognosis.

关键词： Intestinal barrier Inflammatory bowel disease Bibliometrics Visualization Hotspots

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鲜食花生‖鲜食玉米高值化生产技术

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中国油料作物学报 2024年第3期46卷 518-523页

作者：南镇武孟维伟张佳蕾郭峰王建国刘柱张正万书波山东省农业科学院山东济南250100

在玉米花生带状复合种植技术的基础上,利用鲜食玉米生育期短、鲜食花生提前收获的特点,创新发展了鲜食花生‖鲜食玉米高值化生产技术,该技术在黄淮地区可以实现鲜食花生‖鲜食玉米一年两季种植。本文通过分析该技术在适宜模式、品种和... 详细信息

在玉米花生带状复合种植技术的基础上,利用鲜食玉米生育期短、鲜食花生提前收获的特点,创新发展了鲜食花生‖鲜食玉米高值化生产技术,该技术在黄淮地区可以实现鲜食花生‖鲜食玉米一年两季种植。本文通过分析该技术在适宜模式、品种和机械的选择以及抢墒播种、水肥管理、病虫草防控、旺长调控、收获与储运等环节的关键要点,及其主要优势和应用前景,以期为该技术在粮油主产区推广应用提供技术支撑。

关键词：鲜食花生鲜食玉米带状复合种植高值化

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Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction

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Neural Regeneration Research 2022年第6期17卷 1310-1317页

作者： Lu-Lu Yao Si Yuan zhen-nan wu Jian-Yu Luo Xiao-Rong Tang Chun-Zhi Tang Shuai Cui Neng-Gui Xu South China Research Center for Acupuncture and Moxibustion Medical College of Acupuncture Moxibustion and RehabilitationGuangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Research Institute of Acupuncture and Meridian Anhui University of Chinese MedicineHefeiAnhui ProvinceChina

Acupuncture at acupoints Baihui(GV20)and Dazhui(GV14)has been shown to promote functional recovery after ***,the contribution of the contralateral primary sensory cortex(S1)to recovery remains *** this study,unilateral local ischemic infarction of the primary motor cortex(M1)was induced by photothrombosis in a mouse ***(EA)was subsequently performed at acupoints GV20 and GV14 and neuronal activity and functional connectivity of contralateral S1 and M1 were detected using in vivo and in vitro electrophysiological recording *** results showed that blood perfusion and neuronal interaction between contralateral M1 and S1 is impaired after unilateral M1 *** neuronal excitability and activity were also disturbed,which was rescued by ***,the effectiveness of EA treatment was inhibited after virus-mediated neuronal ablation of the contralateral *** conclude that neuronal activity of the contralateral S1 is important for EA-mediated recovery after focal M1 *** study provides insight into how the S1-M1 circuit might be involved in the mechanism of EA treatment of unilateral cerebral *** animal experiments were approved by the Committee for Care and Use of Research Animals of Guangzhou University of Chinese Medicine(approval No.20200407009)April 7,2020.

关键词： brain plasticity electroacupuncture electrophysiology recording neuronal activity primary motor cortex primary sensory cortex stroke

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Millet/peanut intercropping at a moderate N rate increases crop productivity and N use efficiency,as well as economic benefits,under rain-fed conditions

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Journal of Integrative Agriculture 2023年第3期22卷 738-751页

作者： LIU Zhu nan zhen-wu LIN Song-ming YU Hai-qiu XIE Li-yong MENG Wei-wei ZHANG zheng WAN Shu-bo Shandong Academy of Agricultural Sciences Jinan 250100P.R.China Agronomy College Shenyang Agricultural UniversityShenyang 110866P.R.China College of Life Sciences Shandong Normal UniversityJinan 250014P.R.China

Cereal and legume intercropping has been widely adopted to increase crop productivity in sustainable farming systems *** different intercropping combinations,millet and peanut intercropping can be adapted to most waterlimited ***,there are few studies on the differences in yield characteristics and nitrogen use efficiency between millet/peanut intercropping and monocultures under different nitrogen (N) application *** objective of this study was to determine the yield advantages and economic benefits,as well as the appropriate N application rate,of millet/peanut intercropping.A two-yearfield experiment was conducted with three cropping patterns (monoculture millet,monoculture peanut and millet/peanut intercropping) and four N rates (0,75,150 and 225 kg ha^(-1)).The results showed that the land equivalent ratio (LER) and net effect (NE) of the intercropping system reached their highest levels at the N input of 150 kg ha^(-1)in 2018 and 2019 (1.04 for LER,0.347 Mg ha^(-1)for NE,averaged across two years).Millet was the dominant crop in the intercropping system (aggressivity of millet and peanut (Amp)>0,competitive ratio of millet and peanut (CRmp)>1),and millet yields achieved their highest values at N inputs of 225 kg ha^(-1)for monoculture and 150 kg ha^(-1)for *** reached its highest levels with N inputs of 150 kg ha^(-1)for all planting patterns over the two *** combined with an N input of 150 kg ha^(-1)achieved the highest net income of 2 791 USD ha^(-1),with a benefit-cost ratio of 1.56,averaged over the two *** the perspective of economics and agricultural sustainable development,millet/peanut intercropping at 150 kg N ha^(-1)seems to be a promising alternative to millet or peanut monoculture.

关键词： millet peanut intercropping N input yield economics

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Engineering high-performance dielectric chiral shells with enhanced chiral fields for sensitive chiral biosensor

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Rare Metals 2024年第3期43卷 1197-1206页

作者： Yi-Fan Wang Shan-Shan Huang zhen-Dong Dai Shi-Lin Xian Xuan-nan wu Fu-Hua Gao Yi-Dong Hou College of Physics Sichuan UniversityChengdu610065China Graduate School of Sichuan University Sichuan UniversityChengdu610065China

Chiral metamaterials have been a topic of significant research interest in recent years due to their potential for various applications in nanophotonic devices and chiral ***,the intrinsic Ohmic loss in surface plasmonic resonance has limited their practical use,resulting in large light dissipation and weak chiroptical ***,we report on the development of high-performance dielectric chiral shells(DCS)through a two-step Si deposition process on a self-assembled microsphere *** form DCS sample completely oyercomes the cancelation effect originated from the disorder property of the micro-sphere monolayer in macroscale,and at a wavelength of approximately 710 nm,the measured optimal chiral signal(g-factor)and transmittance can reach up to 0.7 and 0.3,*** strong chiroptical effect comes from the asymmetric circular displacement currents(i.e.,magnetic modes)enabled by the specific shell *** chiral shell geometry,electromagnetic properties,sensor sensitivity of chiral molecules and figure of merit are systematically *** DCSs demonstrate highly sensitive detection of chiral biomolecules owing to their easily accessible geometry and enhanced uniform chiral field.

关键词： Dielectric chiral shells(DCS) Si deposition Magnetic resonance Highly sensitive sensor Chiral field

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Left ventricular thrombosis caused cerebral embolism during venoarterial extracorporeal membrane oxygenation support: A case report

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World Journal of Clinical Cases 2024年第5期12卷 973-979页

作者： Yao-Bang Bai Feng Zhao zhen-Hua wu Guo-Ning Shi nan Jiang Intensive Care Unit Department of Cardiac SurgeryTianjin Chest HospitalTianjin 300222China Department of Cardiac Surgery Tianjin Chest HospitalTianjin 300222China

BACKGROUND Venoarterial(VA)extracorporeal membrane oxygenation(ECMO),an effective short-term circulatory support method for refractory cardiogenic shock,is widely ***,retrospective analyses have shown that VA-ECMO-assisted cases were associated with a relatively high mortality rate of approximately 60%.Embolization in important organs caused by complications of left ventricular thrombosis(LVT)during VA-ECMO is also an important *** the incidence of LVT during VA-ECMO is not high,the consequences of embolization are *** SUMMARY A 37-year-old female patient was admitted to hospital because of fever for 4 d and palpitations for 3 *** excluding the diagnosis of coronary heart disease,we established a diagnosis of“clinically explosive myocarditis”.The patient still had unstable hemodynamics after drug treatment supported by VA-ECMO,with heparin for *** day 4 of ECMO support,a left ventricular thro-mbus attached to the papillary muscle root of the mitral valve was found by transthoracic *** ventricular decompression was performed and ECMO was successfully removed,but the patient eventually died of multiple cerebral *** LVT with high mobility during VA-ECMO may cause embolism in important ***,a"wait and see"strategy should be avoided.

关键词： Venoarterial extracorporeal membrane oxygenation Left ventricular thrombosis Cerebral embolism Magnetic Resonance Imaging Therapy Case report

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Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis(Invited)

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激光与光电子学进展 2024年第6期61卷 260-271页

作者： Liu zhen wu Yang Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina

The last two decades have witnessed the invention and development of super-resolution microscopy(SRM)that breaks the diffraction limit of light and pushes the fluorescence microscopy resolution to several *** SRM is widely used in biological studies,such as resolving subdiffraction structures,molecular mapping,tracking single molecules,probing protein-protein interactions,and observing organelle dynamics,its direct application in translational medicine,such as disease diagnosis,is still *** their small size,cilia play a crucial role as organelles in cell signaling and motility,with defects in cilia leading to *** to other miniature organelles and macromolecular complexes,cilia are ideal for super-resolution *** this review,we will 1)introduce cilia and ciliopathy,2)show how SRM extends our knowledge of cilia,and 3)focus on how SRM improves the diagnosis of motile ciliopathies.

关键词： diagnosis limit spite

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An interlaminar damage shell model for typical composite structures

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Chinese Journal of Aeronautics 2024年第1期37卷 118-137页

作者： Jie ZHOU zhen wu zhengliang LIU Xiaohui REN School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China National Key Laboratory of Strength and Structural Integrity Xi’an 710065China School of Mechanical Engineering Xi’an Aeronautical UniversityXi’an 710065China

Using the plate/shell elements in commercial software,accurate analysis of interlaminar initial damage in typical composite structures is still a challenging *** propose an accurate and efficient model for analysis of interlaminar initial damage,the following work is carried out:(A)A higher-order theory is firstly proposed by introducing the local Legendre polynomials,and then a novel shell element containing initial damage prediction is developed,which can directly predict transverse shear stresses without any postprocessing *** variables at each node are independent of number of layers,so the proposed model is more efficient than the 3D-FEM.(B)Compression experiment is carried out to verify the capability of the proposed *** results obtained from the proposed model are in good agreement with experimental data.(C)Several examples have been analyzed to further assess the capability of the proposed model by comparing to the 3D-FEM ***,accuracy and efficiency have been evaluated in different damage criterion by comparing with the selected *** numerical results show that the proposed model can well predict the initial interlaminar damage as well as other ***,the model is implemented with UEL subroutine,so that the present approach can be readily utilized to analyze the initial damage in typical composite structures.

关键词： Compression experiment Finite element method Initial damage Interlaminar stress Plate/shell element

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Double-stranded DNA-nucleic acid dye complex-sensitized biocatalytic photosynthesis:Base pairing-switched regeneration of nicotinamide cofactor

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Journal of Energy Chemistry 2024年第7期94卷 618-624页

作者： zhen Dong Yanying Wang Dan Li Peng wu College of Chemistry Sichuan UniversityChengdu 610064SichuanChina Analytical&Testing Centre State Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064SichuanChina School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanChina

Photo-biocatalysis,the combination of photosensitization and biocatalysis,is an emerging solution for sunlight-based renewable *** is thus important to develop light antennas with both good light har-vesting and efficient electron ***,the intriguing electrical conductivity of dsDNA and its host effect(for nucleic acid dyes to harvest light)were explored simultaneously to develop a dsDNA-based light antenna for *** SYBR Green I(SG)as the example of the nucleic acid dye,the proposed SG-dsDNA system was found to be capable for visible-light-driven reduced nicotinamide adenine dinucleotide(NADH)regeneration,and the turnover frequency of which(1.35 min^(-1))exceeded most of the existing photocatalytic *** SG can only be hosted by dsDNA,meanwhile dsDNA can be formed through hybridization between single strand DNA and its complementary strand,the pro-posed system adds an extra control of the photocatalytic activity(DNA base pairing-based switch).When integrating the SG-dsDNA system with NADH-dependent horse liver alcohol dehydrogenase(HLADH),successful synthesis of 2-phenylpropanol(a crucial intermediates of profens manufacturing)was achieved.

关键词： Photosynthesis dsDNA SYBRGreenI TICT 2-phenylpropanol

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High-throughput and simultaneous inertial separation of tumor cells and clusters from malignant effusions using spiral-contraction-expansion channels

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Microsystems & nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren Dan wu Zhonghua Ni nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

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