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Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms

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Chinese Chemical Letters 2024年第3期35卷 66-75页

作者： Ya-nan tang Dingding Jiang Xuejun Wang Yunqi Liu Dacheng Wei State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Institute of Molecular Materials and Devices Fudan UniversityShanghai 200433China

The outbreak of COVID-19 has drawn great attention around the world.SARS-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation period.In particular,the emergence of asymptomatic infections has made the epidemic even more severe.Therefore,early diagnosis and timely management of suspected cases are essential measures to control the spread of the virus.Developing simple,portable,and accurate diagnostic techniques for SARS-CoV-2 is the key to epidemic prevention.The advantages of point-of-care testing technology make it play an increasingly important role in viral detection and screening.This review summarizes the point-of-care testing platforms developed by nucleic acid detection,immunological detection,and nanomaterial-based biosensors detection.Furthermore,this paper provides a prospect for designing future highly accurate,cheap,and convenient SARS-CoV-2 diagnostic technology.

关键词： COVID-19 Point-of-care testing platforms Nucleic acid detection Asymptomatic infection Biosensors

Endoscopic submucosal dissection combined with adjuvant chemotherapy for early-stage neuroendocrine carcinoma of the esophagus:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3164-3169页

作者： nan tang Zhen Feng Department of Gastroenterology Shanghai Xuhui Center HospitalShanghai 200031China

BACKGROUND Neuroendocrine carcinoma(NEC)of the esophagus is rare and highly aggressive,and lacks biological features.Currently,there are no established standard treatments for this cancer.In this report,we describe a patient with large-cell NEC of the esophagus who was successfully treated using endoscopic submucosal dissection(ESD)combined with adjuvant chemotherapy.CASE SUMMARY A 55-year-old woman presented with intermittent mild dysphagia for 2 mo.Gastroscopy revealed a disc-shaped protruding lesion about 18 mm×18 mm in size on the upper esophagus.Endoscopic ultrasonography demonstrated that the bulged lesion originated from the muscularis mucosa.We assessed en bloc resections using ESD for therapeutic diagnosis to devise a safe and appropriate treatment.Histopathological examination revealed a poorly differentiated neoplasm comprising of large cells with marked nuclear atypia and multifocal necrosis.In addition,the specimens had a negative horizontal margin and vertical margins.Depth of invasion was classified as submucosa 2(SM2)without lymphovascular invasion.These histopathological results were consistent with a diagnosis of esophageal NEC,large cell type.Adjuvant therapy has been considered for ESD patients with SM2/SM3 lesions and patients with poorly differentiated lesions.After comprehensive consideration,we initiated combination treatment,i.e.,ESD plus adjuvant chemotherapy.The patient remained disease-free at the 2-year follow-up.CONCLUSION En bloc resection approach using ESD may play a vital role as a diagnostic and therapeutic modality for esophageal NEC.

关键词： Esophagus Neuroendocrine carcinoma Endoscopy Dissection Case report

New horizons for therapeutic applications of nanozymes in oral infection

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Particuology 2023年第9期80卷 61-73页

作者： Yanting Cai Yue Li Jin Zhang nan tang Xingfu Bao Zhen Liu Department of Orthodontics Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilinUniversityChangchun130021China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of ChemicalTechnologyBeijing100029China

As a category of nanomaterials with excellent catalytic efficiency,great substrate specificity,and highrecovery efficiency,nanozymes have attracted increasing attention in various biomedical applications.Currently,numbers of nanozyme-assisted strategies have been well developed for the theranostics ofvarious diseases by taking advantages of their multienzyme-like characteristics,low cost,and highstability.As the most prevalent oral diseases,oral infection poses a global hazard to human health,andcurrent therapeutic options are insufficient to resolve all the clinical issues.Based on their admirableactivity,nanozymes can be frequently employed in the identification and treatment of various oral infectious disorders.Herein,we provide a brief review focused on the classification of nanozymes,analysesof nanozyme-based antibacterial mechanism,research progress in oral bacterial control,and representative studies of nanozyme-assisted oral inflammatory management.Moreover,major challenges andpotential opportunities regarding the use of nanozymes in oral infectious diseases are also highlightedand discussed.This review not only summarizes the recent studies of nanozymes in oral infection butalso promotes the further development of enzyme-mimetic strategies towards various oral diseases.

关键词： nanozymes Oral infection Antibacterial therapy Anti-inflammatory therapy

Severe Klebsiella pneumoniae pneumonia complicated by acute intra-abdominal multiple arterial thrombosis and bacterial embolism:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11101-11110页

作者： Xiao-Li Bao nan tang Yang-Zhong Wang Department of Respiratory and Critical Care Medicine Chongqing University Fuling HospitalChongqing 408000China

BACKGROUND Klebsiella pneumoniae(K.pneumoniae)is a clinically common Gram-negative bacillus that can cause community-and hospital-acquired infections and lead to pneumonia,liver abscesses,bloodstream infections,and other infectious diseases;however,severe pneumonia caused by hypervirulent K.pneumoniae(hv Kp)complicated by acute intra-abdominal multiple arterial thrombosis and bacterial embolism is rarely seen in the clinical setting and has not been reported in the literature.CASE SUMMARY A 51-year-old man was hospitalized with fever and dyspnea.Persistent mild pain in the middle and upper abdomen began at dawn on the 3rd day following admission and developed into persistent severe pain in the left upper abdomen 8h later.Based on chest computed tomography(CT),bronchoscopy,bronchoalveolar lavage fluid metagenomic next-generation sequencing,abdominal aortic CT angiography(CTA),and culture of the superior mesenteric artery embolus,adult community-acquired severe hv Kp pneumonia complicated by acute intraabdominal multiple arterial thrombosis and bacterial embolism was diagnosed.Notably,he recovered and was discharged from the hospital after receiving effective meropenem anti-infection,endovascular contact thrombolytic,and systemic anticoagulant therapies and undergoing percutaneous thrombus aspiration.Ten days later,the patient returned to the hospital for abdominal CTA examination,which indicated blocked initial common pathway of the celiac trunk and superior mesenteric artery,and local stenosis.Therefore,celiac trunk artery stenting was performed in Chongqing Hospital,and postoperative recovery was good.CONCLUSION We report a case of hv Kp severe pneumonia complicated by acute intra-abdominal multiple arterial thrombosis and bacterial embolism and suggest that clinicians should consider the possibility of a Gram-negative bacillus infection and conduct effective pathogen detection in a timely fashion when managing patients with severe community-acquired pneumonia before obtaining bacteriologic and drug sensitivity

关键词： Klebsiella pneumoniae Severe pneumonia Acute mesenteric ischemia Superior mesenteric artery embolism Case report

The diversity of adult lung epithelial stem cells and their niche in homeostasis and regeneration

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Science China(Life Sciences) 2021年第12期64卷 2045-2059页

作者： Yanxiao Wang nan tang National Institute of Biological Sciences Beijing 102206China

The adult lung,a workhorse for gas exchange,is continually subjected to a barrage of assaults from the inhaled particles and pathogens.Hence,homeostatic maintenance is of paramount importance.Epithelial stem cells interact with their particular niche in the adult lung to orchestrate both natural tissue rejuvenation and robust post-injury regeneration.Advances in single-cell sequencing,lineage tracing,and living tissue imaging have deepened our understanding about stem cell heterogeneities,transition states,and specific cell lineage markers.In this review,we provided an overview of the known stem/progenitor cells and their subpopulations in different regions of the adult lung,and explored the regulatory networks in stem cells and their respective niche which collectively coordinated stem cell quiescence and regeneration states.We finally discussed relationships between dysregulated stem cell function and lung disease.

关键词： lung stem cell regeneration niche

Silencing ribosomal protein L4 enhances the inhibitory effects of triptolide on non-small cell lung cancer cells by disrupting the mouse double minute 2 protein–P53 tumor suppressor pathway

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生物细胞(英文) 2023年第9期47卷 2009-2026页

作者： nan tang YAJING ZHAN JIAYAN MAO ANKANG YIN WEI WANG JUAN WANG School of Medical Technology and Information Engineering Zhejiang Chinese Medical UniversityHangzhou310053China Zhejiang Chinese Medical University Hangzhou310053China Department of Clinical Laboratory Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang ProvinceZhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou310012China

Non-small cell lung cancer(NSCLC)is a malignant tumor with high incidence worldwide.Triptolide(TP),extracted from Tripterygium wilfordii Hook F,exhibits potent broad-spectrum antitumor activity.Although some mechanisms through which TP inhibits NSCLC are well understood,those that involve ribosomal proteins remain yet to be understood.In this study,the transcriptome and proteome were integrated and analyzed.Our data indicated ribosomal protein L4(RPL4)to be a core hub protein in the protein-protein interaction network.RPL4 is overexpressed in NSCLC tissues and cells.Transfection with siRPL4 or TP treatment alone arrested the cell cycle in the G1 phase,induced cell apoptosis,and repressed cell invasion.Compared to treating cells with TP alone or siRPL4,treating them with siRPL4–TP enhanced the inhibition of NSCLC cells.Reduced RPL4 expression reinforced the inhibitory effects of TP on NSCLC cells by disrupting the MDM2-P53 pathway and by altering the expression of PARP1/Snail/cyclin D1.In vivo assays verified that TP induced cell apoptosis and reduced RPL4 expression in xenografts.These findings provide clues to facilitate the development of effective TP-based therapeutic strategies to kill NSCLC cells.

关键词： NSCLC RPL4 Triptolide Proteomics Transcriptome

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数据要素赋能创新模式演进

社会科学战线 2024年第3期345卷 51-58页

作者：潘家栋肖文唐楠中共浙江省委党校工商管理教研部浙江杭州311123 浙江大学经济学院浙江杭州310058 上海财经大学金融学院上海200433

数据要素赋能创新模式演进是数字时代创新发展的必然趋势。创新模式演进是要素优化组合、重构生产函数的过程,通过要素融合共生、主体协作共生、产业融通共生实现资源优化配置,形成创新演进的内在路径。数据要素作为新型生产要素,可以... 详细信息

数据要素赋能创新模式演进是数字时代创新发展的必然趋势。创新模式演进是要素优化组合、重构生产函数的过程,通过要素融合共生、主体协作共生、产业融通共生实现资源优化配置,形成创新演进的内在路径。数据要素作为新型生产要素,可以优化创新要素配置,变革创新组织体系,促使创新链、产业链深度融合,构建创新空间网络,赋能创新模式演进。数据要素高度集聚也会导致平台垄断,遏制创新效率的提高。发挥数据要素价值,赋能创新模式演进需要加速数字技术攻关及应用、加大科研数据共享的力度、加快完善数据要素流通机制、加强数据要素规范使用保障等。

关键词：数据要素创新模式资源配置经济—技术特征平台垄断

DEEPEYE: An Automatic Big Data Visualization Framework

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Big Data Mining and Analytics 2018年第1期1卷 75-82页

作者： Xuedi Qin Yuyu Luo nan tang Guoliang Li Department of Computer Science Tsinghua University Qatar Computing Research Institute HBKU

Data visualization transforms data into images to aid the understanding of data; therefore, it is an invaluable tool for explaining the significance of data to visually inclined people. Given a(big) dataset, the essential task of visualization is to visualize the data to tell compelling stories by selecting, filtering, and transforming the data, and picking the right visualization type such as bar charts or line charts. Our ultimate goal is to automate this task that currently requires heavy user intervention in the existing visualization systems. An evolutionized system in the field faces the following three main challenges:(1) Visualization verification: to determine whether a visualization for a given dataset is interesting, from the viewpoint of human understanding;(2) Visualization search space: a "boring" dataset may become interesting after an arbitrary combination of operations such as selections,joins, and aggregations, among others;(3) On-time responses: do not deplete the user's patience. In this paper,we present the DEEPEYE system to address these challenges. This system solves the first challenge by training a binary classifier to decide whether a particular visualization is good for a given dataset, and by using a supervised learning to rank model to rank the above good visualizations. It also considers popular visualization operations, such as grouping and binning, which can manipulate the data, and this will determine the search space. Our proposed system tackles the third challenge by incorporating database optimization techniques for sharing computations and pruning.

关键词： big data automatic data visualization visualization verification visualization ranking visualization search space

Single-cell RNA sequencing profiling of the effects of aging on alveolar stem cells

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Science China(Life Sciences) 2019年第8期62卷 1028-1037页

作者： Tingting Lv Kewu Jiang Jiawen Wang nan tang Huaping Dai Chen Wang Department of Pulmonary and Critical Care Medicine Center of Respiratory Medicine China-Japan Friendship Hospital National ClinicalResearch Center for Respiratory Diseases Institute of Respiratory Medicine Chinese Academy of Medical Sciences Beijing100029China Graduate School of Peking Union Medical College Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing100005China National Institute of Biological Sciences Beijing102206China

The aging of alveolar stem cells has been linked to many chronic lung diseases, including pulmonary fibrosis. However, the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have not been well characterized. Here we conducted a single-cell RNA sequencing(scRNA-seq) analysis of alveolar stem cells of 3-month-old and 12-month-old mice to characterize the aging effect on alveolar stem cells. Our results have shown that the transcriptomes of alveolar stem cells of 3-month-old and 12-month-old mice are not significantly different under the steady condition. However, after a bleomycin-induced lung injury, the alveolar stem cells of 12-month-old mice show enhanced inflammatory responses and decreased lipid metabolism. Our study suggests a close relationship among aging, lipid metabolism, inflammatory responses and chronic lung diseases.

关键词： single-cell RNA sequencing (scRNA-seq) aging pulmonary alveolar stem cells inflammation response lipid metabolism