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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah Mona Al Hammad Fatima ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher mustafa mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

Evaluation of the Neurodevelopmental Outcome of Toddlers with Spinal Dysraphism after Surgical Repair Using ASQ-3^™ Scores

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Open Journal of Modern Neurosurgery 2024年第1期14卷 14-29页

作者： Mujahid Imam Fawaz Eljili Marhoom Sawsan Aldeaf ali Awad Ahmed Zidan mohamed mustafa Ahmed Sanna Taha Neurosurgery Department National Center for Neurological Sciences (NCNS) Khartoum Sudan Neurosurgery Department Royal Care International Hospital Khartoum Sudan Al Ribat Neurospine Center Khartoum Sudan Neurosurgery Department Haj Almardi (Al Tamyouz) Hospital Khartoum Sudan Neurosurgery Department Al Jazeera Trauma Center Khartoum Sudan

Background: Spinal dysraphism represents a wide spectrum of congenital abnormalities of the spine. Myelomeningocele is considered the most common malformation and the most common we saw in our community, with its morbidity problems seen commonly in the postoperative period. ASQ-3TM Scores are the ages and stages questionnaire, third edition, and represent a tool to assess the development progress, especially in toddlers. Objectives: Evaluation of neurodevelopmental outcome among Sudanese toddlers with spinal dysraphism after surgical closure with or without a VP shunt using ASQ-3TM Scores. Methodology: This is a retrospective hospital-based study of 84 patients who underwent myelomeningocele repair at the National Center for Neurological Sciences (NCNS) during the period from 2017 up to 2019. Data were collected through a constructed questionnaire, including ASQ-3TM Scores. Data were processed and analyzed using the Statistical Package for Social Science (SPSS) computer program. Version 25. Results: 84 patients were included in this study;all patients were diagnosed with spinal dysraphism. Out of them, 51 (60.7%) were 2 years old, 33 (39.3%) were 3 years old, 45 (53.6%) were male, 45 (53.6%) of patients mothers attended ANC irregularly, and 54 (64.3%) their mothers didn’t receive folate supplements. 44 (52.3%) of patients underwent MMC repair only, while 40 (47.7%) underwent MMC repair and VP shunt. The commonest postoperative complication was infection, reported in 12 (14.3%) of patients, followed by VP shunt revision in 9 (10.7%) of patients. Neurological assessment showed that the majority of patients need further assessment with a professional, 57 (67.9%) of children don’t walk, run, or climb like other toddlers as their parent’s state;also, half of patients (42, 50%) had medical problems, and 27 (32.1%) of their parent’s state that they do not talk like other toddlers their age. There was a statistically significant association

关键词： Toddlers’ Neurodevelopmental Outcome Myelomeningocele Evaluation ASQ-3™ Scores Spinal Dysraphasim Neurodevelopmental Outcome

Dynamics of Plate Equations with Memory Driven by Multiplicative Noise on Bounded Domains

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1492-1521页

作者： mohamed Y. A. Bakhet Abdelmajid ali Dafallah Jing Wang Qiaozhen Ma Fadlallah mustafa Mosa Ahmed Eshag mohamed Paride O. Lolika Makur Mukuac Chinor School of Mathematics University of Juba Juba South Sudan Department of Mathematics Faculty of Petroleum and Hydrology Engineering Alsalam University Almugled Sudan College of Mathematics and Statistics Northwest Normal University Lanzhou China Department of Mathematics and Physics Faculty of Education University of Kassala Kassala Sudan Department of Mathematics School of Education University of Juba Juba South Sudan

This article examines the dynamics for stochastic plate equations with linear memory in the case of bounded domain. We investigate the existence of solutions and bounded absorbing set by using the uniform pullback attractors on the tails estimates, and the asymptotic compactness of the random dynamical system is proved by decomposition method, and then we obtain the existence of a random attractor.

关键词： Plate Equations Random Attractors Memory Term Dynamical Systems

Prevalence of retinopathy of prematurity in Brunei Darussalam

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 381-384页

作者： nadir ali mohamed ali Joshua George Nayan Joshi Elizabeth Chong Department of Ophthalmology RIPAS Hospital Department of Neonatology RIPAS Hospital

AIM: To identify the prevalence of retinopathy of prematurity (ROP) among preterm neonates admitted to Department of Neonatology, RIPAS hospital, Brunei Darussalam. ·METHODS: We studied 67 preterm infants fulfilling the eligibility criteria for ROP screening. All infants studied were admitted to the Department of Neonatology, RIPAS Hospital, within a period of one year. Birth weight (BW), gestational age (GA), corrected age at each review, initial and final diagnoses and number of reviews required was recorded for each infant. Infants were followed up two weekly until they reach a corrected age of 40 weeks or complete vascularization was noted. Prevalence of ROP was identified. Descriptive analysis, regression analysis and independent-sample t-test were used to statistically check for differences between ROP and non -ROP groups. ·RESULTS: A total number of 201 ROP screenings were carried out for 67 preterm infants. Males outnumbered females (56.7%). The mean number of reviews per child was (3.19 ±1.1) times (range: 1 -6 times), the mean GA among the preterm babies examined was (29.5 ±2.6) weeks (range: 23 -36 weeks), and the mean BW was 1300 ±500g (range: 660 -3600g). The prevalence of ROP among the examined infants was 34.8% . Prevalence of threshold disease that required laser treatment was 25.4% . Prevalence of ROP among those with extremely low BW was 86.7% compared to 27.8% in those with very low BW. Respiratory distress and congenital heart diseases were significantly associated with higher incidence of ROP. ·CONCLUSION: Lower BW, lower GA and female gender are associated with higher risk of developing ROP among preterm infants in Brunei Darussalam.

关键词： retinopathy of prematurity preterm very low birth weight extremely low birth weight

Limbal leproma in lepromatous leprosy

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International Journal of Ophthalmology(English edition) 2011年第6期4卷 678-681页

作者： Irimpan Lazar Francis nadir ali mohamed ali Pemasiri Upali Telisinghe Nayan Joshi Department of Ophthalmology RIPAS Hospital Department of Pathology RIPAS Hospital

Dear Sir, W e are writing to you to present an unusual case of leproma growing at the limbus of a lepromatous leprosy patient. This the first report of ocular leprosy in Brunei, where leprosy is extremely rare. Leprosy, otherwise known as Hansen’s disease, is a chronic granulomatous communicable infection caused by Mycobacterium leprae and its genetic variant (Mycobacterium lepromatosis) [1]. A leproma is a superficial, ci

关键词： Limbal leproma in lepromatous leprosy oral Figure

Electrodes based on nano-tree-like vanadium nitride and carbon nanotubes for micro-supercapacitors

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Journal of Materials Science & Technology 2018年第6期34卷 976-982页

作者： nadir Ouldhamadouche Amine Achour Raul Lucio-Porto Mohammad Islam Shahram Solayman ali Arman Azin Ahmadpourian Hamed Achour Laurent Le Bri-zoual mohamed Abdou Djouadi Thierry Brousse Laboratoire de Génie Physique Université lbn Khaldoun BP P 78 Zaaroura 14000 Tiaret Algeria National Institute of Scientific Research 1650 Bd. Lionel-Boulet Varennes QCJ3X1P7 Canada Universidad Autónoma de Nuevo León Facultad de lngeniería Mecdnica y Eléctrica San Nicolas de los Garza 66450 Nuevo León Mexico Universidad Autónoma de Nuevo León Centro de lnnovación Investigación y Desarrollo en lngeniería y Tecnología Apodaca 66600 Nuevo León Mexico Deanship of Scientific Research Advanced Manufacturing Institute King Saud University P.O. Box 800 Riyadh 11421 Saucli Arabia Department of Physics Science and Research Branch Islamic Azad University Tehran Iran Vacuum Technology Group ACECR Sharif Branch Tehrun Iran Young Researchers and Elite Club Arak Branch Islamic Azad University Arak Iran Institute of Condensed Matter Physics Ecole Polytechnique Fédérale de Lausanne (EPFL) CH-1015 Lausanne Switzerland University of Rennes 1 Institut d'Electronique et de Télécommunications IETR - UMR CNRS 6164 Campus de Beaulieu -Bat 11D 263 Av General Leclerc 35042 Rennes cedex France Institut des MateriauxJean Rouxel (IMN) Universite de Nantes CNRS 2 rue de la Houssiniere BP32229 44322 Nantes Cedex 3 France Reseau sur le Stockage Electrochimique de l'Energie (RS2E) FR CNRS 3459 France

Vanadium nitride （VN） was deposited by DC-sputtering on a vertically aligned carbon nanotube （CNTs） template for the purpose of nano-structuration. This led to the fabrication of hierarchically composite electrodes consisting of porous and nanostructured VN grown on vertically aligned CNTs in a nano-treelike configuration for micro-supercapacitor application. The electrodes show excellent performance with an areal capacitance as high as 37.5 mF cm^-2 at a scan rate of 2 mV s^-1 in a 0.5 M K2504 mild electrolyte solution. Furthermore, the capacitance decay was only 15% after 20,000 consecutive cycles. Moreover, the capacitance was found to increase with VN deposit thickness. The X-ray photoelectron spectroscopy analyses of the electrodes before and after cycling suggest that the oxide layers that form at the VN surface is the responsible for the redox energy storage in this material. Such electrodes can compete with other transition metal nitride based electrodes for micro-supercapacitors.

关键词： Vanadium nitride CNTs Micro-supercapacitors Surface chemistry

Malicious URL Classification Using Artificial Fish Swarm Optimization and Deep Learning

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Computers, Materials & Continua 2023年第1期74卷 607-621页

作者： Anwer mustafa Hilal Aisha Hassan Abdalla Hashim Heba G.mohamed mohamed K.Nour Mashael M.Asiri ali M.Al-Sharafi Mahmoud Othman Abdelwahed Motwakel Department of Electrical and Computer Engineering International Islamic University Malaysia 53100 Kuala LumpurMalaysia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia Department of Electrical Engineering College of EngineeringPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Computer Science College of Computers and Information TechnologyUniversity of BishaSaudi Arabia Department of Computer Science Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt

Cybersecurity-related solutions have become familiar since it ensures security and privacy against cyberattacks in this digital *** Uniform Resource Locators(URLs)can be embedded in email or Twitter and used to lure vulnerable internet users to implement malicious data in their *** may result in compromised security of the systems,scams,and other such *** attacks hijack huge quantities of the available data,incurring heavy financial *** the same time,Machine Learning(ML)and Deep Learning(DL)models paved the way for designing models that can detect malicious URLs accurately and classify *** this motivation,the current article develops an Artificial Fish Swarm Algorithm(AFSA)with Deep Learning Enabled Malicious URL Detection and Classification(AFSADL-MURLC)*** presented AFSADL-MURLC model intends to differentiate the malicious URLs from genuine *** attain this,AFSADL-MURLC model initially carries out data preprocessing and makes use of glove-based word embedding *** addition,the created vector model is then passed onto Gated Recurrent Unit(GRU)classification to recognize the malicious ***,AFSA is applied to the proposed model to enhance the efficiency of GRU *** proposed AFSADL-MURLC technique was experimentally validated using benchmark dataset sourced from Kaggle *** simulation results confirmed the supremacy of the proposed AFSADL-MURLC model over recent approaches under distinct measures.

关键词： Malicious URL cybersecurity deep learning machine learning metaheuristics gated recurrent unit

LASIK治疗苏丹青少年难治性屈光参差性弱视(英文)

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国际眼科杂志 2009年第1期9卷 21-24页

作者： Kamal Hashim Binnawi Sara Mursi nadir ali mohamed ali 联邦卫生部国家防盲计划办公室苏丹喀士穆

目的:评价准分子激光原位角膜磨镶术(LASIK)联合遮盖疗法治疗青少年屈光参差性弱视的疗效,并将其与传统光学矫正联合遮盖疗法的疗效进行比较。方法:回顾性病例对照研究,屈光参差性弱视患者19例,年龄10～17岁。A组包括患屈光参差性弱视... 详细信息

目的:评价准分子激光原位角膜磨镶术(LASIK)联合遮盖疗法治疗青少年屈光参差性弱视的疗效,并将其与传统光学矫正联合遮盖疗法的疗效进行比较。方法:回顾性病例对照研究,屈光参差性弱视患者19例,年龄10～17岁。A组包括患屈光参差性弱视的青少年10例,光学矫正联合遮盖疗法后,他们的视力不能改善。这些患者后接受LASIK联合遮盖疗法。B组包括年龄相匹配的屈光参差性弱视患者9例作为对照,他们适应光学矫正联合遮盖疗法。分析A组的术后视力,并与B组进行比较。结果:A组,术前平均球性屈光不正度数为-8.9±5.2D,术后为-1.9±2.0D;术前平均最佳矫正视力为0.25±0.18,治疗后提高至0.50±0.26。B组,治疗前平均最佳矫正视力为0.27±0.18,治疗后提高至0.50±0.28。两组治疗后最佳矫正视力相比较,无统计学差异。结论:对于经过传统的光学矫正联合遮盖疗法而不能提高视力的青少年屈光参差性弱视患者,LASIK为他们提供了一个可行的治疗方法,其治疗效果与传统疗法相当。

关键词：准分子激光原位角膜磨镶术屈光参差弱视青少年

疑似自然消退型视网膜母细胞瘤伴牵引型视网膜脱离和晶状体脱位1例(英文)

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国际眼科杂志 2009年第3期9卷 423-424页

作者： Visvaraja Subrayan nadir ali mohamed ali Dinesh Kumar Patel 马来亚大学医学院眼科马来西亚吉隆坡

我们报告了1例疑似盲眼中自然消退型视网膜母细胞瘤病例。肿瘤稳定,无眼外扩散长达20a。其他症状包括:带状角膜病变,白瞳,晶状体脱位,视网膜肿块钙化和牵引型视网膜脱离。

关键词：视网膜母细胞瘤钙化牵引型视网膜脱离