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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos végvári Marion Arce valentina Pérez Marcela Alcota Alicia Morales Rolando vernal Mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RnA sequencing(scRnA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SnCA,CA1,HBB,SLC4A1,and AnK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SnCA,FTH1,HSPB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRnA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

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LeafSpotnet:A deep learning framework for detecting leaf spot disease in jasmine plants

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Artificial Intelligence in Agriculture 2024年第2期12卷 1-18页

作者： Shwetha v Arnav Bhagwat vijaya Laxmi Department of Electrical and Electronics Engineering Manipal Institute of TechnologyManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia

Leaf blight spot disease,caused by bacteria and fungi,poses a threat to plant health,leading to leaf discoloration and diminished agricultural *** response,we present a Mobilenetv3 based classifier designed for the Jasmine plant,leveraging lightweight Convolutional neural networks(Cnns)to accurately identify disease *** model integrates depth wise convolution layers and max pool layers for enhanced feature extraction,focusing on crucial low level features indicative of the *** preprocessing techniques,including data augmentation with Conditional GAn and Particle Swarm Optimization for feature selection,the classifier achieves robust *** on curated datasets demonstrates an outstanding 97%training accuracy,highlighting its *** world testing with diverse conditions,such as extreme camera angles and varied lighting,attests to the model's resilience,yielding test accuracies between 94%and 96%.The dataset's tailored design for Cnn based classification ensures result ***,the model's lightweight classification,marked by fast computation time and reduced size,positions it as an efficient solution for real time *** comprehensive approach underscores the proposed classifier's significance in addressing leaf blight spot dis-ease challenges in commercial crops.

关键词： Cnn Detection Leaf CGAn Augmentation Classification Swarm optimization Disease detection Tomato leaf Casava leaf

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A novel diurnal and seasonal variation analysis of BTEX in Bengaluru urban area

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Research in Cold and Arid Regions 2024年第1期16卷 14-19页

作者： H.n.Sowmya M.Dinamani G.P.Shivashankara H.K.Ramaraju B.S.Surendra vijaya v.Shanbhag R.Prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemistry Dayananda Sagar College of EngineeringBangalore 560078India Department of Physics GFGCVijayanagarBengaluru 560040India

In the urban atmosphere of Bengaluru, various volatile organic compounds(vOCs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have shown an increasing trend in concentration. The present research was conducted during summer and monsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru Metropolitan City. Hourly sample data was collected using a BTEX analyzer(Model GC955-600) and subsequently transformed into daily, monthly, and seasonal values. The study revealed distinct patterns in benzene concentrations. Benzene levels were lowest during the early morning hours, specifically from 1:00 *** 7:00 a.m.. Concentrations then increased from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corresponding to the morning and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic levels. These diurnal variations in benzene concentration are influenced by meteorological parameters. Comparing the two seasons, higher concentrations of Benzene, EthylBenzene, and MP-xylene were observed during the summer season. This increase is attributed to the elevated temperatures during summer, which promote the vaporization of BTEX compounds. Conversely, lower BTEX concentrations were recorded during the monsoon season due to the wet deposition process. The observed positive correlation(r > 0.5) among BTEX parameters strongly suggests a common source, most likely originating from vehicular emissions.

关键词： BTEX Summer variation Meteorological parameters Correlation

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Hepatic perivascular epithelioid cell tumors:Benign,malignant,and uncertain malignant potential

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World Journal of Gastroenterology 2024年第18期30卷 2374-2378页

作者： Marcelo Fabián Amante División Patología Hospital General de Agudos Cosme ArgerichBuenos Aires C1155AHAArgentina División Patología Hospital Alemán de Buenos AiresBuenos Aires C1155AHAArgentina

In 2013,the World Health Organization defined perivascular epithelioid cell tumor(PEComa)as“a mesenchymal tumor which shows a local association with vessel walls and usually expresses melanocyte and smooth muscle markers.”This generic definition seems to better fit the PEComa family,which includes angiomyolipoma,clear cell sugar tumor of the lung,lymphangioleiomyomatosis,and a group of histologically and immunophenotypically similar tumors that include primary extrapulmonary sugar tumor and clear cell myomelanocytic *** cell tumors with this immunophenotypic pattern have also had their malignant variants *** localizing to the liver,preoperative radiological diagnosis has proven to be very difficult,and most patients have been diagnosed with hepatocellular carcinoma,focal nodular hyperplasia,hemangioma,or hepatic adenoma based on imaging *** of a malignant variant of the liver have been ***,reports of malignant variants of these lesions have increased in recent ***,we support the use of the Folpe criteria,which in 2005 established the criteria for categorizing a PEComa as benign,malignant,or of uncertain malignant *** they are not considered ideal,they currently seem to be the best approach and could be used for the categorization of liver tumors.

关键词： PEComas Liver Pathology Malignant Benign Uncertain malignant potential

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Contributions to the knowledge of Antarctodon sobrali(Mammalia:Astrapotheria)from the Eocene of Antarctica

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Advances in Polar Science 2024年第1期35卷 48-62页

作者： Javier n.GELFO Consejo nacional de Investigaciones Científicasy Técnicas(COnICET) Buenos Aires C1425FQBArgentina División Paleontología vertebrados Museo de La PlataFacultad de Ciencias Naturales y Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Astrapotheria constitutes one of the five orders of extinct South American native ungulates,with a fossil record that also extends to the Eocene of the Antarctic *** contrast to the abundant specimens known for litoptern Sparnotheriodontidae and metatherians,astrapotheres are represented by scant remains assigned to the endemic Antarctodon sobrali and indeterminate astrapotheres,restricted to levels 35C_(u0)and 35n of the Cucullaea I Allomember of the La Meseta *** discovery of alower molar assignable to this species in the Eocene levels of Seymour(Marambio)Island,enables a revision of the diagnosis and the homologies of the dental characters used to describe this taxon.A reanalysis of its phylogenetic relationships reveals the nearly simultaneous presence of basal astrapotheres in the early Eocene of Itaboraí(Brazil),Patagonia,and West *** taxa are characterized by lacking dental specializations usually associated with more abrasive diets like terminal forms of Uruguaytheriinae and *** appears to have thrived on the Antarctic continent during the Early Eocene Climatic Optimum within the paleoclimatic context of a hot-house *** present conditions in Antarctica where no terrestrial mammals inhabit,the early Eocene climate was characterized by warmer temperatures and a biologically diverse environment rich in primary producers,dominated by nothofagus forests,encompassing both deciduous and evergreen forests,which supported a diverse assemblage of continental vertebrates.

关键词： Astrapotheria Antarctodon Eocene Seymour Island La Meseta Formation

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Computational study of flow separation in truncated ideal contour nozzles under high-altitude conditions

International Journal of Fluid Engineering

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International Journal of Fluid Engineering 2024年第1期 21-30页

作者： Ijas Muhammed v v Shamsia Banu n Abhilash Suryan vincent Lijo David Simurda Heuy Dong Kim College of Engineering Trivandrum Government Engineering College Thrissur Faculty of Mechanical Engineering Technical University of Liberec Andong national University

Flow separation in rocket nozzles has been studied mostly under sea-level conditions, which fail to take into account changes in ambient density and ambient pressure during the flight of a rocket. In the present study, numerical analysis is conducted of flow characteristics within a truncated ideal contour(TIC) nozzle to investigate the influence of ambient density and pressure on flow separation. Six different altitudes from a typical flight are considered, from a very low altitude to a high altitude. The flow is analyzed by varying the nozzle pressure ratios corresponding to these altitudes. Both cold flow and hot flow simulations are conducted. The locations of separation positions at various altitude conditions are accurately captured and are found to be in good agreement with experimental results. The results of the study establish that for a given nozzle pressure ratio, the flow separation point is shifted upstream with increasing altitude. This clearly points to a dependence of separation position on the altitude of operation for TIC rocket nozzles.

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CoopAI-Route: DRL Empowered Multi-Agent Cooperative System for Efficient QoS-Aware Routing for network Slicing in Multi-Domain SDn

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2449-2486页

作者： Meignanamoorthi Dhandapani v.vetriselvi R.Aishwarya College of Engineering Guindy Anna UniversityChennai600025India

The emergence of beyond 5G networks has the potential for seamless and intelligent connectivity on a global *** slicing is crucial in delivering services for different,demanding vertical applications in this ***-generation applications have time-sensitive requirements and depend on the most efficient routing path to ensure packets reach their intended ***,the existing IP(Internet Protocol)over a multi-domain network faces challenges in enforcing network slicing due to minimal collaboration and information sharing among network *** inter-domain routing methods,like Border Gateway Protocol(BGP),cannot make routing decisions based on performance,which frequently results in traffic flowing across congested paths that are never *** address these issues,we propose CoopAI-Route,a multi-agent cooperative deep reinforcement learning(DRL)system utilizing hierarchical software-defined networks(SDn).This framework enforces network slicing in multi-domain networks and cooperative communication with various administrators to find performance-based routes in intra-and ***-Route employs the Distributed Global Topology(DGT)algorithm to define inter-domain Quality of Service(QoS)***-Route uses a DRL agent with a message-passing multi-agent Twin-Delayed Deep Deterministic Policy Gradient method to ensure optimal end-to-end routes adapted to the specific requirements of network slicing *** evaluation demonstrates CoopAI-Route’s commendable performance in scalability,link failure handling,and adaptability to evolving topologies compared to state-of-the-art methods.

关键词： 6G multi-domain multi-agent routing DRL SDn

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Distributed Dynamic Load in Structural Dynamics by the Impulse-Based Force Estimation Algorithm

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2865-2891页

作者： Yuantian Qin Yucheng Zhang vadim v.Silberschmidt College of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing210016China Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLE113TUUK

This paper proposes a novel approach for identifying distributed dynamic loads in the time *** polynomial andmodal analysis,the load is transformed intomodal space for coefficient *** allows the distributed dynamic load with a two-dimensional form in terms of time and space to be simultaneously identified in the form of modal force,thereby achieving dimensionality *** Impulse-based Force Estimation Algorithm is proposed to identify dynamic loads in the time ***,the algorithm establishes a recursion scheme based on convolution integral,enabling it to identify loads with a long history and rapidly changing forms over ***,the algorithm introduces moving mean and polynomial fitting to detrend,enhancing its applicability in load *** aforementioned methodology successfully accomplishes the reconstruction of distributed,instead of centralized,dynamic loads on the continuum in the time domain by utilizing acceleration *** validate the effectiveness of the method,computational and experimental verification were conducted.

关键词： Distributed force estimation time domain deconvolution recursion

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Using fused filament fabrication to improve the tribocorrosion behaviour of 17-4 PH SS in comparison to other metal forming techniques

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Friction 2024年第10期12卷 2325-2343页

作者： Cristina GARCÍA-CABEZÓn Juan Alfonso nARAnJO Celia GARCÍA-HERnÁnDEZ Cristina BERGES Gemma HERRAnZ Fernando MARTÍn-PEDROSA Materials Engineering E.I.I.Universidad de ValladolidValladolid 47011Spain InEI-Escuela Técnica Superior de Ingeniería Industrial(ETSII) Universidad de Castilla La ManchaCastilla-La Mancha 13071Spain

Fused filament fabrication(FFF)is one of the additive manufacturing processes which has gained more interest because of its simplicity and *** technology is similar to the conventional metal injection moulding(MIM)process,consisting of the feedstock preparation of metal powder and polymer binders,followed by layer-by-layer 3D printing(FFF)or injection(MIM)to create green parts and,finally,debinding and ***,both technologies provide near-dense *** work presents an in-depth study of the processing method’s *** porosity,microstructure,hardness,corrosion,and tribocorrosion behaviour are compared for 17-4 PH SS samples processed from powder by additive manufacturing using FFF and MIM,as well as conventional powder metallurgy(PM)*** samples exhibited the highest macro and microhardness,while corrosion behaviour was similar for both MIM and FFF samples,but superior in comparison to conventional PM ***,the FFF-as fabricated samples displayed a significant improvement in tribocorrosion resistance that could be explained by the higher proportion of delta ferrite and retained austenite in their microstructure.

关键词： 17-4 PH SS fused filament fabrication(FFF) metal injection moulding(MIM) corrosion behaviour powder metallurgy(PM) tribocorrosion behaviour

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The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： D A Baghdasaryan v A Harutynyan E M Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(nPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different nPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the nPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

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